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The map label for this gene is purM

Identifier: 78044305

GI number: 78044305

Start: 952700

End: 953731

Strand: Direct

Name: purM

Synonym: CHY_1076

Alternate gene names: 78044305

Gene position: 952700-953731 (Clockwise)

Preceding gene: 78043394

Following gene: 78045060

Centisome position: 39.67

GC content: 47.29

Gene sequence:

>1032_bases
ATGGAGGAGTTAACGTATAAAGCTGCCGGGGTCGATATCGATGCCGGCATGGATGTGGTCCGGCGCATTAAATCGGAAGT
GGAGAAAACTTTAAACCCAAATGTTCTGGCCGGCATTGGCGGTTTTTCCGCCCTTTATTGTTTGGATGTTACGGGATATA
ACGAGCCGGTTTTAGTTTCATCGACCGATGGGGTGGGAACAAAGCTTAAGATAGCTCAGGCACTGGGAAAATACGACACC
ATAGGCATTGATTTGGTAGCGATGGTGGTTAACGATTTACTCACTGTGGGAGCTAAACCGCTGTTTTTCCTGGATTACGT
TGCGGTGGGCAAGCTAAATCCGGAACAGGTGGCCGACTTGGTGAAGGGAATGGCGGAAGGCTGCCTTGAGGCAGACTGCG
CCCTGGTTGGGGGAGAAACGGCGGAAATGCCCGGGGTTTACCATCCCGGAGATTTTGATATTGCCGGCTTTGGTGTGGGG
GTTGTGGAAAAAAGCAAGATAATCGATGGAAGTTCCGTTAAAGCCGGTGATGTTATAATTGGCGTTGCTTCCTCGGGGAT
CCACAGTAACGGTTTAAGTCTTGCCCGAAAGGCTCTCTTGGAGTACGGTAACTATCATCTTACCGCTTATGTCGAGGAGT
TTGGGAAAACCCTGGGGGAAGAACTTTTAACTCCTACCCGGATTTATGTAAAGCCAGTACTTGATTTAATGCAAAAGGTG
GAGATAAAAGGTATGGCCCATATTACCGGCGGCGGGATTGTAGATAATCTTCCCCGGATTTTACCGGAAAAGGTAGAGGC
GCGGATAACCGTGAACTGGGAAATACCAAAAATTTTTAAGTTAATTGAAAAGGCCGGGAATGTGCCGCGAAGGGAAATGT
GGCGGACATTTAACATGGGCATTGGTTTTATTTTAATCGTGGAGGAGGCAAAGGTTCAGGAAGCAATTAAAACGTTAGAG
AGTTTTAATTATAAGGCATGGGTAATTGGAGAAATTACCGCGGGGGAACGCAGGGTGATTATTAATGAATAG

Upstream 100 bases:

>100_bases
TTAGAAGGCTTACTTGGGATTTTTAAGGAACGGGATTTTTGTCTTGCTTGCTTTACCGGGGATTACCCGGTACCGATAAA
TTAATGGTGGGGGTAAGACC

Downstream 100 bases:

>100_bases
GGAGGAAGAAAATGTTAAACTTAGGGGTTTTGGCTTCGGGACGGGGGAGTAACTTTCAGGCGATTATTGATGCGATTGCG
TGGGGAGTTTTGCCGGCAAA

Product: phosphoribosylformylglycinamidine cyclo-ligase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase

Number of amino acids: Translated: 343; Mature: 343

Protein sequence:

>343_residues
MEELTYKAAGVDIDAGMDVVRRIKSEVEKTLNPNVLAGIGGFSALYCLDVTGYNEPVLVSSTDGVGTKLKIAQALGKYDT
IGIDLVAMVVNDLLTVGAKPLFFLDYVAVGKLNPEQVADLVKGMAEGCLEADCALVGGETAEMPGVYHPGDFDIAGFGVG
VVEKSKIIDGSSVKAGDVIIGVASSGIHSNGLSLARKALLEYGNYHLTAYVEEFGKTLGEELLTPTRIYVKPVLDLMQKV
EIKGMAHITGGGIVDNLPRILPEKVEARITVNWEIPKIFKLIEKAGNVPRREMWRTFNMGIGFILIVEEAKVQEAIKTLE
SFNYKAWVIGEITAGERRVIINE

Sequences:

>Translated_343_residues
MEELTYKAAGVDIDAGMDVVRRIKSEVEKTLNPNVLAGIGGFSALYCLDVTGYNEPVLVSSTDGVGTKLKIAQALGKYDT
IGIDLVAMVVNDLLTVGAKPLFFLDYVAVGKLNPEQVADLVKGMAEGCLEADCALVGGETAEMPGVYHPGDFDIAGFGVG
VVEKSKIIDGSSVKAGDVIIGVASSGIHSNGLSLARKALLEYGNYHLTAYVEEFGKTLGEELLTPTRIYVKPVLDLMQKV
EIKGMAHITGGGIVDNLPRILPEKVEARITVNWEIPKIFKLIEKAGNVPRREMWRTFNMGIGFILIVEEAKVQEAIKTLE
SFNYKAWVIGEITAGERRVIINE
>Mature_343_residues
MEELTYKAAGVDIDAGMDVVRRIKSEVEKTLNPNVLAGIGGFSALYCLDVTGYNEPVLVSSTDGVGTKLKIAQALGKYDT
IGIDLVAMVVNDLLTVGAKPLFFLDYVAVGKLNPEQVADLVKGMAEGCLEADCALVGGETAEMPGVYHPGDFDIAGFGVG
VVEKSKIIDGSSVKAGDVIIGVASSGIHSNGLSLARKALLEYGNYHLTAYVEEFGKTLGEELLTPTRIYVKPVLDLMQKV
EIKGMAHITGGGIVDNLPRILPEKVEARITVNWEIPKIFKLIEKAGNVPRREMWRTFNMGIGFILIVEEAKVQEAIKTLE
SFNYKAWVIGEITAGERRVIINE

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family

Homologues:

Organism=Homo sapiens, GI4503915, Length=334, Percent_Identity=45.5089820359281, Blast_Score=309, Evalue=2e-84,
Organism=Homo sapiens, GI209869995, Length=334, Percent_Identity=45.5089820359281, Blast_Score=309, Evalue=2e-84,
Organism=Homo sapiens, GI209869993, Length=334, Percent_Identity=45.5089820359281, Blast_Score=309, Evalue=2e-84,
Organism=Escherichia coli, GI1788845, Length=341, Percent_Identity=54.5454545454545, Blast_Score=355, Evalue=3e-99,
Organism=Caenorhabditis elegans, GI17567511, Length=349, Percent_Identity=40.974212034384, Blast_Score=241, Evalue=3e-64,
Organism=Saccharomyces cerevisiae, GI6321203, Length=334, Percent_Identity=45.8083832335329, Blast_Score=297, Evalue=2e-81,
Organism=Drosophila melanogaster, GI24582400, Length=289, Percent_Identity=40.8304498269896, Blast_Score=223, Evalue=1e-58,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR5_CARHZ (Q3AD62)

Other databases:

- EMBL:   CP000141
- RefSeq:   YP_359922.1
- ProteinModelPortal:   Q3AD62
- SMR:   Q3AD62
- STRING:   Q3AD62
- GeneID:   3727422
- GenomeReviews:   CP000141_GR
- KEGG:   chy:CHY_1076
- NMPDR:   fig|246194.3.peg.876
- TIGR:   CHY_1076
- eggNOG:   COG0150
- HOGENOM:   HBG531222
- OMA:   DMYGADD
- BioCyc:   CHYD246194:CHY_1076-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00741_B
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188
- TIGRFAMs:   TIGR00878

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.3.1

Molecular weight: Translated: 37031; Mature: 37031

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEELTYKAAGVDIDAGMDVVRRIKSEVEKTLNPNVLAGIGGFSALYCLDVTGYNEPVLVS
CCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCEEEEEEEECCCCCCEEEE
STDGVGTKLKIAQALGKYDTIGIDLVAMVVNDLLTVGAKPLFFLDYVAVGKLNPEQVADL
CCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHH
VKGMAEGCLEADCALVGGETAEMPGVYHPGDFDIAGFGVGVVEKSKIIDGSSVKAGDVII
HHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCEEECCCCEEECCCCCCCCCCCCCCEEE
GVASSGIHSNGLSLARKALLEYGNYHLTAYVEEFGKTLGEELLTPTRIYVKPVLDLMQKV
EEECCCCCCCCHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
EIKGMAHITGGGIVDNLPRILPEKVEARITVNWEIPKIFKLIEKAGNVPRREMWRTFNMG
HHCCEEEEECCCHHHHHHHHCCHHCCEEEEEEECHHHHHHHHHHHCCCCHHHHHHHHCCC
IGFILIVEEAKVQEAIKTLESFNYKAWVIGEITAGERRVIINE
CEEEEEEEHHHHHHHHHHHHHCCCEEEEEEEECCCCEEEEECC
>Mature Secondary Structure
MEELTYKAAGVDIDAGMDVVRRIKSEVEKTLNPNVLAGIGGFSALYCLDVTGYNEPVLVS
CCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCEEEEEEEECCCCCCEEEE
STDGVGTKLKIAQALGKYDTIGIDLVAMVVNDLLTVGAKPLFFLDYVAVGKLNPEQVADL
CCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHH
VKGMAEGCLEADCALVGGETAEMPGVYHPGDFDIAGFGVGVVEKSKIIDGSSVKAGDVII
HHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCEEECCCCEEECCCCCCCCCCCCCCEEE
GVASSGIHSNGLSLARKALLEYGNYHLTAYVEEFGKTLGEELLTPTRIYVKPVLDLMQKV
EEECCCCCCCCHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
EIKGMAHITGGGIVDNLPRILPEKVEARITVNWEIPKIFKLIEKAGNVPRREMWRTFNMG
HHCCEEEEECCCHHHHHHHHCCHHCCEEEEEEECHHHHHHHHHHHCCCCHHHHHHHHCCC
IGFILIVEEAKVQEAIKTLESFNYKAWVIGEITAGERRVIINE
CEEEEEEEHHHHHHHHHHHHHCCCEEEEEEEECCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA