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The map label for this gene is cysM [C]

Identifier: 77457462

GI number: 77457462

Start: 1406737

End: 1407831

Strand: Direct

Name: cysM [C]

Synonym: Pfl01_1235

Alternate gene names: 77457462

Gene position: 1406737-1407831 (Clockwise)

Preceding gene: 77457458

Following gene: 77457466

Centisome position: 21.85

GC content: 63.56

Gene sequence:

>1095_bases
ATGAGCGACAACCGACAGTGGGCCCGCGAAGCCATCCGGATCATCGAAGCGGACTTCCAGCGCAGCGCCGACACCCACCT
GATCCCTTTGCCGCTGCCGGGTTTTCCGGGCATCAAACTGTACTTCAAGGACGAGTCCAGCCACCCGACCGGCAGCCTCA
AGCATCGGCTGGCCCGGTCGCTGTTTCTTTACGCGTTGTGTAATGGCTGGCTCAAACCCGGGGCGCCGGTGATCGAGGCG
TCCAGCGGATCGACGGCGATTTCCGAAGCGTACTTCGCACGGATGCTCGGCCTGCCGTTCATTGCGGTGATGCCGGCGAC
CACCTCCAAGGAGAAGATTGCGCAGATCGCCTTCTACGGTGGCCAGAGTCATCTGGTGGATGATCCGACCCAGATCTACG
CCGAATCCGAACGCCTGGCCCGCGAGCACGACGGTCACTTCATCGACCAGTTCACCTACGCCGAGCGCGCCACCGACTGG
CGGGCGAACAACAACATCGCCGAGTCGATCTTCCAGCAGATGCGCTATGAGCAGCATCCATGCCCGGCCTGGCTGATTTC
CAGCCCCGGCACCGGTGGTACCACGGCGACCCTGGGGCGTTACGTACGTTATCGCCAGCACTGCACTCGCGTGCTGTGCG
CCGATGCCGAGCGTTCGGTGTTCTTCGACTTTTACCAGAGCGGCGATGCCAGCCTGCGTCTGGACCACGGTTCGCGGATC
GAAGGGATCGGCCGGCCGCGGGTAGAAGCGTCGTTCCTGCCGAAGGTAATCGATGCGATGGTCAAGGTGCCGGACGCCTT
GTCGCTGGCGGCCATGCATTACCTGGCGCAGCGTCTGGGCCGGCATGTTGGCGGGTCGAGCGGCACTAACCTGATCGGCG
CATTGATGGCGGCGCAGCAGATGAAAGCGGCGGGGGAGTCGGGCTCGATCGTGGCGATCCTGTGCGATGGTGGCGAGCGT
TACGCGGACACCTATTACGATCAGGCGTGGCTCAAGGCGCAAGGCTATGAACTGGATGGATTGATGGCGGCCGTGGCAGC
GAGTGCCGAGCAGGGTGAGGCGCTGCCGGCCTCGGTTCTGCGTGCCAATATCTGA

Upstream 100 bases:

>100_bases
ATTGAAGTTCAGCTGTATCTGTCGGTGCTGTAGGTTTTTTCCTAAGCTTGGGGCTGAGCCTGTGAAGGCATTTTTGCCCG
ATTCAACGAGAACAACAGCC

Downstream 100 bases:

>100_bases
CGCTGAAAACGACTGTGGGAGCGAATTTGCTCCCACAGGTTTTTACAGTGTTTCAGGTGGTGCGGATCAGTCTTTCAGAC
CGAGGATGTCACGCGCCACC

Product: pyridoxal-5'-phosphate-dependent enzyme subunit beta

Products: NA

Alternate protein names: O-acetylserine (Thiol)-lyase; O-acetylserine sulfhydrylase; CSase [H]

Number of amino acids: Translated: 364; Mature: 363

Protein sequence:

>364_residues
MSDNRQWAREAIRIIEADFQRSADTHLIPLPLPGFPGIKLYFKDESSHPTGSLKHRLARSLFLYALCNGWLKPGAPVIEA
SSGSTAISEAYFARMLGLPFIAVMPATTSKEKIAQIAFYGGQSHLVDDPTQIYAESERLAREHDGHFIDQFTYAERATDW
RANNNIAESIFQQMRYEQHPCPAWLISSPGTGGTTATLGRYVRYRQHCTRVLCADAERSVFFDFYQSGDASLRLDHGSRI
EGIGRPRVEASFLPKVIDAMVKVPDALSLAAMHYLAQRLGRHVGGSSGTNLIGALMAAQQMKAAGESGSIVAILCDGGER
YADTYYDQAWLKAQGYELDGLMAAVAASAEQGEALPASVLRANI

Sequences:

>Translated_364_residues
MSDNRQWAREAIRIIEADFQRSADTHLIPLPLPGFPGIKLYFKDESSHPTGSLKHRLARSLFLYALCNGWLKPGAPVIEA
SSGSTAISEAYFARMLGLPFIAVMPATTSKEKIAQIAFYGGQSHLVDDPTQIYAESERLAREHDGHFIDQFTYAERATDW
RANNNIAESIFQQMRYEQHPCPAWLISSPGTGGTTATLGRYVRYRQHCTRVLCADAERSVFFDFYQSGDASLRLDHGSRI
EGIGRPRVEASFLPKVIDAMVKVPDALSLAAMHYLAQRLGRHVGGSSGTNLIGALMAAQQMKAAGESGSIVAILCDGGER
YADTYYDQAWLKAQGYELDGLMAAVAASAEQGEALPASVLRANI
>Mature_363_residues
SDNRQWAREAIRIIEADFQRSADTHLIPLPLPGFPGIKLYFKDESSHPTGSLKHRLARSLFLYALCNGWLKPGAPVIEAS
SGSTAISEAYFARMLGLPFIAVMPATTSKEKIAQIAFYGGQSHLVDDPTQIYAESERLAREHDGHFIDQFTYAERATDWR
ANNNIAESIFQQMRYEQHPCPAWLISSPGTGGTTATLGRYVRYRQHCTRVLCADAERSVFFDFYQSGDASLRLDHGSRIE
GIGRPRVEASFLPKVIDAMVKVPDALSLAAMHYLAQRLGRHVGGSSGTNLIGALMAAQQMKAAGESGSIVAILCDGGERY
ADTYYDQAWLKAQGYELDGLMAAVAASAEQGEALPASVLRANI

Specific function: As it is highly similar to bacterial and plant cysteine synthases, it is possible that it catalyzes a related reaction [H]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=307, Percent_Identity=27.0358306188925, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI295821200, Length=307, Percent_Identity=27.0358306188925, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI4557415, Length=307, Percent_Identity=27.0358306188925, Blast_Score=89, Evalue=7e-18,
Organism=Escherichia coli, GI2367138, Length=297, Percent_Identity=28.956228956229, Blast_Score=93, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71996324, Length=367, Percent_Identity=32.425068119891, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17539800, Length=366, Percent_Identity=28.4153005464481, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17539640, Length=371, Percent_Identity=28.5714285714286, Blast_Score=147, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI17562970, Length=300, Percent_Identity=26.3333333333333, Blast_Score=68, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17534315, Length=318, Percent_Identity=27.0440251572327, Blast_Score=66, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6321594, Length=343, Percent_Identity=26.2390670553936, Blast_Score=87, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6321449, Length=333, Percent_Identity=27.027027027027, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24643623, Length=315, Percent_Identity=25.7142857142857, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI20129101, Length=315, Percent_Identity=25.7142857142857, Blast_Score=75, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 39894; Mature: 39762

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDNRQWAREAIRIIEADFQRSADTHLIPLPLPGFPGIKLYFKDESSHPTGSLKHRLARS
CCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCEEEEEECCCCCCCHHHHHHHHHH
LFLYALCNGWLKPGAPVIEASSGSTAISEAYFARMLGLPFIAVMPATTSKEKIAQIAFYG
HHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHEEEC
GQSHLVDDPTQIYAESERLAREHDGHFIDQFTYAERATDWRANNNIAESIFQQMRYEQHP
CCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCC
CPAWLISSPGTGGTTATLGRYVRYRQHCTRVLCADAERSVFFDFYQSGDASLRLDHGSRI
CCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHEEHHHHHCCCCEEEECCCCCC
EGIGRPRVEASFLPKVIDAMVKVPDALSLAAMHYLAQRLGRHVGGSSGTNLIGALMAAQQ
CCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
MKAAGESGSIVAILCDGGERYADTYYDQAWLKAQGYELDGLMAAVAASAEQGEALPASVL
HHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHH
RANI
HCCC
>Mature Secondary Structure 
SDNRQWAREAIRIIEADFQRSADTHLIPLPLPGFPGIKLYFKDESSHPTGSLKHRLARS
CCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCEEEEEECCCCCCCHHHHHHHHHH
LFLYALCNGWLKPGAPVIEASSGSTAISEAYFARMLGLPFIAVMPATTSKEKIAQIAFYG
HHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHEEEC
GQSHLVDDPTQIYAESERLAREHDGHFIDQFTYAERATDWRANNNIAESIFQQMRYEQHP
CCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCC
CPAWLISSPGTGGTTATLGRYVRYRQHCTRVLCADAERSVFFDFYQSGDASLRLDHGSRI
CCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHEEHHHHHCCCCEEEECCCCCC
EGIGRPRVEASFLPKVIDAMVKVPDALSLAAMHYLAQRLGRHVGGSSGTNLIGALMAAQQ
CCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
MKAAGESGSIVAILCDGGERYADTYYDQAWLKAQGYELDGLMAAVAASAEQGEALPASVL
HHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHH
RANI
HCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]