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The map label for this gene is mmgC [H]

Identifier: 77459878

GI number: 77459878

Start: 4138330

End: 4139493

Strand: Direct

Name: mmgC [H]

Synonym: Pfl01_3656

Alternate gene names: 77459878

Gene position: 4138330-4139493 (Clockwise)

Preceding gene: 77459876

Following gene: 77459879

Centisome position: 64.28

GC content: 61.25

Gene sequence:

>1164_bases
ATGAGCTACCCATCCCTGAACTTTGCCCTCGGCGAAACCATCGACATGCTGCGCGATCAGGTTCAGTCCTTCGTTGCCAA
GGAGATCGCGCCGCGTGCCGCGCAGATCGACAGCGACAACCTGTTCCCCGCTGATCTGTGGCGCAAGTTCGGTGACATGG
GCCTGCTCGGCATCACCGTACCGGAAGAGTACGGCGGCGCTGGTCTGGGTTACCTGGCGCACGTGGTGGCGATGGAAGAA
ATCAGCCGTGGCTCGGCCTCGGTGGCGTTGTCCTACGGCGCCCACTCCAACCTCTGCGTGAACCAGATCAACCGCAATGG
CAACCACGAACAGAAAGCCAAATACCTGCCAAAACTGATCAGCGGCGAACACGTCGGTGCCCTCGCCATGAGCGAGCCGA
ACGCCGGTTCCGACGTGGTTTCGATGAAACTGCGGGCCGATAAACGCGGCGACCGTTTCGTGCTCAACGGCAGCAAGACC
TGGATCACTAACGGCCCCGACGCCAACACCTACGTGATCTACGCCAAGACCGACCTGGAAAAAGGCCCGCACGGCATCAC
CGCGTTCATCGTCGAACGTGACTGGAAAGGCTTCAGCCGCAGCAACAAGTTCGACAAGCTCGGCATGCGCGGCTCCAACA
CTTGCGAGCTGTTCTTCGATGACGTCGAAGTGCCGGAAGAAAACATCCTCGGCGTGCTCAACGGCGGCGTGAAAGTGCTG
ATGAGCGGCCTCGACTACGAGCGCGTTGTCCTGTCCGGTGGCCCGACCGGGATCATGCAGGCGTGCATGGACCTGATCGT
GCCGTACATCCACGACCGCAAGCAGTTCGGCCAGAGCATCGGTGAATTCCAGCTGATCCAGGGCAAGGTCGCCGACATGT
ACACCCAGCTCAATGCCAGCCGCGCCTACCTCTACGCTGTGGCCCAGGCCTGCGAGCGCAACGAAACCACCCGCAAGGAT
GCCGCCGGCGTGATCCTCTATACCGCCGAACGCGCCACGCAAATGGCTCTGGACGCGATCCAGATTCTCGGCGGCAACGG
CTACATCAACGAATTCCCGGCCGGCCGTCTGCTGCGTGACGCCAAACTGTACGAAATCGGCGCTGGCACCAGTGAGATCC
GTCGCATGCTGATCGGCCGCGAACTGTTCAACGAAACCCGCTAA

Upstream 100 bases:

>100_bases
AAGGGTGATTGACAGCCATTCGTCACAGGCTTACGTTAACGTAAAGGTGAGAACTGAAACGCCCTTCTCCCCACCCTACA
AAAAAGCCAAAAGGTGACCC

Downstream 100 bases:

>100_bases
ACGGAGCTGTCCATGGCTATCCTGCATACCCAGCTCAACCCTCGTTCAGCGGAGTTCGCCGCCAACAGCGCGGCGATGCT
CAAACAGGTCGACGTCCTGC

Product: isovaleryl-CoA dehydrogenase

Products: 3-methylbut-2-enoyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 387; Mature: 386

Protein sequence:

>387_residues
MSYPSLNFALGETIDMLRDQVQSFVAKEIAPRAAQIDSDNLFPADLWRKFGDMGLLGITVPEEYGGAGLGYLAHVVAMEE
ISRGSASVALSYGAHSNLCVNQINRNGNHEQKAKYLPKLISGEHVGALAMSEPNAGSDVVSMKLRADKRGDRFVLNGSKT
WITNGPDANTYVIYAKTDLEKGPHGITAFIVERDWKGFSRSNKFDKLGMRGSNTCELFFDDVEVPEENILGVLNGGVKVL
MSGLDYERVVLSGGPTGIMQACMDLIVPYIHDRKQFGQSIGEFQLIQGKVADMYTQLNASRAYLYAVAQACERNETTRKD
AAGVILYTAERATQMALDAIQILGGNGYINEFPAGRLLRDAKLYEIGAGTSEIRRMLIGRELFNETR

Sequences:

>Translated_387_residues
MSYPSLNFALGETIDMLRDQVQSFVAKEIAPRAAQIDSDNLFPADLWRKFGDMGLLGITVPEEYGGAGLGYLAHVVAMEE
ISRGSASVALSYGAHSNLCVNQINRNGNHEQKAKYLPKLISGEHVGALAMSEPNAGSDVVSMKLRADKRGDRFVLNGSKT
WITNGPDANTYVIYAKTDLEKGPHGITAFIVERDWKGFSRSNKFDKLGMRGSNTCELFFDDVEVPEENILGVLNGGVKVL
MSGLDYERVVLSGGPTGIMQACMDLIVPYIHDRKQFGQSIGEFQLIQGKVADMYTQLNASRAYLYAVAQACERNETTRKD
AAGVILYTAERATQMALDAIQILGGNGYINEFPAGRLLRDAKLYEIGAGTSEIRRMLIGRELFNETR
>Mature_386_residues
SYPSLNFALGETIDMLRDQVQSFVAKEIAPRAAQIDSDNLFPADLWRKFGDMGLLGITVPEEYGGAGLGYLAHVVAMEEI
SRGSASVALSYGAHSNLCVNQINRNGNHEQKAKYLPKLISGEHVGALAMSEPNAGSDVVSMKLRADKRGDRFVLNGSKTW
ITNGPDANTYVIYAKTDLEKGPHGITAFIVERDWKGFSRSNKFDKLGMRGSNTCELFFDDVEVPEENILGVLNGGVKVLM
SGLDYERVVLSGGPTGIMQACMDLIVPYIHDRKQFGQSIGEFQLIQGKVADMYTQLNASRAYLYAVAQACERNETTRKDA
AGVILYTAERATQMALDAIQILGGNGYINEFPAGRLLRDAKLYEIGAGTSEIRRMLIGRELFNETR

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=375, Percent_Identity=64.2666666666667, Blast_Score=504, Evalue=1e-143,
Organism=Homo sapiens, GI226958414, Length=338, Percent_Identity=67.7514792899408, Blast_Score=488, Evalue=1e-138,
Organism=Homo sapiens, GI4557233, Length=378, Percent_Identity=41.7989417989418, Blast_Score=290, Evalue=2e-78,
Organism=Homo sapiens, GI4501859, Length=367, Percent_Identity=37.6021798365123, Blast_Score=258, Evalue=6e-69,
Organism=Homo sapiens, GI21361497, Length=374, Percent_Identity=38.2352941176471, Blast_Score=246, Evalue=2e-65,
Organism=Homo sapiens, GI187960098, Length=385, Percent_Identity=35.0649350649351, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI4557231, Length=385, Percent_Identity=35.0649350649351, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI4501857, Length=373, Percent_Identity=31.6353887399464, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI76496475, Length=385, Percent_Identity=34.025974025974, Blast_Score=209, Evalue=5e-54,
Organism=Homo sapiens, GI4557235, Length=385, Percent_Identity=34.025974025974, Blast_Score=208, Evalue=6e-54,
Organism=Homo sapiens, GI7656849, Length=366, Percent_Identity=32.2404371584699, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI4503943, Length=372, Percent_Identity=29.8387096774194, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI7669494, Length=368, Percent_Identity=30.4347826086957, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI48976061, Length=396, Percent_Identity=21.969696969697, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI211971008, Length=396, Percent_Identity=21.969696969697, Blast_Score=75, Evalue=7e-14,
Organism=Escherichia coli, GI87081958, Length=383, Percent_Identity=29.242819843342, Blast_Score=172, Evalue=4e-44,
Organism=Escherichia coli, GI1786223, Length=383, Percent_Identity=28.7206266318538, Blast_Score=171, Evalue=1e-43,
Organism=Escherichia coli, GI87082384, Length=259, Percent_Identity=26.6409266409266, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI87081702, Length=334, Percent_Identity=24.8502994011976, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17538396, Length=382, Percent_Identity=65.1832460732984, Blast_Score=518, Evalue=1e-147,
Organism=Caenorhabditis elegans, GI17569725, Length=381, Percent_Identity=36.2204724409449, Blast_Score=248, Evalue=3e-66,
Organism=Caenorhabditis elegans, GI17506239, Length=384, Percent_Identity=34.8958333333333, Blast_Score=246, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI17534899, Length=381, Percent_Identity=35.9580052493438, Blast_Score=243, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI17508101, Length=377, Percent_Identity=34.2175066312997, Blast_Score=233, Evalue=9e-62,
Organism=Caenorhabditis elegans, GI17570075, Length=381, Percent_Identity=33.3333333333333, Blast_Score=229, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI17533517, Length=378, Percent_Identity=31.7460317460317, Blast_Score=207, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI71990804, Length=278, Percent_Identity=39.2086330935252, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI71985184, Length=350, Percent_Identity=33.1428571428571, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=39.3939393939394, Blast_Score=186, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17505929, Length=372, Percent_Identity=31.7204301075269, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI71982178, Length=274, Percent_Identity=36.1313868613139, Blast_Score=184, Evalue=7e-47,
Organism=Caenorhabditis elegans, GI17551932, Length=367, Percent_Identity=29.4277929155313, Blast_Score=177, Evalue=9e-45,
Organism=Caenorhabditis elegans, GI17534353, Length=363, Percent_Identity=28.9256198347107, Blast_Score=168, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI71985192, Length=283, Percent_Identity=33.2155477031802, Blast_Score=168, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI17531909, Length=246, Percent_Identity=30.4878048780488, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI21355753, Length=384, Percent_Identity=63.0208333333333, Blast_Score=486, Evalue=1e-138,
Organism=Drosophila melanogaster, GI21356377, Length=377, Percent_Identity=40.8488063660477, Blast_Score=294, Evalue=5e-80,
Organism=Drosophila melanogaster, GI24646207, Length=377, Percent_Identity=38.7267904509284, Blast_Score=281, Evalue=4e-76,
Organism=Drosophila melanogaster, GI24666513, Length=377, Percent_Identity=36.3395225464191, Blast_Score=253, Evalue=1e-67,
Organism=Drosophila melanogaster, GI24660351, Length=384, Percent_Identity=36.4583333333333, Blast_Score=243, Evalue=2e-64,
Organism=Drosophila melanogaster, GI281363737, Length=382, Percent_Identity=33.7696335078534, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI19920834, Length=382, Percent_Identity=29.0575916230367, Blast_Score=163, Evalue=1e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.10

Molecular weight: Translated: 42470; Mature: 42339

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYPSLNFALGETIDMLRDQVQSFVAKEIAPRAAQIDSDNLFPADLWRKFGDMGLLGITV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCHHHHHHHHCCCCEEEEEC
PEEYGGAGLGYLAHVVAMEEISRGSASVALSYGAHSNLCVNQINRNGNHEQKAKYLPKLI
CHHHCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHCCCCCHHHHHHHHHHHH
SGEHVGALAMSEPNAGSDVVSMKLRADKRGDRFVLNGSKTWITNGPDANTYVIYAKTDLE
CCCCCCEEEECCCCCCCCEEEEEEECCCCCCEEEECCCEEEEECCCCCCEEEEEEECCCC
KGPHGITAFIVERDWKGFSRSNKFDKLGMRGSNTCELFFDDVEVPEENILGVLNGGVKVL
CCCCCEEEEEEECCCCCCCCCCCCHHCCCCCCCEEEEEECCCCCCHHHHHHHHCCCHHHH
MSGLDYERVVLSGGPTGIMQACMDLIVPYIHDRKQFGQSIGEFQLIQGKVADMYTQLNAS
HCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHHCCC
RAYLYAVAQACERNETTRKDAAGVILYTAERATQMALDAIQILGGNGYINEFPAGRLLRD
HHHHHHHHHHHHCCCCCHHHCCCEEEEECHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHH
AKLYEIGAGTSEIRRMLIGRELFNETR
CCEEEECCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SYPSLNFALGETIDMLRDQVQSFVAKEIAPRAAQIDSDNLFPADLWRKFGDMGLLGITV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCHHHHHHHHCCCCEEEEEC
PEEYGGAGLGYLAHVVAMEEISRGSASVALSYGAHSNLCVNQINRNGNHEQKAKYLPKLI
CHHHCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHCCCCCHHHHHHHHHHHH
SGEHVGALAMSEPNAGSDVVSMKLRADKRGDRFVLNGSKTWITNGPDANTYVIYAKTDLE
CCCCCCEEEECCCCCCCCEEEEEEECCCCCCEEEECCCEEEEECCCCCCEEEEEEECCCC
KGPHGITAFIVERDWKGFSRSNKFDKLGMRGSNTCELFFDDVEVPEENILGVLNGGVKVL
CCCCCEEEEEEECCCCCCCCCCCCHHCCCCCCCEEEEEECCCCCCHHHHHHHHCCCHHHH
MSGLDYERVVLSGGPTGIMQACMDLIVPYIHDRKQFGQSIGEFQLIQGKVADMYTQLNAS
HCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHHCCC
RAYLYAVAQACERNETTRKDAAGVILYTAERATQMALDAIQILGGNGYINEFPAGRLLRD
HHHHHHHHHHHHCCCCCHHHCCCEEEEECHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHH
AKLYEIGAGTSEIRRMLIGRELFNETR
CCEEEECCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3-methylbutanoyl-CoA; acceptor

Specific reaction: 3-methylbutanoyl-CoA + acceptor = 3-methylbut-2-enoyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]