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The map label for this gene is trpC [H]

Identifier: 78358520

GI number: 78358520

Start: 3441665

End: 3442426

Strand: Reverse

Name: trpC [H]

Synonym: Dde_3481

Alternate gene names: 78358520

Gene position: 3442426-3441665 (Counterclockwise)

Preceding gene: 78358521

Following gene: 78358519

Centisome position: 92.28

GC content: 60.89

Gene sequence:

>762_bases
ATGCTTAGCCGTTTTGCCGCAGCAAAGGAGGCCGAAATTGCAGTGCTGTGCGCCCGGGAACGGGCCGGTACGCTGCCGCA
GGCGTACCGGGGTGCCCGTCCGGTGTTTTCGCAGGCGCTGCGGCGTCCCGGACTGGTGACCATTGCAGAATACAAACGGG
CATCACCTTCAAAGGGCGACATAGCACCGGAACTGACACCGGAACAGGTGGCGGCGGCGTATGCCGGTGCCGGTGCGGGA
GCTCTTTCCGTCCTGACGGAGGAAACCTATTTCCGGGGCAGTCTGGGCTATCTGGAACGCATGGCATTTTGCGGACTGCC
CATGTTGCGCAAGGATTTCATACTGCACCCGCTGCAGGTGGTGCAGACGGCGGCGACTCCTGCGTCGGCGCTGCTGCTGG
TGGTACGCATGCTGGAGGGTGCAGACGGTGTGCGGCGTCTTATAGAGGCGGCCCATGAAAAAAGTCTGGAGGCCGTAGTG
GAGGTTTTTGACGAGCAAGATCTTGAAATAGCGCGCAAAGCTGGCGCGCGGATAATACAGGTGAATAACAGGGACCTGTC
CACGTTGCGCACGAGCCTTGCCATTTCCGGCAGGTTGGTTAAGGAACGGGATGCGGCCGAATGCTGGATTTCGGCAAGCG
GCATCACCGGAACCAACCACAGGAAGTATGTCGAGGCGCTGGGGTTTGACGCCATGCTTGTGGGCACTGTGCTCATGAGC
GGGGGCGACCCCGCGGGAAACCTCGTCAGGCTTCTGCAATAG

Upstream 100 bases:

>100_bases
GGGCTGGCGGTGTATCTGATGGAGGATTCCATGCCTATTTCCGCAGCCATGGCCCGTGCGCGGCAGGCTGTTGCCGGCGG
CGCCGGCGGGAAGGTGCTGG

Downstream 100 bases:

>100_bases
GACAGGAGAGTTTGAGGCCATGTTTGTTGAAAAAGACGCCCTGACAAAGGTGTGCGGCATTACCCGTCAACAGGACGCCG
ATTTGTGCGTCGAGCTGGAC

Product: indole-3-glycerol phosphate synthase

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 253; Mature: 253

Protein sequence:

>253_residues
MLSRFAAAKEAEIAVLCARERAGTLPQAYRGARPVFSQALRRPGLVTIAEYKRASPSKGDIAPELTPEQVAAAYAGAGAG
ALSVLTEETYFRGSLGYLERMAFCGLPMLRKDFILHPLQVVQTAATPASALLLVVRMLEGADGVRRLIEAAHEKSLEAVV
EVFDEQDLEIARKAGARIIQVNNRDLSTLRTSLAISGRLVKERDAAECWISASGITGTNHRKYVEALGFDAMLVGTVLMS
GGDPAGNLVRLLQ

Sequences:

>Translated_253_residues
MLSRFAAAKEAEIAVLCARERAGTLPQAYRGARPVFSQALRRPGLVTIAEYKRASPSKGDIAPELTPEQVAAAYAGAGAG
ALSVLTEETYFRGSLGYLERMAFCGLPMLRKDFILHPLQVVQTAATPASALLLVVRMLEGADGVRRLIEAAHEKSLEAVV
EVFDEQDLEIARKAGARIIQVNNRDLSTLRTSLAISGRLVKERDAAECWISASGITGTNHRKYVEALGFDAMLVGTVLMS
GGDPAGNLVRLLQ
>Mature_253_residues
MLSRFAAAKEAEIAVLCARERAGTLPQAYRGARPVFSQALRRPGLVTIAEYKRASPSKGDIAPELTPEQVAAAYAGAGAG
ALSVLTEETYFRGSLGYLERMAFCGLPMLRKDFILHPLQVVQTAATPASALLLVVRMLEGADGVRRLIEAAHEKSLEAVV
EVFDEQDLEIARKAGARIIQVNNRDLSTLRTSLAISGRLVKERDAAECWISASGITGTNHRKYVEALGFDAMLVGTVLMS
GGDPAGNLVRLLQ

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=218, Percent_Identity=33.9449541284404, Blast_Score=102, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6322638, Length=218, Percent_Identity=34.4036697247706, Blast_Score=104, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 27164; Mature: 27164

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSRFAAAKEAEIAVLCARERAGTLPQAYRGARPVFSQALRRPGLVTIAEYKRASPSKGD
CCCCHHCCCCCCEEEEEEHHHCCCCHHHHCCCCHHHHHHHCCCCCEEEHHHHCCCCCCCC
IAPELTPEQVAAAYAGAGAGALSVLTEETYFRGSLGYLERMAFCGLPMLRKDFILHPLQV
CCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHH
VQTAATPASALLLVVRMLEGADGVRRLIEAAHEKSLEAVVEVFDEQDLEIARKAGARIIQ
HHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCEEEE
VNNRDLSTLRTSLAISGRLVKERDAAECWISASGITGTNHRKYVEALGFDAMLVGTVLMS
ECCCHHHHHHHHHHHHCCHHHCCCHHHHEEECCCCCCCCHHHHHHHHCCHHHHHHHHHHC
GGDPAGNLVRLLQ
CCCCHHHHHHHCC
>Mature Secondary Structure
MLSRFAAAKEAEIAVLCARERAGTLPQAYRGARPVFSQALRRPGLVTIAEYKRASPSKGD
CCCCHHCCCCCCEEEEEEHHHCCCCHHHHCCCCHHHHHHHCCCCCEEEHHHHCCCCCCCC
IAPELTPEQVAAAYAGAGAGALSVLTEETYFRGSLGYLERMAFCGLPMLRKDFILHPLQV
CCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHH
VQTAATPASALLLVVRMLEGADGVRRLIEAAHEKSLEAVVEVFDEQDLEIARKAGARIIQ
HHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCEEEE
VNNRDLSTLRTSLAISGRLVKERDAAECWISASGITGTNHRKYVEALGFDAMLVGTVLMS
ECCCHHHHHHHHHHHHCCHHHCCCHHHHEEECCCCCCCCHHHHHHHHCCHHHHHHHHHHC
GGDPAGNLVRLLQ
CCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12566566 [H]