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The map label for this gene is edd [H]

Identifier: 78065222

GI number: 78065222

Start: 636737

End: 638593

Strand: Direct

Name: edd [H]

Synonym: Bcep18194_A3746

Alternate gene names: 78065222

Gene position: 636737-638593 (Clockwise)

Preceding gene: 78065220

Following gene: 78065223

Centisome position: 17.24

GC content: 68.82

Gene sequence:

>1857_bases
ATGACGTCGCTGCACCCCACTCTGGCGAAGGTCACCGAACGCGTGATCGCCCGCAGCCAATCGACCCGTTTCGCCTATCT
GCAGCGCATCGACGGCGCGCAGGGCAAGTTCCCGGCACGCGGTGCGCTGTCGTGCGCGAACCTCGCGCACGGCTTCGCCG
GCCTCGAGGGCAACGACAAGTTCTCGATCAAGGCGATCCGCGAGCCGAACATCGGCATCGTGTCCTCGTACAACGAGATG
CTGTCCGCGCATGCGCCGTACAAGGATTTCCCGGAGATCATCAAGGCGGCCGCGCGCGAGAACGGCGGTGTCGCGCAGTT
CGCGGGCGGCGTGCCGGCGATGTGCGACGGCGTCACGCAGGGCAACCCGGGGATGGAGCTGTCGCTGTTCTCGCGCGAAG
CGATCGCGATGGGTACGGCCATCGCACTCACGCACAACATGTTCGACGCGGCGCTCTGCCTCGGCATCTGCGACAAGATC
GTGCCGGGCCTGCTGATCGGCGCGTTGCAGTTCGGCCACCTGCCGACGATCTTCGTGCCGGCCGGCCCGATGACGAGCGG
CCTGTCGAACGACGACAAGGCGAAGATCCGCCAGCAGTTCGCGACCGGCCAGGTCGGCCGCGATGCGCTGCTCGAAGCCG
AATCGGCCGCGTATCACGGCCACGGCACCTGCACGTTCTACGGCACCGCGAACAGCAACCAGATGCTGATGGAGCTGATG
GGCCTGCACCTGCCGGGCTCGGCATTCGTTCACCCGCACACGCCGCTGCGCACCGCGCTCACCGCCGAGGCCGCGCGCCG
CGTGCTTGACCTGACCGTCGAGCGCGGCCATTACACGCCGATCGGCCACGTGATCGACGAGAAGGCGATCGTCAACGGAA
TCGTCGCGCTGCTCGCGACGGGCGGCTCGACCAATCACACGCTGCACCTCGTCGCGATCGCACGCGCGGCCGGCATCCTG
ATCGACTGGAACGACTTCGACGAACTGTCGGCCGTCGTGCCGCTGCTCGCGAAGATCTACCCGAACGGCAAGGCCGACGT
GAACCACTTCCACGCGGCGGGCGGCGTGGCCTTCCTGGTCCGCAACCTGCTCGAAGGCGGGCTGTTGCACGAGGACGTGA
CGACGGTCGCCGGCCGTGGCCTGTCGCACTACACGAAGGAGCCGAAGCTGATCGACGGCAAGCTGACGTGGGTCGACGGC
GCGCCCGAGAGCCACGACACGAAGGTGCTGCGCGGCATCCGCGACCCGTTCCAGCCGGACGGTGGCCTGCGCCTGATGCA
GGGTCGACTCGGTCGCGGCGTGATCAAGATTTCGGCGGTCGCGCCCGAGCACCGCAAGGTGACGGCGCCCGCGATCGTGT
TCGATTCGCAGGAATCCGTGCAGGAAGCATTCGATCGCGGCGAGCTGAAGCGCGATTTCGTCGCGGTCGTGCGCTTCCAG
GGCGCGCGCGCGAACGGGATGCCCGAACTGCACCGTTTGACGCCGCTGCTCGGCGTGCTGCAGGATCAGGGCTTCCATGT
CGCGCTCGTCACCGACGGCCGCATGTCGGGTGCGTCGGGCAAGGTGCCGGCGGTGATCCACGTGTCGCCGGAGGCGCTGC
TGGCCGGCCCGCTCGGCAAGGTGAAGACGGGCGATACGCTCGTGATCGACGCGGAAGCCGGCGTGCTCGACATCGAGGTC
GACGCCGCCGAGTGGCAGGCGCGCCCGGTCGCGCAGCCGCTGCACCAGGCCGAGAACGAGGTCGGTTTCGGGCGTGAACT
GTTCGGCGTGTTCCGCGCGGCCGCCGCGCCGGCCGAGCAGGGCGCATCGGTTTTCGGCGCGCTGGTCGGCGAAACGGCCG
CCCACGTCGCCGCATGA

Upstream 100 bases:

>100_bases
TATGTAGTTTTTCTACTAGACTGACTTCGTTCTGTCGACGCGTTCGACCGTCCCCACGATTCCAACCGCCGGTGTCGGCC
GGCATACAGGAGCGCCCAGC

Downstream 100 bases:

>100_bases
ATTTCAAGGAGCCAATTCAATGAAGACGATTGCTGAAATCGTGAAGCTGGGCCCGGTCATCCCGGTGCTCGCATTCGACT
CGGTCGAGCAGGGCGAACAC

Product: phosphogluconate dehydratase

Products: NA

Alternate protein names: 6-phosphogluconate dehydratase [H]

Number of amino acids: Translated: 618; Mature: 617

Protein sequence:

>618_residues
MTSLHPTLAKVTERVIARSQSTRFAYLQRIDGAQGKFPARGALSCANLAHGFAGLEGNDKFSIKAIREPNIGIVSSYNEM
LSAHAPYKDFPEIIKAAARENGGVAQFAGGVPAMCDGVTQGNPGMELSLFSREAIAMGTAIALTHNMFDAALCLGICDKI
VPGLLIGALQFGHLPTIFVPAGPMTSGLSNDDKAKIRQQFATGQVGRDALLEAESAAYHGHGTCTFYGTANSNQMLMELM
GLHLPGSAFVHPHTPLRTALTAEAARRVLDLTVERGHYTPIGHVIDEKAIVNGIVALLATGGSTNHTLHLVAIARAAGIL
IDWNDFDELSAVVPLLAKIYPNGKADVNHFHAAGGVAFLVRNLLEGGLLHEDVTTVAGRGLSHYTKEPKLIDGKLTWVDG
APESHDTKVLRGIRDPFQPDGGLRLMQGRLGRGVIKISAVAPEHRKVTAPAIVFDSQESVQEAFDRGELKRDFVAVVRFQ
GARANGMPELHRLTPLLGVLQDQGFHVALVTDGRMSGASGKVPAVIHVSPEALLAGPLGKVKTGDTLVIDAEAGVLDIEV
DAAEWQARPVAQPLHQAENEVGFGRELFGVFRAAAAPAEQGASVFGALVGETAAHVAA

Sequences:

>Translated_618_residues
MTSLHPTLAKVTERVIARSQSTRFAYLQRIDGAQGKFPARGALSCANLAHGFAGLEGNDKFSIKAIREPNIGIVSSYNEM
LSAHAPYKDFPEIIKAAARENGGVAQFAGGVPAMCDGVTQGNPGMELSLFSREAIAMGTAIALTHNMFDAALCLGICDKI
VPGLLIGALQFGHLPTIFVPAGPMTSGLSNDDKAKIRQQFATGQVGRDALLEAESAAYHGHGTCTFYGTANSNQMLMELM
GLHLPGSAFVHPHTPLRTALTAEAARRVLDLTVERGHYTPIGHVIDEKAIVNGIVALLATGGSTNHTLHLVAIARAAGIL
IDWNDFDELSAVVPLLAKIYPNGKADVNHFHAAGGVAFLVRNLLEGGLLHEDVTTVAGRGLSHYTKEPKLIDGKLTWVDG
APESHDTKVLRGIRDPFQPDGGLRLMQGRLGRGVIKISAVAPEHRKVTAPAIVFDSQESVQEAFDRGELKRDFVAVVRFQ
GARANGMPELHRLTPLLGVLQDQGFHVALVTDGRMSGASGKVPAVIHVSPEALLAGPLGKVKTGDTLVIDAEAGVLDIEV
DAAEWQARPVAQPLHQAENEVGFGRELFGVFRAAAAPAEQGASVFGALVGETAAHVAA
>Mature_617_residues
TSLHPTLAKVTERVIARSQSTRFAYLQRIDGAQGKFPARGALSCANLAHGFAGLEGNDKFSIKAIREPNIGIVSSYNEML
SAHAPYKDFPEIIKAAARENGGVAQFAGGVPAMCDGVTQGNPGMELSLFSREAIAMGTAIALTHNMFDAALCLGICDKIV
PGLLIGALQFGHLPTIFVPAGPMTSGLSNDDKAKIRQQFATGQVGRDALLEAESAAYHGHGTCTFYGTANSNQMLMELMG
LHLPGSAFVHPHTPLRTALTAEAARRVLDLTVERGHYTPIGHVIDEKAIVNGIVALLATGGSTNHTLHLVAIARAAGILI
DWNDFDELSAVVPLLAKIYPNGKADVNHFHAAGGVAFLVRNLLEGGLLHEDVTTVAGRGLSHYTKEPKLIDGKLTWVDGA
PESHDTKVLRGIRDPFQPDGGLRLMQGRLGRGVIKISAVAPEHRKVTAPAIVFDSQESVQEAFDRGELKRDFVAVVRFQG
ARANGMPELHRLTPLLGVLQDQGFHVALVTDGRMSGASGKVPAVIHVSPEALLAGPLGKVKTGDTLVIDAEAGVLDIEVD
AAEWQARPVAQPLHQAENEVGFGRELFGVFRAAAAPAEQGASVFGALVGETAAHVAA

Specific function: KEY ENZYME IN THE ENTNER-DOUDOROFF PATHWAY. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI1788157, Length=602, Percent_Identity=59.1362126245847, Blast_Score=715, Evalue=0.0,
Organism=Escherichia coli, GI48994964, Length=546, Percent_Identity=31.3186813186813, Blast_Score=204, Evalue=2e-53,
Organism=Escherichia coli, GI2367371, Length=480, Percent_Identity=31.25, Blast_Score=159, Evalue=4e-40,
Organism=Escherichia coli, GI1786464, Length=505, Percent_Identity=30.6930693069307, Blast_Score=149, Evalue=7e-37,
Organism=Saccharomyces cerevisiae, GI6322476, Length=486, Percent_Identity=29.2181069958848, Blast_Score=181, Evalue=4e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004786
- InterPro:   IPR015928
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.12 [H]

Molecular weight: Translated: 65320; Mature: 65188

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSLHPTLAKVTERVIARSQSTRFAYLQRIDGAQGKFPARGALSCANLAHGFAGLEGNDK
CCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCC
FSIKAIREPNIGIVSSYNEMLSAHAPYKDFPEIIKAAARENGGVAQFAGGVPAMCDGVTQ
EEEEEECCCCCCEEECHHHHHHCCCCHHHHHHHHHHHHHCCCCEEECCCCCCHHHCCCCC
GNPGMELSLFSREAIAMGTAIALTHNMFDAALCLGICDKIVPGLLIGALQFGHLPTIFVP
CCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
AGPMTSGLSNDDKAKIRQQFATGQVGRDALLEAESAAYHGHGTCTFYGTANSNQMLMELM
CCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCEECCCEEEEEEECCCCCHHHHHHH
GLHLPGSAFVHPHTPLRTALTAEAARRVLDLTVERGHYTPIGHVIDEKAIVNGIVALLAT
CCCCCCCCEECCCCCHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHCC
GGSTNHTLHLVAIARAAGILIDWNDFDELSAVVPLLAKIYPNGKADVNHFHAAGGVAFLV
CCCCCCEEEEEEEEHHCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCCHHHHCCHHHHHH
RNLLEGGLLHEDVTTVAGRGLSHYTKEPKLIDGKLTWVDGAPESHDTKVLRGIRDPFQPD
HHHHCCCCCHHHHHHHHCCCCHHHCCCCCEECCEEEEECCCCCCCHHHHHHHHCCCCCCC
GGLRLMQGRLGRGVIKISAVAPEHRKVTAPAIVFDSQESVQEAFDRGELKRDFVAVVRFQ
CCCEEECCCCCCCEEEEEEECCCCCCEECCEEEECCHHHHHHHHHHCCHHHHHHHHHEEC
GARANGMPELHRLTPLLGVLQDQGFHVALVTDGRMSGASGKVPAVIHVSPEALLAGPLGK
CCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCEEEEECCHHHHCCCCCC
VKTGDTLVIDAEAGVLDIEVDAAEWQARPVAQPLHQAENEVGFGRELFGVFRAAAAPAEQ
CCCCCEEEEECCCCEEEEEECHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHH
GASVFGALVGETAAHVAA
HHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TSLHPTLAKVTERVIARSQSTRFAYLQRIDGAQGKFPARGALSCANLAHGFAGLEGNDK
CCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCC
FSIKAIREPNIGIVSSYNEMLSAHAPYKDFPEIIKAAARENGGVAQFAGGVPAMCDGVTQ
EEEEEECCCCCCEEECHHHHHHCCCCHHHHHHHHHHHHHCCCCEEECCCCCCHHHCCCCC
GNPGMELSLFSREAIAMGTAIALTHNMFDAALCLGICDKIVPGLLIGALQFGHLPTIFVP
CCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
AGPMTSGLSNDDKAKIRQQFATGQVGRDALLEAESAAYHGHGTCTFYGTANSNQMLMELM
CCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCEECCCEEEEEEECCCCCHHHHHHH
GLHLPGSAFVHPHTPLRTALTAEAARRVLDLTVERGHYTPIGHVIDEKAIVNGIVALLAT
CCCCCCCCEECCCCCHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHCC
GGSTNHTLHLVAIARAAGILIDWNDFDELSAVVPLLAKIYPNGKADVNHFHAAGGVAFLV
CCCCCCEEEEEEEEHHCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCCHHHHCCHHHHHH
RNLLEGGLLHEDVTTVAGRGLSHYTKEPKLIDGKLTWVDGAPESHDTKVLRGIRDPFQPD
HHHHCCCCCHHHHHHHHCCCCHHHCCCCCEECCEEEEECCCCCCCHHHHHHHHCCCCCCC
GGLRLMQGRLGRGVIKISAVAPEHRKVTAPAIVFDSQESVQEAFDRGELKRDFVAVVRFQ
CCCEEECCCCCCCEEEEEEECCCCCCEECCEEEECCHHHHHHHHHHCCHHHHHHHHHEEC
GARANGMPELHRLTPLLGVLQDQGFHVALVTDGRMSGASGKVPAVIHVSPEALLAGPLGK
CCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCEEEEECCHHHHCCCCCC
VKTGDTLVIDAEAGVLDIEVDAAEWQARPVAQPLHQAENEVGFGRELFGVFRAAAAPAEQ
CCCCCEEEEECCCCEEEEEECHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHH
GASVFGALVGETAAHVAA
HHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8045900; 10984043 [H]