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The map label for this gene is ribD [H]

Identifier: 78065536

GI number: 78065536

Start: 988955

End: 990076

Strand: Reverse

Name: ribD [H]

Synonym: Bcep18194_A4064

Alternate gene names: 78065536

Gene position: 990076-988955 (Counterclockwise)

Preceding gene: 78065537

Following gene: 78065535

Centisome position: 26.8

GC content: 70.5

Gene sequence:

>1122_bases
ATGTTCTCGGATATCGATTTCGCCCACATGCAGCGCGCGCTGACGCTCGCCGCGCGCGGCATGTATACGACGGCGCCGAA
CCCGCGTGTCGGCTGCGTGATCGTCAAGGACGGCGAGGTGATCGGCGAAGGCTTCACGCAGCCGGCCGGCCAGGATCACG
CTGAAGTGCAGGCGCTGAAGGACGCGCGTGCCCGCGGCTACGACGTTGCCGGTTCGACCGTCTACGTGACGCTCGAGCCG
TGCAGCCATTTCGGCCGCACGCCGCCGTGCGCGAACGCGCTGATCGAAGCACGCGTCGCGAAGGTCGTCGCCGCGATGGA
AGACCCGAACCCGCAGGTATCGGGGCGCGGTCTCGGGATGCTGCGCGACGCGGGCATCGACGTGCGCTGCGGGCTGCTCG
CGCATGAAGCCGGTGAGCTGAACATCGGCTTCGTGTCGCGGATGACGCGCGGCCGCCCGTGGGTGCGGATGAAGACCGCC
GCGTCGCTCGACGGCCGCACCGCGCTGCCGTCCGGCGAAAGCCAGTGGATCACCGGCGAGGCCGCGCGCCTCGACGGGCA
TGCGTGGCGTGCGCGCGCCTGCGCGATCCTCACCGGCATCGGCACCGTGCGCGAAGACAATCCGCTGCTGACCGTGCGCG
GCATCGACACGCCGCGCCAGCCGCAGCGCATCCTGGTGGACAGCCGCCTCGACCTGCCGCTCGATGCGCGGCTGCTCGAA
GGCGCGCCGCTGCTGATCTTCTGCGGCCGGCTCGACGCCGCCAGTGAATTACGTGCGAACGTGCTGAAGGCCCGTGGCGC
GGAAATCGTGCCGATCGCGAATGCGCAAGGCAAGGTCGACCTGCCCGCGATGCTGGCAGCGCTCGGCGCGCGCGGCGTCA
ACGAGCTGCACGTCGAGGCGGGCCACAAGCTGAACGGCTCGCTGCTGCGCGAGCAGTGCGTCGACGAATTGCTCGTCTAC
CTCGCGCCGAGCCTGCTGGGCGCCGATGCGGCCGGCATGTTCGACCTCGCGGCTCCGGCGAACCTCGACGCACGTACGCG
GTTGTCGTTCCACGGGTTCGAGCGGGTCGGCGACGATCTGCGAATCCTCGCGCGCTTCGCGCCGCCCGACGCCGCTCACT
GA

Upstream 100 bases:

>100_bases
CTTCGTGTCGAGCACGCACGACGACGCGGTGATCGACGCGACGCTCGCGGCCGCGCGCCGCGCATTCGCGGCACTCGCTG
CCTGACCCGGGTCCGCGCGC

Downstream 100 bases:

>100_bases
ACGGGAGCGTCACGATGTTTAGCGGCATTGTCGCGGCCGTCGGCCGTATCGAATCGATCCAGCCGCTCGGCGCGTCGGCC
GATGCGGGTGTGCGCCTCAC

Product: 5-amino-6-(5-phosphoribosylamino)uracil reductase / diaminohydroxyphosphoribosylaminopyrimidine deaminase

Products: NA

Alternate protein names: Diaminohydroxyphosphoribosylaminopyrimidine deaminase; DRAP deaminase; Riboflavin-specific deaminase; 5-amino-6-(5-phosphoribosylamino)uracil reductase; HTP reductase [H]

Number of amino acids: Translated: 373; Mature: 373

Protein sequence:

>373_residues
MFSDIDFAHMQRALTLAARGMYTTAPNPRVGCVIVKDGEVIGEGFTQPAGQDHAEVQALKDARARGYDVAGSTVYVTLEP
CSHFGRTPPCANALIEARVAKVVAAMEDPNPQVSGRGLGMLRDAGIDVRCGLLAHEAGELNIGFVSRMTRGRPWVRMKTA
ASLDGRTALPSGESQWITGEAARLDGHAWRARACAILTGIGTVREDNPLLTVRGIDTPRQPQRILVDSRLDLPLDARLLE
GAPLLIFCGRLDAASELRANVLKARGAEIVPIANAQGKVDLPAMLAALGARGVNELHVEAGHKLNGSLLREQCVDELLVY
LAPSLLGADAAGMFDLAAPANLDARTRLSFHGFERVGDDLRILARFAPPDAAH

Sequences:

>Translated_373_residues
MFSDIDFAHMQRALTLAARGMYTTAPNPRVGCVIVKDGEVIGEGFTQPAGQDHAEVQALKDARARGYDVAGSTVYVTLEP
CSHFGRTPPCANALIEARVAKVVAAMEDPNPQVSGRGLGMLRDAGIDVRCGLLAHEAGELNIGFVSRMTRGRPWVRMKTA
ASLDGRTALPSGESQWITGEAARLDGHAWRARACAILTGIGTVREDNPLLTVRGIDTPRQPQRILVDSRLDLPLDARLLE
GAPLLIFCGRLDAASELRANVLKARGAEIVPIANAQGKVDLPAMLAALGARGVNELHVEAGHKLNGSLLREQCVDELLVY
LAPSLLGADAAGMFDLAAPANLDARTRLSFHGFERVGDDLRILARFAPPDAAH
>Mature_373_residues
MFSDIDFAHMQRALTLAARGMYTTAPNPRVGCVIVKDGEVIGEGFTQPAGQDHAEVQALKDARARGYDVAGSTVYVTLEP
CSHFGRTPPCANALIEARVAKVVAAMEDPNPQVSGRGLGMLRDAGIDVRCGLLAHEAGELNIGFVSRMTRGRPWVRMKTA
ASLDGRTALPSGESQWITGEAARLDGHAWRARACAILTGIGTVREDNPLLTVRGIDTPRQPQRILVDSRLDLPLDARLLE
GAPLLIFCGRLDAASELRANVLKARGAEIVPIANAQGKVDLPAMLAALGARGVNELHVEAGHKLNGSLLREQCVDELLVY
LAPSLLGADAAGMFDLAAPANLDARTRLSFHGFERVGDDLRILARFAPPDAAH

Specific function: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate [H]

COG id: COG1985

COG function: function code H; Pyrimidine reductase, riboflavin biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the HTP reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786616, Length=367, Percent_Identity=47.1389645776567, Blast_Score=300, Evalue=1e-82,
Organism=Escherichia coli, GI145693172, Length=176, Percent_Identity=34.0909090909091, Blast_Score=76, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193
- InterPro:   IPR004794
- InterPro:   IPR011549
- InterPro:   IPR002734 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1; PF01872 RibD_C [H]

EC number: =3.5.4.26; =1.1.1.193 [H]

Molecular weight: Translated: 39805; Mature: 39805

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSDIDFAHMQRALTLAARGMYTTAPNPRVGCVIVKDGEVIGEGFTQPAGQDHAEVQALK
CCCCCCHHHHHHHHHHHHCCCEECCCCCCEEEEEEECCCEECCCCCCCCCCCHHHHHHHH
DARARGYDVAGSTVYVTLEPCSHFGRTPPCANALIEARVAKVVAAMEDPNPQVSGRGLGM
HHHHCCCCCCCCEEEEEECCHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCE
LRDAGIDVRCGLLAHEAGELNIGFVSRMTRGRPWVRMKTAASLDGRTALPSGESQWITGE
EECCCCCEEEEEEECCCCCCCHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCEEECC
AARLDGHAWRARACAILTGIGTVREDNPLLTVRGIDTPRQPQRILVDSRLDLPLDARLLE
HHHCCCCHHHHHHHHHEECCCCCCCCCCEEEEECCCCCCCCCEEEECCCCCCCCCHHHHC
GAPLLIFCGRLDAASELRANVLKARGAEIVPIANAQGKVDLPAMLAALGARGVNELHVEA
CCCEEEEECCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHCCCCCEEEEEC
GHKLNGSLLREQCVDELLVYLAPSLLGADAAGMFDLAAPANLDARTRLSFHGFERVGDDL
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCEEEEEHHHHHHCCCC
RILARFAPPDAAH
EEEEEECCCCCCC
>Mature Secondary Structure
MFSDIDFAHMQRALTLAARGMYTTAPNPRVGCVIVKDGEVIGEGFTQPAGQDHAEVQALK
CCCCCCHHHHHHHHHHHHCCCEECCCCCCEEEEEEECCCEECCCCCCCCCCCHHHHHHHH
DARARGYDVAGSTVYVTLEPCSHFGRTPPCANALIEARVAKVVAAMEDPNPQVSGRGLGM
HHHHCCCCCCCCEEEEEECCHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCE
LRDAGIDVRCGLLAHEAGELNIGFVSRMTRGRPWVRMKTAASLDGRTALPSGESQWITGE
EECCCCCEEEEEEECCCCCCCHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCEEECC
AARLDGHAWRARACAILTGIGTVREDNPLLTVRGIDTPRQPQRILVDSRLDLPLDARLLE
HHHCCCCHHHHHHHHHEECCCCCCCCCCEEEEECCCCCCCCCEEEECCCCCCCCCHHHHC
GAPLLIFCGRLDAASELRANVLKARGAEIVPIANAQGKVDLPAMLAALGARGVNELHVEA
CCCEEEEECCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHCCCCCEEEEEC
GHKLNGSLLREQCVDELLVYLAPSLLGADAAGMFDLAAPANLDARTRLSFHGFERVGDDL
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCEEEEEHHHHHHCCCC
RILARFAPPDAAH
EEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1406588; 9278503; 9068650 [H]