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The map label for this gene is nuoF2 [H]

Identifier: 78222328

GI number: 78222328

Start: 1232496

End: 1234205

Strand: Direct

Name: nuoF2 [H]

Synonym: Gmet_1110

Alternate gene names: 78222328

Gene position: 1232496-1234205 (Clockwise)

Preceding gene: 78222327

Following gene: 78222329

Centisome position: 30.83

GC content: 69.06

Gene sequence:

>1710_bases
ATGAACAGGGCTGATCTCAGGCATATGGCCGAGGCGGAGCAGGAGCGTCAGGAGCGGTTCCGTTGCCGGATCATGGTCTG
CGCCGGTACGCCGTGCCTGTCGGCGGGGGCCCAGACGGTTCTCGATTCCCTGCGGAAGGCGCTGGCCGAGAGCCGCCTTG
ACGCCGAGATCGAGGCAGTGGCCAGCGGGTGCATGGGGCCGTGCAGCAGGGGGCCCCTCGTCAAGGTACGCCAGCAGGGG
AAGAAGGAGATCATCTTCGAGCGGGTCACCCCCGAGCTGGCGCGGCAGATACTCCTTTCCCTCGCCAAGGGGCGCCGGCC
GCCGACAGTGTCGGCCCTGCCGCCGGATTTCCCGTTCCTGGCTCGTCAGATGAAGGTGGTGCTGGCCAACAGCGGCTCCA
TCAACCCCGAGCGGGTCGAGGAATACGTGGCTGCCGGGGGGTACGGCGCCCTGGCCCATGCCCTCCACGAGCTGACCCCC
GACGACGTCTGCCGCGAGGTGTCCGTCTCGGGCCTCCGGGGGAGGGGGGGCGCCGGTTACCCCACCGGCGTCAAGTGGAA
CCTGGCCCGCAAGGCCAACGGCGAGCGGAAGTATGTGGTGGCCAACGGCGACGAGGGAGACCCCGGCGCCTACATGGACC
GCTCCATCATGGAGTCGGATCCCCACCGGATCCTGGAGGGGATGGCCTTGGCCGGATACGCCATCGGCGCCGAACAGGGG
TTCATCTATGTGCGGGGCGAGTACTACCTGGCGGGGAGGCGGCTGGAGGCGGCCATCCGAGCCGCGGAACGCGCGGGGCT
CCTGGGGAGCCGGGTCTTCGGGAGCAATTTCAACTTCCGGATCGATATCCGCACCGGCGCCGGCGCCTTTGTCTGCGGCG
AGGAAACGTCGCTCATGGCCTCCATCATGGGGAGACGGGGCCAGCCGCGACAGCGCCCCCCCTATCCGGCCCAGCAGGGG
CTCTGGGGATGCCCCACCCTCATCAACAACGTGGAGACCCTCGCCACCGTGCCGGCCATCATGGGGAAAGGGGGGAACTG
GTACGCGGGGATCGGCTCGGCCGGAAGCAAGGGGACCAAGGTCTACGCCCTTGCCGGCCAGGTGGAGATCGCGGGGCTCA
TCGAGGTCCCCATGGGGACGACCCTGCGGGAGGTGGTCTTTGACATCGGCGGCGGCATTCCCGGCGGGAAGCGCTTCAAG
GCGGCCCAGTCGGGGGGGCCGTCGGGAGGGTGCATCCCGTCCGGGGAGCTGGACACTCCCCTCGACTACGAGAGCATGCA
GCGGGTCGGCACCATCATGGGGTCAGGGGGGCTCATCATAATGGACGAGACGAGCTGCATGCCCGACGTGGCTTCCTTCT
TTCTGGATTTCTGCCGGGACGAGAGCTGCGGCAAGTGCGTCCCCTGCCGGGTCGGCACTGTGGAGATGCACCGGCTGCTG
CGGAGGATCACGGGGGGGACCGCCACCATGGACGACCTGGCGAAGCTGGAGGAACTCTGCGAGCTGGTGGGGGCCGCGAG
CCTCTGCGGCCTCGGCATGACCGCCCCCAACCCGGTCTTGAGTACGCTCCGCTACTTCCGGGACGAGTACGTGGAACACA
TCAGCCGGCACCGTTGCGCGGCCGGCGTCTGCTCCATGGCGGAAGTGCCCGCCGGCCCCGAGCAGGAGGCGCTGCTGCAC
GCCATGGGTGGTGCCGGGGAGGAGGCGTGA

Upstream 100 bases:

>100_bases
ATTCGGCCGTTGTCGCGGTAAAGGCGCTTCAGGAGAGCGGCCGGCCCCGGCCGAACGATGAGGGAGGGGTGCGGCAGGAG
GGGGGAGGGGGGAGAACCCC

Downstream 100 bases:

>100_bases
TGTCGGTCGTGACCCTGACCATCGACGGCGAGCTGGTGAGCGGCCGGCGGGGGGAGACGCTCCTCCAGGTGATCCGCGAG
CACGGCTTGGCGCTTCCCAC

Product: respiratory-chain NADH dehydrogenase domain-containing protein

Products: NA

Alternate protein names: NADH dehydrogenase I subunit F 2; NDH-1 subunit F 2 [H]

Number of amino acids: Translated: 569; Mature: 569

Protein sequence:

>569_residues
MNRADLRHMAEAEQERQERFRCRIMVCAGTPCLSAGAQTVLDSLRKALAESRLDAEIEAVASGCMGPCSRGPLVKVRQQG
KKEIIFERVTPELARQILLSLAKGRRPPTVSALPPDFPFLARQMKVVLANSGSINPERVEEYVAAGGYGALAHALHELTP
DDVCREVSVSGLRGRGGAGYPTGVKWNLARKANGERKYVVANGDEGDPGAYMDRSIMESDPHRILEGMALAGYAIGAEQG
FIYVRGEYYLAGRRLEAAIRAAERAGLLGSRVFGSNFNFRIDIRTGAGAFVCGEETSLMASIMGRRGQPRQRPPYPAQQG
LWGCPTLINNVETLATVPAIMGKGGNWYAGIGSAGSKGTKVYALAGQVEIAGLIEVPMGTTLREVVFDIGGGIPGGKRFK
AAQSGGPSGGCIPSGELDTPLDYESMQRVGTIMGSGGLIIMDETSCMPDVASFFLDFCRDESCGKCVPCRVGTVEMHRLL
RRITGGTATMDDLAKLEELCELVGAASLCGLGMTAPNPVLSTLRYFRDEYVEHISRHRCAAGVCSMAEVPAGPEQEALLH
AMGGAGEEA

Sequences:

>Translated_569_residues
MNRADLRHMAEAEQERQERFRCRIMVCAGTPCLSAGAQTVLDSLRKALAESRLDAEIEAVASGCMGPCSRGPLVKVRQQG
KKEIIFERVTPELARQILLSLAKGRRPPTVSALPPDFPFLARQMKVVLANSGSINPERVEEYVAAGGYGALAHALHELTP
DDVCREVSVSGLRGRGGAGYPTGVKWNLARKANGERKYVVANGDEGDPGAYMDRSIMESDPHRILEGMALAGYAIGAEQG
FIYVRGEYYLAGRRLEAAIRAAERAGLLGSRVFGSNFNFRIDIRTGAGAFVCGEETSLMASIMGRRGQPRQRPPYPAQQG
LWGCPTLINNVETLATVPAIMGKGGNWYAGIGSAGSKGTKVYALAGQVEIAGLIEVPMGTTLREVVFDIGGGIPGGKRFK
AAQSGGPSGGCIPSGELDTPLDYESMQRVGTIMGSGGLIIMDETSCMPDVASFFLDFCRDESCGKCVPCRVGTVEMHRLL
RRITGGTATMDDLAKLEELCELVGAASLCGLGMTAPNPVLSTLRYFRDEYVEHISRHRCAAGVCSMAEVPAGPEQEALLH
AMGGAGEEA
>Mature_569_residues
MNRADLRHMAEAEQERQERFRCRIMVCAGTPCLSAGAQTVLDSLRKALAESRLDAEIEAVASGCMGPCSRGPLVKVRQQG
KKEIIFERVTPELARQILLSLAKGRRPPTVSALPPDFPFLARQMKVVLANSGSINPERVEEYVAAGGYGALAHALHELTP
DDVCREVSVSGLRGRGGAGYPTGVKWNLARKANGERKYVVANGDEGDPGAYMDRSIMESDPHRILEGMALAGYAIGAEQG
FIYVRGEYYLAGRRLEAAIRAAERAGLLGSRVFGSNFNFRIDIRTGAGAFVCGEETSLMASIMGRRGQPRQRPPYPAQQG
LWGCPTLINNVETLATVPAIMGKGGNWYAGIGSAGSKGTKVYALAGQVEIAGLIEVPMGTTLREVVFDIGGGIPGGKRFK
AAQSGGPSGGCIPSGELDTPLDYESMQRVGTIMGSGGLIIMDETSCMPDVASFFLDFCRDESCGKCVPCRVGTVEMHRLL
RRITGGTATMDDLAKLEELCELVGAASLCGLGMTAPNPVLSTLRYFRDEYVEHISRHRCAAGVCSMAEVPAGPEQEALLH
AMGGAGEEA

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI260656005, Length=380, Percent_Identity=40.2631578947368, Blast_Score=305, Evalue=9e-83,
Organism=Homo sapiens, GI20149568, Length=380, Percent_Identity=40.2631578947368, Blast_Score=305, Evalue=1e-82,
Organism=Escherichia coli, GI1788620, Length=397, Percent_Identity=40.5541561712846, Blast_Score=324, Evalue=9e-90,
Organism=Caenorhabditis elegans, GI17531727, Length=372, Percent_Identity=38.7096774193548, Blast_Score=287, Evalue=1e-77,
Organism=Drosophila melanogaster, GI19920794, Length=380, Percent_Identity=37.8947368421053, Blast_Score=291, Evalue=7e-79,
Organism=Drosophila melanogaster, GI45550452, Length=377, Percent_Identity=39.5225464190981, Blast_Score=290, Evalue=2e-78,
Organism=Drosophila melanogaster, GI24653819, Length=388, Percent_Identity=31.1855670103093, Blast_Score=217, Evalue=2e-56,
Organism=Drosophila melanogaster, GI24653817, Length=358, Percent_Identity=29.0502793296089, Blast_Score=187, Evalue=2e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 60683; Mature: 60683

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS00645 COMPLEX1_51K_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRADLRHMAEAEQERQERFRCRIMVCAGTPCLSAGAQTVLDSLRKALAESRLDAEIEAV
CCHHHHHHHHHHHHHHHHHHEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
ASGCMGPCSRGPLVKVRQQGKKEIIFERVTPELARQILLSLAKGRRPPTVSALPPDFPFL
HHHCCCCCCCCCCHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHH
ARQMKVVLANSGSINPERVEEYVAAGGYGALAHALHELTPDDVCREVSVSGLRGRGGAGY
HHHHHEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCC
PTGVKWNLARKANGERKYVVANGDEGDPGAYMDRSIMESDPHRILEGMALAGYAIGAEQG
CCCCEEEEHHCCCCCEEEEEECCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHEEEECCCC
FIYVRGEYYLAGRRLEAAIRAAERAGLLGSRVFGSNFNFRIDIRTGAGAFVCGEETSLMA
EEEEECEEEECCHHHHHHHHHHHHHCCHHHHHCCCCCEEEEEEECCCCEEEECCHHHHHH
SIMGRRGQPRQRPPYPAQQGLWGCPTLINNVETLATVPAIMGKGGNWYAGIGSAGSKGTK
HHHCCCCCCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCE
VYALAGQVEIAGLIEVPMGTTLREVVFDIGGGIPGGKRFKAAQSGGPSGGCIPSGELDTP
EEEEECCEEEEEEEECCCCHHHHHHHHHHCCCCCCCCCEEHHCCCCCCCCCCCCCCCCCC
LDYESMQRVGTIMGSGGLIIMDETSCMPDVASFFLDFCRDESCGKCVPCRVGTVEMHRLL
CCHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHH
RRITGGTATMDDLAKLEELCELVGAASLCGLGMTAPNPVLSTLRYFRDEYVEHISRHRCA
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
AGVCSMAEVPAGPEQEALLHAMGGAGEEA
HHHHHHHHCCCCCCHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNRADLRHMAEAEQERQERFRCRIMVCAGTPCLSAGAQTVLDSLRKALAESRLDAEIEAV
CCHHHHHHHHHHHHHHHHHHEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
ASGCMGPCSRGPLVKVRQQGKKEIIFERVTPELARQILLSLAKGRRPPTVSALPPDFPFL
HHHCCCCCCCCCCHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHH
ARQMKVVLANSGSINPERVEEYVAAGGYGALAHALHELTPDDVCREVSVSGLRGRGGAGY
HHHHHEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCC
PTGVKWNLARKANGERKYVVANGDEGDPGAYMDRSIMESDPHRILEGMALAGYAIGAEQG
CCCCEEEEHHCCCCCEEEEEECCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHEEEECCCC
FIYVRGEYYLAGRRLEAAIRAAERAGLLGSRVFGSNFNFRIDIRTGAGAFVCGEETSLMA
EEEEECEEEECCHHHHHHHHHHHHHCCHHHHHCCCCCEEEEEEECCCCEEEECCHHHHHH
SIMGRRGQPRQRPPYPAQQGLWGCPTLINNVETLATVPAIMGKGGNWYAGIGSAGSKGTK
HHHCCCCCCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCE
VYALAGQVEIAGLIEVPMGTTLREVVFDIGGGIPGGKRFKAAQSGGPSGGCIPSGELDTP
EEEEECCEEEEEEEECCCCHHHHHHHHHHCCCCCCCCCEEHHCCCCCCCCCCCCCCCCCC
LDYESMQRVGTIMGSGGLIIMDETSCMPDVASFFLDFCRDESCGKCVPCRVGTVEMHRLL
CCHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHH
RRITGGTATMDDLAKLEELCELVGAASLCGLGMTAPNPVLSTLRYFRDEYVEHISRHRCA
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
AGVCSMAEVPAGPEQEALLHAMGGAGEEA
HHHHHHHHCCCCCCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481432 [H]