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The map label for this gene is eda [H]

Identifier: 78065223

GI number: 78065223

Start: 638613

End: 639239

Strand: Direct

Name: eda [H]

Synonym: Bcep18194_A3747

Alternate gene names: 78065223

Gene position: 638613-639239 (Clockwise)

Preceding gene: 78065222

Following gene: 78065224

Centisome position: 17.29

GC content: 68.42

Gene sequence:

>627_bases
ATGAAGACGATTGCTGAAATCGTGAAGCTGGGCCCGGTCATCCCGGTGCTCGCATTCGACTCGGTCGAGCAGGGCGAACA
CGTGTCGCGTGCATTGCACGCGGGCGGCGTGAAGGTGCTCGAGATCACGCTGCGCACGCCGGCCGGCCTGGAAGCGATCC
AGCGCGCCAGCCAGCTCGCGGACGACATCGTCGTCGGCGTCGGCACGATCACGAAGCCCGAGCATTGCGAGCAGGCGAAG
CGCGCGGGCGCGAAGTTCGGCGTGTCGCCGGGCCTGACGAAGGAGCTGCACCTCGCGTCGCTCGACGCGGGCCTGCCGCT
GCTGCCGGGCGTGATGACGCCGAGCGACATCATCCAGGCGCTCGAATTCGGCTATGAGATCGTGAAGTTCTTCCCTGCGC
AGCAGGCGGGCGGCGTGCCGATGCTGCAGGCGTTCCACGGCCCGTTCCCGGCGCTGAAGTTCTGCCCGACCGGCGGCATC
ACCGTCGAAACGGCACCGAACTTCCTGAAACTGCCGAACGTCGTGTGCGTCGGCGGTTCGTGGCTCACGCCGAAAGCCGC
GCTTGCCGCGCAGGACTGGGCCGAAGTCACGCGCCTCGCGCAAGCCGCGAGCCAGCTCCCCCGCTGA

Upstream 100 bases:

>100_bases
GCGGCCGCCGCGCCGGCCGAGCAGGGCGCATCGGTTTTCGGCGCGCTGGTCGGCGAAACGGCCGCCCACGTCGCCGCATG
AATTTCAAGGAGCCAATTCA

Downstream 100 bases:

>100_bases
GACTTGTACGAAATGACGGTTTGACCCTCGGAAATCAGGCGCTTAGTGCTTGTTTTACCGAGGGTTTTTGCTGATGGAAC
CGGTTCTATCCGCGGACCGT

Product: 2-keto-3-deoxy-phosphogluconate aldolase

Products: NA

Alternate protein names: 4-hydroxy-2-oxoglutarate aldolase; 2-keto-4-hydroxyglutarate aldolase; KHG-aldolase; 2-dehydro-3-deoxy-phosphogluconate aldolase; 2-keto-3-deoxy-6-phosphogluconate aldolase; KDPG-aldolase; Phospho-2-dehydro-3-deoxygluconate aldolase; Phospho-2-keto-3-deoxygluconate aldolase [H]

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MKTIAEIVKLGPVIPVLAFDSVEQGEHVSRALHAGGVKVLEITLRTPAGLEAIQRASQLADDIVVGVGTITKPEHCEQAK
RAGAKFGVSPGLTKELHLASLDAGLPLLPGVMTPSDIIQALEFGYEIVKFFPAQQAGGVPMLQAFHGPFPALKFCPTGGI
TVETAPNFLKLPNVVCVGGSWLTPKAALAAQDWAEVTRLAQAASQLPR

Sequences:

>Translated_208_residues
MKTIAEIVKLGPVIPVLAFDSVEQGEHVSRALHAGGVKVLEITLRTPAGLEAIQRASQLADDIVVGVGTITKPEHCEQAK
RAGAKFGVSPGLTKELHLASLDAGLPLLPGVMTPSDIIQALEFGYEIVKFFPAQQAGGVPMLQAFHGPFPALKFCPTGGI
TVETAPNFLKLPNVVCVGGSWLTPKAALAAQDWAEVTRLAQAASQLPR
>Mature_208_residues
MKTIAEIVKLGPVIPVLAFDSVEQGEHVSRALHAGGVKVLEITLRTPAGLEAIQRASQLADDIVVGVGTITKPEHCEQAK
RAGAKFGVSPGLTKELHLASLDAGLPLLPGVMTPSDIIQALEFGYEIVKFFPAQQAGGVPMLQAFHGPFPALKFCPTGGI
TVETAPNFLKLPNVVCVGGSWLTPKAALAAQDWAEVTRLAQAASQLPR

Specific function: KEY ENZYME IN THE ENTNER-DOUDOROFF PATHWAY. PARTICIPATES IN THE REGULATION OF THE INTRACELLULAR LEVEL OF GLYOXYLATE. [C]

COG id: COG0800

COG function: function code G; 2-keto-3-deoxy-6-phosphogluconate aldolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the KHG/KDPG aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1788156, Length=205, Percent_Identity=42.9268292682927, Blast_Score=164, Evalue=4e-42,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000887
- InterPro:   IPR013785 [H]

Pfam domain/function: PF01081 Aldolase [H]

EC number: =4.1.3.16; =4.1.2.14 [H]

Molecular weight: Translated: 21844; Mature: 21844

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: PS00159 ALDOLASE_KDPG_KHG_1 ; PS00160 ALDOLASE_KDPG_KHG_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTIAEIVKLGPVIPVLAFDSVEQGEHVSRALHAGGVKVLEITLRTPAGLEAIQRASQLA
CCHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHCCEEEEEEEECCCCCHHHHHHHHHHH
DDIVVGVGTITKPEHCEQAKRAGAKFGVSPGLTKELHLASLDAGLPLLPGVMTPSDIIQA
HHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHH
LEFGYEIVKFFPAQQAGGVPMLQAFHGPFPALKFCPTGGITVETAPNFLKLPNVVCVGGS
HHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCEECCCCCEEEECCCCCCCCCCEEEECCC
WLTPKAALAAQDWAEVTRLAQAASQLPR
CCCCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKTIAEIVKLGPVIPVLAFDSVEQGEHVSRALHAGGVKVLEITLRTPAGLEAIQRASQLA
CCHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHCCEEEEEEEECCCCCHHHHHHHHHHH
DDIVVGVGTITKPEHCEQAKRAGAKFGVSPGLTKELHLASLDAGLPLLPGVMTPSDIIQA
HHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHH
LEFGYEIVKFFPAQQAGGVPMLQAFHGPFPALKFCPTGGITVETAPNFLKLPNVVCVGGS
HHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCEECCCCCEEEECCCCCCCCCCEEEECCC
WLTPKAALAAQDWAEVTRLAQAASQLPR
CCCCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8145647 [H]