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The map label for this gene is prsA2 [H]

Identifier: 77458729

GI number: 77458729

Start: 2862637

End: 2863569

Strand: Direct

Name: prsA2 [H]

Synonym: Pfl01_2504

Alternate gene names: 77458729

Gene position: 2862637-2863569 (Clockwise)

Preceding gene: 77458728

Following gene: 77458730

Centisome position: 44.46

GC content: 63.77

Gene sequence:

>933_bases
ATGGTAATCAGCGCCGCTGCGGTGGCGCTGTTGGTGGTGGCCGTGGCGCTGGTGGTGCGGCCGGGCAATGACCCGGTCGC
CGCCCAGCAACCGGCGCCGGTGATTGCGGCGAACAGTGGGCCTGCGGTGGCGCGGTTGGGTAATCAGCAGGTTTCACCGG
AGGAATTGCAGGCATTGCTGGCGGCTGTTCCACCGCAAACCCGCGAGCAACTGCGCGGTAATCGTGAGGCGCTGGAGCGC
TGGATTCGTTCACGCCTGGCTGAAAAAGCCGTGTTGGAGCAGGCCGACGCTCAGGGTTGGGCGCAGCGTCCGGACGTGGT
TCGGCAAACCCGCGCCGCCACCGAACAGATCGTGTTCCGCGACTATTTGCAGTCGGTGAGCCAAGTGCCGGCCGATTATC
CGAGCGCTGCAGAGTTGCAGCAGGCGTATGACGCGGGCAAGGCCAATTGGCAGACGCCGGCGCTGTATCGGGTCAGCCAG
ATTTTCCTCGGGGTCAACGAACCACAGAATCTTGAGGCGGTGCGCAAGCAGGCGACGGAGTTGAGCAAGAAAGCCCAGGC
AACCTCGGCAGACTTTGCAGGCCTGGCCAAGGAGTTTTCCCAGGATCGGCTAACCGCTGAGCGCGGCGGCGACACCGGCC
TGCAACCGTTGCAGCAACTGGTGCCGGAAGTGCGTGGTGTCGTGGCGCGGCTCAAGGTTGGCGCGGTTTCCGATCCCGTT
CAAAGCAGCGGCGGCTTCCACGTGATCAAACTCACTGAGCAACAACCGGCCCGCACCGCGACCCTCGACGAATTGCGTGA
CCAACTGACCCAGGCCTTGCGGGCACAGCGTCAGGAACAGATCGCCCAGGCCTATCTGGACGGCATGCTCAACACCGCAA
CGCTGAGTATCGACGGGGCCGAGCTCAATAAGGTGCTGGAGACCAAACCCTAA

Upstream 100 bases:

>100_bases
AGGAGTTCATCGTGTATCTGCGTGATTTCACCCAGAACGCGGCTGCCACCCAGGCTCCAAAGGTTGAGCAAGAGGAAGTC
GCGCTGTGACAAAACCTGCC

Downstream 100 bases:

>100_bases
GCGCGGCACACCAAAACAAAGATCGACAGGGAGTCATCGATGTCATTCACCGAACCCGCAGCACGACCGAGCAGCGCCGA
TTTCCGCTGGCCCCGGGACA

Product: PpiC-type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MVISAAAVALLVVAVALVVRPGNDPVAAQQPAPVIAANSGPAVARLGNQQVSPEELQALLAAVPPQTREQLRGNREALER
WIRSRLAEKAVLEQADAQGWAQRPDVVRQTRAATEQIVFRDYLQSVSQVPADYPSAAELQQAYDAGKANWQTPALYRVSQ
IFLGVNEPQNLEAVRKQATELSKKAQATSADFAGLAKEFSQDRLTAERGGDTGLQPLQQLVPEVRGVVARLKVGAVSDPV
QSSGGFHVIKLTEQQPARTATLDELRDQLTQALRAQRQEQIAQAYLDGMLNTATLSIDGAELNKVLETKP

Sequences:

>Translated_310_residues
MVISAAAVALLVVAVALVVRPGNDPVAAQQPAPVIAANSGPAVARLGNQQVSPEELQALLAAVPPQTREQLRGNREALER
WIRSRLAEKAVLEQADAQGWAQRPDVVRQTRAATEQIVFRDYLQSVSQVPADYPSAAELQQAYDAGKANWQTPALYRVSQ
IFLGVNEPQNLEAVRKQATELSKKAQATSADFAGLAKEFSQDRLTAERGGDTGLQPLQQLVPEVRGVVARLKVGAVSDPV
QSSGGFHVIKLTEQQPARTATLDELRDQLTQALRAQRQEQIAQAYLDGMLNTATLSIDGAELNKVLETKP
>Mature_310_residues
MVISAAAVALLVVAVALVVRPGNDPVAAQQPAPVIAANSGPAVARLGNQQVSPEELQALLAAVPPQTREQLRGNREALER
WIRSRLAEKAVLEQADAQGWAQRPDVVRQTRAATEQIVFRDYLQSVSQVPADYPSAAELQQAYDAGKANWQTPALYRVSQ
IFLGVNEPQNLEAVRKQATELSKKAQATSADFAGLAKEFSQDRLTAERGGDTGLQPLQQLVPEVRGVVARLKVGAVSDPV
QSSGGFHVIKLTEQQPARTATLDELRDQLTQALRAQRQEQIAQAYLDGMLNTATLSIDGAELNKVLETKP

Specific function: Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins. Important for the secretion of the protective antigen. The three psrA proteins in this organism show different but overlapping

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023059
- InterPro:   IPR000297
- InterPro:   IPR023058
- InterPro:   IPR008880 [H]

Pfam domain/function: PF00639 Rotamase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 33460; Mature: 33460

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
0.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVISAAAVALLVVAVALVVRPGNDPVAAQQPAPVIAANSGPAVARLGNQQVSPEELQALL
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCHHHHCCCCCCCHHHHHHHH
AAVPPQTREQLRGNREALERWIRSRLAEKAVLEQADAQGWAQRPDVVRQTRAATEQIVFR
HHCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
DYLQSVSQVPADYPSAAELQQAYDAGKANWQTPALYRVSQIFLGVNEPQNLEAVRKQATE
HHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHH
LSKKAQATSADFAGLAKEFSQDRLTAERGGDTGLQPLQQLVPEVRGVVARLKVGAVSDPV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCH
QSSGGFHVIKLTEQQPARTATLDELRDQLTQALRAQRQEQIAQAYLDGMLNTATLSIDGA
HCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECHH
ELNKVLETKP
HHHHHHCCCC
>Mature Secondary Structure
MVISAAAVALLVVAVALVVRPGNDPVAAQQPAPVIAANSGPAVARLGNQQVSPEELQALL
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCHHHHCCCCCCCHHHHHHHH
AAVPPQTREQLRGNREALERWIRSRLAEKAVLEQADAQGWAQRPDVVRQTRAATEQIVFR
HHCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
DYLQSVSQVPADYPSAAELQQAYDAGKANWQTPALYRVSQIFLGVNEPQNLEAVRKQATE
HHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHH
LSKKAQATSADFAGLAKEFSQDRLTAERGGDTGLQPLQQLVPEVRGVVARLKVGAVSDPV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCH
QSSGGFHVIKLTEQQPARTATLDELRDQLTQALRAQRQEQIAQAYLDGMLNTATLSIDGA
HCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECHH
ELNKVLETKP
HHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12721629; 12606539 [H]