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The map label for this gene is trpF [H]

Identifier: 78358519

GI number: 78358519

Start: 3441001

End: 3441645

Strand: Reverse

Name: trpF [H]

Synonym: Dde_3480

Alternate gene names: 78358519

Gene position: 3441645-3441001 (Counterclockwise)

Preceding gene: 78358520

Following gene: 78358518

Centisome position: 92.26

GC content: 61.71

Gene sequence:

>645_bases
ATGTTTGTTGAAAAAGACGCCCTGACAAAGGTGTGCGGCATTACCCGTCAACAGGACGCCGATTTGTGCGTCGAGCTGGA
CGCCGACCTTGTGGGTTTTGTCTTTCACCCCGAAAGCCCGCGCTGCATGACTCCCGAAGCCGTGCGCGCCATCGAGACGC
CCGGACTTATGCGTACAGGCGTTTTTGTCAACCAGACTGCGGACGAGGTGCGGCTGATCATGCAGCGCGCCCGTCTGGAC
GTGGCGCAGCTGCACGGCGGGCAGGACGAGGCTTTCTGCACCAGAGTGGGCAGAAGCCGTGTGATCAAAGTGCTGTGGCC
TGCAACGTATGCAACCCGCAGCGAGCTGGAAGACGACATGCGGCGGTTTGCCCATTGTTCGCGCTTCATGCTTTTCGACG
CGGGCACTTCGGGCGGCGGTTCGGGCGCCACGCTGGACTGGAAATGGCTGGCGGGCACTCCGGGCATTAAAACATGGTTT
GTTGCAGGTGGTCTGGGACCGGATACGCTGGCGGAAGCCATCCGTCAGTGCAATCCTTGCGGCGTCGATCTGAATTCCGG
CGTCGAGTCCGCTCCCGGCATCAAAGATGAAGCGCGGCTGCGCGCCTGCTTCCGCATTCTCGGCGGAGACCATCGCCCCA
TGTAG

Upstream 100 bases:

>100_bases
GGGTTTGACGCCATGCTTGTGGGCACTGTGCTCATGAGCGGGGGCGACCCCGCGGGAAACCTCGTCAGGCTTCTGCAATA
GGACAGGAGAGTTTGAGGCC

Downstream 100 bases:

>100_bases
GGCGGTGATGTCTCTCCTGCGGCGGCGGGTGTCCGGCGGCTTCTGCACTGTGCGGTGCGCAATGCACCGGCAGAACAAGG
ACTGGACATGAAAAAAGGGT

Product: phosphoribosylanthranilate isomerase

Products: NA

Alternate protein names: PRAI [H]

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MFVEKDALTKVCGITRQQDADLCVELDADLVGFVFHPESPRCMTPEAVRAIETPGLMRTGVFVNQTADEVRLIMQRARLD
VAQLHGGQDEAFCTRVGRSRVIKVLWPATYATRSELEDDMRRFAHCSRFMLFDAGTSGGGSGATLDWKWLAGTPGIKTWF
VAGGLGPDTLAEAIRQCNPCGVDLNSGVESAPGIKDEARLRACFRILGGDHRPM

Sequences:

>Translated_214_residues
MFVEKDALTKVCGITRQQDADLCVELDADLVGFVFHPESPRCMTPEAVRAIETPGLMRTGVFVNQTADEVRLIMQRARLD
VAQLHGGQDEAFCTRVGRSRVIKVLWPATYATRSELEDDMRRFAHCSRFMLFDAGTSGGGSGATLDWKWLAGTPGIKTWF
VAGGLGPDTLAEAIRQCNPCGVDLNSGVESAPGIKDEARLRACFRILGGDHRPM
>Mature_214_residues
MFVEKDALTKVCGITRQQDADLCVELDADLVGFVFHPESPRCMTPEAVRAIETPGLMRTGVFVNQTADEVRLIMQRARLD
VAQLHGGQDEAFCTRVGRSRVIKVLWPATYATRSELEDDMRRFAHCSRFMLFDAGTSGGGSGATLDWKWLAGTPGIKTWF
VAGGLGPDTLAEAIRQCNPCGVDLNSGVESAPGIKDEARLRACFRILGGDHRPM

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0135

COG function: function code E; Phosphoribosylanthranilate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpF family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=201, Percent_Identity=34.3283582089552, Blast_Score=94, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6320210, Length=211, Percent_Identity=28.436018957346, Blast_Score=78, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR001240
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00697 PRAI [H]

EC number: =5.3.1.24 [H]

Molecular weight: Translated: 23416; Mature: 23416

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
3.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFVEKDALTKVCGITRQQDADLCVELDADLVGFVFHPESPRCMTPEAVRAIETPGLMRTG
CCCCHHHHHHHHCCCCCCCCCEEEEECCCEEEEEECCCCCCCCCHHHHHHHCCCCCEECC
VFVNQTADEVRLIMQRARLDVAQLHGGQDEAFCTRVGRSRVIKVLWPATYATRSELEDDM
EEEECCHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHEEEEEECCHHHHHHHHHHHH
RRFAHCSRFMLFDAGTSGGGSGATLDWKWLAGTPGIKTWFVAGGLGPDTLAEAIRQCNPC
HHHHHHHHEEEEECCCCCCCCCCEEEEEEECCCCCCCEEEEECCCCHHHHHHHHHCCCCC
GVDLNSGVESAPGIKDEARLRACFRILGGDHRPM
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MFVEKDALTKVCGITRQQDADLCVELDADLVGFVFHPESPRCMTPEAVRAIETPGLMRTG
CCCCHHHHHHHHCCCCCCCCCEEEEECCCEEEEEECCCCCCCCCHHHHHHHCCCCCEECC
VFVNQTADEVRLIMQRARLDVAQLHGGQDEAFCTRVGRSRVIKVLWPATYATRSELEDDM
EEEECCHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHEEEEEECCHHHHHHHHHHHH
RRFAHCSRFMLFDAGTSGGGSGATLDWKWLAGTPGIKTWFVAGGLGPDTLAEAIRQCNPC
HHHHHHHHEEEEECCCCCCCCCCEEEEEEECCCCCCCEEEEECCCCHHHHHHHHHCCCCC
GVDLNSGVESAPGIKDEARLRACFRILGGDHRPM
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA