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The map label for this gene is trpF [H]

Identifier: 78048427

GI number: 78048427

Start: 3263678

End: 3264346

Strand: Reverse

Name: trpF [H]

Synonym: XCV2871

Alternate gene names: 78048427

Gene position: 3264346-3263678 (Counterclockwise)

Preceding gene: 78048428

Following gene: 78048425

Centisome position: 63.04

GC content: 65.02

Gene sequence:

>669_bases
ATGAATCGATCGCTGTACCGCACCCGTATCAAGTTTTGTGGCATGACCCGCGCCGGCGATATCCGGCTGGCCGGCGAGCT
GGGTGTGGACGCGGTAGGTTTCATCTTTGCGCATGGCAGCCCCCGGCGCGTGGCGCCGGCCGAGGCGCGCGCGATGCGCC
AGGCCACTGCGCCGATGGTCGATGTGGTGGCGTTGTTCCGCAACAATTCCAAGGAAGAAGTGCGCGAAGTGGTGCGCACC
GTGCGCCCGACCTTGTTGCAGTTCCATGGCGAGGAAGACGACGCGTTCTGCCGTAGCTTCAACCTGCCGTATCTCAAGGC
GGTGCCGATGGGCAGCAGCGGCGTGAATGGCGAGGACGCCAACGCGCGCACGCTGCAGTTGTCGTATCCCAATACCGCTG
GCTTTCTGTTCGACAGCCATGCGCCCGGCGCGGGCGGCGGCACCGGCAAGACCTTCGACTGGTCGCGCTTGCCCACCGGC
TTGCACCGTCCGTTTCTGCTGGCCGGTGGCATCAACGCCGACAACGTGTTCGACGCCATCGTGGCCACGTTGCCTTGGGG
CGTGGACGTTTCCAGTGGCGTGGAGTTGGCGCCCGGCATCAAGGACGGCCACAAGATGCGCAAGTTCGTCGAGGAAGTGC
GGCGGGCGGATTGTCACGACATGTCGTGA

Upstream 100 bases:

>100_bases
GCGACCGCACTGTGGCCGGCCCGACAGCGCCGCCACAAGGTCTGGTATTTATCGGACCTCTGTATCCTGCAGAGTGGCAT
CTGCCTGCTGAGGTGACCCA

Downstream 100 bases:

>100_bases
GGGTGATTGGGGTTCGGGATTCGTGGCAGCGGCTATGCCGAGGCATCTCAAGCGCTGCTTCTTGCCTGCAACACCGCTGC
GTCAGGATCCACTGGACAGT

Product: N-(5'-phosphoribosyl)anthranilate isomerase

Products: NA

Alternate protein names: PRAI [H]

Number of amino acids: Translated: 222; Mature: 222

Protein sequence:

>222_residues
MNRSLYRTRIKFCGMTRAGDIRLAGELGVDAVGFIFAHGSPRRVAPAEARAMRQATAPMVDVVALFRNNSKEEVREVVRT
VRPTLLQFHGEEDDAFCRSFNLPYLKAVPMGSSGVNGEDANARTLQLSYPNTAGFLFDSHAPGAGGGTGKTFDWSRLPTG
LHRPFLLAGGINADNVFDAIVATLPWGVDVSSGVELAPGIKDGHKMRKFVEEVRRADCHDMS

Sequences:

>Translated_222_residues
MNRSLYRTRIKFCGMTRAGDIRLAGELGVDAVGFIFAHGSPRRVAPAEARAMRQATAPMVDVVALFRNNSKEEVREVVRT
VRPTLLQFHGEEDDAFCRSFNLPYLKAVPMGSSGVNGEDANARTLQLSYPNTAGFLFDSHAPGAGGGTGKTFDWSRLPTG
LHRPFLLAGGINADNVFDAIVATLPWGVDVSSGVELAPGIKDGHKMRKFVEEVRRADCHDMS
>Mature_222_residues
MNRSLYRTRIKFCGMTRAGDIRLAGELGVDAVGFIFAHGSPRRVAPAEARAMRQATAPMVDVVALFRNNSKEEVREVVRT
VRPTLLQFHGEEDDAFCRSFNLPYLKAVPMGSSGVNGEDANARTLQLSYPNTAGFLFDSHAPGAGGGTGKTFDWSRLPTG
LHRPFLLAGGINADNVFDAIVATLPWGVDVSSGVELAPGIKDGHKMRKFVEEVRRADCHDMS

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0135

COG function: function code E; Phosphoribosylanthranilate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpF family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=204, Percent_Identity=31.3725490196078, Blast_Score=84, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6320210, Length=224, Percent_Identity=30.8035714285714, Blast_Score=82, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR001240
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00697 PRAI [H]

EC number: =5.3.1.24 [H]

Molecular weight: Translated: 24135; Mature: 24135

Theoretical pI: Translated: 8.50; Mature: 8.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRSLYRTRIKFCGMTRAGDIRLAGELGVDAVGFIFAHGSPRRVAPAEARAMRQATAPMV
CCCHHHHHHHHHHCCCCCCCEEEECCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHCHHH
DVVALFRNNSKEEVREVVRTVRPTLLQFHGEEDDAFCRSFNLPYLKAVPMGSSGVNGEDA
HHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCEEEECCCCCCCCCCCC
NARTLQLSYPNTAGFLFDSHAPGAGGGTGKTFDWSRLPTGLHRPFLLAGGINADNVFDAI
CCEEEEEECCCCCCEEEECCCCCCCCCCCCCCCHHHCCCCCCCCEEEECCCCHHHHHHHH
VATLPWGVDVSSGVELAPGIKDGHKMRKFVEEVRRADCHDMS
HHHCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNRSLYRTRIKFCGMTRAGDIRLAGELGVDAVGFIFAHGSPRRVAPAEARAMRQATAPMV
CCCHHHHHHHHHHCCCCCCCEEEECCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHCHHH
DVVALFRNNSKEEVREVVRTVRPTLLQFHGEEDDAFCRSFNLPYLKAVPMGSSGVNGEDA
HHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCEEEECCCCCCCCCCCC
NARTLQLSYPNTAGFLFDSHAPGAGGGTGKTFDWSRLPTGLHRPFLLAGGINADNVFDAI
CCEEEEEECCCCCCEEEECCCCCCCCCCCCCCCHHHCCCCCCCCEEEECCCCHHHHHHHH
VATLPWGVDVSSGVELAPGIKDGHKMRKFVEEVRRADCHDMS
HHHCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]