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The map label for this gene is udg [H]

Identifier: 78222642

GI number: 78222642

Start: 1600403

End: 1601755

Strand: Direct

Name: udg [H]

Synonym: Gmet_1430

Alternate gene names: 78222642

Gene position: 1600403-1601755 (Clockwise)

Preceding gene: 78222640

Following gene: 78222643

Centisome position: 40.04

GC content: 58.24

Gene sequence:

>1353_bases
GTGAAAATCTGTGTCATTGGCTCCGGGTATGTGGGCCTTGTCGCTGGAACCTGCTTCGCCGAAAGCGGCAACACTGTCAT
TTGCGTTGATGTTAACCAGGAGAAGATTGAAGGACTCAAGCAGGGGATTCTCCCCATATACGAACCGGGCCTCAAGGAGC
TGGTTCTCCGCAATAGCGCCGAGGGGCGCCTTTCCTTCACTACCGACCTGGCGTCAGCGGTGAAGGAATCACTCATCTGC
TTCATAGCCGTAGGGACACCGCCGGGGGAAGACGGTTCGGCCGATCTTCAGCATGTTCTTGCCGTGGCCCGGGAAATTGG
TCGCAACATGGAGGGGTTCAAGATCATCGTCGACAAGTCGACGGTACCGGTTGGCACCGCTGATAAGGTGAGACGGGCCG
CCCAGGAGGAACTCGATCGCCGCGGTGCCGCCTACGAGTTCGACGTGGTGTCGAACCCGGAATTTCTCAAGGAAGGCGCC
GCAATCGACGACTTCATGAAGCCCGACCGGGTCGTTATCGGTGCCGACAATGTCCGTACCGCAGAGATCATGAAAGAGCT
CTATTCCCCTTTCATGAGAAAGACCAACCGCCTTATCGTCATGGACGTCCACAGCGCCGAAATGACCAAATATGCCGCCA
ATGCCATGCTCGCCACCCGCATCTCGTTCATGAACCAGATAGCGAACCTCTGCGAGCGGATGGGTGCGGATGTGTCAGCC
GTGCGCGAGGGGATCGGATCCGATTCTCGGATCGGCTACGATTTCCTTTTTCCCGGCGTCGGTTACGGCGGCTCGTGCTT
CCCGAAGGACGTGAAGGCCCTCATCAAGACCGCCGAGGAATGCGAGTACGACTTTGTCCTGCTGAAGTCGGTGGAGGAAG
TCAACGAACGGCAAAAGGCGATCCTCATAGACAAAATGATCGCCCATTTCTCCCGGGACAACGGGGCGTCACCCCTTGCA
GGAAAGACCATCGCCATCTGGGGGCTCTCGTTCAAGCCCCGCACCGACGATATGCGCGAAGCTCCCTCCATCGTCATCAT
CAGCAAGCTCCTCGAAATGGGCGCCACGGTCCTGGCGCACGATCCCGAAGCGGTCAAGGAAGCGAAAAAGATCTTCGGCG
ACCGGATAACCTACACCAGTACCAACCAGTACGAGATTCTCAAGGGGGCCGACGCGCTCGCCATCATTACGGAGTGGAAC
GAGTACCGCAACCCTGACTTCGAGCGCATCAGCGCAAGCCTCACCGCCCCGGTTATCTTCGACGGCCGGAACCTCTACAA
TCCGCGGCGGATGAAGGAGATCGGCTTCACGTACCACTCCATCGGCCGTAACGGTTCGGCCTTTACCGGTTAG

Upstream 100 bases:

>100_bases
TGGAGGTAGGCGTGGATACCATTTCTGAGGAAAATCACTGGAAGTTTCAGCGTTTTTTATGATATGTTGAAACGCTAAAT
TATGTCTGAGGAGTTGCATT

Downstream 100 bases:

>100_bases
CAGGAGCAAGCAATGCGTGTTCTGGTAACCGGCGGGGCAGGGTTCATTGGCTCCCATCTGTGCGAGCGGTTGGTCAGTGA
CGGCCACGAGGTTCTCTGTG

Product: UDP-glucose/GDP-mannose dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH [H]

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MKICVIGSGYVGLVAGTCFAESGNTVICVDVNQEKIEGLKQGILPIYEPGLKELVLRNSAEGRLSFTTDLASAVKESLIC
FIAVGTPPGEDGSADLQHVLAVAREIGRNMEGFKIIVDKSTVPVGTADKVRRAAQEELDRRGAAYEFDVVSNPEFLKEGA
AIDDFMKPDRVVIGADNVRTAEIMKELYSPFMRKTNRLIVMDVHSAEMTKYAANAMLATRISFMNQIANLCERMGADVSA
VREGIGSDSRIGYDFLFPGVGYGGSCFPKDVKALIKTAEECEYDFVLLKSVEEVNERQKAILIDKMIAHFSRDNGASPLA
GKTIAIWGLSFKPRTDDMREAPSIVIISKLLEMGATVLAHDPEAVKEAKKIFGDRITYTSTNQYEILKGADALAIITEWN
EYRNPDFERISASLTAPVIFDGRNLYNPRRMKEIGFTYHSIGRNGSAFTG

Sequences:

>Translated_450_residues
MKICVIGSGYVGLVAGTCFAESGNTVICVDVNQEKIEGLKQGILPIYEPGLKELVLRNSAEGRLSFTTDLASAVKESLIC
FIAVGTPPGEDGSADLQHVLAVAREIGRNMEGFKIIVDKSTVPVGTADKVRRAAQEELDRRGAAYEFDVVSNPEFLKEGA
AIDDFMKPDRVVIGADNVRTAEIMKELYSPFMRKTNRLIVMDVHSAEMTKYAANAMLATRISFMNQIANLCERMGADVSA
VREGIGSDSRIGYDFLFPGVGYGGSCFPKDVKALIKTAEECEYDFVLLKSVEEVNERQKAILIDKMIAHFSRDNGASPLA
GKTIAIWGLSFKPRTDDMREAPSIVIISKLLEMGATVLAHDPEAVKEAKKIFGDRITYTSTNQYEILKGADALAIITEWN
EYRNPDFERISASLTAPVIFDGRNLYNPRRMKEIGFTYHSIGRNGSAFTG
>Mature_450_residues
MKICVIGSGYVGLVAGTCFAESGNTVICVDVNQEKIEGLKQGILPIYEPGLKELVLRNSAEGRLSFTTDLASAVKESLIC
FIAVGTPPGEDGSADLQHVLAVAREIGRNMEGFKIIVDKSTVPVGTADKVRRAAQEELDRRGAAYEFDVVSNPEFLKEGA
AIDDFMKPDRVVIGADNVRTAEIMKELYSPFMRKTNRLIVMDVHSAEMTKYAANAMLATRISFMNQIANLCERMGADVSA
VREGIGSDSRIGYDFLFPGVGYGGSCFPKDVKALIKTAEECEYDFVLLKSVEEVNERQKAILIDKMIAHFSRDNGASPLA
GKTIAIWGLSFKPRTDDMREAPSIVIISKLLEMGATVLAHDPEAVKEAKKIFGDRITYTSTNQYEILKGADALAIITEWN
EYRNPDFERISASLTAPVIFDGRNLYNPRRMKEIGFTYHSIGRNGSAFTG

Specific function: Catalyzes The Oxidation Of Udp-Mannac To Udp-N- Acetylmannosaminuronic Acid (Udp-Mannaca). [C]

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=479, Percent_Identity=37.5782881002088, Blast_Score=271, Evalue=1e-72,
Organism=Homo sapiens, GI296040438, Length=381, Percent_Identity=36.4829396325459, Blast_Score=214, Evalue=2e-55,
Organism=Homo sapiens, GI296040443, Length=321, Percent_Identity=36.7601246105919, Blast_Score=182, Evalue=8e-46,
Organism=Escherichia coli, GI48994968, Length=416, Percent_Identity=28.3653846153846, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1788340, Length=378, Percent_Identity=25.3968253968254, Blast_Score=132, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17560350, Length=471, Percent_Identity=35.8811040339703, Blast_Score=264, Evalue=9e-71,
Organism=Drosophila melanogaster, GI17136908, Length=477, Percent_Identity=37.1069182389937, Blast_Score=272, Evalue=4e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 49386; Mature: 49386

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKICVIGSGYVGLVAGTCFAESGNTVICVDVNQEKIEGLKQGILPIYEPGLKELVLRNSA
CEEEEEECCHHHHHHHHEEECCCCEEEEEECCHHHHHHHHHCCCCCCCCCHHHHHHCCCC
EGRLSFTTDLASAVKESLICFIAVGTPPGEDGSADLQHVLAVAREIGRNMEGFKIIVDKS
CCCEEEHHHHHHHHHHCEEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECC
TVPVGTADKVRRAAQEELDRRGAAYEFDVVSNPEFLKEGAAIDDFMKPDRVVIGADNVRT
CCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHCCCCHHHHCCCCEEEEECCCCCH
AEIMKELYSPFMRKTNRLIVMDVHSAEMTKYAANAMLATRISFMNQIANLCERMGADVSA
HHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
VREGIGSDSRIGYDFLFPGVGYGGSCFPKDVKALIKTAEECEYDFVLLKSVEEVNERQKA
HHHCCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
ILIDKMIAHFSRDNGASPLAGKTIAIWGLSFKPRTDDMREAPSIVIISKLLEMGATVLAH
HHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCHHHHCCCHHHHHHHHHCCCEEEEC
DPEAVKEAKKIFGDRITYTSTNQYEILKGADALAIITEWNEYRNPDFERISASLTAPVIF
CHHHHHHHHHHHCCCEEECCCCCEEEEECCCEEEEEECCHHHCCCCHHHHHHHCCCCEEE
DGRNLYNPRRMKEIGFTYHSIGRNGSAFTG
CCCCCCCHHHHHHHCCHHHHCCCCCCCCCC
>Mature Secondary Structure
MKICVIGSGYVGLVAGTCFAESGNTVICVDVNQEKIEGLKQGILPIYEPGLKELVLRNSA
CEEEEEECCHHHHHHHHEEECCCCEEEEEECCHHHHHHHHHCCCCCCCCCHHHHHHCCCC
EGRLSFTTDLASAVKESLICFIAVGTPPGEDGSADLQHVLAVAREIGRNMEGFKIIVDKS
CCCEEEHHHHHHHHHHCEEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECC
TVPVGTADKVRRAAQEELDRRGAAYEFDVVSNPEFLKEGAAIDDFMKPDRVVIGADNVRT
CCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHCCCCHHHHCCCCEEEEECCCCCH
AEIMKELYSPFMRKTNRLIVMDVHSAEMTKYAANAMLATRISFMNQIANLCERMGADVSA
HHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
VREGIGSDSRIGYDFLFPGVGYGGSCFPKDVKALIKTAEECEYDFVLLKSVEEVNERQKA
HHHCCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
ILIDKMIAHFSRDNGASPLAGKTIAIWGLSFKPRTDDMREAPSIVIISKLLEMGATVLAH
HHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCHHHHCCCHHHHHHHHHCCCEEEEC
DPEAVKEAKKIFGDRITYTSTNQYEILKGADALAIITEWNEYRNPDFERISASLTAPVIF
CHHHHHHHHHHHCCCEEECCCCCEEEEECCCEEEEEECCHHHCCCCHHHHHHHCCCCEEE
DGRNLYNPRRMKEIGFTYHSIGRNGSAFTG
CCCCCCCHHHHHHHCCHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]