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The map label for this gene is yngE [H]

Identifier: 77459879

GI number: 77459879

Start: 4139506

End: 4141113

Strand: Direct

Name: yngE [H]

Synonym: Pfl01_3657

Alternate gene names: 77459879

Gene position: 4139506-4141113 (Clockwise)

Preceding gene: 77459878

Following gene: 77459880

Centisome position: 64.29

GC content: 63.93

Gene sequence:

>1608_bases
ATGGCTATCCTGCATACCCAGCTCAACCCTCGTTCAGCGGAGTTCGCCGCCAACAGCGCGGCGATGCTCAAACAGGTCGA
CGTCCTGCACACCCTGCTCGCCCAAGTGGCCCAGGGTGGCGGCGCGAAAGCTCAGGAACGTCACACCTCACGCGGCAAAC
TGCTGCCCCGTGAGCGGATCAACCGCTTGCTCGATCCGGGCTCGCCGTTTCTGGAAATCAGCCAGTTGGCCGCTCACGCC
GTGTATGGCGAAGAAGTGCCGGCCGCTGGCGTGATTGCCGGGATTGGCCGCGTGGAAGGCGTCGAGTGCATGATCGTCGC
CAACGACGCGACCGTGAAAGGCGGCTCGTACTACCCGCTGACCGTGAAGAAACACCTGCGTGCCCAGACCATCGCTCAGC
AAAACCGTCTGCCATGCATTTATCTGGTGGACTCGGGCGGCGCCAACCTGCCGCGTCAGGACGAAGTGTTTCCGGATCGC
GAGCACTTCGGGCGGATCTTCTTCAATCAGGCCAACATGAGCGCCATGGGCATTCCGCAGATTGCGGTGGTCATGGGTTC
CTGCACCGCCGGCGGCGCTTACGTGCCGGCGATGGCCGACGAAGCGATCATGGTGCGCAATCAGGCGACGATTTTCCTCG
CCGGCCCGCCGCTGGTGAAAGCCGCGACCGGTGAAGTGGTCAGCGCCGAAGACCTCGGCGGGGCCGATGTGCACTGCAAG
ACTTCCGGGGTCGCCGACCATTACGCAGAAAGCGATGAGCACGCCCTCGCCCTCGCCCGCCGCAGCGTCGCCAACCTCAA
CTGGCGCAAGCTCGGCGAAGTGCAGCAGCGCGCGCCGATTGCGCCGCTGTACGCCAGCGAAGAGTTGTACGGCGTGGTGT
CGGCGGACGCCAAGCAGCCGTTCGATGTGCGTGAAGTGATTGCGCGACTGGTCGACGGTTCGGTGTTCGATGAATTCAAG
GCACTGTTCGGTACGACGTTGGTGTGTGGTTTCGCTCATCTGCATGGCTACCCGATCGCGATCCTCGCCAACAACGGCAT
CCTGTTCGCCGAAGCCGCGCAAAAAGGCGCGCACTTCATCGAACTGGCCTGCCAGCGCGGCATTCCGCTGCTGTTCCTGC
AGAACATCACAGGGTTTATGGTCGGCCAGAAATACGAGGCCGGCGGCATCGCCAAACACGGCGCCAAACTGGTGACCGCC
GTGGCGTGCGCCAAGGTGCCGAAATTCACCGTGATCATCGGCGGCAGCTTCGGTGCCGGTAACTACGGCATGTGCGGGCG
GGCCTACGATCCGCGCTTCCTGTGGATGTGGCCGAACGCGCGGATCGGCGTGATGGGCGCCGAACAGGCGGCCGGCGTGC
TGGTTCAGGTCAAGCGCGAGCAGGCCGAACGCAGCGGCCAAGCCTTCAGCGCCGAGCAGGAAAGCGAGATCAAGCAACCG
ATTCTCGACCAGTACGAAGAACAGGGTCACCCCTACTACTCCAGCGCACGGCTGTGGGACGACGGCGTCATCGACCCGGC
GCAGACCCGCGATGTATTGGCCCTGGCCTTGTCCGCGTCGTTGAACGCGCCTATCGAACCGAGCCGCTTCGGCGTGTTCC
GGATGTGA

Upstream 100 bases:

>100_bases
TGACGCCAAACTGTACGAAATCGGCGCTGGCACCAGTGAGATCCGTCGCATGCTGATCGGCCGCGAACTGTTCAACGAAA
CCCGCTAAACGGAGCTGTCC

Downstream 100 bases:

>100_bases
TCGGGAGAACCTCATGAGCGACTTCAACACCCTCGAATTGCACAGCGACCCACGGGGTTTCGCGACCCTGTGGCTGAGCC
GCGAAGAAAAAAACAACGCG

Product: propionyl-CoA carboxylase

Products: ADP; phosphate; (S)-methylmalonyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 535; Mature: 534

Protein sequence:

>535_residues
MAILHTQLNPRSAEFAANSAAMLKQVDVLHTLLAQVAQGGGAKAQERHTSRGKLLPRERINRLLDPGSPFLEISQLAAHA
VYGEEVPAAGVIAGIGRVEGVECMIVANDATVKGGSYYPLTVKKHLRAQTIAQQNRLPCIYLVDSGGANLPRQDEVFPDR
EHFGRIFFNQANMSAMGIPQIAVVMGSCTAGGAYVPAMADEAIMVRNQATIFLAGPPLVKAATGEVVSAEDLGGADVHCK
TSGVADHYAESDEHALALARRSVANLNWRKLGEVQQRAPIAPLYASEELYGVVSADAKQPFDVREVIARLVDGSVFDEFK
ALFGTTLVCGFAHLHGYPIAILANNGILFAEAAQKGAHFIELACQRGIPLLFLQNITGFMVGQKYEAGGIAKHGAKLVTA
VACAKVPKFTVIIGGSFGAGNYGMCGRAYDPRFLWMWPNARIGVMGAEQAAGVLVQVKREQAERSGQAFSAEQESEIKQP
ILDQYEEQGHPYYSSARLWDDGVIDPAQTRDVLALALSASLNAPIEPSRFGVFRM

Sequences:

>Translated_535_residues
MAILHTQLNPRSAEFAANSAAMLKQVDVLHTLLAQVAQGGGAKAQERHTSRGKLLPRERINRLLDPGSPFLEISQLAAHA
VYGEEVPAAGVIAGIGRVEGVECMIVANDATVKGGSYYPLTVKKHLRAQTIAQQNRLPCIYLVDSGGANLPRQDEVFPDR
EHFGRIFFNQANMSAMGIPQIAVVMGSCTAGGAYVPAMADEAIMVRNQATIFLAGPPLVKAATGEVVSAEDLGGADVHCK
TSGVADHYAESDEHALALARRSVANLNWRKLGEVQQRAPIAPLYASEELYGVVSADAKQPFDVREVIARLVDGSVFDEFK
ALFGTTLVCGFAHLHGYPIAILANNGILFAEAAQKGAHFIELACQRGIPLLFLQNITGFMVGQKYEAGGIAKHGAKLVTA
VACAKVPKFTVIIGGSFGAGNYGMCGRAYDPRFLWMWPNARIGVMGAEQAAGVLVQVKREQAERSGQAFSAEQESEIKQP
ILDQYEEQGHPYYSSARLWDDGVIDPAQTRDVLALALSASLNAPIEPSRFGVFRM
>Mature_534_residues
AILHTQLNPRSAEFAANSAAMLKQVDVLHTLLAQVAQGGGAKAQERHTSRGKLLPRERINRLLDPGSPFLEISQLAAHAV
YGEEVPAAGVIAGIGRVEGVECMIVANDATVKGGSYYPLTVKKHLRAQTIAQQNRLPCIYLVDSGGANLPRQDEVFPDRE
HFGRIFFNQANMSAMGIPQIAVVMGSCTAGGAYVPAMADEAIMVRNQATIFLAGPPLVKAATGEVVSAEDLGGADVHCKT
SGVADHYAESDEHALALARRSVANLNWRKLGEVQQRAPIAPLYASEELYGVVSADAKQPFDVREVIARLVDGSVFDEFKA
LFGTTLVCGFAHLHGYPIAILANNGILFAEAAQKGAHFIELACQRGIPLLFLQNITGFMVGQKYEAGGIAKHGAKLVTAV
ACAKVPKFTVIIGGSFGAGNYGMCGRAYDPRFLWMWPNARIGVMGAEQAAGVLVQVKREQAERSGQAFSAEQESEIKQPI
LDQYEEQGHPYYSSARLWDDGVIDPAQTRDVLALALSASLNAPIEPSRFGVFRM

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI11545863, Length=536, Percent_Identity=66.4179104477612, Blast_Score=732, Evalue=0.0,
Organism=Homo sapiens, GI119943100, Length=500, Percent_Identity=32.2, Blast_Score=216, Evalue=5e-56,
Organism=Homo sapiens, GI295821216, Length=520, Percent_Identity=31.1538461538462, Blast_Score=205, Evalue=7e-53,
Organism=Homo sapiens, GI310133460, Length=146, Percent_Identity=61.6438356164384, Blast_Score=162, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI17552936, Length=537, Percent_Identity=62.3836126629423, Blast_Score=706, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147362, Length=491, Percent_Identity=33.1975560081466, Blast_Score=230, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI25147359, Length=491, Percent_Identity=33.1975560081466, Blast_Score=230, Evalue=2e-60,
Organism=Drosophila melanogaster, GI24586065, Length=550, Percent_Identity=65.8181818181818, Blast_Score=757, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.3

Molecular weight: Translated: 57407; Mature: 57276

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAILHTQLNPRSAEFAANSAAMLKQVDVLHTLLAQVAQGGGAKAQERHTSRGKLLPRERI
CEEEEECCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCHHHH
NRLLDPGSPFLEISQLAAHAVYGEEVPAAGVIAGIGRVEGVECMIVANDATVKGGSYYPL
HHHHCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCEEEEEEECCCEECCCCEEEE
TVKKHLRAQTIAQQNRLPCIYLVDSGGANLPRQDEVFPDREHFGRIFFNQANMSAMGIPQ
HHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHHCEEEEECCCCCCCCCCE
IAVVMGSCTAGGAYVPAMADEAIMVRNQATIFLAGPPLVKAATGEVVSAEDLGGADVHCK
EEEEEECCCCCCEECCCCCCCEEEEECCEEEEEECCCEEEECCCCEEECCCCCCCCEEEE
TSGVADHYAESDEHALALARRSVANLNWRKLGEVQQRAPIAPLYASEELYGVVSADAKQP
CCCCHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEECCCHHEEEEECCCCCC
FDVREVIARLVDGSVFDEFKALFGTTLVCGFAHLHGYPIAILANNGILFAEAAQKGAHFI
CCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEHHHHCCCHHH
ELACQRGIPLLFLQNITGFMVGQKYEAGGIAKHGAKLVTAVACAKVPKFTVIIGGSFGAG
HHHHHCCCCEEEECCCHHHHCCCEECCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCC
NYGMCGRAYDPRFLWMWPNARIGVMGAEQAAGVLVQVKREQAERSGQAFSAEQESEIKQP
CCCCCCCCCCCEEEEECCCCEEEEEECHHHCCEEEEEEHHHHHHCCCCCCCHHHHHHHHH
ILDQYEEQGHPYYSSARLWDDGVIDPAQTRDVLALALSASLNAPIEPSRFGVFRM
HHHHHHHCCCCEECCCEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AILHTQLNPRSAEFAANSAAMLKQVDVLHTLLAQVAQGGGAKAQERHTSRGKLLPRERI
EEEEECCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCHHHH
NRLLDPGSPFLEISQLAAHAVYGEEVPAAGVIAGIGRVEGVECMIVANDATVKGGSYYPL
HHHHCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCEEEEEEECCCEECCCCEEEE
TVKKHLRAQTIAQQNRLPCIYLVDSGGANLPRQDEVFPDREHFGRIFFNQANMSAMGIPQ
HHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHHCEEEEECCCCCCCCCCE
IAVVMGSCTAGGAYVPAMADEAIMVRNQATIFLAGPPLVKAATGEVVSAEDLGGADVHCK
EEEEEECCCCCCEECCCCCCCEEEEECCEEEEEECCCEEEECCCCEEECCCCCCCCEEEE
TSGVADHYAESDEHALALARRSVANLNWRKLGEVQQRAPIAPLYASEELYGVVSADAKQP
CCCCHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEECCCHHEEEEECCCCCC
FDVREVIARLVDGSVFDEFKALFGTTLVCGFAHLHGYPIAILANNGILFAEAAQKGAHFI
CCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEHHHHCCCHHH
ELACQRGIPLLFLQNITGFMVGQKYEAGGIAKHGAKLVTAVACAKVPKFTVIIGGSFGAG
HHHHHCCCCEEEECCCHHHHCCCEECCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCC
NYGMCGRAYDPRFLWMWPNARIGVMGAEQAAGVLVQVKREQAERSGQAFSAEQESEIKQP
CCCCCCCCCCCEEEEECCCCEEEEEECHHHCCEEEEEEHHHHHHCCCCCCCHHHHHHHHH
ILDQYEEQGHPYYSSARLWDDGVIDPAQTRDVLALALSASLNAPIEPSRFGVFRM
HHHHHHHCCCCEECCCEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; propanoyl-CoA; HCO3-

Specific reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]