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The map label for this gene is degP [H]

Identifier: 77457592

GI number: 77457592

Start: 1538520

End: 1539968

Strand: Direct

Name: degP [H]

Synonym: Pfl01_1365

Alternate gene names: 77457592

Gene position: 1538520-1539968 (Clockwise)

Preceding gene: 77457591

Following gene: 77457594

Centisome position: 23.9

GC content: 58.66

Gene sequence:

>1449_bases
ATGTCGATACCAAGCTTGAAGTCTTATCTCTCCATTTTCGCCACGGTGCTGGTGCTCGGTCAGGCTGTTCCTGCAGTCCA
TGCGGCTGAGGCGGCCAGCCCGGCCAACCTGCCGGATTTCACCCAGCTGGTCGAACAGGCCTCGCCTGCGGTGGTGAACA
TCAGTACCACGCAAAAGCTGCCGGATCGCAAAGTGAACCAGCAAATGCCCGACCTGGAAGGCTTGCCGCCGATGCTGCGC
GAGTTCTTCGAGCGCGGCATGCCGCCGCAACAGCGTTCTCCGCGTGGTGATCGCCAGCGTGAAGCGCAGTCGCTGGGGTC
GGGCTTTATCATTTCGCCGGATGGCTACATCCTGACCAATAACCATGTGATCGCCGATGCCGACGAAATCCTCGTCCGTC
TGGCTGATCGCAGTGAAATGAAAGCCAAGCTGATCGGCACCGACCCACGCTCCGACGTGGCGCTGCTGAAAATCGAAGGC
AAGGATCTGCCAGTGCTGAAACTCGGCAAATCCCAGGACCTGAAAGCCGGTCAATGGGTGGTGGCAATCGGTTCGCCATT
CGGCTTTGATCACACCGTGACTCAAGGCATCGTCAGTGCCGTCGGTCGCAGCCTGCCGAATGAAAACTACGTGCCGTTCA
TCCAGACCGACGTACCGATCAACCCGGGTAACTCCGGTGGCCCGCTGTTCAATCTGAACGGTGAAGTGGTCGGGATCAAC
TCGCAGATCTACACCCGTTCCGGTGGCTTCATGGGCGTGTCGTTCGCCATTCCGATCGACGTGGCAATGGACGTTTCCAA
TCAGCTGAAAAGCGGCGGCAAAGTCAGCCGTGGCTGGTTGGGCGTTGTCATCCAGGAAGTGAACAAGGATCTGGCCGAGT
CGTTCGGTCTGGATAAACCGGCCGGTGCACTGGTCGCACAGATTCAGGATGACGGCCCGGCTGCAAAGGGCGGCCTGCAA
GTGGGTGACGTGATCCTGAGCATGAACGGTCAACCGATCGTCATGTCTGCTGACCTGCCACATCTGGTGGGTGCGTTGAA
GGCTGGCGCCAAGGCCAACCTCGAAGTGATTCGTGACGGCAAGCGCAAGAATGTCGAGCTGACTGTCGGCGCCATTCCAG
ATGAAGACAAGGAACTGGATGCTCTGCCGAAATCTGGTGCTGAAACCAACAGCAATCGTCTGGGGGTATCGGTTGCCGAG
CTGAGCGCCGAGCAGAAGAAAACCTACGACCTCAAAGGTGGTGTGGTGATCAAGGAAGTGCAGGACGGTCCTGCAGCCCT
GATCGGTCTGCAACCGGGCGACATCATCACCCACCTGAACAATCAGGCCATCGGTTCTTCCAAGGAGTTCGCCGAGATCG
CCAAGGCGCTGCCGAAGAACCGTTCGGTGTCGATGCGCGTTCTGCGTCAGGGGCGTGCCAGCTTCATCACGTTCAAACTG
GCTGAATGA

Upstream 100 bases:

>100_bases
CTGGCCTTGTTTGTTGTTCCCGGAACAAAAATGCCGGCCTGTGGTTTCCGGTGTTCCTTGCTCCATATCGCTTAACCCTG
CTCGTCGTAACGGGAGCTGT

Downstream 100 bases:

>100_bases
TCCAGTTGTCTAAGAAGTGAAAAGAAACCGCCTCGAAAGAGGCGGTTTTTTTGTGTCCGGAATTTGCCTCGGCGCGGGTT
AACCCATCATGTCCTTGACC

Product: peptidase S1C, Do

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 482; Mature: 481

Protein sequence:

>482_residues
MSIPSLKSYLSIFATVLVLGQAVPAVHAAEAASPANLPDFTQLVEQASPAVVNISTTQKLPDRKVNQQMPDLEGLPPMLR
EFFERGMPPQQRSPRGDRQREAQSLGSGFIISPDGYILTNNHVIADADEILVRLADRSEMKAKLIGTDPRSDVALLKIEG
KDLPVLKLGKSQDLKAGQWVVAIGSPFGFDHTVTQGIVSAVGRSLPNENYVPFIQTDVPINPGNSGGPLFNLNGEVVGIN
SQIYTRSGGFMGVSFAIPIDVAMDVSNQLKSGGKVSRGWLGVVIQEVNKDLAESFGLDKPAGALVAQIQDDGPAAKGGLQ
VGDVILSMNGQPIVMSADLPHLVGALKAGAKANLEVIRDGKRKNVELTVGAIPDEDKELDALPKSGAETNSNRLGVSVAE
LSAEQKKTYDLKGGVVIKEVQDGPAALIGLQPGDIITHLNNQAIGSSKEFAEIAKALPKNRSVSMRVLRQGRASFITFKL
AE

Sequences:

>Translated_482_residues
MSIPSLKSYLSIFATVLVLGQAVPAVHAAEAASPANLPDFTQLVEQASPAVVNISTTQKLPDRKVNQQMPDLEGLPPMLR
EFFERGMPPQQRSPRGDRQREAQSLGSGFIISPDGYILTNNHVIADADEILVRLADRSEMKAKLIGTDPRSDVALLKIEG
KDLPVLKLGKSQDLKAGQWVVAIGSPFGFDHTVTQGIVSAVGRSLPNENYVPFIQTDVPINPGNSGGPLFNLNGEVVGIN
SQIYTRSGGFMGVSFAIPIDVAMDVSNQLKSGGKVSRGWLGVVIQEVNKDLAESFGLDKPAGALVAQIQDDGPAAKGGLQ
VGDVILSMNGQPIVMSADLPHLVGALKAGAKANLEVIRDGKRKNVELTVGAIPDEDKELDALPKSGAETNSNRLGVSVAE
LSAEQKKTYDLKGGVVIKEVQDGPAALIGLQPGDIITHLNNQAIGSSKEFAEIAKALPKNRSVSMRVLRQGRASFITFKL
AE
>Mature_481_residues
SIPSLKSYLSIFATVLVLGQAVPAVHAAEAASPANLPDFTQLVEQASPAVVNISTTQKLPDRKVNQQMPDLEGLPPMLRE
FFERGMPPQQRSPRGDRQREAQSLGSGFIISPDGYILTNNHVIADADEILVRLADRSEMKAKLIGTDPRSDVALLKIEGK
DLPVLKLGKSQDLKAGQWVVAIGSPFGFDHTVTQGIVSAVGRSLPNENYVPFIQTDVPINPGNSGGPLFNLNGEVVGINS
QIYTRSGGFMGVSFAIPIDVAMDVSNQLKSGGKVSRGWLGVVIQEVNKDLAESFGLDKPAGALVAQIQDDGPAAKGGLQV
GDVILSMNGQPIVMSADLPHLVGALKAGAKANLEVIRDGKRKNVELTVGAIPDEDKELDALPKSGAETNSNRLGVSVAEL
SAEQKKTYDLKGGVVIKEVQDGPAALIGLQPGDIITHLNNQAIGSSKEFAEIAKALPKNRSVSMRVLRQGRASFITFKLA
E

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=351, Percent_Identity=35.3276353276353, Blast_Score=172, Evalue=7e-43,
Organism=Homo sapiens, GI22129776, Length=257, Percent_Identity=38.9105058365759, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI24308541, Length=250, Percent_Identity=38.4, Blast_Score=151, Evalue=2e-36,
Organism=Homo sapiens, GI7019477, Length=253, Percent_Identity=38.7351778656126, Blast_Score=143, Evalue=3e-34,
Organism=Escherichia coli, GI1786356, Length=474, Percent_Identity=39.0295358649789, Blast_Score=277, Evalue=1e-75,
Organism=Escherichia coli, GI1789629, Length=474, Percent_Identity=36.2869198312236, Blast_Score=241, Evalue=6e-65,
Organism=Escherichia coli, GI1789630, Length=302, Percent_Identity=36.0927152317881, Blast_Score=181, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24646839, Length=290, Percent_Identity=36.551724137931, Blast_Score=151, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 51162; Mature: 51031

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIPSLKSYLSIFATVLVLGQAVPAVHAAEAASPANLPDFTQLVEQASPAVVNISTTQKL
CCCCHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCHHHHHHHHCCCCEEEEECCCCC
PDRKVNQQMPDLEGLPPMLREFFERGMPPQQRSPRGDRQREAQSLGSGFIISPDGYILTN
CCHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCEEECCCCEEEEC
NHVIADADEILVRLADRSEMKAKLIGTDPRSDVALLKIEGKDLPVLKLGKSQDLKAGQWV
CEEEECHHHHHHHHHCCCCCEEEEECCCCCCCEEEEEECCCCCCEEECCCCCCCCCCCEE
VAIGSPFGFDHTVTQGIVSAVGRSLPNENYVPFIQTDVPINPGNSGGPLFNLNGEVVGIN
EEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCEEECCCCEEEEC
SQIYTRSGGFMGVSFAIPIDVAMDVSNQLKSGGKVSRGWLGVVIQEVNKDLAESFGLDKP
CEEEEECCCEEEEEEEEEEEEEECCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCC
AGALVAQIQDDGPAAKGGLQVGDVILSMNGQPIVMSADLPHLVGALKAGAKANLEVIRDG
CCCEEEEECCCCCCCCCCCEEEEEEEECCCCEEEEECCCHHHHHHHHCCCCCCHHEEECC
KRKNVELTVGAIPDEDKELDALPKSGAETNSNRLGVSVAELSAEQKKTYDLKGGVVIKEV
CCCCEEEEEECCCCCCCHHHCCCCCCCCCCCCCCEEEHHHHCHHHHHCEECCCCEEEEEE
QDGPAALIGLQPGDIITHLNNQAIGSSKEFAEIAKALPKNRSVSMRVLRQGRASFITFKL
CCCCEEEEECCCCHHHHHCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHCCCCEEEEEEE
AE
CC
>Mature Secondary Structure 
SIPSLKSYLSIFATVLVLGQAVPAVHAAEAASPANLPDFTQLVEQASPAVVNISTTQKL
CCCHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCHHHHHHHHCCCCEEEEECCCCC
PDRKVNQQMPDLEGLPPMLREFFERGMPPQQRSPRGDRQREAQSLGSGFIISPDGYILTN
CCHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCEEECCCCEEEEC
NHVIADADEILVRLADRSEMKAKLIGTDPRSDVALLKIEGKDLPVLKLGKSQDLKAGQWV
CEEEECHHHHHHHHHCCCCCEEEEECCCCCCCEEEEEECCCCCCEEECCCCCCCCCCCEE
VAIGSPFGFDHTVTQGIVSAVGRSLPNENYVPFIQTDVPINPGNSGGPLFNLNGEVVGIN
EEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCEEECCCCEEEEC
SQIYTRSGGFMGVSFAIPIDVAMDVSNQLKSGGKVSRGWLGVVIQEVNKDLAESFGLDKP
CEEEEECCCEEEEEEEEEEEEEECCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCC
AGALVAQIQDDGPAAKGGLQVGDVILSMNGQPIVMSADLPHLVGALKAGAKANLEVIRDG
CCCEEEEECCCCCCCCCCCEEEEEEEECCCCEEEEECCCHHHHHHHHCCCCCCHHEEECC
KRKNVELTVGAIPDEDKELDALPKSGAETNSNRLGVSVAELSAEQKKTYDLKGGVVIKEV
CCCCEEEEEECCCCCCCHHHCCCCCCCCCCCCCCEEEHHHHCHHHHHCEECCCCEEEEEE
QDGPAALIGLQPGDIITHLNNQAIGSSKEFAEIAKALPKNRSVSMRVLRQGRASFITFKL
CCCCEEEEECCCCHHHHHCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHCCCCEEEEEEE
AE
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7861951 [H]