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The map label for this gene is mucB [H]

Identifier: 77457591

GI number: 77457591

Start: 1537351

End: 1538313

Strand: Direct

Name: mucB [H]

Synonym: Pfl01_1364

Alternate gene names: 77457591

Gene position: 1537351-1538313 (Clockwise)

Preceding gene: 77457590

Following gene: 77457592

Centisome position: 23.88

GC content: 57.74

Gene sequence:

>963_bases
ATGCGCGCCATACCTCTACTTTCGCTTCTGCTCAGCGGCTGGTTCATTGTTCCAGCCCACGCCGACGAGGCTCAGGACTG
GTTGACCCGCCTGGGCCAGGCCGAGCAGCAGCAAAGCTTTCACGGCACATTCGTTTACGAGCGTAACGGTAGCTTTTCTA
CCCACAACATCTGGCATCGCGTACAGAATGGCCAGGTCCGCGAGCGTTTGCTTCAGCTCGACGGTTCGGCTCAGGAAGTC
GTGCGCATTGATGGACATACTCAATGCGTCAGCGGCACTCTGATTGCGGGGCTTGGGGATTCTCCCAATTCCGCCGCTCG
CCCTCTCGATCCCCAAAAGCTGAAGAACTGGTATGAGCTTGCCGTCATTGGCAAGTCACGTGTGGCAGGACGCGAAGCGG
TGATCGTATCGCTGACGCCCCGTGATCAGCACCGCTACGGCTTCGAACTGCATCTGGACAAGGAAACGGGTCTGCCGCTC
AAGTCGCTGCTGTTGAACGACAAGGGGCAGTTGCTTGAGAGGTTCCAGTTCACGCGGCTGGATACTTCTGAAATTCCGTC
CGATAAAGACCTGCAAGCCAACTCCGATTGCAAGACAGTCACTCTCGACAGCGACAAGGCTTCTGCGGTCAAGACCGCAC
AGGTCTGGCGTTCTGACTGGCTGCCTCCTGGCTTCGAACTCACCAGTAGTTCCTCGCACAAGGATCCGGAAACCAAGACC
CAGGTCAACAGCCTGATGTATGACGATGGTCTTGCCCGCTTCTCTGTTTTCCTGGAGCCGCTGAATGGCGCAACCGTCAC
CGATACCCGAACTCAACTGGGCCCGACCGTTGCCGTATCCCGTCGTTTGACTACGCCTCAAGGCGAAATGATGGTGACGG
TCGTCGGCGAGATTCCAATCGGGACCGCCGAACGGATTGCCCTGTCGATGCGCAATGATGGCGCTGCAACCAGCAAGCAG
TGA

Upstream 100 bases:

>100_bases
GTTACCTGCGTCAACACGCTCAACAGGCTGCCTTGAAAGGCACCGAGAGCGCGCTGCCATATGCACGTGCAGCAAGCCTG
GAAAACCGTTAAGGGGGATC

Downstream 100 bases:

>100_bases
GCTGATTCCAGCTATCTCCACTTCGTCGTCGAGACGTGAAATGTTTGCTGAGCATTTTCATTTGCAAAACACCCGAAAAT
TTTTTATAGGTCAGAGCCTC

Product: sigma-E regulatory protein, MucB/RseB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
MRAIPLLSLLLSGWFIVPAHADEAQDWLTRLGQAEQQQSFHGTFVYERNGSFSTHNIWHRVQNGQVRERLLQLDGSAQEV
VRIDGHTQCVSGTLIAGLGDSPNSAARPLDPQKLKNWYELAVIGKSRVAGREAVIVSLTPRDQHRYGFELHLDKETGLPL
KSLLLNDKGQLLERFQFTRLDTSEIPSDKDLQANSDCKTVTLDSDKASAVKTAQVWRSDWLPPGFELTSSSSHKDPETKT
QVNSLMYDDGLARFSVFLEPLNGATVTDTRTQLGPTVAVSRRLTTPQGEMMVTVVGEIPIGTAERIALSMRNDGAATSKQ

Sequences:

>Translated_320_residues
MRAIPLLSLLLSGWFIVPAHADEAQDWLTRLGQAEQQQSFHGTFVYERNGSFSTHNIWHRVQNGQVRERLLQLDGSAQEV
VRIDGHTQCVSGTLIAGLGDSPNSAARPLDPQKLKNWYELAVIGKSRVAGREAVIVSLTPRDQHRYGFELHLDKETGLPL
KSLLLNDKGQLLERFQFTRLDTSEIPSDKDLQANSDCKTVTLDSDKASAVKTAQVWRSDWLPPGFELTSSSSHKDPETKT
QVNSLMYDDGLARFSVFLEPLNGATVTDTRTQLGPTVAVSRRLTTPQGEMMVTVVGEIPIGTAERIALSMRNDGAATSKQ
>Mature_320_residues
MRAIPLLSLLLSGWFIVPAHADEAQDWLTRLGQAEQQQSFHGTFVYERNGSFSTHNIWHRVQNGQVRERLLQLDGSAQEV
VRIDGHTQCVSGTLIAGLGDSPNSAARPLDPQKLKNWYELAVIGKSRVAGREAVIVSLTPRDQHRYGFELHLDKETGLPL
KSLLLNDKGQLLERFQFTRLDTSEIPSDKDLQANSDCKTVTLDSDKASAVKTAQVWRSDWLPPGFELTSSSSHKDPETKT
QVNSLMYDDGLARFSVFLEPLNGATVTDTRTQLGPTVAVSRRLTTPQGEMMVTVVGEIPIGTAERIALSMRNDGAATSKQ

Specific function: Negative regulator of the sigma factor AlgU. Plays a role in the differentiation of P.aeruginosa into the alginate- producing form. Inactivation of mucB causes conversion to mucoidy [H]

COG id: COG3026

COG function: function code T; Negative regulator of sigma E activity

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the rseB family [H]

Homologues:

Organism=Escherichia coli, GI1788924, Length=297, Percent_Identity=26.9360269360269, Blast_Score=85, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005588 [H]

Pfam domain/function: PF03888 MucB_RseB [H]

EC number: NA

Molecular weight: Translated: 35376; Mature: 35376

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAIPLLSLLLSGWFIVPAHADEAQDWLTRLGQAEQQQSFHGTFVYERNGSFSTHNIWHR
CCCHHHHHHHHCCCEEEECCCCHHHHHHHHHCCHHHHHCCCCEEEEECCCCCCHHHHHHH
VQNGQVRERLLQLDGSAQEVVRIDGHTQCVSGTLIAGLGDSPNSAARPLDPQKLKNWYEL
HCCCHHHHHHHHCCCCHHHEEEECCCCEEECCEEEEECCCCCCCCCCCCCHHHHHCEEEE
AVIGKSRVAGREAVIVSLTPRDQHRYGFELHLDKETGLPLKSLLLNDKGQLLERFQFTRL
EEECCCCCCCCEEEEEEECCCCCCCCCEEEEECCCCCCCHHHHHHCCHHHHHHHHHHHCC
DTSEIPSDKDLQANSDCKTVTLDSDKASAVKTAQVWRSDWLPPGFELTSSSSHKDPETKT
CHHHCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCCCEECCCCCCCCCHHHH
QVNSLMYDDGLARFSVFLEPLNGATVTDTRTQLGPTVAVSRRLTTPQGEMMVTVVGEIPI
HHHHHHHHCCHHEEEHEEECCCCCEEECCHHHCCCEEEEHCCCCCCCCCEEEEEEECCCC
GTAERIALSMRNDGAATSKQ
CCHHHEEEEECCCCCCCCCC
>Mature Secondary Structure
MRAIPLLSLLLSGWFIVPAHADEAQDWLTRLGQAEQQQSFHGTFVYERNGSFSTHNIWHR
CCCHHHHHHHHCCCEEEECCCCHHHHHHHHHCCHHHHHCCCCEEEEECCCCCCHHHHHHH
VQNGQVRERLLQLDGSAQEVVRIDGHTQCVSGTLIAGLGDSPNSAARPLDPQKLKNWYEL
HCCCHHHHHHHHCCCCHHHEEEECCCCEEECCEEEEECCCCCCCCCCCCCHHHHHCEEEE
AVIGKSRVAGREAVIVSLTPRDQHRYGFELHLDKETGLPLKSLLLNDKGQLLERFQFTRL
EEECCCCCCCCEEEEEEECCCCCCCCCEEEEECCCCCCCHHHHHHCCHHHHHHHHHHHCC
DTSEIPSDKDLQANSDCKTVTLDSDKASAVKTAQVWRSDWLPPGFELTSSSSHKDPETKT
CHHHCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCCCEECCCCCCCCCHHHH
QVNSLMYDDGLARFSVFLEPLNGATVTDTRTQLGPTVAVSRRLTTPQGEMMVTVVGEIPI
HHHHHHHHCCHHEEEHEEECCCCCEEECCHHHCCCEEEEHCCCCCCCCCEEEEEEECCCC
GTAERIALSMRNDGAATSKQ
CCHHHEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8412698; 8378309; 8444793; 10984043 [H]