Click here to switch to the map view.

The map label for this gene is atoC [H]

Identifier: 77458817

GI number: 77458817

Start: 2970482

End: 2971807

Strand: Direct

Name: atoC [H]

Synonym: Pfl01_2592

Alternate gene names: 77458817

Gene position: 2970482-2971807 (Clockwise)

Preceding gene: 77458813

Following gene: 77458827

Centisome position: 46.14

GC content: 59.73

Gene sequence:

>1326_bases
ATGAGCGAAGCGCCTGCATTAAGACGTTTATTGGTCGTCGACCCGTGCGACGACTGTCACCGATTGTTGCCGGGTTTACG
TGCCGTGGGTTGGGACGTCGACAGTTGCAGCCTGGAAAATGCCGCCGACCGAAGCTGCGATGTCGGCCTGTTGCGATTAC
AGCCTTTTCACCTGGAACGTCCCGAAGCCGTCAAAGAGCTGATCAGCCGCAGTGGCACCGAGTGGATCGCCGTGCTGAAT
CAGGAAGTGCTGCGCTTGCAGAACGTCGGCGATTTCGTTTGCGAGTGGTTTTTCGATTTCCATACCTTGCCGTTCGACGT
GTCGCGGGTGCAGGTCACCCTCGGAAGGGCGTTCGGCATGGCGCGGTTGCGCGGTCAGGGCACAATTCACGTCGATCAGC
AGGAACATGAACTGCTGGGCGACAGCAAACCGATCCGCGAGCTGCGCAAGTTGCTGAGTAAACTGGCCCCCACCGAGTCG
CCGGTTTTGATCCGCGGCGAAAGCGGTACCGGCAAGGAACTGGTCGCCCGCACCCTGCACCGGCAGTCGCAACGCCACAG
CAAACCGTTTGTGGCGATCAACTGCGGTGCGATTCCCGAGCATTTGATCCAGTCCGAATTGTTCGGCCATGAGAAAGGTG
CGTTTACCGGCGCTCATCAACGCAAGGTCGGGCGTATCGAAGCAGCCAATGGCGGCACTTTGTTTCTCGATGAAATCGGT
GATCTGCCGTTGGAGCTGCAAGCCAATCTGTTGCGTTTTCTCCAGGAAAAACACATTGAACGGGTCGGCGGCAGTCAACC
GATTCCGGTGGATGTGCGGGTATTGGCGGCGACTCACGTCGATCTTGAGGCCGCGATCGCGAAAAAGCGCTTCCGCGAGG
ACTTGTACTACCGTCTTAACGTCCTGCAGGTGGTAACCGCGCCGTTACGCGAGCGCCACGGCGATCTGTCGATGCTGGCC
AACCACTTTTCCCATTTCTACAGCCATGAAACCGGCCGTCGTCCGCGCAGCTTCAGTGAAGACGCGCTGATCGCCATGGG
CAAACACGACTGGCCGGGCAATGTCCGCGAACTGGCCAACCGGGTGCGTCGAGGCCTGGTGCTGGCCGAAGGGCGGCAAA
TCGAAGCGCGTGACCTGGGGCTGATCAGCCAGCAGTCGATCGCGGCACCGATGGGCACCCTGGAAGACTACAAGACCCGC
GCCGAACGCCAGGCGTTGTGCGATGTGTTGAACCGGCACAGCGACAATCTCAGCGTTGCCGCCAAAGTGCTGGGGGTTTC
CCGACCGACTTTCTATCGTTTGCTGCACAAGCACCAGATCCGCTAG

Upstream 100 bases:

>100_bases
CGATACAAGACGCCGTCAAATTCTTGCTAATGTAACAGTCAGGTTTGCCAAATGACTGTTTTTACGATCATTTCCTAAAA
TTTGGCGCCAAGGAACAGTC

Downstream 100 bases:

>100_bases
GGCGCGGCGCTTTCTGAGTCCAGGAAGCTGAAAAGGCCCGCTGCGATGCAAGTCGCAGCGGGCCTTTTCATGCTGTTGCG
GTTTAGAAGTAATACGGGAA

Product: sigma-54 dependent trancsriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 441; Mature: 440

Protein sequence:

>441_residues
MSEAPALRRLLVVDPCDDCHRLLPGLRAVGWDVDSCSLENAADRSCDVGLLRLQPFHLERPEAVKELISRSGTEWIAVLN
QEVLRLQNVGDFVCEWFFDFHTLPFDVSRVQVTLGRAFGMARLRGQGTIHVDQQEHELLGDSKPIRELRKLLSKLAPTES
PVLIRGESGTGKELVARTLHRQSQRHSKPFVAINCGAIPEHLIQSELFGHEKGAFTGAHQRKVGRIEAANGGTLFLDEIG
DLPLELQANLLRFLQEKHIERVGGSQPIPVDVRVLAATHVDLEAAIAKKRFREDLYYRLNVLQVVTAPLRERHGDLSMLA
NHFSHFYSHETGRRPRSFSEDALIAMGKHDWPGNVRELANRVRRGLVLAEGRQIEARDLGLISQQSIAAPMGTLEDYKTR
AERQALCDVLNRHSDNLSVAAKVLGVSRPTFYRLLHKHQIR

Sequences:

>Translated_441_residues
MSEAPALRRLLVVDPCDDCHRLLPGLRAVGWDVDSCSLENAADRSCDVGLLRLQPFHLERPEAVKELISRSGTEWIAVLN
QEVLRLQNVGDFVCEWFFDFHTLPFDVSRVQVTLGRAFGMARLRGQGTIHVDQQEHELLGDSKPIRELRKLLSKLAPTES
PVLIRGESGTGKELVARTLHRQSQRHSKPFVAINCGAIPEHLIQSELFGHEKGAFTGAHQRKVGRIEAANGGTLFLDEIG
DLPLELQANLLRFLQEKHIERVGGSQPIPVDVRVLAATHVDLEAAIAKKRFREDLYYRLNVLQVVTAPLRERHGDLSMLA
NHFSHFYSHETGRRPRSFSEDALIAMGKHDWPGNVRELANRVRRGLVLAEGRQIEARDLGLISQQSIAAPMGTLEDYKTR
AERQALCDVLNRHSDNLSVAAKVLGVSRPTFYRLLHKHQIR
>Mature_440_residues
SEAPALRRLLVVDPCDDCHRLLPGLRAVGWDVDSCSLENAADRSCDVGLLRLQPFHLERPEAVKELISRSGTEWIAVLNQ
EVLRLQNVGDFVCEWFFDFHTLPFDVSRVQVTLGRAFGMARLRGQGTIHVDQQEHELLGDSKPIRELRKLLSKLAPTESP
VLIRGESGTGKELVARTLHRQSQRHSKPFVAINCGAIPEHLIQSELFGHEKGAFTGAHQRKVGRIEAANGGTLFLDEIGD
LPLELQANLLRFLQEKHIERVGGSQPIPVDVRVLAATHVDLEAAIAKKRFREDLYYRLNVLQVVTAPLRERHGDLSMLAN
HFSHFYSHETGRRPRSFSEDALIAMGKHDWPGNVRELANRVRRGLVLAEGRQIEARDLGLISQQSIAAPMGTLEDYKTRA
ERQALCDVLNRHSDNLSVAAKVLGVSRPTFYRLLHKHQIR

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=455, Percent_Identity=36.9230769230769, Blast_Score=281, Evalue=5e-77,
Organism=Escherichia coli, GI1790437, Length=435, Percent_Identity=36.551724137931, Blast_Score=271, Evalue=5e-74,
Organism=Escherichia coli, GI1789233, Length=327, Percent_Identity=42.8134556574924, Blast_Score=255, Evalue=4e-69,
Organism=Escherichia coli, GI1790299, Length=367, Percent_Identity=38.6920980926431, Blast_Score=246, Evalue=3e-66,
Organism=Escherichia coli, GI87082117, Length=311, Percent_Identity=44.3729903536978, Blast_Score=241, Evalue=6e-65,
Organism=Escherichia coli, GI1788905, Length=350, Percent_Identity=39.4285714285714, Blast_Score=235, Evalue=3e-63,
Organism=Escherichia coli, GI1789087, Length=305, Percent_Identity=40.655737704918, Blast_Score=234, Evalue=6e-63,
Organism=Escherichia coli, GI1786524, Length=317, Percent_Identity=43.217665615142, Blast_Score=219, Evalue=4e-58,
Organism=Escherichia coli, GI87081872, Length=320, Percent_Identity=41.25, Blast_Score=213, Evalue=2e-56,
Organism=Escherichia coli, GI87082152, Length=327, Percent_Identity=38.8379204892966, Blast_Score=204, Evalue=1e-53,
Organism=Escherichia coli, GI1787583, Length=297, Percent_Identity=37.3737373737374, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI87081858, Length=305, Percent_Identity=28.8524590163934, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1789828, Length=241, Percent_Identity=34.8547717842324, Blast_Score=132, Evalue=6e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 49618; Mature: 49486

Theoretical pI: Translated: 8.33; Mature: 8.33

Prosite motif: PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEAPALRRLLVVDPCDDCHRLLPGLRAVGWDVDSCSLENAADRSCDVGLLRLQPFHLER
CCCCCCHHHEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCCC
PEAVKELISRSGTEWIAVLNQEVLRLQNVGDFVCEWFFDFHTLPFDVSRVQVTLGRAFGM
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
ARLRGQGTIHVDQQEHELLGDSKPIRELRKLLSKLAPTESPVLIRGESGTGKELVARTLH
HHHCCCCCEEECCHHHHHCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHH
RQSQRHSKPFVAINCGAIPEHLIQSELFGHEKGAFTGAHQRKVGRIEAANGGTLFLDEIG
HHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCHHHHHCCCEEECCCCEEEEHHHC
DLPLELQANLLRFLQEKHIERVGGSQPIPVDVRVLAATHVDLEAAIAKKRFREDLYYRLN
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHH
VLQVVTAPLRERHGDLSMLANHFSHFYSHETGRRPRSFSEDALIAMGKHDWPGNVRELAN
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCHHHHHHH
RVRRGLVLAEGRQIEARDLGLISQQSIAAPMGTLEDYKTRAERQALCDVLNRHSDNLSVA
HHHHCEEEECCCEECHHHCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHH
AKVLGVSRPTFYRLLHKHQIR
HHHHHCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
SEAPALRRLLVVDPCDDCHRLLPGLRAVGWDVDSCSLENAADRSCDVGLLRLQPFHLER
CCCCCHHHEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCCC
PEAVKELISRSGTEWIAVLNQEVLRLQNVGDFVCEWFFDFHTLPFDVSRVQVTLGRAFGM
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
ARLRGQGTIHVDQQEHELLGDSKPIRELRKLLSKLAPTESPVLIRGESGTGKELVARTLH
HHHCCCCCEEECCHHHHHCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHH
RQSQRHSKPFVAINCGAIPEHLIQSELFGHEKGAFTGAHQRKVGRIEAANGGTLFLDEIG
HHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCHHHHHCCCEEECCCCEEEEHHHC
DLPLELQANLLRFLQEKHIERVGGSQPIPVDVRVLAATHVDLEAAIAKKRFREDLYYRLN
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHH
VLQVVTAPLRERHGDLSMLANHFSHFYSHETGRRPRSFSEDALIAMGKHDWPGNVRELAN
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCHHHHHHH
RVRRGLVLAEGRQIEARDLGLISQQSIAAPMGTLEDYKTRAERQALCDVLNRHSDNLSVA
HHHHCEEEECCCEECHHHCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHH
AKVLGVSRPTFYRLLHKHQIR
HHHHHCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]