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The map label for this gene is hemL [H]

Identifier: 78065537

GI number: 78065537

Start: 990092

End: 991375

Strand: Reverse

Name: hemL [H]

Synonym: Bcep18194_A4065

Alternate gene names: 78065537

Gene position: 991375-990092 (Counterclockwise)

Preceding gene: 78065538

Following gene: 78065536

Centisome position: 26.84

GC content: 68.38

Gene sequence:

>1284_bases
ATGTCCAACAATCAGATCCTCTTCGAACGCGCCCAGAAGACCATTCCCGGCGGCGTCAACTCGCCGGTGCGCGCATTCCG
TTCGGTCGGCGGCACGCCGCGCTTCGTCGCGCGCGCGCAAGGCCCGTATTTCTGGGATGCCGACGGCAAGCAGTACATCG
ACTACATCGGCTCGTGGGGCCCGATGATCGTCGGCCACGTCCATCCGGAAGTGCTGTCGGCCGTGCAGAACGTGCTCGCC
GATGGTTTCTCGTTCGGCGCGCCGACCGAAGCCGAGATCGAGATCGCCGAGGAAATCTGCAAGCTCGTGCCGTCGATCGA
GCAGGTGCGGATGGTGTCGAGCGGCACCGAGGCCACGATGAGCGCGCTGCGTCTCGCGCGCGGCTTCACCGGCCGCAGCC
GCATCGTCAAGTTCGAGGGCTGCTACCACGGCCACGCGGACAGCCTGCTCGTGAAGGCCGGCTCGGGCCTGCTGACGTTC
GGCAACCCGACGTCGGCCGGCGTGCCCGCCGACATCGCTAAACACACGACCGTCCTCGAATACAACAACGTCGCCGCGCT
CGAAGAAGCGTTCGGCGCGTTCGGCGACGAGATCGCCGCCGTGATCGTCGAGCCGGTCGCGGGCAACATGAACCTCGTGC
GCGGCACGCCGGAATTCCTGAACGCGCTGCGCGCGCTGTGCACGAAGCACGGCGCCGTGCTGATCTTCGACGAAGTGATG
TGCGGGTTCCGCGTCGCGCTCGGCGGCGCACAGCAACATTACGGGATCACGGCCGACCTCACCTGCCTCGGCAAGGTGAT
CGGCGGCGGGATGCCGGCTGCCGCGTTCGGCGGCCGCCGCGACATCATGGCCCACCTCGCGCCGCTCGGCGGCGTCTACC
AGGCCGGCACGCTGTCGGGCAACCCGATCGCGGTCGCCGCGGGCTTGAAGACGCTGCAGTTGATCCAGGCACCTGGCTTC
TACGACGCGCTCACCGCGCAGACGAAGCGGCTCGCCGACGGCCTCGCGGCCGAAGCGCGTGCGGCCGGCGTGCCGTTCGT
GGCCGACTCGATCGGCGCGATGTTCGGCCTCTACTTCACCGAACGCGTGCCGACCAGCTTCGCCGAAGTGACGAAGAGCG
ATACCGAGCGCTTCAACCGCTTCTTCCACCTGATGCTCGACGAAGGCGTGTACTTCGCGCCGTCCGCGTACGAGGCCGGC
TTCGTGTCGAGCACGCACGACGACGCGGTGATCGACGCGACGCTCGCGGCCGCGCGCCGCGCATTCGCGGCACTCGCTGC
CTGA

Upstream 100 bases:

>100_bases
GGCTCGCCGCGCGCGTCTCCGGTACAATCGGACGATCGTTCCGCCCAGGCGCCGCGGCCCGTGCACAGGCCCCCGCGCCC
CTCTCTCGCAGGTTTCGTCC

Downstream 100 bases:

>100_bases
CCCGGGTCCGCGCGCATGTTCTCGGATATCGATTTCGCCCACATGCAGCGCGCGCTGACGCTCGCCGCGCGCGGCATGTA
TACGACGGCGCCGAACCCGC

Product: glutamate-1-semialdehyde aminotransferase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT [H]

Number of amino acids: Translated: 427; Mature: 426

Protein sequence:

>427_residues
MSNNQILFERAQKTIPGGVNSPVRAFRSVGGTPRFVARAQGPYFWDADGKQYIDYIGSWGPMIVGHVHPEVLSAVQNVLA
DGFSFGAPTEAEIEIAEEICKLVPSIEQVRMVSSGTEATMSALRLARGFTGRSRIVKFEGCYHGHADSLLVKAGSGLLTF
GNPTSAGVPADIAKHTTVLEYNNVAALEEAFGAFGDEIAAVIVEPVAGNMNLVRGTPEFLNALRALCTKHGAVLIFDEVM
CGFRVALGGAQQHYGITADLTCLGKVIGGGMPAAAFGGRRDIMAHLAPLGGVYQAGTLSGNPIAVAAGLKTLQLIQAPGF
YDALTAQTKRLADGLAAEARAAGVPFVADSIGAMFGLYFTERVPTSFAEVTKSDTERFNRFFHLMLDEGVYFAPSAYEAG
FVSSTHDDAVIDATLAAARRAFAALAA

Sequences:

>Translated_427_residues
MSNNQILFERAQKTIPGGVNSPVRAFRSVGGTPRFVARAQGPYFWDADGKQYIDYIGSWGPMIVGHVHPEVLSAVQNVLA
DGFSFGAPTEAEIEIAEEICKLVPSIEQVRMVSSGTEATMSALRLARGFTGRSRIVKFEGCYHGHADSLLVKAGSGLLTF
GNPTSAGVPADIAKHTTVLEYNNVAALEEAFGAFGDEIAAVIVEPVAGNMNLVRGTPEFLNALRALCTKHGAVLIFDEVM
CGFRVALGGAQQHYGITADLTCLGKVIGGGMPAAAFGGRRDIMAHLAPLGGVYQAGTLSGNPIAVAAGLKTLQLIQAPGF
YDALTAQTKRLADGLAAEARAAGVPFVADSIGAMFGLYFTERVPTSFAEVTKSDTERFNRFFHLMLDEGVYFAPSAYEAG
FVSSTHDDAVIDATLAAARRAFAALAA
>Mature_426_residues
SNNQILFERAQKTIPGGVNSPVRAFRSVGGTPRFVARAQGPYFWDADGKQYIDYIGSWGPMIVGHVHPEVLSAVQNVLAD
GFSFGAPTEAEIEIAEEICKLVPSIEQVRMVSSGTEATMSALRLARGFTGRSRIVKFEGCYHGHADSLLVKAGSGLLTFG
NPTSAGVPADIAKHTTVLEYNNVAALEEAFGAFGDEIAAVIVEPVAGNMNLVRGTPEFLNALRALCTKHGAVLIFDEVMC
GFRVALGGAQQHYGITADLTCLGKVIGGGMPAAAFGGRRDIMAHLAPLGGVYQAGTLSGNPIAVAAGLKTLQLIQAPGFY
DALTAQTKRLADGLAAEARAAGVPFVADSIGAMFGLYFTERVPTSFAEVTKSDTERFNRFFHLMLDEGVYFAPSAYEAGF
VSSTHDDAVIDATLAAARRAFAALAA

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=291, Percent_Identity=27.8350515463918, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI284507298, Length=209, Percent_Identity=28.2296650717703, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1786349, Length=426, Percent_Identity=60.5633802816901, Blast_Score=535, Evalue=1e-153,
Organism=Escherichia coli, GI1789016, Length=381, Percent_Identity=32.2834645669291, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1789759, Length=311, Percent_Identity=29.5819935691318, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI1788044, Length=331, Percent_Identity=32.3262839879154, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI1787560, Length=361, Percent_Identity=30.4709141274238, Blast_Score=125, Evalue=6e-30,
Organism=Escherichia coli, GI145693181, Length=346, Percent_Identity=31.5028901734104, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1786991, Length=294, Percent_Identity=28.5714285714286, Blast_Score=95, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI25144271, Length=340, Percent_Identity=25.5882352941176, Blast_Score=105, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI71992977, Length=338, Percent_Identity=26.0355029585799, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI32564660, Length=357, Percent_Identity=23.249299719888, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI25144274, Length=187, Percent_Identity=27.807486631016, Blast_Score=72, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6323470, Length=348, Percent_Identity=27.2988505747126, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6324432, Length=342, Percent_Identity=26.0233918128655, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21357415, Length=298, Percent_Identity=25.503355704698, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI21356575, Length=358, Percent_Identity=25.1396648044693, Blast_Score=82, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =5.4.3.8 [H]

Molecular weight: Translated: 45002; Mature: 44871

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNNQILFERAQKTIPGGVNSPVRAFRSVGGTPRFVARAQGPYFWDADGKQYIDYIGSWG
CCCCCCHHHHHHHHCCCCCCHHHHHHHHCCCCCCEEEECCCCEEECCCCHHHHHHHCCCC
PMIVGHVHPEVLSAVQNVLADGFSFGAPTEAEIEIAEEICKLVPSIEQVRMVSSGTEATM
CEEEECCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCHHHHH
SALRLARGFTGRSRIVKFEGCYHGHADSLLVKAGSGLLTFGNPTSAGVPADIAKHTTVLE
HHHHHHHCCCCCCCEEEEECCCCCCCCCEEEECCCCEEEECCCCCCCCCHHHHHCCEEEE
YNNVAALEEAFGAFGDEIAAVIVEPVAGNMNLVRGTPEFLNALRALCTKHGAVLIFDEVM
ECCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHCCCEEEEHHHH
CGFRVALGGAQQHYGITADLTCLGKVIGGGMPAAAFGGRRDIMAHLAPLGGVYQAGTLSG
HHHHHHHCCCHHCCCCCHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHCCCCCEECCCCCC
NPIAVAAGLKTLQLIQAPGFYDALTAQTKRLADGLAAEARAAGVPFVADSIGAMFGLYFT
CCEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
ERVPTSFAEVTKSDTERFNRFFHLMLDEGVYFAPSAYEAGFVSSTHDDAVIDATLAAARR
HHCCHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHH
AFAALAA
HHHHHCC
>Mature Secondary Structure 
SNNQILFERAQKTIPGGVNSPVRAFRSVGGTPRFVARAQGPYFWDADGKQYIDYIGSWG
CCCCCHHHHHHHHCCCCCCHHHHHHHHCCCCCCEEEECCCCEEECCCCHHHHHHHCCCC
PMIVGHVHPEVLSAVQNVLADGFSFGAPTEAEIEIAEEICKLVPSIEQVRMVSSGTEATM
CEEEECCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCHHHHH
SALRLARGFTGRSRIVKFEGCYHGHADSLLVKAGSGLLTFGNPTSAGVPADIAKHTTVLE
HHHHHHHCCCCCCCEEEEECCCCCCCCCEEEECCCCEEEECCCCCCCCCHHHHHCCEEEE
YNNVAALEEAFGAFGDEIAAVIVEPVAGNMNLVRGTPEFLNALRALCTKHGAVLIFDEVM
ECCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHCCCEEEEHHHH
CGFRVALGGAQQHYGITADLTCLGKVIGGGMPAAAFGGRRDIMAHLAPLGGVYQAGTLSG
HHHHHHHCCCHHCCCCCHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHCCCCCEECCCCCC
NPIAVAAGLKTLQLIQAPGFYDALTAQTKRLADGLAAEARAAGVPFVADSIGAMFGLYFT
CCEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
ERVPTSFAEVTKSDTERFNRFFHLMLDEGVYFAPSAYEAGFVSSTHDDAVIDATLAAARR
HHCCHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHH
AFAALAA
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA