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The map label for this gene is hisA

Identifier: 78043937

GI number: 78043937

Start: 964992

End: 965723

Strand: Direct

Name: hisA

Synonym: CHY_1089

Alternate gene names: 78043937

Gene position: 964992-965723 (Clockwise)

Preceding gene: 78043511

Following gene: 78044843

Centisome position: 40.18

GC content: 44.54

Gene sequence:

>732_bases
ATGATTTTAATACCAGCAATAGATTTAATGGGGAAAAAAGTGGTGCGGCTTACGCAGGGGGAAAAAGAGCGGAAAACCGA
ATACCCGATTTCGCCCGTGGAGCTGGCCTTAAAGTATCAGGAAGCGGGAGCCAGGCTAATTCATGTCGTGGATTTGGATC
GTGCTTTTACCGGGGAAAGTGAAAATTTTGAAGTCATTGCCGAAATTATTAAAAATGTTTCCATACCGGTACAGGTCGGT
GGAGGCATAAGAGATATTGAAAGTTTTCGGGAGTTAATAGACTTAGGAGTTTCCCGGGTTATTGTAGGGACGATAGCGGT
AACCAATCCGGAGCTTTTAGAGGAGATGCTTACCCTTGACCGGGATAAGGTTGCGGTCGGGATTGATGCCAAAAACGGCT
GGGTAGCAATTAAAGGCTGGGTGGAAAGTTCCAATTACCGGGCTTTGGACCTGGCCTATAAGGTTAAGGAAATGGGAGTT
ACCACAATAATTTATACCGACATTGCCCGGGACGGGAGTTTAACCGGGCCCAATTTTAATGAAACTTTAAAGCTTGCCAT
TGATACCGGTTTAAAGGTAATAGCCTCGGGTGGTATTTCTGGTTTAGAGGATTTAAGACGCTGGCGGGAACTCGGGGAAA
ACAAAATCTACGGGGTTATTGCCGGAAAAGCAATATTAGAAGGTAAAATTGATTTAAAAGAAGGGATTAGGATACTGGAA
GGGGAGTCTTAA

Upstream 100 bases:

>100_bases
CGGCGGCGGTAAGGCGGGGCAGTATTATTGGCTTTCAGTTTCATCCGGAAAAAAGCGGACCGGTGGGAAGGCAGATACTT
AAGAATTTGAGGGAGATGCT

Downstream 100 bases:

>100_bases
TGTTAACGGTGCGGATAATTCCCTGCCTGGATGTGAATAAAGGGCGGGTGGTAAAAGGGGTAAATTTCTTAAACCTTGTG
GATGCCGGAGACCCGGTTGA

Product: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Number of amino acids: Translated: 243; Mature: 243

Protein sequence:

>243_residues
MILIPAIDLMGKKVVRLTQGEKERKTEYPISPVELALKYQEAGARLIHVVDLDRAFTGESENFEVIAEIIKNVSIPVQVG
GGIRDIESFRELIDLGVSRVIVGTIAVTNPELLEEMLTLDRDKVAVGIDAKNGWVAIKGWVESSNYRALDLAYKVKEMGV
TTIIYTDIARDGSLTGPNFNETLKLAIDTGLKVIASGGISGLEDLRRWRELGENKIYGVIAGKAILEGKIDLKEGIRILE
GES

Sequences:

>Translated_243_residues
MILIPAIDLMGKKVVRLTQGEKERKTEYPISPVELALKYQEAGARLIHVVDLDRAFTGESENFEVIAEIIKNVSIPVQVG
GGIRDIESFRELIDLGVSRVIVGTIAVTNPELLEEMLTLDRDKVAVGIDAKNGWVAIKGWVESSNYRALDLAYKVKEMGV
TTIIYTDIARDGSLTGPNFNETLKLAIDTGLKVIASGGISGLEDLRRWRELGENKIYGVIAGKAILEGKIDLKEGIRILE
GES
>Mature_243_residues
MILIPAIDLMGKKVVRLTQGEKERKTEYPISPVELALKYQEAGARLIHVVDLDRAFTGESENFEVIAEIIKNVSIPVQVG
GGIRDIESFRELIDLGVSRVIVGTIAVTNPELLEEMLTLDRDKVAVGIDAKNGWVAIKGWVESSNYRALDLAYKVKEMGV
TTIIYTDIARDGSLTGPNFNETLKLAIDTGLKVIASGGISGLEDLRRWRELGENKIYGVIAGKAILEGKIDLKEGIRILE
GES

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family

Homologues:

Organism=Escherichia coli, GI87082028, Length=248, Percent_Identity=32.6612903225806, Blast_Score=127, Evalue=8e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS4_CARHZ (Q3AD49)

Other databases:

- EMBL:   CP000141
- RefSeq:   YP_359935.1
- ProteinModelPortal:   Q3AD49
- SMR:   Q3AD49
- STRING:   Q3AD49
- GeneID:   3726404
- GenomeReviews:   CP000141_GR
- KEGG:   chy:CHY_1089
- NMPDR:   fig|246194.3.peg.1136
- TIGR:   CHY_1089
- eggNOG:   COG0106
- HOGENOM:   HBG541613
- OMA:   SIIYTDI
- BioCyc:   CHYD246194:CHY_1089-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01014
- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR00007

Pfam domain/function: PF00977 His_biosynth; SSF51366 RibP_bind_barrel

EC number: =5.3.1.16

Molecular weight: Translated: 26647; Mature: 26647

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: NA

Important sites: ACT_SITE 8-8 ACT_SITE 129-129

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILIPAIDLMGKKVVRLTQGEKERKTEYPISPVELALKYQEAGARLIHVVDLDRAFTGES
CEEECCHHHHCHHHEEECCCCHHCCCCCCCCHHHHEEEEHHCCCEEEEEEECCHHCCCCC
ENFEVIAEIIKNVSIPVQVGGGIRDIESFRELIDLGVSRVIVGTIAVTNPELLEEMLTLD
CCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHCHHHEEEEEEEECCHHHHHHHHHCC
RDKVAVGIDAKNGWVAIKGWVESSNYRALDLAYKVKEMGVTTIIYTDIARDGSLTGPNFN
CCCEEEEEECCCCEEEEEEEEECCCCEEEHHHHHHHHCCCEEEEEEECCCCCCCCCCCCC
ETLKLAIDTGLKVIASGGISGLEDLRRWRELGENKIYGVIAGKAILEGKIDLKEGIRILE
CEEEEEECCCEEEEECCCCCCHHHHHHHHHCCCCEEEEEEECCEEEECCCCHHHCCEEEC
GES
CCC
>Mature Secondary Structure
MILIPAIDLMGKKVVRLTQGEKERKTEYPISPVELALKYQEAGARLIHVVDLDRAFTGES
CEEECCHHHHCHHHEEECCCCHHCCCCCCCCHHHHEEEEHHCCCEEEEEEECCHHCCCCC
ENFEVIAEIIKNVSIPVQVGGGIRDIESFRELIDLGVSRVIVGTIAVTNPELLEEMLTLD
CCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHCHHHEEEEEEEECCHHHHHHHHHCC
RDKVAVGIDAKNGWVAIKGWVESSNYRALDLAYKVKEMGVTTIIYTDIARDGSLTGPNFN
CCCEEEEEECCCCEEEEEEEEECCCCEEEHHHHHHHHCCCEEEEEEECCCCCCCCCCCCC
ETLKLAIDTGLKVIASGGISGLEDLRRWRELGENKIYGVIAGKAILEGKIDLKEGIRILE
CEEEEEECCCEEEEECCCCCCHHHHHHHHHCCCCEEEEEEECCEEEECCCCHHHCCEEEC
GES
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA