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The map label for this gene is mucA [H]

Identifier: 77457590

GI number: 77457590

Start: 1536755

End: 1537342

Strand: Direct

Name: mucA [H]

Synonym: Pfl01_1363

Alternate gene names: 77457590

Gene position: 1536755-1537342 (Clockwise)

Preceding gene: 77457589

Following gene: 77457591

Centisome position: 23.87

GC content: 57.82

Gene sequence:

>588_bases
ATGAGTCGTGAAGCCCTGCAGGAATCGCTGTCCGCAGTGATGGATAACGAAGCGGACGAACTGGAATTGCGTCGAGTGCT
CAATGCACTGGACGATGTTGAAACCCGTGAAACCTGGGCTCGTTATCAGATCGCTCGGGCAGCCATGCACAAGGATCTGT
TGCTCCCACGTCTGGATCTTGCTGCGGCCGTTTCTGCTGCGCTGGAAGACGAAGCAACTCCTGCCAAAGTGTCCCGCGGC
CCATGGCGCAGCCTTGGTCGTCTGGCCGTAGCTGCCTCGGTGACCGTTGCCGTACTGGCGGGTGTTCGTCTGTACAATCA
GGACGAAATCGCTGGCGTCGAACTCGCTCAGCAATCCAATCAGCCAGTGCTGGCTACCCCTCAGGTAAAAGGCCCGGCGG
TATTGGCAGGCTATAATGAGAGTTCTGAAGCTACTGGCCCAATGGCCAATGGTGTACTGCAAGGTCAGCCAGGCTGGCAC
GATCAGCGTCTGCCAGGTTACCTGCGTCAACACGCTCAACAGGCTGCCTTGAAAGGCACCGAGAGCGCGCTGCCATATGC
ACGTGCAGCAAGCCTGGAAAACCGTTAA

Upstream 100 bases:

>100_bases
CGCTCCCGGATTTTCCGCGCCCGGGAGGCCATCGATAAAGCCCTGCAGCCGTTGTTGCAGGAAAACTAAAGACAGCGGCG
ACAGCCAAGAGAGGAACGCC

Downstream 100 bases:

>100_bases
GGGGGATCATGCGCGCCATACCTCTACTTTCGCTTCTGCTCAGCGGCTGGTTCATTGTTCCAGCCCACGCCGACGAGGCT
CAGGACTGGTTGACCCGCCT

Product: anti sigma-E protein, RseA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 195; Mature: 194

Protein sequence:

>195_residues
MSREALQESLSAVMDNEADELELRRVLNALDDVETRETWARYQIARAAMHKDLLLPRLDLAAAVSAALEDEATPAKVSRG
PWRSLGRLAVAASVTVAVLAGVRLYNQDEIAGVELAQQSNQPVLATPQVKGPAVLAGYNESSEATGPMANGVLQGQPGWH
DQRLPGYLRQHAQQAALKGTESALPYARAASLENR

Sequences:

>Translated_195_residues
MSREALQESLSAVMDNEADELELRRVLNALDDVETRETWARYQIARAAMHKDLLLPRLDLAAAVSAALEDEATPAKVSRG
PWRSLGRLAVAASVTVAVLAGVRLYNQDEIAGVELAQQSNQPVLATPQVKGPAVLAGYNESSEATGPMANGVLQGQPGWH
DQRLPGYLRQHAQQAALKGTESALPYARAASLENR
>Mature_194_residues
SREALQESLSAVMDNEADELELRRVLNALDDVETRETWARYQIARAAMHKDLLLPRLDLAAAVSAALEDEATPAKVSRGP
WRSLGRLAVAASVTVAVLAGVRLYNQDEIAGVELAQQSNQPVLATPQVKGPAVLAGYNESSEATGPMANGVLQGQPGWHD
QRLPGYLRQHAQQAALKGTESALPYARAASLENR

Specific function: Negative regulator of the sigma factor AlgU. Plays a role in the differentiation of P.aeruginosa into the alginate- producing form. Inactivation of mucA causes a switch from the non- mucoid to mucoid state resulting in constitutive expression of alginate

COG id: COG3073

COG function: function code T; Negative regulator of sigma E activity

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the rseA family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005573
- InterPro:   IPR005572 [H]

Pfam domain/function: PF03873 RseA_C; PF03872 RseA_N [H]

EC number: NA

Molecular weight: Translated: 20989; Mature: 20858

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSREALQESLSAVMDNEADELELRRVLNALDDVETRETWARYQIARAAMHKDLLLPRLDL
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
AAAVSAALEDEATPAKVSRGPWRSLGRLAVAASVTVAVLAGVRLYNQDEIAGVELAQQSN
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCC
QPVLATPQVKGPAVLAGYNESSEATGPMANGVLQGQPGWHDQRLPGYLRQHAQQAALKGT
CCEEECCCCCCCEEEECCCCCCCCCCCHHCCEECCCCCCCCCCCCHHHHHHHHHHHHCCC
ESALPYARAASLENR
HHHCCHHHHHCCCCC
>Mature Secondary Structure 
SREALQESLSAVMDNEADELELRRVLNALDDVETRETWARYQIARAAMHKDLLLPRLDL
CHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
AAAVSAALEDEATPAKVSRGPWRSLGRLAVAASVTVAVLAGVRLYNQDEIAGVELAQQSN
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCC
QPVLATPQVKGPAVLAGYNESSEATGPMANGVLQGQPGWHDQRLPGYLRQHAQQAALKGT
CCEEECCCCCCCEEEECCCCCCCCCCCHHCCEECCCCCCCCCCCCHHHHHHHHHHHHCCC
ESALPYARAASLENR
HHHCCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8412698; 8378309; 10984043 [H]