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The map label for this gene is glnS1 [H]

Identifier: 162139861

GI number: 162139861

Start: 2375469

End: 2377166

Strand: Direct

Name: glnS1 [H]

Synonym: Nmul_A2083

Alternate gene names: 162139861

Gene position: 2375469-2377166 (Clockwise)

Preceding gene: 82703198

Following gene: 82703204

Centisome position: 74.6

GC content: 52.94

Gene sequence:

>1698_bases
TTGAACGAAAAAGCTACACCTGGCGACGTAACGCTGTGCGCGTCCAATTTCATACGCAATATCATCGAAGAAGACAATCG
CACCGGCAAGTGGAACGGGCGGGTTGAAACGCGCTTCCCCCCCGAACCCAACGGCTACCTGCATATCGGTCATGCCAAAA
GCATTTGCCTAAATTTCGGCCTGGCGCGGGACTATAAAGGAATATGTCATCTGCGCTTCGATGACACCAACCCCGAAAAA
GAAGAGCAGGAGTATGTCGATTCAATAATGGATGCGGTAAGATGGCTCGGCTTCGAATGGGGCGAGTATCTGCACTATGC
GTCGGACTATTTTGACAAACTATACGAGTTTGCCGAATATCTCATCAAGCAGGGTAAAGCATACGTAGACAGCCTTACTG
CCGAGGAAATCCGCGCGTTGCGGGGCACGCTTACCGAGGCGGGCGAAAACAGCCCCTACCGCGACCGCTCCATCGAGGAA
AATCTTGACCTGTTTCGCCGCATGAAGGCGGGTGAGTTTCCTGACGGCGCTCACGTTCTGCGCGCCAGAATCGATATGGC
TTCCCCTAATATCAATCTGCGCGATCCCGTAATTTACCGGATTCGCCATGTCCGCCATCACCGGACGGGTGACAAATGGT
GTATTTATCCGATGTATGACTACACCCACTGCATATCGGATGCGCTGGAAAGGATCACGCACTCGCTGTGCACGCTGGAA
TTCGAGGATCACCGTCCCCTCTATGACTGGATACTGGATCGATTGACAGATGTTGTTCCCTGTCATCCGCAACAGATCGA
ATTCGCGCGTTTGAATCTCACCTACACCGTCATGAGCAAGCGCAAGCTGATCGAATTGGTCAGCGGGAGTTTTGTGGATG
GATGGGATGATCCGCGCATGAATACCCTTGCCGGAGTGAGACGCCGCGGTTATACACCGGAATCCATCCGCCTGTTTGCG
GAACGCATCGGCGTCAGCAAAGCCGATTCATGGATAGACATGGGCATTCTGGAAGAATGCCTGCGCGAAGACATGAATGA
GCGTGCGCAGCGGCGGCTGGCTATCCTCGCCCCCCTCAAGGTCGTTATCGATAACTATCCTGAAAATGCCGAGGAAGAGT
GCCTTGCCCCCAATCATCCCCAAAAGCCGGAATGGGGAAGCCGTATCGTACACCTGACGAAAACGATCTACATAGAACGC
AGTGATTTTATGGAGAATCCTCCCAAGGGGTATTTCCGCCTGTCACCTGGAGGCGAAGTAAGGTTGCGGTACGCCTACAT
CGTAAAATGCGTAGATGTTGTGAAAGGGGTCAATGGCGAAATCCTGGAAATCCATTGCACCTATGATCCGGACAGCAAGA
GCGGCACGCCCGGAGCCGATAAACGCAAGGTCAAGGGGAATATTCACTGGCTCTCAGCCGTCCACGCGCAACAAGCGGAA
GTACGGCTTTATGATCGCTTGTTCACTCAGGCTCACCCTGATACAGGCGGGCGGGACTATAAAGCATTTCTGAATCCGGA
TTCAAAGAAGGTCCTTGCAGCCTATGTCGAGCCCGTACTCATGACAGCACAACCTGAGGAACGTTTTCAATTCGAGCGTC
ATGGCTATTTCGTCGCAGATCTGAAGGAAACAAAATCGGGAAAACCTGTATTCAATCGCGCGGTCACCCTGCGTGACTCG
TGGGGAAAACCGGGTTGA

Upstream 100 bases:

>100_bases
CCGGGCAAGCACAAACGAACAGGAGAGAGCAGAACCGCGTTCCCGCTTGCCACGAATTCCCGGAAAAGACGAGCAGGAAT
TCCCTTTCGAGAGGTCCAGT

Downstream 100 bases:

>100_bases
TTTCGGACAAGTATGCTGGCTCCGCTGCAAGCAGGATAGCGCCAATTTGTGTGCTTTGCTCCCGCCGCCGGTTGAATGGA
CTGCTTGTATCGAGATATCA

Product: glutaminyl-tRNA synthetase

Products: NA

Alternate protein names: Glutamine--tRNA ligase; GlnRS [H]

Number of amino acids: Translated: 565; Mature: 565

Protein sequence:

>565_residues
MNEKATPGDVTLCASNFIRNIIEEDNRTGKWNGRVETRFPPEPNGYLHIGHAKSICLNFGLARDYKGICHLRFDDTNPEK
EEQEYVDSIMDAVRWLGFEWGEYLHYASDYFDKLYEFAEYLIKQGKAYVDSLTAEEIRALRGTLTEAGENSPYRDRSIEE
NLDLFRRMKAGEFPDGAHVLRARIDMASPNINLRDPVIYRIRHVRHHRTGDKWCIYPMYDYTHCISDALERITHSLCTLE
FEDHRPLYDWILDRLTDVVPCHPQQIEFARLNLTYTVMSKRKLIELVSGSFVDGWDDPRMNTLAGVRRRGYTPESIRLFA
ERIGVSKADSWIDMGILEECLREDMNERAQRRLAILAPLKVVIDNYPENAEEECLAPNHPQKPEWGSRIVHLTKTIYIER
SDFMENPPKGYFRLSPGGEVRLRYAYIVKCVDVVKGVNGEILEIHCTYDPDSKSGTPGADKRKVKGNIHWLSAVHAQQAE
VRLYDRLFTQAHPDTGGRDYKAFLNPDSKKVLAAYVEPVLMTAQPEERFQFERHGYFVADLKETKSGKPVFNRAVTLRDS
WGKPG

Sequences:

>Translated_565_residues
MNEKATPGDVTLCASNFIRNIIEEDNRTGKWNGRVETRFPPEPNGYLHIGHAKSICLNFGLARDYKGICHLRFDDTNPEK
EEQEYVDSIMDAVRWLGFEWGEYLHYASDYFDKLYEFAEYLIKQGKAYVDSLTAEEIRALRGTLTEAGENSPYRDRSIEE
NLDLFRRMKAGEFPDGAHVLRARIDMASPNINLRDPVIYRIRHVRHHRTGDKWCIYPMYDYTHCISDALERITHSLCTLE
FEDHRPLYDWILDRLTDVVPCHPQQIEFARLNLTYTVMSKRKLIELVSGSFVDGWDDPRMNTLAGVRRRGYTPESIRLFA
ERIGVSKADSWIDMGILEECLREDMNERAQRRLAILAPLKVVIDNYPENAEEECLAPNHPQKPEWGSRIVHLTKTIYIER
SDFMENPPKGYFRLSPGGEVRLRYAYIVKCVDVVKGVNGEILEIHCTYDPDSKSGTPGADKRKVKGNIHWLSAVHAQQAE
VRLYDRLFTQAHPDTGGRDYKAFLNPDSKKVLAAYVEPVLMTAQPEERFQFERHGYFVADLKETKSGKPVFNRAVTLRDS
WGKPG
>Mature_565_residues
MNEKATPGDVTLCASNFIRNIIEEDNRTGKWNGRVETRFPPEPNGYLHIGHAKSICLNFGLARDYKGICHLRFDDTNPEK
EEQEYVDSIMDAVRWLGFEWGEYLHYASDYFDKLYEFAEYLIKQGKAYVDSLTAEEIRALRGTLTEAGENSPYRDRSIEE
NLDLFRRMKAGEFPDGAHVLRARIDMASPNINLRDPVIYRIRHVRHHRTGDKWCIYPMYDYTHCISDALERITHSLCTLE
FEDHRPLYDWILDRLTDVVPCHPQQIEFARLNLTYTVMSKRKLIELVSGSFVDGWDDPRMNTLAGVRRRGYTPESIRLFA
ERIGVSKADSWIDMGILEECLREDMNERAQRRLAILAPLKVVIDNYPENAEEECLAPNHPQKPEWGSRIVHLTKTIYIER
SDFMENPPKGYFRLSPGGEVRLRYAYIVKCVDVVKGVNGEILEIHCTYDPDSKSGTPGADKRKVKGNIHWLSAVHAQQAE
VRLYDRLFTQAHPDTGGRDYKAFLNPDSKKVLAAYVEPVLMTAQPEERFQFERHGYFVADLKETKSGKPVFNRAVTLRDS
WGKPG

Specific function: Unknown

COG id: COG0008

COG function: function code J; Glutamyl- and glutaminyl-tRNA synthetases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI4826960, Length=541, Percent_Identity=45.4713493530499, Blast_Score=428, Evalue=1e-120,
Organism=Homo sapiens, GI62241042, Length=512, Percent_Identity=34.9609375, Blast_Score=269, Evalue=5e-72,
Organism=Escherichia coli, GI1786895, Length=551, Percent_Identity=59.3466424682396, Blast_Score=659, Evalue=0.0,
Organism=Escherichia coli, GI1788743, Length=311, Percent_Identity=25.4019292604502, Blast_Score=87, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17543332, Length=535, Percent_Identity=41.4953271028037, Blast_Score=395, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17511007, Length=519, Percent_Identity=32.3699421965318, Blast_Score=236, Evalue=3e-62,
Organism=Saccharomyces cerevisiae, GI6324742, Length=569, Percent_Identity=41.6520210896309, Blast_Score=407, Evalue=1e-114,
Organism=Saccharomyces cerevisiae, GI6321192, Length=520, Percent_Identity=35.5769230769231, Blast_Score=270, Evalue=5e-73,
Organism=Drosophila melanogaster, GI17864488, Length=550, Percent_Identity=43.2727272727273, Blast_Score=433, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24649466, Length=513, Percent_Identity=32.3586744639376, Blast_Score=238, Evalue=1e-62,

Paralogues:

None

Copy number: 520 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1200 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004514
- InterPro:   IPR022861
- InterPro:   IPR000924
- InterPro:   IPR020061
- InterPro:   IPR020058
- InterPro:   IPR020059
- InterPro:   IPR020056
- InterPro:   IPR011035
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00749 tRNA-synt_1c; PF03950 tRNA-synt_1c_C [H]

EC number: =6.1.1.18 [H]

Molecular weight: Translated: 65320; Mature: 65320

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEKATPGDVTLCASNFIRNIIEEDNRTGKWNGRVETRFPPEPNGYLHIGHAKSICLNFG
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCEEEECCHHHHHHHCC
LARDYKGICHLRFDDTNPEKEEQEYVDSIMDAVRWLGFEWGEYLHYASDYFDKLYEFAEY
CCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
LIKQGKAYVDSLTAEEIRALRGTLTEAGENSPYRDRSIEENLDLFRRMKAGEFPDGAHVL
HHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHH
RARIDMASPNINLRDPVIYRIRHVRHHRTGDKWCIYPMYDYTHCISDALERITHSLCTLE
HHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHEEE
FEDHRPLYDWILDRLTDVVPCHPQQIEFARLNLTYTVMSKRKLIELVSGSFVDGWDDPRM
ECCCCCHHHHHHHHHHHHCCCCCCCEEEEEEEEEEEEHHHHHHHHHHCCCCCCCCCCCCH
NTLAGVRRRGYTPESIRLFAERIGVSKADSWIDMGILEECLREDMNERAQRRLAILAPLK
HHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVIDNYPENAEEECLAPNHPQKPEWGSRIVHLTKTIYIERSDFMENPPKGYFRLSPGGEV
HHHCCCCCCCHHHCCCCCCCCCCCHHHHHEEEEEEEEEECHHHCCCCCCCEEEECCCCCE
RLRYAYIVKCVDVVKGVNGEILEIHCTYDPDSKSGTPGADKRKVKGNIHWLSAVHAQQAE
EEHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCCCCCEECCCEEEEHHHHHHHHH
VRLYDRLFTQAHPDTGGRDYKAFLNPDSKKVLAAYVEPVLMTAQPEERFQFERHGYFVAD
HHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCEEEEE
LKETKSGKPVFNRAVTLRDSWGKPG
HHHCCCCCCHHHHEEEEECCCCCCC
>Mature Secondary Structure
MNEKATPGDVTLCASNFIRNIIEEDNRTGKWNGRVETRFPPEPNGYLHIGHAKSICLNFG
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCEEEECCHHHHHHHCC
LARDYKGICHLRFDDTNPEKEEQEYVDSIMDAVRWLGFEWGEYLHYASDYFDKLYEFAEY
CCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
LIKQGKAYVDSLTAEEIRALRGTLTEAGENSPYRDRSIEENLDLFRRMKAGEFPDGAHVL
HHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHH
RARIDMASPNINLRDPVIYRIRHVRHHRTGDKWCIYPMYDYTHCISDALERITHSLCTLE
HHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHEEE
FEDHRPLYDWILDRLTDVVPCHPQQIEFARLNLTYTVMSKRKLIELVSGSFVDGWDDPRM
ECCCCCHHHHHHHHHHHHCCCCCCCEEEEEEEEEEEEHHHHHHHHHHCCCCCCCCCCCCH
NTLAGVRRRGYTPESIRLFAERIGVSKADSWIDMGILEECLREDMNERAQRRLAILAPLK
HHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVIDNYPENAEEECLAPNHPQKPEWGSRIVHLTKTIYIERSDFMENPPKGYFRLSPGGEV
HHHCCCCCCCHHHCCCCCCCCCCCHHHHHEEEEEEEEEECHHHCCCCCCCEEEECCCCCE
RLRYAYIVKCVDVVKGVNGEILEIHCTYDPDSKSGTPGADKRKVKGNIHWLSAVHAQQAE
EEHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCCCCCEECCCEEEEHHHHHHHHH
VRLYDRLFTQAHPDTGGRDYKAFLNPDSKKVLAAYVEPVLMTAQPEERFQFERHGYFVAD
HHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCEEEEE
LKETKSGKPVFNRAVTLRDSWGKPG
HHHCCCCCCHHHHEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12700255 [H]