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The map label for this gene is phbA [H]

Identifier: 78066560

GI number: 78066560

Start: 2128895

End: 2130076

Strand: Reverse

Name: phbA [H]

Synonym: Bcep18194_A5091

Alternate gene names: 78066560

Gene position: 2130076-2128895 (Counterclockwise)

Preceding gene: 78066561

Following gene: 78066559

Centisome position: 57.66

GC content: 69.29

Gene sequence:

>1182_bases
ATGACGGACGTAGTGATCGTATCGGCCGCGCGGACCGCGGTCGGCAAATTCGGCGGTTCGCTTGCGAAGATTGCGGCGCC
CGAACTGGGCGCGACGGTGATCCGCGCGGTGCTGGAGCGTGCGGGCGTGAAGCCCGAGCAGGTGAGCGAAGTGATCATGG
GCCAGGTGCTGACGGCCGGTTCCGGGCAGAACCCGGCACGGCAGTCGCTGATCAAGGCCGGGCTGCCGACGGCAGTGCCG
GGGATGACGATCAACAAGGTGTGCGGCTCGGGCCTGAAGGCCGTGATGCTGGCGGCGAACGCGATCGTCGCGGGGGATGC
CGAGATCGTGATCGCGGGCGGCCAGGAGAACATGAGCGCGTCGCCGCACGTGCTGCCGGGCTCGCGCGACGGGTTCCGCA
TGGGCGACGCGAAGCTGGTCGACACGATGATCGTCGACGGCCTGTGGGACGTGTACAACCAGTACCACATGGGCATCACG
GCGGAGAACGTCGCGAAGGAATACGGGATCACGCGCGAAGAGCAGGACGCCTTCGCGGCGCTGTCGCAGAACAAGGCGGA
AGCCGCGCAGAAGGCCGGCCGCTTCAACGACGAGATCGTGCCGGTGGCGATTCCGCAACGCAAGGGCGAGCCGCTGCAGT
TCGCCACCGATGAATTCGTGCGTCACGGCGTGACGGCGGAATCGCTGTCCGGGCTGAAGCCGGCATTCTCGAAGGACGGC
TCGGTGACGGCGGCGAACGCGTCGGGGCTGAACGACGGTGCGGCGGCGGTGCTGGTGATGTCGGCGCAGAAGGCGGCGGC
ACTCGGCCTGACGCCGCTGGCGCGGATCAAGGCGTATGCGAACGCGGGCGTGGATCCGAGCGTGATGGGCATGGGCCCGG
TGCCGGCCTCGCGCCGGTGCCTGGAGCGCGCGGGCTGGACGCCGGGCGACCTGGACCTGATGGAGATCAACGAGGCGTTC
GCGGCGCAGGCGCTGGCGGTGCACAAGCAGATGGGCTGGGACACGTCGAAGGTGAACGTGAACGGCGGGGCGATCGCGAT
CGGCCACCCGATCGGCGCGTCGGGCTGCCGGATCCTGGTGACGCTGCTGCACGAGATGGCCAAGCGCGATGCGAAGCGCG
GGCTGGCGTCGCTGTGTATCGGCGGCGGGATGGGCGTCGCACTCGCGGTCGAGCGTCCGTAA

Upstream 100 bases:

>100_bases
ACGAAAACCGGACAGCGGCGCAGGCTGTCCGGTGCACCGCAGTTTTTTTAACAGGGCCGGTAGCGATGCGCCGTGTCGTG
CGGGCCTGGAGGAAAGAGAA

Downstream 100 bases:

>100_bases
GCGGCCGTTCGTAACCGGCCGTTCGCGACCAGCGAACCGAATCCGTGTGCCGGCCGATTGCGGCTTCGGCCGGCGTCACG
TGAAGTCAGAGGGGGCCTCC

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MTDVVIVSAARTAVGKFGGSLAKIAAPELGATVIRAVLERAGVKPEQVSEVIMGQVLTAGSGQNPARQSLIKAGLPTAVP
GMTINKVCGSGLKAVMLAANAIVAGDAEIVIAGGQENMSASPHVLPGSRDGFRMGDAKLVDTMIVDGLWDVYNQYHMGIT
AENVAKEYGITREEQDAFAALSQNKAEAAQKAGRFNDEIVPVAIPQRKGEPLQFATDEFVRHGVTAESLSGLKPAFSKDG
SVTAANASGLNDGAAAVLVMSAQKAAALGLTPLARIKAYANAGVDPSVMGMGPVPASRRCLERAGWTPGDLDLMEINEAF
AAQALAVHKQMGWDTSKVNVNGGAIAIGHPIGASGCRILVTLLHEMAKRDAKRGLASLCIGGGMGVALAVERP

Sequences:

>Translated_393_residues
MTDVVIVSAARTAVGKFGGSLAKIAAPELGATVIRAVLERAGVKPEQVSEVIMGQVLTAGSGQNPARQSLIKAGLPTAVP
GMTINKVCGSGLKAVMLAANAIVAGDAEIVIAGGQENMSASPHVLPGSRDGFRMGDAKLVDTMIVDGLWDVYNQYHMGIT
AENVAKEYGITREEQDAFAALSQNKAEAAQKAGRFNDEIVPVAIPQRKGEPLQFATDEFVRHGVTAESLSGLKPAFSKDG
SVTAANASGLNDGAAAVLVMSAQKAAALGLTPLARIKAYANAGVDPSVMGMGPVPASRRCLERAGWTPGDLDLMEINEAF
AAQALAVHKQMGWDTSKVNVNGGAIAIGHPIGASGCRILVTLLHEMAKRDAKRGLASLCIGGGMGVALAVERP
>Mature_392_residues
TDVVIVSAARTAVGKFGGSLAKIAAPELGATVIRAVLERAGVKPEQVSEVIMGQVLTAGSGQNPARQSLIKAGLPTAVPG
MTINKVCGSGLKAVMLAANAIVAGDAEIVIAGGQENMSASPHVLPGSRDGFRMGDAKLVDTMIVDGLWDVYNQYHMGITA
ENVAKEYGITREEQDAFAALSQNKAEAAQKAGRFNDEIVPVAIPQRKGEPLQFATDEFVRHGVTAESLSGLKPAFSKDGS
VTAANASGLNDGAAAVLVMSAQKAAALGLTPLARIKAYANAGVDPSVMGMGPVPASRRCLERAGWTPGDLDLMEINEAFA
AQALAVHKQMGWDTSKVNVNGGAIAIGHPIGASGCRILVTLLHEMAKRDAKRGLASLCIGGGMGVALAVERP

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=391, Percent_Identity=56.0102301790281, Blast_Score=440, Evalue=1e-123,
Organism=Homo sapiens, GI4557237, Length=393, Percent_Identity=44.7837150127226, Blast_Score=323, Evalue=2e-88,
Organism=Homo sapiens, GI167614485, Length=390, Percent_Identity=44.3589743589744, Blast_Score=322, Evalue=6e-88,
Organism=Homo sapiens, GI4501853, Length=398, Percent_Identity=42.713567839196, Blast_Score=270, Evalue=1e-72,
Organism=Homo sapiens, GI4504327, Length=424, Percent_Identity=30.8962264150943, Blast_Score=182, Evalue=5e-46,
Organism=Homo sapiens, GI194353979, Length=395, Percent_Identity=32.1518987341772, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI19923233, Length=385, Percent_Identity=23.8961038961039, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI302344767, Length=334, Percent_Identity=24.251497005988, Blast_Score=66, Evalue=5e-11,
Organism=Homo sapiens, GI302344760, Length=334, Percent_Identity=24.251497005988, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI87082165, Length=392, Percent_Identity=62.5, Blast_Score=491, Evalue=1e-140,
Organism=Escherichia coli, GI1788554, Length=393, Percent_Identity=60.3053435114504, Blast_Score=448, Evalue=1e-127,
Organism=Escherichia coli, GI1787663, Length=404, Percent_Identity=45.7920792079208, Blast_Score=323, Evalue=2e-89,
Organism=Escherichia coli, GI48994986, Length=399, Percent_Identity=42.3558897243108, Blast_Score=273, Evalue=2e-74,
Organism=Escherichia coli, GI1788683, Length=409, Percent_Identity=33.9853300733496, Blast_Score=196, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI133906874, Length=390, Percent_Identity=46.1538461538462, Blast_Score=332, Evalue=2e-91,
Organism=Caenorhabditis elegans, GI25147385, Length=387, Percent_Identity=42.6356589147287, Blast_Score=302, Evalue=2e-82,
Organism=Caenorhabditis elegans, GI17535921, Length=396, Percent_Identity=41.9191919191919, Blast_Score=282, Evalue=2e-76,
Organism=Caenorhabditis elegans, GI17535917, Length=392, Percent_Identity=32.6530612244898, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17551802, Length=428, Percent_Identity=32.2429906542056, Blast_Score=186, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6325229, Length=397, Percent_Identity=41.5617128463476, Blast_Score=285, Evalue=6e-78,
Organism=Saccharomyces cerevisiae, GI6322031, Length=399, Percent_Identity=40.3508771929825, Blast_Score=236, Evalue=4e-63,
Organism=Drosophila melanogaster, GI24655093, Length=392, Percent_Identity=57.1428571428571, Blast_Score=450, Evalue=1e-126,
Organism=Drosophila melanogaster, GI24640423, Length=393, Percent_Identity=46.0559796437659, Blast_Score=323, Evalue=9e-89,
Organism=Drosophila melanogaster, GI17648125, Length=390, Percent_Identity=45.3846153846154, Blast_Score=315, Evalue=5e-86,
Organism=Drosophila melanogaster, GI17137578, Length=425, Percent_Identity=30.8235294117647, Blast_Score=176, Evalue=2e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40438; Mature: 40307

Theoretical pI: Translated: 7.55; Mature: 7.55

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDVVIVSAARTAVGKFGGSLAKIAAPELGATVIRAVLERAGVKPEQVSEVIMGQVLTAG
CCCEEEEEHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC
SGQNPARQSLIKAGLPTAVPGMTINKVCGSGLKAVMLAANAIVAGDAEIVIAGGQENMSA
CCCCHHHHHHHHCCCCCCCCCCCHHHHHCCCHHHHHHHHHHEEECCCEEEEECCCCCCCC
SPHVLPGSRDGFRMGDAKLVDTMIVDGLWDVYNQYHMGITAENVAKEYGITREEQDAFAA
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHH
LSQNKAEAAQKAGRFNDEIVPVAIPQRKGEPLQFATDEFVRHGVTAESLSGLKPAFSKDG
HHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCHHHHHHHHCCCCHHHHCCCCCCCCCCC
SVTAANASGLNDGAAAVLVMSAQKAAALGLTPLARIKAYANAGVDPSVMGMGPVPASRRC
CEEECCCCCCCCCCEEEEEEECHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
LERAGWTPGDLDLMEINEAFAAQALAVHKQMGWDTSKVNVNGGAIAIGHPIGASGCRILV
HHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCEEEECCCCCCCHHHHHH
TLLHEMAKRDAKRGLASLCIGGGMGVALAVERP
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECC
>Mature Secondary Structure 
TDVVIVSAARTAVGKFGGSLAKIAAPELGATVIRAVLERAGVKPEQVSEVIMGQVLTAG
CCEEEEEHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC
SGQNPARQSLIKAGLPTAVPGMTINKVCGSGLKAVMLAANAIVAGDAEIVIAGGQENMSA
CCCCHHHHHHHHCCCCCCCCCCCHHHHHCCCHHHHHHHHHHEEECCCEEEEECCCCCCCC
SPHVLPGSRDGFRMGDAKLVDTMIVDGLWDVYNQYHMGITAENVAKEYGITREEQDAFAA
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHH
LSQNKAEAAQKAGRFNDEIVPVAIPQRKGEPLQFATDEFVRHGVTAESLSGLKPAFSKDG
HHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCHHHHHHHHCCCCHHHHCCCCCCCCCCC
SVTAANASGLNDGAAAVLVMSAQKAAALGLTPLARIKAYANAGVDPSVMGMGPVPASRRC
CEEECCCCCCCCCCEEEEEEECHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
LERAGWTPGDLDLMEINEAFAAQALAVHKQMGWDTSKVNVNGGAIAIGHPIGASGCRILV
HHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCEEEECCCCCCCHHHHHH
TLLHEMAKRDAKRGLASLCIGGGMGVALAVERP
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2670935; 2670936 [H]