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The map label for this gene is nuoM [H]

Identifier: 78048397

GI number: 78048397

Start: 3233340

End: 3234842

Strand: Reverse

Name: nuoM [H]

Synonym: XCV2841

Alternate gene names: 78048397

Gene position: 3234842-3233340 (Counterclockwise)

Preceding gene: 78048398

Following gene: 78048396

Centisome position: 62.47

GC content: 61.61

Gene sequence:

>1503_bases
GTGTCGAACTGGCCTTTACTGTCTATCTTGATCTGGCTGCCGATTATCGGTGGCGCCCTGATCCTTGCGTTGCGCAACGC
CGAGACTGCCCGCTGGGCGTCTTTGGCGGTAGCGGTGGCGACCTTTGCGCTGAGTCTGCCGCTGCTGGGCTACGACACTG
CCAATGACGCCATGCAGTTCATCGAACTGCATACTTGGATCCCGGCCTACAACATCGGCTACAACCTGGGCGTGGATGGC
ATCGCGGTCGCGTTGATCGTGCTGACCACGCTGGTGACGGTGCTGGCCCTGATCGGAGCCTGGCGCTCGATCGATAAGCG
CGTCAATCAGTACGTCGCTGCCTTCCTGATTCTGGAAGGCGTCACGGTCGGCATCTTCGCCGCCACCGACGCGATGTTGT
TCTACGTGTTCTTCGAAGCCATGCTGATCCCGATGTTCCTGATCATCGGCGTCTGGGGCGGCCCGCGGCGCATCTACGCG
GCGATGAAGTTCTTCCTCTATACCTTCCTCGGCTCGGTGCTGATGTTGGTGGGCCTGGTGTATCTGTATCTGAAGGGCGG
CAGCTTCCAGCTCGCCGACCTGTATGCGCTGCAGCTGACCGCCAAGGAACAGACCTGGATCTTCTTCGCATTCCTGATCG
CCTTTGCGGTCAAGGTGCCGATGTTCCCGGTGCACACCTGGTTGCCGGACGCGCACGTCGAGGCGCCGACCGCCGGTTCG
GTGATCCTGGCGGCGATTGCGTTGAAGATCGGCGGCTACGGCTTCCTGCGCTTCAACCTGCCGATCGTGCCCGACGCGAG
CCATGAGTTCGCCTGGCTGGTCATCACGCTGTCGCTGATTGCGGTGATCTATGTCGGCTTGGTGGCGTTGGTGCAGGACG
ACATGAAGAAGCTGGTGGCGTATTCGTCCATCGCGCACATGGGTTTCGTCACGCTCGGTACCTTTATCGCCTTCACCCTG
GTACGCGAGTACGGCAGCACTGACGCTGCGCGTCTGGGCCTGCAGGGCGCGATGGTGCAGATGATCTCGCACGGTTTCGT
GTCCGGCGCGATGTTCTCGTGCATCGGCGTGCTCTACGACCGCATGCATACCCGTCGCATCGCCGATTACGGCGGCGTGG
TCAACGTGATGCCCTGGTTCGCCACCTTCTCCATGTTGTTCTTCATGGCGAATGCCGGCCTGCCGGGAACCAGTGGTTTC
GTCGGCGAGTTCATGGTCATCCTGGCCAGCTTCCAGAAACATCCGTTGGTTGCCTTCGGCGCCGCCACCACGCTGGTGAT
CACCGCTGCGTACACGCTGTGGCTGTACAAGCGCGTGTTCTTCGGCGAAGTGGCCAACGCACACGTGGCCGAGCTGAAAG
ACATCAATGGCCGCGAAGCATTCGTGCTGGGGGTGTTCGCCGCTGGCGTGCTGGCCCTTGGCCTGTACCCGAAGCCGCTG
ACCGATCTGATGGAACCGTCGATCGCCAAGCTGGCGACCCAGATTGCCGCGACCAAGCTCTGA

Upstream 100 bases:

>100_bases
GTTTCCTCTATCACTACGCCTTCGCAATGATCATCGGTTTGATCGCCTTGTTGGCGGTACTGATGCATTTCTGGCGTTGA
CCTGTACGGAATAAGAAAAC

Downstream 100 bases:

>100_bases
CCGCTTGCCGTACGTTTTGATTTTCAGGATTTAATGATGACCACGCCAACGCTCGCGCCGTTGACCACCGCTGACCTAGC
TCCGCTCGTACCGGAGCTGG

Product: NADH dehydrogenase subunit M

Products: NA

Alternate protein names: NADH dehydrogenase I subunit M; NDH-1 subunit M [H]

Number of amino acids: Translated: 500; Mature: 499

Protein sequence:

>500_residues
MSNWPLLSILIWLPIIGGALILALRNAETARWASLAVAVATFALSLPLLGYDTANDAMQFIELHTWIPAYNIGYNLGVDG
IAVALIVLTTLVTVLALIGAWRSIDKRVNQYVAAFLILEGVTVGIFAATDAMLFYVFFEAMLIPMFLIIGVWGGPRRIYA
AMKFFLYTFLGSVLMLVGLVYLYLKGGSFQLADLYALQLTAKEQTWIFFAFLIAFAVKVPMFPVHTWLPDAHVEAPTAGS
VILAAIALKIGGYGFLRFNLPIVPDASHEFAWLVITLSLIAVIYVGLVALVQDDMKKLVAYSSIAHMGFVTLGTFIAFTL
VREYGSTDAARLGLQGAMVQMISHGFVSGAMFSCIGVLYDRMHTRRIADYGGVVNVMPWFATFSMLFFMANAGLPGTSGF
VGEFMVILASFQKHPLVAFGAATTLVITAAYTLWLYKRVFFGEVANAHVAELKDINGREAFVLGVFAAGVLALGLYPKPL
TDLMEPSIAKLATQIAATKL

Sequences:

>Translated_500_residues
MSNWPLLSILIWLPIIGGALILALRNAETARWASLAVAVATFALSLPLLGYDTANDAMQFIELHTWIPAYNIGYNLGVDG
IAVALIVLTTLVTVLALIGAWRSIDKRVNQYVAAFLILEGVTVGIFAATDAMLFYVFFEAMLIPMFLIIGVWGGPRRIYA
AMKFFLYTFLGSVLMLVGLVYLYLKGGSFQLADLYALQLTAKEQTWIFFAFLIAFAVKVPMFPVHTWLPDAHVEAPTAGS
VILAAIALKIGGYGFLRFNLPIVPDASHEFAWLVITLSLIAVIYVGLVALVQDDMKKLVAYSSIAHMGFVTLGTFIAFTL
VREYGSTDAARLGLQGAMVQMISHGFVSGAMFSCIGVLYDRMHTRRIADYGGVVNVMPWFATFSMLFFMANAGLPGTSGF
VGEFMVILASFQKHPLVAFGAATTLVITAAYTLWLYKRVFFGEVANAHVAELKDINGREAFVLGVFAAGVLALGLYPKPL
TDLMEPSIAKLATQIAATKL
>Mature_499_residues
SNWPLLSILIWLPIIGGALILALRNAETARWASLAVAVATFALSLPLLGYDTANDAMQFIELHTWIPAYNIGYNLGVDGI
AVALIVLTTLVTVLALIGAWRSIDKRVNQYVAAFLILEGVTVGIFAATDAMLFYVFFEAMLIPMFLIIGVWGGPRRIYAA
MKFFLYTFLGSVLMLVGLVYLYLKGGSFQLADLYALQLTAKEQTWIFFAFLIAFAVKVPMFPVHTWLPDAHVEAPTAGSV
ILAAIALKIGGYGFLRFNLPIVPDASHEFAWLVITLSLIAVIYVGLVALVQDDMKKLVAYSSIAHMGFVTLGTFIAFTLV
REYGSTDAARLGLQGAMVQMISHGFVSGAMFSCIGVLYDRMHTRRIADYGGVVNVMPWFATFSMLFFMANAGLPGTSGFV
GEFMVILASFQKHPLVAFGAATTLVITAAYTLWLYKRVFFGEVANAHVAELKDINGREAFVLGVFAAGVLALGLYPKPLT
DLMEPSIAKLATQIAATKL

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=383, Percent_Identity=33.1592689295039, Blast_Score=200, Evalue=3e-51,
Organism=Homo sapiens, GI251831117, Length=378, Percent_Identity=24.3386243386243, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI1788613, Length=508, Percent_Identity=36.8110236220472, Blast_Score=309, Evalue=3e-85,
Organism=Escherichia coli, GI1788827, Length=284, Percent_Identity=26.4084507042254, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI1788831, Length=301, Percent_Identity=26.578073089701, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1788829, Length=429, Percent_Identity=24.7086247086247, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI145693160, Length=434, Percent_Identity=24.1935483870968, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1788614, Length=401, Percent_Identity=25.9351620947631, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI2367154, Length=309, Percent_Identity=26.537216828479, Blast_Score=72, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918
- InterPro:   IPR000260 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01059 Oxidored_q5_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 54401; Mature: 54270

Theoretical pI: Translated: 7.81; Mature: 7.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNWPLLSILIWLPIIGGALILALRNAETARWASLAVAVATFALSLPLLGYDTANDAMQF
CCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
IELHTWIPAYNIGYNLGVDGIAVALIVLTTLVTVLALIGAWRSIDKRVNQYVAAFLILEG
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
VTVGIFAATDAMLFYVFFEAMLIPMFLIIGVWGGPRRIYAAMKFFLYTFLGSVLMLVGLV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
YLYLKGGSFQLADLYALQLTAKEQTWIFFAFLIAFAVKVPMFPVHTWLPDAHVEAPTAGS
HHHHCCCCEEEEHEEEEEEECCCCHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCHH
VILAAIALKIGGYGFLRFNLPIVPDASHEFAWLVITLSLIAVIYVGLVALVQDDMKKLVA
HHHHHHHHHHCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YSSIAHMGFVTLGTFIAFTLVREYGSTDAARLGLQGAMVQMISHGFVSGAMFSCIGVLYD
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RMHTRRIADYGGVVNVMPWFATFSMLFFMANAGLPGTSGFVGEFMVILASFQKHPLVAFG
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCEEEEH
AATTLVITAAYTLWLYKRVFFGEVANAHVAELKDINGREAFVLGVFAAGVLALGLYPKPL
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCH
TDLMEPSIAKLATQIAATKL
HHHHCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SNWPLLSILIWLPIIGGALILALRNAETARWASLAVAVATFALSLPLLGYDTANDAMQF
CCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
IELHTWIPAYNIGYNLGVDGIAVALIVLTTLVTVLALIGAWRSIDKRVNQYVAAFLILEG
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
VTVGIFAATDAMLFYVFFEAMLIPMFLIIGVWGGPRRIYAAMKFFLYTFLGSVLMLVGLV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
YLYLKGGSFQLADLYALQLTAKEQTWIFFAFLIAFAVKVPMFPVHTWLPDAHVEAPTAGS
HHHHCCCCEEEEHEEEEEEECCCCHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCHH
VILAAIALKIGGYGFLRFNLPIVPDASHEFAWLVITLSLIAVIYVGLVALVQDDMKKLVA
HHHHHHHHHHCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YSSIAHMGFVTLGTFIAFTLVREYGSTDAARLGLQGAMVQMISHGFVSGAMFSCIGVLYD
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RMHTRRIADYGGVVNVMPWFATFSMLFFMANAGLPGTSGFVGEFMVILASFQKHPLVAFG
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCEEEEH
AATTLVITAAYTLWLYKRVFFGEVANAHVAELKDINGREAFVLGVFAAGVLALGLYPKPL
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCH
TDLMEPSIAKLATQIAATKL
HHHHCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8566820 [H]