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The map label for this gene is hemD [H]

Identifier: 78043231

GI number: 78043231

Start: 1075393

End: 1076424

Strand: Direct

Name: hemD [H]

Synonym: CHY_1209

Alternate gene names: 78043231

Gene position: 1075393-1076424 (Clockwise)

Preceding gene: 78044433

Following gene: 78045155

Centisome position: 44.78

GC content: 34.11

Gene sequence:

>1032_bases
ATGAGTAATTCGCTTACCTGCCGGGTTTTGGTAGGGGAAAAAGTTGATTACTTTTTAAATTCGGAATTGTTTTTTCGGGG
ATTACGGGACGCAAAAAATATTTATTTTTTTGATGAAGAACTTGATTTTATTTTAAAAAATTTTGTAAATACTCACTTGG
TAAGTGAACTGCCCAGCAACGTTACCGGAGAAGATGTAATATTAATTACTAAAAAAGAAGATTTGTTAAAGACTTTTCCT
TTAAAAAATTATTGTTTTTACAATTTACAACATTTTTTAAATAATGGCCCTCTGGCGGGAGTGCGGGTTTTAATTCCAAG
GACAGAAGCTGATGAAAAGCGAGAATGCGGGCGTTTTGGTGCCATAGGTATTGAAGTACCGCTGTTAAAAATAACGTATA
TTCCTGATGAAAGGATTTTACAGTTAGATTTTTCCGCTTATGATTGGCTTATCTTTACCAGTGCCCACGGTGTAGAGGGC
TTTTTTTTCAATTTAAATTATTTTAATGTAAGTTTAGAAAATTTCATTGGGAAAATTGCGGTTGTTGGGGAAAAAACAGC
AAAAGCATTAAAAAAATATGGTCTTACCGCGGATTTTTCTCCCCAAAAATTTACGGCAAAAGATTTAGCCCTGGAGCTAA
CTACCTCCGGAATGATTCAAAAAGGGGTTATAGTCATTCAAGGAAATCTTGGAAGACCCGAGCTTTTGGAGATTTTGGCC
CGAAATAATATTCCCACTAAAAAACTGGTTGTTTATGAAAATGCTCCCAATGTCGATATTAAACCTTTTTTAAATGGTTT
ATTGAAAGCTAAATTAATTGACGTGCTTTTCTTTACAAGTCCTTCAACTTTTAATAATTTCTATCAATTTATTAGTGATG
AAAACTTAGCAAAAAATCTACCGCATTTTGCTATTGGGCCCACCACCTATGAGGCTTTTTTGCAAAAAGATATTCGGAGA
AAATATTTTTCCTCAGAACATACCCTTGAGGGTTTATGGCAAACTTTGAAAAATCATTGGCAAGGAGAGTGA

Upstream 100 bases:

>100_bases
GGAAGTATTGAGGAACCGGAGAAAGTGGGGATTAGTTTAGCGGAGGAACTTTTAACGAAAGGCGCCCAAAAAATCTTAGA
GGAAATCAGGCGGGATGCCA

Downstream 100 bases:

>100_bases
ATTGGGTTATGGATTTAAAGCTACGGATGCGGCGGCTTCGGGCTAATGAGAAAATACGTTCTATGGTTCGGGAAAACCAC
TTACATCCCGAAGATTTTAT

Product: uroporphyrinogen-III synthase

Products: NA

Alternate protein names: UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 343; Mature: 342

Protein sequence:

>343_residues
MSNSLTCRVLVGEKVDYFLNSELFFRGLRDAKNIYFFDEELDFILKNFVNTHLVSELPSNVTGEDVILITKKEDLLKTFP
LKNYCFYNLQHFLNNGPLAGVRVLIPRTEADEKRECGRFGAIGIEVPLLKITYIPDERILQLDFSAYDWLIFTSAHGVEG
FFFNLNYFNVSLENFIGKIAVVGEKTAKALKKYGLTADFSPQKFTAKDLALELTTSGMIQKGVIVIQGNLGRPELLEILA
RNNIPTKKLVVYENAPNVDIKPFLNGLLKAKLIDVLFFTSPSTFNNFYQFISDENLAKNLPHFAIGPTTYEAFLQKDIRR
KYFSSEHTLEGLWQTLKNHWQGE

Sequences:

>Translated_343_residues
MSNSLTCRVLVGEKVDYFLNSELFFRGLRDAKNIYFFDEELDFILKNFVNTHLVSELPSNVTGEDVILITKKEDLLKTFP
LKNYCFYNLQHFLNNGPLAGVRVLIPRTEADEKRECGRFGAIGIEVPLLKITYIPDERILQLDFSAYDWLIFTSAHGVEG
FFFNLNYFNVSLENFIGKIAVVGEKTAKALKKYGLTADFSPQKFTAKDLALELTTSGMIQKGVIVIQGNLGRPELLEILA
RNNIPTKKLVVYENAPNVDIKPFLNGLLKAKLIDVLFFTSPSTFNNFYQFISDENLAKNLPHFAIGPTTYEAFLQKDIRR
KYFSSEHTLEGLWQTLKNHWQGE
>Mature_342_residues
SNSLTCRVLVGEKVDYFLNSELFFRGLRDAKNIYFFDEELDFILKNFVNTHLVSELPSNVTGEDVILITKKEDLLKTFPL
KNYCFYNLQHFLNNGPLAGVRVLIPRTEADEKRECGRFGAIGIEVPLLKITYIPDERILQLDFSAYDWLIFTSAHGVEGF
FFNLNYFNVSLENFIGKIAVVGEKTAKALKKYGLTADFSPQKFTAKDLALELTTSGMIQKGVIVIQGNLGRPELLEILAR
NNIPTKKLVVYENAPNVDIKPFLNGLLKAKLIDVLFFTSPSTFNNFYQFISDENLAKNLPHFAIGPTTYEAFLQKDIRRK
YFSSEHTLEGLWQTLKNHWQGE

Specific function: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III [H]

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen-III synthase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003754 [H]

Pfam domain/function: PF02602 HEM4 [H]

EC number: =4.2.1.75 [H]

Molecular weight: Translated: 39194; Mature: 39062

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNSLTCRVLVGEKVDYFLNSELFFRGLRDAKNIYFFDEELDFILKNFVNTHLVSELPSN
CCCCEEEEEEECCCHHHHHCCHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCC
VTGEDVILITKKEDLLKTFPLKNYCFYNLQHFLNNGPLAGVRVLIPRTEADEKRECGRFG
CCCCEEEEEECCHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHCCCCC
AIGIEVPLLKITYIPDERILQLDFSAYDWLIFTSAHGVEGFFFNLNYFNVSLENFIGKIA
CEEEEEEEEEEEECCCCEEEEEECCCEEEEEEEECCCCCEEEEEEEEEEEEHHHHHCEEE
VVGEKTAKALKKYGLTADFSPQKFTAKDLALELTTSGMIQKGVIVIQGNLGRPELLEILA
EECHHHHHHHHHHCCCCCCCCCCCCHHHEEEEEECCCCHHCCEEEEECCCCCHHHHHHHH
RNNIPTKKLVVYENAPNVDIKPFLNGLLKAKLIDVLFFTSPSTFNNFYQFISDENLAKNL
HCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHCCCCHHHCC
PHFAIGPTTYEAFLQKDIRRKYFSSEHTLEGLWQTLKNHWQGE
CCEEECCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SNSLTCRVLVGEKVDYFLNSELFFRGLRDAKNIYFFDEELDFILKNFVNTHLVSELPSN
CCCEEEEEEECCCHHHHHCCHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCC
VTGEDVILITKKEDLLKTFPLKNYCFYNLQHFLNNGPLAGVRVLIPRTEADEKRECGRFG
CCCCEEEEEECCHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHCCCCC
AIGIEVPLLKITYIPDERILQLDFSAYDWLIFTSAHGVEGFFFNLNYFNVSLENFIGKIA
CEEEEEEEEEEEECCCCEEEEEECCCEEEEEEEECCCCCEEEEEEEEEEEEHHHHHCEEE
VVGEKTAKALKKYGLTADFSPQKFTAKDLALELTTSGMIQKGVIVIQGNLGRPELLEILA
EECHHHHHHHHHHCCCCCCCCCCCCHHHEEEEEECCCCHHCCEEEEECCCCCHHHHHHHH
RNNIPTKKLVVYENAPNVDIKPFLNGLLKAKLIDVLFFTSPSTFNNFYQFISDENLAKNL
HCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHCCCCHHHCC
PHFAIGPTTYEAFLQKDIRRKYFSSEHTLEGLWQTLKNHWQGE
CCEEECCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1672867; 9384377; 2110138 [H]