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The map label for this gene is tpmT [H]

Identifier: 78047052

GI number: 78047052

Start: 1685415

End: 1686071

Strand: Reverse

Name: tpmT [H]

Synonym: XCV1496

Alternate gene names: 78047052

Gene position: 1686071-1685415 (Counterclockwise)

Preceding gene: 78047053

Following gene: 78047050

Centisome position: 32.56

GC content: 63.62

Gene sequence:

>657_bases
ATGGACACGAATTTCTGGTTGGAACGTTGGCAGCTGGGACACACCGGCTTTCATCAGCAAGAGGTATTGCCGCTGCTGCA
AAAGCACTGGCACGCACTGGATCTGCCGAAGGAAGCGCGCGTGCTGGTGCCCCTGTGCGGCAAGACGCTGGACATGCATT
GGCTGGCGGCGCAAGGCCATCGCGTGCTTGGCGTGGAGCTGTCGCCGCTGGCGGTGACGCAATTCTTCGATGAGGCGGGC
CTTCAACCGCAGCGTCACAGCAGCGCTGCTGGCGAGCATTTCATCGCCGGCCCGATCGAGATCATCTGCGGCGATGCATT
CGCGCTGGACGCCAGCGCGCTGGCCGACTGCACGGCCGTCTACGACCGCGCCGCACTGGTCGCGCTACCGGCCGAACTGC
GCCAGCATTACCTGCAAACGGTCTACGCGCCGTTGCCCACACACTGCCACGGCCTGCTGATCACCCTGGAATATCCGCAG
GCTGAAAAGGCCGGCCCGCCGTTCTCGGTGGACGCAACGCACGTGCATGCACTTTTCGATTCCGCCTGGCAGGTAGACCA
GCTGGAACACCGCGACATCCTCGATCAGGAACCACGCTTCCGCGATGAAGGCGTCACCGGGTTATCGACGGCTGTCTATC
GCCTGCAAGGCCGCTGA

Upstream 100 bases:

>100_bases
GCAGTCGCAAACGCACAGCCAACGCCGCGCACCGCTTCAGAACGCGCCACGCCCCGCTCTCGCATGACCACAGTGGAGAC
AGCCACTGACAAGGCAACGC

Downstream 100 bases:

>100_bases
AACGGCCGTCGGGCGCTGCACGCCCATCACGTGGCAATTGCATGTCTGCATGCGGCAAGCGTGGGTGGCGGATCAGGACA
GCGCGGCATTGCGCCATGCG

Product: thiopurine S-methyltransferase

Products: NA

Alternate protein names: Thiopurine methyltransferase [H]

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MDTNFWLERWQLGHTGFHQQEVLPLLQKHWHALDLPKEARVLVPLCGKTLDMHWLAAQGHRVLGVELSPLAVTQFFDEAG
LQPQRHSSAAGEHFIAGPIEIICGDAFALDASALADCTAVYDRAALVALPAELRQHYLQTVYAPLPTHCHGLLITLEYPQ
AEKAGPPFSVDATHVHALFDSAWQVDQLEHRDILDQEPRFRDEGVTGLSTAVYRLQGR

Sequences:

>Translated_218_residues
MDTNFWLERWQLGHTGFHQQEVLPLLQKHWHALDLPKEARVLVPLCGKTLDMHWLAAQGHRVLGVELSPLAVTQFFDEAG
LQPQRHSSAAGEHFIAGPIEIICGDAFALDASALADCTAVYDRAALVALPAELRQHYLQTVYAPLPTHCHGLLITLEYPQ
AEKAGPPFSVDATHVHALFDSAWQVDQLEHRDILDQEPRFRDEGVTGLSTAVYRLQGR
>Mature_218_residues
MDTNFWLERWQLGHTGFHQQEVLPLLQKHWHALDLPKEARVLVPLCGKTLDMHWLAAQGHRVLGVELSPLAVTQFFDEAG
LQPQRHSSAAGEHFIAGPIEIICGDAFALDASALADCTAVYDRAALVALPAELRQHYLQTVYAPLPTHCHGLLITLEYPQ
AEKAGPPFSVDATHVHALFDSAWQVDQLEHRDILDQEPRFRDEGVTGLSTAVYRLQGR

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. TPMT family [H]

Homologues:

Organism=Homo sapiens, GI4507653, Length=216, Percent_Identity=32.4074074074074, Blast_Score=112, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022474
- InterPro:   IPR008854
- InterPro:   IPR016822 [H]

Pfam domain/function: PF05724 TPMT [H]

EC number: =2.1.1.67 [H]

Molecular weight: Translated: 24334; Mature: 24334

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTNFWLERWQLGHTGFHQQEVLPLLQKHWHALDLPKEARVLVPLCGKTLDMHWLAAQGH
CCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCEEEECCCC
RVLGVELSPLAVTQFFDEAGLQPQRHSSAAGEHFIAGPIEIICGDAFALDASALADCTAV
EEEEEEECHHHHHHHHHHHCCCCCCCCCCCCCCEECCCEEEEECCCHHCCHHHHHHHHHH
YDRAALVALPAELRQHYLQTVYAPLPTHCHGLLITLEYPQAEKAGPPFSVDATHVHALFD
HHHHHHEECHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHH
SAWQVDQLEHRDILDQEPRFRDEGVTGLSTAVYRLQGR
CCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHEEECCC
>Mature Secondary Structure
MDTNFWLERWQLGHTGFHQQEVLPLLQKHWHALDLPKEARVLVPLCGKTLDMHWLAAQGH
CCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCEEEECCCC
RVLGVELSPLAVTQFFDEAGLQPQRHSSAAGEHFIAGPIEIICGDAFALDASALADCTAV
EEEEEEECHHHHHHHHHHHCCCCCCCCCCCCCCEECCCEEEEECCCHHCCHHHHHHHHHH
YDRAALVALPAELRQHYLQTVYAPLPTHCHGLLITLEYPQAEKAGPPFSVDATHVHALFD
HHHHHHEECHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHH
SAWQVDQLEHRDILDQEPRFRDEGVTGLSTAVYRLQGR
CCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]