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The map label for this gene is ung

Identifier: 77457576

GI number: 77457576

Start: 1524128

End: 1524823

Strand: Direct

Name: ung

Synonym: Pfl01_1349

Alternate gene names: 77457576

Gene position: 1524128-1524823 (Clockwise)

Preceding gene: 77457574

Following gene: 77457581

Centisome position: 23.67

GC content: 60.49

Gene sequence:

>696_bases
ATGACTGCTGACGACCGTATCAAACTCGAACCGAGCTGGAAGGAGGCACTGCGTGCCGAATTCGACCAGCCCTACATGAC
AGAGTTGCGCACTTTTCTGCAGCAGGAGCGGGCGGCCGGCAAGGAAATCTATCCGCCGGGACCGATGATCTTCAACGCGT
TGAACTCGACGCCGCTGGACAAGGTGAAAGTGGTCATTCTCGGCCAGGATCCGTACCACGGCCCGGGCCAGGCCCACGGC
TTGTGCTTCTCGGTGCAACCGGGCGTGCCGGCGCCGCCATCGTTGGTCAACATCTATAAAGAGTTGAAGCGCGACCTGAA
CATCGACATCCCCAACCACGGCTATCTGCAGAGCTGGGCCGATCAGGGCGTGTTGATGCTCAACACCACCATGACCGTCG
AGCGTGCCAACGCCAACGCGCACAAGGACAAGGGCTGGCAGTTCTTCACGGACCGGATCATTGAGGTGGTCAGCCAGAAA
CAACCGCATCTGGTATTCATGCTGTGGGGCGCCCATGCGCAGAGCAAGCAGAAGCTGATCGATGCCACCAAGCATCTGGT
ACTGACTTCGGTGCACCCGTCGCCGCTGTCGGCCTATCGCGGTTTCCTTGGCTGCGGGCATTTCAGCCGCACCAACAAAT
TCCTGGAGCAGAACGGCGAAGCGCCGATCGAGTGGCGCCTGCCGCCGGTGGTCTGA

Upstream 100 bases:

>100_bases
ATGATCGCTGTGTGGGAAAGTGCCGGATCTGCGTCAGATCAATTGACAAGCGTGGTCGGCTTTCCTAGGGTTCGCCCCAT
TGTTTTTGCCGGGTATGACC

Downstream 100 bases:

>100_bases
TGCTCAGGGCTGGCGGTTCCAGTATTTGAATAACGGTTCCGCCAGAAACAGCACGAACAACAACCGCATCACCTGCATTG
CCGTCACCAGCGGCACCGAC

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG

Number of amino acids: Translated: 231; Mature: 230

Protein sequence:

>231_residues
MTADDRIKLEPSWKEALRAEFDQPYMTELRTFLQQERAAGKEIYPPGPMIFNALNSTPLDKVKVVILGQDPYHGPGQAHG
LCFSVQPGVPAPPSLVNIYKELKRDLNIDIPNHGYLQSWADQGVLMLNTTMTVERANANAHKDKGWQFFTDRIIEVVSQK
QPHLVFMLWGAHAQSKQKLIDATKHLVLTSVHPSPLSAYRGFLGCGHFSRTNKFLEQNGEAPIEWRLPPVV

Sequences:

>Translated_231_residues
MTADDRIKLEPSWKEALRAEFDQPYMTELRTFLQQERAAGKEIYPPGPMIFNALNSTPLDKVKVVILGQDPYHGPGQAHG
LCFSVQPGVPAPPSLVNIYKELKRDLNIDIPNHGYLQSWADQGVLMLNTTMTVERANANAHKDKGWQFFTDRIIEVVSQK
QPHLVFMLWGAHAQSKQKLIDATKHLVLTSVHPSPLSAYRGFLGCGHFSRTNKFLEQNGEAPIEWRLPPVV
>Mature_230_residues
TADDRIKLEPSWKEALRAEFDQPYMTELRTFLQQERAAGKEIYPPGPMIFNALNSTPLDKVKVVILGQDPYHGPGQAHGL
CFSVQPGVPAPPSLVNIYKELKRDLNIDIPNHGYLQSWADQGVLMLNTTMTVERANANAHKDKGWQFFTDRIIEVVSQKQ
PHLVFMLWGAHAQSKQKLIDATKHLVLTSVHPSPLSAYRGFLGCGHFSRTNKFLEQNGEAPIEWRLPPVV

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family

Homologues:

Organism=Homo sapiens, GI19718751, Length=216, Percent_Identity=52.3148148148148, Blast_Score=236, Evalue=1e-62,
Organism=Homo sapiens, GI6224979, Length=216, Percent_Identity=52.3148148148148, Blast_Score=236, Evalue=1e-62,
Organism=Escherichia coli, GI1788934, Length=217, Percent_Identity=53.9170506912442, Blast_Score=249, Evalue=8e-68,
Organism=Caenorhabditis elegans, GI17556304, Length=216, Percent_Identity=49.537037037037, Blast_Score=220, Evalue=4e-58,
Organism=Saccharomyces cerevisiae, GI6323620, Length=238, Percent_Identity=44.1176470588235, Blast_Score=191, Evalue=6e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UNG_PSEPF (Q3KGL4)

Other databases:

- EMBL:   CP000094
- RefSeq:   YP_347081.1
- HSSP:   P10186
- ProteinModelPortal:   Q3KGL4
- SMR:   Q3KGL4
- STRING:   Q3KGL4
- GeneID:   3717296
- GenomeReviews:   CP000094_GR
- KEGG:   pfo:Pfl01_1349
- eggNOG:   COG0692
- HOGENOM:   HBG605450
- OMA:   GAHAQKK
- ProtClustDB:   PRK05254
- BioCyc:   PFLU205922:PFL_1349-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00148
- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122
- Gene3D:   G3DSA:3.40.470.10
- PANTHER:   PTHR11264
- TIGRFAMs:   TIGR00628

Pfam domain/function: PF03167 UDG; SSF52141 UDNA_glycsylseSF

EC number: =3.2.2.27

Molecular weight: Translated: 26048; Mature: 25917

Theoretical pI: Translated: 8.25; Mature: 8.25

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: ACT_SITE 70-70

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTADDRIKLEPSWKEALRAEFDQPYMTELRTFLQQERAAGKEIYPPGPMIFNALNSTPLD
CCCCCCEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCCC
KVKVVILGQDPYHGPGQAHGLCFSVQPGVPAPPSLVNIYKELKRDLNIDIPNHGYLQSWA
CEEEEEECCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHH
DQGVLMLNTTMTVERANANAHKDKGWQFFTDRIIEVVSQKQPHLVFMLWGAHAQSKQKLI
CCCEEEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHH
DATKHLVLTSVHPSPLSAYRGFLGCGHFSRTNKFLEQNGEAPIEWRLPPVV
HHHHHEEEEECCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCCEEECCCCCC
>Mature Secondary Structure 
TADDRIKLEPSWKEALRAEFDQPYMTELRTFLQQERAAGKEIYPPGPMIFNALNSTPLD
CCCCCEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCCC
KVKVVILGQDPYHGPGQAHGLCFSVQPGVPAPPSLVNIYKELKRDLNIDIPNHGYLQSWA
CEEEEEECCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHH
DQGVLMLNTTMTVERANANAHKDKGWQFFTDRIIEVVSQKQPHLVFMLWGAHAQSKQKLI
CCCEEEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHH
DATKHLVLTSVHPSPLSAYRGFLGCGHFSRTNKFLEQNGEAPIEWRLPPVV
HHHHHEEEEECCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA