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The map label for this gene is yngG [H]

Identifier: 77457542

GI number: 77457542

Start: 1490354

End: 1491280

Strand: Direct

Name: yngG [H]

Synonym: Pfl01_1315

Alternate gene names: 77457542

Gene position: 1490354-1491280 (Clockwise)

Preceding gene: 77457541

Following gene: 77457543

Centisome position: 23.15

GC content: 64.4

Gene sequence:

>927_bases
ATGATCAGCGATTACTCGCAGACCCTGATCGTCCAGGAAGTCTCGCCCCGGGACGGCCTGCAGATCGAGCCGACCTGGGT
CGAGACCGAAGACAAGATCGCCCTGATCGATCAACTGTCCCGGGCAGGATTCAGCCGCATCGAGGCCGGCTCGTTCGTCT
CGCCCAAAGCGATCCCGGCCCTGCGCGATGGCGAGCAGGTGTTCAAGGGCATCCAGCGCCAGCCGGGGGTGATTTACGTC
GCGCTGATTCCCAACCTCAAGGGGGCGCAACGGGCACTGGAGTCCGGCGCTGATGAACTGAACCTGGTGATGTCCGCCAG
CCAGACCCACAACCTGGCGAACATGCGCATGCGTTGCGAAGCCTCGCTGGTGGCGTTCGGCGAAATCGTGACCTTCGCCA
GCGGCTCGGGCGTGCGGCTCAACGGCAGTATCGCAACGACTTTCGGTTGTCCGTTTGAGGGCAGGATCGACGAAGACCGC
GTGCTGCAAATCCTCGAGGCCTATCAACAGCTCGGCATTCAGGGCATCTCCCTGGCCGACACCACCGGCATGGCCAATCC
GCGACAGGTCGACCGACTGGTGCGGCGGGTGTTGCAGCGGGTTTCGGCGGCGGATCTGACTCTGCACTTTCACAACACCC
GAGGCCTGGGATTGTGCAACGTGCTGGCAGCTTACGAAGCGGGCGCCCGGCGTTTCGACGCGGCGCTGGGCGGGCTCGGC
GGCTGTCCGTTCGCGCCCGGCGCATCGGGCAACATCTGCACCGAAGACCTGGTCAACCTCTGCGATGAAGTCGGCATTCA
CACCGGCATCGATCTGCCGTTGCTGCTGAAACTATCCCGTGGCTTGCCAGCGCTGCTGGGCCACGACGTGCCGGGGCAAC
TGGCCAAGGCCGGACGCAATTGCGATCTGCACCCGATGCCCACCTGA

Upstream 100 bases:

>100_bases
GGTCGGGCCCCGGCCTCGGTCAGCACACCGATGGCATCCTCGCCGGTCTCGGCCTGACCGCTTCTGACATCGAACGCCTG
AAAAACCGGGGGGTGGTGCA

Downstream 100 bases:

>100_bases
TGTCACACGCTCACTGACTTACCCCCAACCAGACAACAAAAACAATCGGACGCCCACCGGCAGTCCGCCTGGAGAAAAAA
CTATGAGCCTCAATGTAATG

Product: hydroxymethylglutaryl-CoA lyase

Products: NA

Alternate protein names: HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase [H]

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MISDYSQTLIVQEVSPRDGLQIEPTWVETEDKIALIDQLSRAGFSRIEAGSFVSPKAIPALRDGEQVFKGIQRQPGVIYV
ALIPNLKGAQRALESGADELNLVMSASQTHNLANMRMRCEASLVAFGEIVTFASGSGVRLNGSIATTFGCPFEGRIDEDR
VLQILEAYQQLGIQGISLADTTGMANPRQVDRLVRRVLQRVSAADLTLHFHNTRGLGLCNVLAAYEAGARRFDAALGGLG
GCPFAPGASGNICTEDLVNLCDEVGIHTGIDLPLLLKLSRGLPALLGHDVPGQLAKAGRNCDLHPMPT

Sequences:

>Translated_308_residues
MISDYSQTLIVQEVSPRDGLQIEPTWVETEDKIALIDQLSRAGFSRIEAGSFVSPKAIPALRDGEQVFKGIQRQPGVIYV
ALIPNLKGAQRALESGADELNLVMSASQTHNLANMRMRCEASLVAFGEIVTFASGSGVRLNGSIATTFGCPFEGRIDEDR
VLQILEAYQQLGIQGISLADTTGMANPRQVDRLVRRVLQRVSAADLTLHFHNTRGLGLCNVLAAYEAGARRFDAALGGLG
GCPFAPGASGNICTEDLVNLCDEVGIHTGIDLPLLLKLSRGLPALLGHDVPGQLAKAGRNCDLHPMPT
>Mature_308_residues
MISDYSQTLIVQEVSPRDGLQIEPTWVETEDKIALIDQLSRAGFSRIEAGSFVSPKAIPALRDGEQVFKGIQRQPGVIYV
ALIPNLKGAQRALESGADELNLVMSASQTHNLANMRMRCEASLVAFGEIVTFASGSGVRLNGSIATTFGCPFEGRIDEDR
VLQILEAYQQLGIQGISLADTTGMANPRQVDRLVRRVLQRVSAADLTLHFHNTRGLGLCNVLAAYEAGARRFDAALGGLG
GCPFAPGASGNICTEDLVNLCDEVGIHTGIDLPLLLKLSRGLPALLGHDVPGQLAKAGRNCDLHPMPT

Specific function: Involved in the catabolism of branched amino acids such as leucine (Probable) [H]

COG id: COG0119

COG function: function code E; Isopropylmalate/homocitrate/citramalate synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA lyase family [H]

Homologues:

Organism=Homo sapiens, GI62198232, Length=293, Percent_Identity=40.2730375426621, Blast_Score=222, Evalue=4e-58,
Organism=Homo sapiens, GI109150422, Length=290, Percent_Identity=36.2068965517241, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI109150427, Length=290, Percent_Identity=36.2068965517241, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI260654708, Length=140, Percent_Identity=37.8571428571429, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17510563, Length=297, Percent_Identity=36.7003367003367, Blast_Score=206, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6320019, Length=229, Percent_Identity=28.82096069869, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6320071, Length=229, Percent_Identity=28.82096069869, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24582381, Length=299, Percent_Identity=40.133779264214, Blast_Score=224, Evalue=7e-59,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000891 [H]

Pfam domain/function: PF00682 HMGL-like [H]

EC number: =4.1.3.4 [H]

Molecular weight: Translated: 32939; Mature: 32939

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS50991 PYR_CT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISDYSQTLIVQEVSPRDGLQIEPTWVETEDKIALIDQLSRAGFSRIEAGSFVSPKAIPA
CCCCCCCEEEEEECCCCCCCEECCEEECCCCHHHHHHHHHHHCHHHCCCCCCCCCCCCCC
LRDGEQVFKGIQRQPGVIYVALIPNLKGAQRALESGADELNLVMSASQTHNLANMRMRCE
CCCHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHCCCCCEEEEEECHHHCCHHHHHHHHH
ASLVAFGEIVTFASGSGVRLNGSIATTFGCPFEGRIDEDRVLQILEAYQQLGIQGISLAD
HHHHHHHHHHEECCCCCEEECCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEC
TTGMANPRQVDRLVRRVLQRVSAADLTLHFHNTRGLGLCNVLAAYEAGARRFDAALGGLG
CCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCC
GCPFAPGASGNICTEDLVNLCDEVGIHTGIDLPLLLKLSRGLPALLGHDVPGQLAKAGRN
CCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHCCCHHHHCCCCCHHHHHCCCC
CDLHPMPT
CCCCCCCC
>Mature Secondary Structure
MISDYSQTLIVQEVSPRDGLQIEPTWVETEDKIALIDQLSRAGFSRIEAGSFVSPKAIPA
CCCCCCCEEEEEECCCCCCCEECCEEECCCCHHHHHHHHHHHCHHHCCCCCCCCCCCCCC
LRDGEQVFKGIQRQPGVIYVALIPNLKGAQRALESGADELNLVMSASQTHNLANMRMRCE
CCCHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHCCCCCEEEEEECHHHCCHHHHHHHHH
ASLVAFGEIVTFASGSGVRLNGSIATTFGCPFEGRIDEDRVLQILEAYQQLGIQGISLAD
HHHHHHHHHHEECCCCCEEECCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEC
TTGMANPRQVDRLVRRVLQRVSAADLTLHFHNTRGLGLCNVLAAYEAGARRFDAALGGLG
CCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCC
GCPFAPGASGNICTEDLVNLCDEVGIHTGIDLPLLLKLSRGLPALLGHDVPGQLAKAGRN
CCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHCCCHHHHCCCCCHHHHHCCCC
CDLHPMPT
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]