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The map label for this gene is nuoN

Identifier: 78048396

GI number: 78048396

Start: 3231843

End: 3233306

Strand: Reverse

Name: nuoN

Synonym: XCV2840

Alternate gene names: 78048396

Gene position: 3233306-3231843 (Counterclockwise)

Preceding gene: 78048397

Following gene: 78048395

Centisome position: 62.44

GC content: 62.77

Gene sequence:

>1464_bases
ATGATGACCACGCCAACGCTCGCGCCGTTGACCACCGCTGACCTAGCTCCGCTCGTACCGGAGCTGGTGCTGATCGGCGG
CGCCTTCGCACTGCTGATGCTCGACCTGTTCGTGAGCCAGCGGAACAAGGTCTGGACCCACCTGTTCTCCGTTGCCGTGC
TTGCCGTGGTGCTCGTGTTGCTTGCAACCGGCACGGGCGGGCAGGGCGATATCTTCAATGGCATGTTCGTCCGCGACACG
GCAGCCGATGTCATGAAGACCGTGATCGTGCTGGTCAGCGGGTTGAGCCTGGTGTATGGCTGGACCTACCTGCGCGAGCG
TAATCTCTACCAGGGCGAAATCCCGGTGCTTGTGTTGTTCGCCACTGCCGGCATGATGCTGCTGGCGTCGGCCGGTAGCC
TGTTGATGGTCTATCTGGGCCTGGAGCTGCTGGCGCTGTGCTCTTACGCACTGGTCGCCTCCAACCGCGACAATGGCCTG
GCCACCGAAGCGGCGATGAAGTATTTCGTGCTCGGGTCGCTGGCGTCGGGTCTGCTGCTATACGGCATGTCGCTGGTCTA
CGGCGCCACCGGTACGCTCAGCCTGGCCGGCATCCACGATGCGATCGAAGGCTCGAACGAACGCACGTTGCTGCTGACCG
GCACCATCTTCATGATCGCTGGCGTCGCCTTCAAGCTGGGTGCTGCACCCTTCCACATGTGGCTGCCCGACGTGTATCAG
GGTGCGCCTGCGCCGATCGCGTTGTTCATCAGCTCGGCGCCCAAGCTTGCGGCGTTCGGTATGGCCTATCGCCTGCTGGA
AGTCGGTATGGGTCCGTTGTCGCCGCAGTGGCATCTGCTGATCGGCGGCTTGTCGGCGGTTTCGCTGGTGGTCGGTAACC
TGATGGCGATTGCGCAGAGCAACCTCAAGCGCATGCTCGCATACTCGACGGTCTCTCATATCGGTTTCCTGCTGATGGGC
GTGGCGGGCGGCGGGGAAGAGGGCTATGCGGCTGCGATGTTCTACGCGGTCAGCTACACCATCATGTCCACCGCTTCGTT
CGGCGCCATCATCGCGCTGTCGCGCAACGGGTTCGAAGCGGAAAACATCGACGACTTCAAGGGACTCAACGCGCGCAATC
CGTGGATGGCTGGTCTGGTGCTGTGCATCATGGCATCGCTTGCAGGTATCCCGCCGTTCCTCGGTTTCTGGACCAAGCTG
GCGGTGCTGGGCGCGGCAGTGAAGGGCGACATGCTGTGGCTGGCGTTGGTCGGTGTGATCTGCGCAGTGATCGGTGCGTA
CTACTACCTGCGCGTCATCAAGGTCATGTACTTCGACGAGCCGGTAGGCGAGCCGTTGCCGGCCAATAACGATCGCGTGC
TCGGCACCGTGCTCGGCGTCAATGCGCTGGCCCTGCTTGCACTTGGTCTGGCCTGGAGTCCGATCATGGTGTGGTGCCAG
CGCGCATTCGCCGGCCTCGCCTAA

Upstream 100 bases:

>100_bases
GCTGACCGATCTGATGGAACCGTCGATCGCCAAGCTGGCGACCCAGATTGCCGCGACCAAGCTCTGACCGCTTGCCGTAC
GTTTTGATTTTCAGGATTTA

Downstream 100 bases:

>100_bases
GACCGCTGCGCCAGCGTTAGGTTTTGCGGCGTCGCATCCTGCATGTGGCGTCGCACTGAAATAAAACCGCGCTTACTGTT
TCGTTTTTGTTGCATTGCGG

Product: NADH dehydrogenase subunit N

Products: NA

Alternate protein names: NADH dehydrogenase I subunit N; NDH-1 subunit N

Number of amino acids: Translated: 487; Mature: 487

Protein sequence:

>487_residues
MMTTPTLAPLTTADLAPLVPELVLIGGAFALLMLDLFVSQRNKVWTHLFSVAVLAVVLVLLATGTGGQGDIFNGMFVRDT
AADVMKTVIVLVSGLSLVYGWTYLRERNLYQGEIPVLVLFATAGMMLLASAGSLLMVYLGLELLALCSYALVASNRDNGL
ATEAAMKYFVLGSLASGLLLYGMSLVYGATGTLSLAGIHDAIEGSNERTLLLTGTIFMIAGVAFKLGAAPFHMWLPDVYQ
GAPAPIALFISSAPKLAAFGMAYRLLEVGMGPLSPQWHLLIGGLSAVSLVVGNLMAIAQSNLKRMLAYSTVSHIGFLLMG
VAGGGEEGYAAAMFYAVSYTIMSTASFGAIIALSRNGFEAENIDDFKGLNARNPWMAGLVLCIMASLAGIPPFLGFWTKL
AVLGAAVKGDMLWLALVGVICAVIGAYYYLRVIKVMYFDEPVGEPLPANNDRVLGTVLGVNALALLALGLAWSPIMVWCQ
RAFAGLA

Sequences:

>Translated_487_residues
MMTTPTLAPLTTADLAPLVPELVLIGGAFALLMLDLFVSQRNKVWTHLFSVAVLAVVLVLLATGTGGQGDIFNGMFVRDT
AADVMKTVIVLVSGLSLVYGWTYLRERNLYQGEIPVLVLFATAGMMLLASAGSLLMVYLGLELLALCSYALVASNRDNGL
ATEAAMKYFVLGSLASGLLLYGMSLVYGATGTLSLAGIHDAIEGSNERTLLLTGTIFMIAGVAFKLGAAPFHMWLPDVYQ
GAPAPIALFISSAPKLAAFGMAYRLLEVGMGPLSPQWHLLIGGLSAVSLVVGNLMAIAQSNLKRMLAYSTVSHIGFLLMG
VAGGGEEGYAAAMFYAVSYTIMSTASFGAIIALSRNGFEAENIDDFKGLNARNPWMAGLVLCIMASLAGIPPFLGFWTKL
AVLGAAVKGDMLWLALVGVICAVIGAYYYLRVIKVMYFDEPVGEPLPANNDRVLGTVLGVNALALLALGLAWSPIMVWCQ
RAFAGLA
>Mature_487_residues
MMTTPTLAPLTTADLAPLVPELVLIGGAFALLMLDLFVSQRNKVWTHLFSVAVLAVVLVLLATGTGGQGDIFNGMFVRDT
AADVMKTVIVLVSGLSLVYGWTYLRERNLYQGEIPVLVLFATAGMMLLASAGSLLMVYLGLELLALCSYALVASNRDNGL
ATEAAMKYFVLGSLASGLLLYGMSLVYGATGTLSLAGIHDAIEGSNERTLLLTGTIFMIAGVAFKLGAAPFHMWLPDVYQ
GAPAPIALFISSAPKLAAFGMAYRLLEVGMGPLSPQWHLLIGGLSAVSLVVGNLMAIAQSNLKRMLAYSTVSHIGFLLMG
VAGGGEEGYAAAMFYAVSYTIMSTASFGAIIALSRNGFEAENIDDFKGLNARNPWMAGLVLCIMASLAGIPPFLGFWTKL
AVLGAAVKGDMLWLALVGVICAVIGAYYYLRVIKVMYFDEPVGEPLPANNDRVLGTVLGVNALALLALGLAWSPIMVWCQ
RAFAGLA

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1007

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 2 (chain N)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 2 family

Homologues:

Organism=Homo sapiens, GI251831108, Length=325, Percent_Identity=25.8461538461538, Blast_Score=83, Evalue=5e-16,
Organism=Escherichia coli, GI145693160, Length=476, Percent_Identity=35.0840336134454, Blast_Score=224, Evalue=7e-60,
Organism=Escherichia coli, GI1788614, Length=376, Percent_Identity=28.4574468085106, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI1788827, Length=330, Percent_Identity=27.5757575757576, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1788831, Length=388, Percent_Identity=24.4845360824742, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI1788829, Length=355, Percent_Identity=25.9154929577465, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1788613, Length=333, Percent_Identity=26.4264264264264, Blast_Score=75, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUON_XANC5 (Q3BRP2)

Other databases:

- EMBL:   AM039952
- RefSeq:   YP_364571.1
- STRING:   Q3BRP2
- GeneID:   3729762
- GenomeReviews:   AM039952_GR
- KEGG:   xcv:XCV2840
- NMPDR:   fig|316273.3.peg.2861
- HOGENOM:   HBG747830
- OMA:   MDMNTLL
- ProtClustDB:   PRK05777
- GO:   GO:0006810
- HAMAP:   MF_00445
- InterPro:   IPR010096
- InterPro:   IPR001750
- TIGRFAMs:   TIGR01770

Pfam domain/function: PF00361 Oxidored_q1

EC number: =1.6.99.5

Molecular weight: Translated: 51405; Mature: 51405

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x15fba760)-; HASH(0x18ea6d8c)-; HASH(0x1810f740)-; HASH(0x17a22fdc)-; HASH(0x191f875c)-; HASH(0x18efb064)-; HASH(0x19108e20)-; HASH(0x1923acd0)-; HASH(0x1893c9b4)-; HASH(0x1922a328)-; HASH(0x18d17ddc)-; HASH(0x191f20bc)-; HASH(0x18444418)-;

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMTTPTLAPLTTADLAPLVPELVLIGGAFALLMLDLFVSQRNKVWTHLFSVAVLAVVLVL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LATGTGGQGDIFNGMFVRDTAADVMKTVIVLVSGLSLVYGWTYLRERNLYQGEIPVLVLF
HHCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHH
ATAGMMLLASAGSLLMVYLGLELLALCSYALVASNRDNGLATEAAMKYFVLGSLASGLLL
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
YGMSLVYGATGTLSLAGIHDAIEGSNERTLLLTGTIFMIAGVAFKLGAAPFHMWLPDVYQ
HHHHHHHCCCCCEEEHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHCCCCHHHHCCHHHC
GAPAPIALFISSAPKLAAFGMAYRLLEVGMGPLSPQWHLLIGGLSAVSLVVGNLMAIAQS
CCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHH
NLKRMLAYSTVSHIGFLLMGVAGGGEEGYAAAMFYAVSYTIMSTASFGAIIALSRNGFEA
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCC
ENIDDFKGLNARNPWMAGLVLCIMASLAGIPPFLGFWTKLAVLGAAVKGDMLWLALVGVI
CCCCHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CAVIGAYYYLRVIKVMYFDEPVGEPLPANNDRVLGTVLGVNALALLALGLAWSPIMVWCQ
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
RAFAGLA
HHHHCCH
>Mature Secondary Structure
MMTTPTLAPLTTADLAPLVPELVLIGGAFALLMLDLFVSQRNKVWTHLFSVAVLAVVLVL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LATGTGGQGDIFNGMFVRDTAADVMKTVIVLVSGLSLVYGWTYLRERNLYQGEIPVLVLF
HHCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHH
ATAGMMLLASAGSLLMVYLGLELLALCSYALVASNRDNGLATEAAMKYFVLGSLASGLLL
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
YGMSLVYGATGTLSLAGIHDAIEGSNERTLLLTGTIFMIAGVAFKLGAAPFHMWLPDVYQ
HHHHHHHCCCCCEEEHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHCCCCHHHHCCHHHC
GAPAPIALFISSAPKLAAFGMAYRLLEVGMGPLSPQWHLLIGGLSAVSLVVGNLMAIAQS
CCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHH
NLKRMLAYSTVSHIGFLLMGVAGGGEEGYAAAMFYAVSYTIMSTASFGAIIALSRNGFEA
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCC
ENIDDFKGLNARNPWMAGLVLCIMASLAGIPPFLGFWTKLAVLGAAVKGDMLWLALVGVI
CCCCHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CAVIGAYYYLRVIKVMYFDEPVGEPLPANNDRVLGTVLGVNALALLALGLAWSPIMVWCQ
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
RAFAGLA
HHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA