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The map label for this gene is hemB [H]

Identifier: 78045155

GI number: 78045155

Start: 1076433

End: 1077410

Strand: Direct

Name: hemB [H]

Synonym: CHY_1210

Alternate gene names: 78045155

Gene position: 1076433-1077410 (Clockwise)

Preceding gene: 78043231

Following gene: 78044427

Centisome position: 44.82

GC content: 43.46

Gene sequence:

>978_bases
ATGGATTTAAAGCTACGGATGCGGCGGCTTCGGGCTAATGAGAAAATACGTTCTATGGTTCGGGAAAACCACTTACATCC
CGAAGATTTTATCTATCCTTTATTTATCGCACCGGGGGAAAAATACCGCAAAGAAGTTAGTTCCATGCCCGGAGTATTTC
AGTTATCCATTGATGAAGCAGTTAAAGAGGCAAAAGAGGTGCATGAGCTTGGTATTCCAGCGGTGATCCTTTTTGGTATT
CCCGAGCATAAAGATGAGTTTGGGTGTGAAGCCTATCAGGACGATGGTATCGTCCAGAGGGCTATAAAAGCAATAAAAAA
AGAAATTCCTGAACTTTATGTTATAACCGATGTTTGTCTCTGCGAATATACCAGTCACGGTCATTGCGGTGTTGTGCGTA
ACGGAGAAGTGATAAACGATGAAACTTTGGAACTTTTAGCAAAAACCGCCGTATCACATGCCAAAGCAGGAGCGGACATG
GTTGCGCCTTCGGATATGATGGATGGAAGGGTAAGGGCTATTCGTGAGGCTTTGGATGAAAATGGATTTTCGCATATCCC
GATCATGGCTTATTCAGCAAAATATGCGTCAGCTTTTTACGGGCCTTTTAGGGAAGCAGCTGAGTCAGCACCGCAATTTG
GCGATCGCCGTTCCTACCAGATGGATCCGGCCAATGGGAATGAGGCCTTAAGGGAAGTATGGTTAGATATTGAAGAAGGT
GCTGACATAGTAATGGTAAAACCGGCTTTAAGCTATCTCGATATAGTTTGGCGGGTAAAACAAGAGTTTGGCTATCCGGT
TTGTGTTTATAATGTTAGTGGAGAATACGCTTTGGTAAAAGCTGCTGCCCGTAATGGTTGGGTTGAGGAAAAGCGGATTG
TATTGGAGATCTTAACCTCAATGAAACGGGCCGGAGCAGATTTAATCATTTCTTATCATGCTAAAGATGTTGTTAAATGG
CTAAAGGAGGCAAAATAA

Upstream 100 bases:

>100_bases
TGCAAAAAGATATTCGGAGAAAATATTTTTCCTCAGAACATACCCTTGAGGGTTTATGGCAAACTTTGAAAAATCATTGG
CAAGGAGAGTGAATTGGGTT

Downstream 100 bases:

>100_bases
ATGTTAGTTTCCTGGAATACCACCAATCAATGCAATTTGTATTGTGAACATTGTTACCGGGATGCGGGAGCAAAGGTTGA
AGAAGAACTATCTACTGAGG

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 325; Mature: 325

Protein sequence:

>325_residues
MDLKLRMRRLRANEKIRSMVRENHLHPEDFIYPLFIAPGEKYRKEVSSMPGVFQLSIDEAVKEAKEVHELGIPAVILFGI
PEHKDEFGCEAYQDDGIVQRAIKAIKKEIPELYVITDVCLCEYTSHGHCGVVRNGEVINDETLELLAKTAVSHAKAGADM
VAPSDMMDGRVRAIREALDENGFSHIPIMAYSAKYASAFYGPFREAAESAPQFGDRRSYQMDPANGNEALREVWLDIEEG
ADIVMVKPALSYLDIVWRVKQEFGYPVCVYNVSGEYALVKAAARNGWVEEKRIVLEILTSMKRAGADLIISYHAKDVVKW
LKEAK

Sequences:

>Translated_325_residues
MDLKLRMRRLRANEKIRSMVRENHLHPEDFIYPLFIAPGEKYRKEVSSMPGVFQLSIDEAVKEAKEVHELGIPAVILFGI
PEHKDEFGCEAYQDDGIVQRAIKAIKKEIPELYVITDVCLCEYTSHGHCGVVRNGEVINDETLELLAKTAVSHAKAGADM
VAPSDMMDGRVRAIREALDENGFSHIPIMAYSAKYASAFYGPFREAAESAPQFGDRRSYQMDPANGNEALREVWLDIEEG
ADIVMVKPALSYLDIVWRVKQEFGYPVCVYNVSGEYALVKAAARNGWVEEKRIVLEILTSMKRAGADLIISYHAKDVVKW
LKEAK
>Mature_325_residues
MDLKLRMRRLRANEKIRSMVRENHLHPEDFIYPLFIAPGEKYRKEVSSMPGVFQLSIDEAVKEAKEVHELGIPAVILFGI
PEHKDEFGCEAYQDDGIVQRAIKAIKKEIPELYVITDVCLCEYTSHGHCGVVRNGEVINDETLELLAKTAVSHAKAGADM
VAPSDMMDGRVRAIREALDENGFSHIPIMAYSAKYASAFYGPFREAAESAPQFGDRRSYQMDPANGNEALREVWLDIEEG
ADIVMVKPALSYLDIVWRVKQEFGYPVCVYNVSGEYALVKAAARNGWVEEKRIVLEILTSMKRAGADLIISYHAKDVVKW
LKEAK

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=304, Percent_Identity=45.3947368421053, Blast_Score=266, Evalue=2e-71,
Organism=Escherichia coli, GI87081728, Length=318, Percent_Identity=50, Blast_Score=300, Evalue=6e-83,
Organism=Saccharomyces cerevisiae, GI6321398, Length=315, Percent_Identity=44.1269841269841, Blast_Score=244, Evalue=1e-65,
Organism=Drosophila melanogaster, GI21358291, Length=302, Percent_Identity=40.3973509933775, Blast_Score=247, Evalue=9e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 36638; Mature: 36638

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLKLRMRRLRANEKIRSMVRENHLHPEDFIYPLFIAPGEKYRKEVSSMPGVFQLSIDEA
CCHHHHHHHHHHHHHHHHHHHHCCCCHHHCEEEEEECCCHHHHHHHHCCCCEEEEEHHHH
VKEAKEVHELGIPAVILFGIPEHKDEFGCEAYQDDGIVQRAIKAIKKEIPELYVITDVCL
HHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEHHHHHH
CEYTSHGHCGVVRNGEVINDETLELLAKTAVSHAKAGADMVAPSDMMDGRVRAIREALDE
HHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHC
NGFSHIPIMAYSAKYASAFYGPFREAAESAPQFGDRRSYQMDPANGNEALREVWLDIEEG
CCCCCCCEEEECHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
ADIVMVKPALSYLDIVWRVKQEFGYPVCVYNVSGEYALVKAAARNGWVEEKRIVLEILTS
CCEEEECHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEHHHHCCCHHHHHHHHHHHHH
MKRAGADLIISYHAKDVVKWLKEAK
HHHCCCCEEEEHHHHHHHHHHHHCC
>Mature Secondary Structure
MDLKLRMRRLRANEKIRSMVRENHLHPEDFIYPLFIAPGEKYRKEVSSMPGVFQLSIDEA
CCHHHHHHHHHHHHHHHHHHHHCCCCHHHCEEEEEECCCHHHHHHHHCCCCEEEEEHHHH
VKEAKEVHELGIPAVILFGIPEHKDEFGCEAYQDDGIVQRAIKAIKKEIPELYVITDVCL
HHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEHHHHHH
CEYTSHGHCGVVRNGEVINDETLELLAKTAVSHAKAGADMVAPSDMMDGRVRAIREALDE
HHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHC
NGFSHIPIMAYSAKYASAFYGPFREAAESAPQFGDRRSYQMDPANGNEALREVWLDIEEG
CCCCCCCEEEECHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
ADIVMVKPALSYLDIVWRVKQEFGYPVCVYNVSGEYALVKAAARNGWVEEKRIVLEILTS
CCEEEECHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEHHHHCCCHHHHHHHHHHHHH
MKRAGADLIISYHAKDVVKWLKEAK
HHHCCCCEEEEHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8123787 [H]