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The map label for this gene is yhfN [H]

Identifier: 78065663

GI number: 78065663

Start: 1125184

End: 1126443

Strand: Reverse

Name: yhfN [H]

Synonym: Bcep18194_A4191

Alternate gene names: 78065663

Gene position: 1126443-1125184 (Counterclockwise)

Preceding gene: 78065665

Following gene: 78065662

Centisome position: 30.49

GC content: 65.56

Gene sequence:

>1260_bases
ATGTCACCCTTTTCGTTCACCCTGCTGTTCGCGCTCGCCGTGCTCGCGATGGTCGTCACCAAGCTGTGGCTCGCGTCGCG
GCAGATCCGCTTCGTCGCGGCGCACCGCAACGGCGTCCCCGCGCAGTTCAGCGCAACCATTCCGCTGACCGCCCACCAGC
GCGCGGCCGACTATACGGTCGAGCGCACCCGGCTGACGATGCTCGAAATCGTCGTCAGCGCGGCCGTGCTGGTCGGCCTC
ACGCTGCTCGGCGGCGTCGGCGCACTCGACACGCTGCTCACCGGCTGGATCGGCCGCGGCTACGGGCAGCAGGTCGCGCT
CGTCGCGGCGGTGCTCGTGATCACGAGCGTCATCGACGTCCCGTTCGAGTATTACCGACAGTTCGGGATCGAACAGCGTT
TCGGCTTCAACCGGATGACGAAGCGGCTGTTCTTCACCGACATGCTGAAGAATTCGCTGCTCGGCGCCGCACTCGGCCTG
CCGCTGCTGTTCGTCGTGCTGTGGCTGATGAACCAGGCCGGCAGCCTGTGGTGGCTGTGGACCTGGATCGTCTGGGTCGC
GTTCCAGATGCTTGTCCTGCTGATCTATCCGACCTTCATCGCACCGATCTTCAACAAGTTCGAACCGCTGAAGGACGACG
CACTGCGCGCGCGCATCGAGTCGCTGATGAAGCGCTGCGGCTTTGCGGCGAAGGGGCTGTTCGTGATGGACGGCAGCCGC
CGCTCCGCGCACGGCAACGCGTACTTCACGGGCTTCGGCGCGTCGAAGCGGATCGTGTTCTTCGACACGCTGCTCGCGCG
CCTGTCCGGCCAGGAAATCGAGGCCGTGCTCGCGCACGAACTCGGCCACTTCAAGCGCCGCCACGTAATGAAGCGGATGC
TCGTGTCGTTCGTGCTGAGCCTCGTGCTGCTCGCGCTGCTCGGCTGGCTTGCACAACGCACGTGGTTCTACACGGGGCTC
GGCGTCACGCCGTCGCTCGACACGAGCAACGCGGGTGCCGCGCTCGTGCTGTTCTTCCTCGCGATTCCCGTGTTCCTGTT
CTTCGCGACGCCGTTCGGCAGCCTCACGTCGCGCAAGCACGAATTCGAGGCCGACGCATTCGCGGCCAGCCAGACCGACG
CGCAGGATCTCGTCAGCGCACTCGTGAAGCTCTATGAGGACAACGCGTCGACGCTGACGCCCGACCCCGTCTACACGGCT
TTCTACTACTCGCATCCGCCTGCGTCGCAGCGGATCGACCGCCTGATGCAGCACGCATGA

Upstream 100 bases:

>100_bases
GGCGGACGGCGCGCGGCGCCGCCCGGGCGGCCGGCATCGCATCAGCGGGGCCGGTCCGCAAGAACATATAATTCTCGCAT
AGAACCCTTTGGCGCCTTCG

Downstream 100 bases:

>100_bases
GCCGGCCGACCTCCCGCAAGCCGGCCCCGCGCGCGTCGAATGCGCAACGGGTCGAAGGCCGCGTGATCGCGGCGCACGGT
CGCCACTACATCGTCGCGCC

Product: Ste24 endopeptidase

Products: NA

Alternate protein names: PSP23 [H]

Number of amino acids: Translated: 419; Mature: 418

Protein sequence:

>419_residues
MSPFSFTLLFALAVLAMVVTKLWLASRQIRFVAAHRNGVPAQFSATIPLTAHQRAADYTVERTRLTMLEIVVSAAVLVGL
TLLGGVGALDTLLTGWIGRGYGQQVALVAAVLVITSVIDVPFEYYRQFGIEQRFGFNRMTKRLFFTDMLKNSLLGAALGL
PLLFVVLWLMNQAGSLWWLWTWIVWVAFQMLVLLIYPTFIAPIFNKFEPLKDDALRARIESLMKRCGFAAKGLFVMDGSR
RSAHGNAYFTGFGASKRIVFFDTLLARLSGQEIEAVLAHELGHFKRRHVMKRMLVSFVLSLVLLALLGWLAQRTWFYTGL
GVTPSLDTSNAGAALVLFFLAIPVFLFFATPFGSLTSRKHEFEADAFAASQTDAQDLVSALVKLYEDNASTLTPDPVYTA
FYYSHPPASQRIDRLMQHA

Sequences:

>Translated_419_residues
MSPFSFTLLFALAVLAMVVTKLWLASRQIRFVAAHRNGVPAQFSATIPLTAHQRAADYTVERTRLTMLEIVVSAAVLVGL
TLLGGVGALDTLLTGWIGRGYGQQVALVAAVLVITSVIDVPFEYYRQFGIEQRFGFNRMTKRLFFTDMLKNSLLGAALGL
PLLFVVLWLMNQAGSLWWLWTWIVWVAFQMLVLLIYPTFIAPIFNKFEPLKDDALRARIESLMKRCGFAAKGLFVMDGSR
RSAHGNAYFTGFGASKRIVFFDTLLARLSGQEIEAVLAHELGHFKRRHVMKRMLVSFVLSLVLLALLGWLAQRTWFYTGL
GVTPSLDTSNAGAALVLFFLAIPVFLFFATPFGSLTSRKHEFEADAFAASQTDAQDLVSALVKLYEDNASTLTPDPVYTA
FYYSHPPASQRIDRLMQHA
>Mature_418_residues
SPFSFTLLFALAVLAMVVTKLWLASRQIRFVAAHRNGVPAQFSATIPLTAHQRAADYTVERTRLTMLEIVVSAAVLVGLT
LLGGVGALDTLLTGWIGRGYGQQVALVAAVLVITSVIDVPFEYYRQFGIEQRFGFNRMTKRLFFTDMLKNSLLGAALGLP
LLFVVLWLMNQAGSLWWLWTWIVWVAFQMLVLLIYPTFIAPIFNKFEPLKDDALRARIESLMKRCGFAAKGLFVMDGSRR
SAHGNAYFTGFGASKRIVFFDTLLARLSGQEIEAVLAHELGHFKRRHVMKRMLVSFVLSLVLLALLGWLAQRTWFYTGLG
VTPSLDTSNAGAALVLFFLAIPVFLFFATPFGSLTSRKHEFEADAFAASQTDAQDLVSALVKLYEDNASTLTPDPVYTAF
YYSHPPASQRIDRLMQHA

Specific function: Unknown Function. Overexpression Of A Truncated Form Of The Htpx Protein Leads To An Increase In The Degradation Of Abnormal Proteins. [C]

COG id: COG0501

COG function: function code O; Zn-dependent protease with chaperone function

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M48B family [H]

Homologues:

Organism=Homo sapiens, GI18379366, Length=443, Percent_Identity=27.9909706546275, Blast_Score=181, Evalue=8e-46,
Organism=Caenorhabditis elegans, GI17505484, Length=421, Percent_Identity=29.6912114014252, Blast_Score=191, Evalue=6e-49,
Organism=Saccharomyces cerevisiae, GI6322577, Length=309, Percent_Identity=39.4822006472492, Blast_Score=218, Evalue=2e-57,
Organism=Drosophila melanogaster, GI19922414, Length=434, Percent_Identity=29.9539170506912, Blast_Score=195, Evalue=6e-50,
Organism=Drosophila melanogaster, GI78707252, Length=411, Percent_Identity=25.0608272506083, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI78707254, Length=411, Percent_Identity=25.0608272506083, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24654305, Length=434, Percent_Identity=26.2672811059908, Blast_Score=117, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001915 [H]

Pfam domain/function: PF01435 Peptidase_M48 [H]

EC number: 3.4.24.- [C]

Molecular weight: Translated: 46740; Mature: 46609

Theoretical pI: Translated: 10.14; Mature: 10.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HCCHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHCC
>Mature Secondary Structure 
SPFSFTLLFALAVLAMVVTKLWLASRQIRFVAAHRNGVPAQFSATIPLTAHQRAADYTV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCEEEECCCCHHHHHHHHHH
ERTRLTMLEIVVSAAVLVGLTLLGGVGALDTLLTGWIGRGYGQQVALVAAVLVITSVIDV
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHC
PFEYYRQFGIEQRFGFNRMTKRLFFTDMLKNSLLGAALGLPLLFVVLWLMNQAGSLWWLW
CHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
TWIVWVAFQMLVLLIYPTFIAPIFNKFEPLKDDALRARIESLMKRCGFAAKGLFVMDGSR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHCCEEEECCCC
RSAHGNAYFTGFGASKRIVFFDTLLARLSGQEIEAVLAHELGHFKRRHVMKRMLVSFVLS
CCCCCCEEEEECCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVLLALLGWLAQRTWFYTGLGVTPSLDTSNAGAALVLFFLAIPVFLFFATPFGSLTSRKH
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHCCHH
EFEADAFAASQTDAQDLVSALVKLYEDNASTLTPDPVYTAFYYSHPPASQRIDRLMQHA
HCCHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 3145906 [H]