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The map label for this gene is parC [H]

Identifier: 78047053

GI number: 78047053

Start: 1686849

End: 1689092

Strand: Reverse

Name: parC [H]

Synonym: XCV1497

Alternate gene names: 78047053

Gene position: 1689092-1686849 (Counterclockwise)

Preceding gene: 78047054

Following gene: 78047052

Centisome position: 32.62

GC content: 64.93

Gene sequence:

>2244_bases
ATGACCGATCTGACCCGCCCCACCTTCCACGGCTTTGAACAGCTGCCGCTGCGCGAATACGCCGAACGCGCCTATCTCGA
CTACTCGATGTATGTGGTGCTCGACCGCGCCCTGCCGTTCCTGGGTGACGGCCTGAAGCCGGTGCAGCGCCGCATCGTCT
ACGCGATGAGCGAGCTGGGCCTGAACGCCGCCGCCAAGCCGAAGAAATCCGCGCGTACCGTGGGCGATGTGATCGGTAAG
TACCACCCGCATGGCGACAGTGCCTGCTATGAGGCGCTGGTACTGATGGCGCAGCCGTTCTCGTACCGTTATCCGCTGAT
CGAAGGCCAGGGCAACTTCGGCTCCACCGACGACCCCAAGTCGTTTGCAGCGATGCGCTACACCGAGTCCAAGCTGACCC
CGATCGCCGAAGTGCTGCTGGGCGAGCTTGGCCAGGGCACCACCGATTGGGCGCCCAACTTCGACGGCACCCTGGAAGAG
CCCACCTGGTTGCCGGCACGCCTGCCGCACCTGCTGCTCAACGGCACCACCGGGATTGCGGTGGGCATGGCCACCGACGT
GCCGCCGCACAATCTCAACGAGATCGTCAGCGCACTGCTGCGGCTGCTCGATGACCCTGACGCCACGGTCGCGCAGCTGT
GCGAGCACGTGCTGGGCCCGGATTACCCGACCACCGCCGAGATCATCACCCCGGCTGCGGACCTGCGGAACATCTACGAG
ACCGGTCACGGCAGCGTGCGCGCGCGCGCCACCTACAAGAAAGAGCACGCCAACATCGTCATCGATGCGCTGCCCTACCA
GGTCTCCCCGTCCAAGGTGATCGAGCAGATCGCCCAGCAGATGCGCGCCAAGAAGCTGCCGTGGCTGGAAGACATCCGCG
ACGAGTCCGACCACACCAGCCCGGTGCGGGTGGTGCTGGTGCCGCGCTCCAATCGCGTCGATGCCGAACAGCTGATGGGC
CACCTGTTCGTTACTACCGATCTTGAGCGCAGCTACCGCGTCAACCTCAACGTGATCGGTCTGGATGGCCGCCCGCAGGT
CAAGAACCTCAAGCACCTGCTGAGCGAATGGCTGAGCTTCCGCAGCGATACGGTGACCCGCCGCCTCAACCATCGCCTGC
AGAAGGTCGAGCGCCGCCTGCACCTGTTGGAAGGCTTGTTGATCGCCTTCCTCAACCTGGACGAAGTGATCCGCATCGTC
CGCAGCGAAGACGAACCCAAGCCGGTGCTGATCTCGCGCTTCGCGCTGAGCGAAGAACAGGCCGAATACATCCTGGAAAC
CAAGCTGCGCCAACTGGCGCGCCTGGAGGAAATGAAGATCCGCGGCGAACAGGAAGCACTCGCCAAGGAACGCGCGCAGA
TCATCGCGATCCTGGAAAGCAAGACCAAGCTGAAGAAGCTGATCAAGGACGAACTGACTGCCGACGCCAAGAAGTTCGGC
GATGCGCGGCGTTCGCCGCTGGTGCAGCGTGGCGCCGCGCAGGCCATCGACGAAACCGAAATGGTGGCCAGCGAACCGAT
GACCGTGGTGCTATCGGAGAAGGGCTGGGTGCGGGCAGCCAAGGGCCACGAGGTGGATCCTGCCGGCATGTCCTACCGCG
AAGGCGATGGCCTGCTGGCGGCAGTGCGCAGCCGCAGCACGCATCAGGTGGCGTTCCTGGATTCGGACGGCCGCGCCTAT
TCCACCGCCGTGCACACCCTGCCCTCGGCGCGTGGCAATGGCGAACCGTTGACCGGACGTTTCTCGCCGGCCTCGGGCGC
GGCGTTCCAGGTCATGGCCAGCGCCGACAACGCCACCCGCTTCGTGCTGGCATCCTCGCACGGCTACGGCTTCGTCACCC
GTTTCGAAAACCTCACCGGCCGCAACAAGGCCGGCAAGGCGATGCTCAATCTCACCACCGGCTCGCATGTGCTGACGCCG
GCCCAGGTAAGCAACCCGCAAACCGACCGCATCGTCGCCGTGACCAGTGCCGGCAATCTGCTGGCGGTGCCGGCCACCGA
CGTGCCCGAGCTGGACAAGGGCAAAGGCAACAAGATCATCGAGATCCCCAAGGCCAAGCTCGGCACCGAACGCGTGGTGG
CCGTGGTGGCGGTCGCACCAGGCAACACGCTGCTGGTGCGCAGCGGCGCACGCACCATGAGCCTGTCGTTCAAGGACCTG
GATACGTATGTGGGTGCGCGTGCGAGCCGTGGATCGTTGTTGCCACGTGGGTGGCAGAAGGTGGACGGGTTGGAGGTGCA
GTAA

Upstream 100 bases:

>100_bases
CATGCGCGCGGCTTGGCATCCCCCGCCGCATCCGGATAATCGGCGCTCTTCGAGCCCGCGCCCCGGCGCGGGTTCCTCTT
CACGCAGGACCTGGCTTTAC

Downstream 100 bases:

>100_bases
TGGACGGCAATTCACTCGTCCGGCGCGCAGCGGCGCGGTTGGGACTGCGGTCGCCTCAGGCTGCTGGGGCGCGGCAGAAG
GTGGATGGGTTGGAGGTGCA

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 747; Mature: 746

Protein sequence:

>747_residues
MTDLTRPTFHGFEQLPLREYAERAYLDYSMYVVLDRALPFLGDGLKPVQRRIVYAMSELGLNAAAKPKKSARTVGDVIGK
YHPHGDSACYEALVLMAQPFSYRYPLIEGQGNFGSTDDPKSFAAMRYTESKLTPIAEVLLGELGQGTTDWAPNFDGTLEE
PTWLPARLPHLLLNGTTGIAVGMATDVPPHNLNEIVSALLRLLDDPDATVAQLCEHVLGPDYPTTAEIITPAADLRNIYE
TGHGSVRARATYKKEHANIVIDALPYQVSPSKVIEQIAQQMRAKKLPWLEDIRDESDHTSPVRVVLVPRSNRVDAEQLMG
HLFVTTDLERSYRVNLNVIGLDGRPQVKNLKHLLSEWLSFRSDTVTRRLNHRLQKVERRLHLLEGLLIAFLNLDEVIRIV
RSEDEPKPVLISRFALSEEQAEYILETKLRQLARLEEMKIRGEQEALAKERAQIIAILESKTKLKKLIKDELTADAKKFG
DARRSPLVQRGAAQAIDETEMVASEPMTVVLSEKGWVRAAKGHEVDPAGMSYREGDGLLAAVRSRSTHQVAFLDSDGRAY
STAVHTLPSARGNGEPLTGRFSPASGAAFQVMASADNATRFVLASSHGYGFVTRFENLTGRNKAGKAMLNLTTGSHVLTP
AQVSNPQTDRIVAVTSAGNLLAVPATDVPELDKGKGNKIIEIPKAKLGTERVVAVVAVAPGNTLLVRSGARTMSLSFKDL
DTYVGARASRGSLLPRGWQKVDGLEVQ

Sequences:

>Translated_747_residues
MTDLTRPTFHGFEQLPLREYAERAYLDYSMYVVLDRALPFLGDGLKPVQRRIVYAMSELGLNAAAKPKKSARTVGDVIGK
YHPHGDSACYEALVLMAQPFSYRYPLIEGQGNFGSTDDPKSFAAMRYTESKLTPIAEVLLGELGQGTTDWAPNFDGTLEE
PTWLPARLPHLLLNGTTGIAVGMATDVPPHNLNEIVSALLRLLDDPDATVAQLCEHVLGPDYPTTAEIITPAADLRNIYE
TGHGSVRARATYKKEHANIVIDALPYQVSPSKVIEQIAQQMRAKKLPWLEDIRDESDHTSPVRVVLVPRSNRVDAEQLMG
HLFVTTDLERSYRVNLNVIGLDGRPQVKNLKHLLSEWLSFRSDTVTRRLNHRLQKVERRLHLLEGLLIAFLNLDEVIRIV
RSEDEPKPVLISRFALSEEQAEYILETKLRQLARLEEMKIRGEQEALAKERAQIIAILESKTKLKKLIKDELTADAKKFG
DARRSPLVQRGAAQAIDETEMVASEPMTVVLSEKGWVRAAKGHEVDPAGMSYREGDGLLAAVRSRSTHQVAFLDSDGRAY
STAVHTLPSARGNGEPLTGRFSPASGAAFQVMASADNATRFVLASSHGYGFVTRFENLTGRNKAGKAMLNLTTGSHVLTP
AQVSNPQTDRIVAVTSAGNLLAVPATDVPELDKGKGNKIIEIPKAKLGTERVVAVVAVAPGNTLLVRSGARTMSLSFKDL
DTYVGARASRGSLLPRGWQKVDGLEVQ
>Mature_746_residues
TDLTRPTFHGFEQLPLREYAERAYLDYSMYVVLDRALPFLGDGLKPVQRRIVYAMSELGLNAAAKPKKSARTVGDVIGKY
HPHGDSACYEALVLMAQPFSYRYPLIEGQGNFGSTDDPKSFAAMRYTESKLTPIAEVLLGELGQGTTDWAPNFDGTLEEP
TWLPARLPHLLLNGTTGIAVGMATDVPPHNLNEIVSALLRLLDDPDATVAQLCEHVLGPDYPTTAEIITPAADLRNIYET
GHGSVRARATYKKEHANIVIDALPYQVSPSKVIEQIAQQMRAKKLPWLEDIRDESDHTSPVRVVLVPRSNRVDAEQLMGH
LFVTTDLERSYRVNLNVIGLDGRPQVKNLKHLLSEWLSFRSDTVTRRLNHRLQKVERRLHLLEGLLIAFLNLDEVIRIVR
SEDEPKPVLISRFALSEEQAEYILETKLRQLARLEEMKIRGEQEALAKERAQIIAILESKTKLKKLIKDELTADAKKFGD
ARRSPLVQRGAAQAIDETEMVASEPMTVVLSEKGWVRAAKGHEVDPAGMSYREGDGLLAAVRSRSTHQVAFLDSDGRAYS
TAVHTLPSARGNGEPLTGRFSPASGAAFQVMASADNATRFVLASSHGYGFVTRFENLTGRNKAGKAMLNLTTGSHVLTPA
QVSNPQTDRIVAVTSAGNLLAVPATDVPELDKGKGNKIIEIPKAKLGTERVVAVVAVAPGNTLLVRSGARTMSLSFKDLD
TYVGARASRGSLLPRGWQKVDGLEVQ

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=191, Percent_Identity=29.3193717277487, Blast_Score=73, Evalue=1e-12,
Organism=Homo sapiens, GI19913406, Length=173, Percent_Identity=28.9017341040462, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI1789396, Length=736, Percent_Identity=60.8695652173913, Blast_Score=937, Evalue=0.0,
Organism=Escherichia coli, GI1788562, Length=752, Percent_Identity=33.2446808510638, Blast_Score=386, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI212645845, Length=511, Percent_Identity=24.4618395303327, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17535065, Length=174, Percent_Identity=29.8850574712644, Blast_Score=72, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=381, Percent_Identity=23.6220472440945, Blast_Score=77, Evalue=7e-15,
Organism=Drosophila melanogaster, GI17136538, Length=196, Percent_Identity=27.5510204081633, Blast_Score=74, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 82184; Mature: 82053

Theoretical pI: Translated: 8.22; Mature: 8.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDLTRPTFHGFEQLPLREYAERAYLDYSMYVVLDRALPFLGDGLKPVQRRIVYAMSELG
CCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHC
LNAAAKPKKSARTVGDVIGKYHPHGDSACYEALVLMAQPFSYRYPLIEGQGNFGSTDDPK
CCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCH
SFAAMRYTESKLTPIAEVLLGELGQGTTDWAPNFDGTLEEPTWLPARLPHLLLNGTTGIA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHCCHHHCCCCCCEE
VGMATDVPPHNLNEIVSALLRLLDDPDATVAQLCEHVLGPDYPTTAEIITPAADLRNIYE
EEEECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHCCCHHHHHHHHH
TGHGSVRARATYKKEHANIVIDALPYQVSPSKVIEQIAQQMRAKKLPWLEDIRDESDHTS
CCCCCEEEEEHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCC
PVRVVLVPRSNRVDAEQLMGHLFVTTDLERSYRVNLNVIGLDGRPQVKNLKHLLSEWLSF
CEEEEEECCCCCCCHHHHHCEEEEEEECCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHH
RSDTVTRRLNHRLQKVERRLHLLEGLLIAFLNLDEVIRIVRSEDEPKPVLISRFALSEEQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCEEEEHHHHCHHH
AEYILETKLRQLARLEEMKIRGEQEALAKERAQIIAILESKTKLKKLIKDELTADAKKFG
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DARRSPLVQRGAAQAIDETEMVASEPMTVVLSEKGWVRAAKGHEVDPAGMSYREGDGLLA
HHHCCHHHHHHHHHHCCHHHHHHCCCEEEEEECCCCEEECCCCCCCCCCCCEECCCCCEE
AVRSRSTHQVAFLDSDGRAYSTAVHTLPSARGNGEPLTGRFSPASGAAFQVMASADNATR
EECCCCCEEEEEECCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEE
FVLASSHGYGFVTRFENLTGRNKAGKAMLNLTTGSHVLTPAQVSNPQTDRIVAVTSAGNL
EEEECCCCCEEEEEHHCCCCCCCCCCEEEEEECCCEEECCHHCCCCCCCEEEEEECCCCE
LAVPATDVPELDKGKGNKIIEIPKAKLGTERVVAVVAVAPGNTLLVRSGARTMSLSFKDL
EEECCCCCCCCCCCCCCEEEECCCCCCCCCEEEEEEEECCCCEEEEECCCCEEEEEHHHH
DTYVGARASRGSLLPRGWQKVDGLEVQ
HHHHCCCCCCCCCCCCCHHHCCCCCCC
>Mature Secondary Structure 
TDLTRPTFHGFEQLPLREYAERAYLDYSMYVVLDRALPFLGDGLKPVQRRIVYAMSELG
CCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHC
LNAAAKPKKSARTVGDVIGKYHPHGDSACYEALVLMAQPFSYRYPLIEGQGNFGSTDDPK
CCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCH
SFAAMRYTESKLTPIAEVLLGELGQGTTDWAPNFDGTLEEPTWLPARLPHLLLNGTTGIA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHCCHHHCCCCCCEE
VGMATDVPPHNLNEIVSALLRLLDDPDATVAQLCEHVLGPDYPTTAEIITPAADLRNIYE
EEEECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHCCCHHHHHHHHH
TGHGSVRARATYKKEHANIVIDALPYQVSPSKVIEQIAQQMRAKKLPWLEDIRDESDHTS
CCCCCEEEEEHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCC
PVRVVLVPRSNRVDAEQLMGHLFVTTDLERSYRVNLNVIGLDGRPQVKNLKHLLSEWLSF
CEEEEEECCCCCCCHHHHHCEEEEEEECCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHH
RSDTVTRRLNHRLQKVERRLHLLEGLLIAFLNLDEVIRIVRSEDEPKPVLISRFALSEEQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCEEEEHHHHCHHH
AEYILETKLRQLARLEEMKIRGEQEALAKERAQIIAILESKTKLKKLIKDELTADAKKFG
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DARRSPLVQRGAAQAIDETEMVASEPMTVVLSEKGWVRAAKGHEVDPAGMSYREGDGLLA
HHHCCHHHHHHHHHHCCHHHHHHCCCEEEEEECCCCEEECCCCCCCCCCCCEECCCCCEE
AVRSRSTHQVAFLDSDGRAYSTAVHTLPSARGNGEPLTGRFSPASGAAFQVMASADNATR
EECCCCCEEEEEECCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEE
FVLASSHGYGFVTRFENLTGRNKAGKAMLNLTTGSHVLTPAQVSNPQTDRIVAVTSAGNL
EEEECCCCCEEEEEHHCCCCCCCCCCEEEEEECCCEEECCHHCCCCCCCEEEEEECCCCE
LAVPATDVPELDKGKGNKIIEIPKAKLGTERVVAVVAVAPGNTLLVRSGARTMSLSFKDL
EEECCCCCCCCCCCCCCEEEECCCCCCCCCEEEEEEEECCCCEEEEECCCCEEEEEHHHH
DTYVGARASRGSLLPRGWQKVDGLEVQ
HHHHCCCCCCCCCCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]