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The map label for this gene is adk

Identifier: 77457297

GI number: 77457297

Start: 1239968

End: 1240618

Strand: Direct

Name: adk

Synonym: Pfl01_1070

Alternate gene names: 77457297

Gene position: 1239968-1240618 (Clockwise)

Preceding gene: 77457296

Following gene: 77457298

Centisome position: 19.26

GC content: 59.91

Gene sequence:

>651_bases
ATGCGCGTCATTCTGCTGGGAGCTCCCGGGGCCGGTAAAGGTACTCAGGCTAAGTTCATCACCGAGAAATTCGGCATTCC
GCAAATCTCCACCGGCGACATGCTGCGTGCCGCGGTCAAGGCCGGCACCGAGCTGGGCATCAAGGCCAAGAGCATCATGG
ATGCCGGCGGCCTGGTGTCGGATGACCTGATCATCGCGCTGGTCAAAGACCGTATCGCTCAAGCCGATTGCGCCAAGGGT
TTCCTGTTCGATGGCTTCCCGCGCACCATTCCTCAGGCTGAAGCGCTGGTGACTGCCGGTGTCGAGCTGGACGCCGTGGT
CGAAATCGCCGTTGAAGACGAAGAAATCGTTCAGCGTATCGCCGGTCGTCGCGTTCACGAGGCCAGCGGCCGCGTTTACC
ACATCGTCTACAACCCGCCGAAAATTGCCGGTAAAGACGACATCACCGGCGAAGAGCTGGTACAGCGCAAGGACGACACC
GAAGAAACCGTGCGTCATCGCCTGTCGGTCTACCACTCGCAGACCAAGCCGCTGGTGGAGTTCTACCAGAACCTGTCCGC
CAAGAACGGTGGCAAGCCGAAGTACAGCCATATCCCTGGCGTCGGTTCGGTTGAAGCGATCACTGCCAAGGTGCTTGAAG
CCCTGAGCTGA

Upstream 100 bases:

>100_bases
ATCAGCCTTTGGCCGTTTGGGCGGCCACGACCCGTTTTATGAGATTGGCCCCACGAGGCGAATCCGTTGTTTTTTATATA
AAAAATTGAGGAGCACATCG

Downstream 100 bases:

>100_bases
AAAACCTGATCCGCTGCATCATCCACGGCCCGCTTGCGGGCCGTAGTTGTTTATACTGGCGCACTTTTTCCCCACCTGAT
TTACGGACACATCGATGAGC

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 216; Mature: 216

Protein sequence:

>216_residues
MRVILLGAPGAGKGTQAKFITEKFGIPQISTGDMLRAAVKAGTELGIKAKSIMDAGGLVSDDLIIALVKDRIAQADCAKG
FLFDGFPRTIPQAEALVTAGVELDAVVEIAVEDEEIVQRIAGRRVHEASGRVYHIVYNPPKIAGKDDITGEELVQRKDDT
EETVRHRLSVYHSQTKPLVEFYQNLSAKNGGKPKYSHIPGVGSVEAITAKVLEALS

Sequences:

>Translated_216_residues
MRVILLGAPGAGKGTQAKFITEKFGIPQISTGDMLRAAVKAGTELGIKAKSIMDAGGLVSDDLIIALVKDRIAQADCAKG
FLFDGFPRTIPQAEALVTAGVELDAVVEIAVEDEEIVQRIAGRRVHEASGRVYHIVYNPPKIAGKDDITGEELVQRKDDT
EETVRHRLSVYHSQTKPLVEFYQNLSAKNGGKPKYSHIPGVGSVEAITAKVLEALS
>Mature_216_residues
MRVILLGAPGAGKGTQAKFITEKFGIPQISTGDMLRAAVKAGTELGIKAKSIMDAGGLVSDDLIIALVKDRIAQADCAKG
FLFDGFPRTIPQAEALVTAGVELDAVVEIAVEDEEIVQRIAGRRVHEASGRVYHIVYNPPKIAGKDDITGEELVQRKDDT
EETVRHRLSVYHSQTKPLVEFYQNLSAKNGGKPKYSHIPGVGSVEAITAKVLEALS

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI7524346, Length=187, Percent_Identity=49.7326203208556, Blast_Score=199, Evalue=1e-51,
Organism=Homo sapiens, GI4502013, Length=220, Percent_Identity=45.9090909090909, Blast_Score=199, Evalue=1e-51,
Organism=Homo sapiens, GI19923437, Length=183, Percent_Identity=47.5409836065574, Blast_Score=178, Evalue=3e-45,
Organism=Homo sapiens, GI310110345, Length=184, Percent_Identity=40.7608695652174, Blast_Score=147, Evalue=6e-36,
Organism=Homo sapiens, GI53832003, Length=184, Percent_Identity=40.7608695652174, Blast_Score=147, Evalue=6e-36,
Organism=Homo sapiens, GI8051579, Length=184, Percent_Identity=40.7608695652174, Blast_Score=147, Evalue=6e-36,
Organism=Homo sapiens, GI53832001, Length=184, Percent_Identity=40.7608695652174, Blast_Score=147, Evalue=6e-36,
Organism=Homo sapiens, GI4502011, Length=183, Percent_Identity=32.2404371584699, Blast_Score=105, Evalue=2e-23,
Organism=Homo sapiens, GI22749187, Length=196, Percent_Identity=28.5714285714286, Blast_Score=100, Evalue=9e-22,
Organism=Homo sapiens, GI28144897, Length=191, Percent_Identity=27.2251308900524, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI28144899, Length=192, Percent_Identity=27.0833333333333, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI21450759, Length=138, Percent_Identity=26.8115942028986, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI237858799, Length=138, Percent_Identity=26.8115942028986, Blast_Score=69, Evalue=3e-12,
Organism=Escherichia coli, GI1786680, Length=215, Percent_Identity=63.2558139534884, Blast_Score=277, Evalue=3e-76,
Organism=Caenorhabditis elegans, GI17552384, Length=188, Percent_Identity=47.3404255319149, Blast_Score=187, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI17537943, Length=185, Percent_Identity=35.6756756756757, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17567503, Length=214, Percent_Identity=31.3084112149533, Blast_Score=100, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17550688, Length=185, Percent_Identity=26.4864864864865, Blast_Score=68, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6320432, Length=188, Percent_Identity=51.5957446808511, Blast_Score=212, Evalue=3e-56,
Organism=Saccharomyces cerevisiae, GI6321018, Length=187, Percent_Identity=43.8502673796791, Blast_Score=146, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6322828, Length=187, Percent_Identity=26.2032085561497, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI22026816, Length=186, Percent_Identity=51.0752688172043, Blast_Score=206, Evalue=1e-53,
Organism=Drosophila melanogaster, GI17737899, Length=183, Percent_Identity=42.0765027322404, Blast_Score=150, Evalue=6e-37,
Organism=Drosophila melanogaster, GI24645822, Length=183, Percent_Identity=42.0765027322404, Blast_Score=150, Evalue=6e-37,
Organism=Drosophila melanogaster, GI17647141, Length=214, Percent_Identity=31.3084112149533, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24663208, Length=214, Percent_Identity=31.3084112149533, Blast_Score=107, Evalue=4e-24,
Organism=Drosophila melanogaster, GI221459597, Length=185, Percent_Identity=25.4054054054054, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI21356893, Length=185, Percent_Identity=25.4054054054054, Blast_Score=71, Evalue=6e-13,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_PSEPF (Q3KHE3)

Other databases:

- EMBL:   CP000094
- RefSeq:   YP_346802.1
- HSSP:   P69441
- ProteinModelPortal:   Q3KHE3
- STRING:   Q3KHE3
- World-2DPAGE:   0008:Q3KHE3
- GeneID:   3716475
- GenomeReviews:   CP000094_GR
- KEGG:   pfo:Pfl01_1070
- eggNOG:   COG0563
- HOGENOM:   HBG630208
- OMA:   RTYHVKY
- ProtClustDB:   PRK00279
- BioCyc:   PFLU205922:PFL_1070-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid

EC number: =2.7.4.3

Molecular weight: Translated: 23189; Mature: 23189

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVILLGAPGAGKGTQAKFITEKFGIPQISTGDMLRAAVKAGTELGIKAKSIMDAGGLVS
CEEEEEECCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHCCCCCCC
DDLIIALVKDRIAQADCAKGFLFDGFPRTIPQAEALVTAGVELDAVVEIAVEDEEIVQRI
HHHHHHHHHHHHHHHHHHCCCEECCCCCCCCHHHHHHHCCCCEEEEEEEEECHHHHHHHH
AGRRVHEASGRVYHIVYNPPKIAGKDDITGEELVQRKDDTEETVRHRLSVYHSQTKPLVE
HCCCEECCCCCEEEEEECCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHH
FYQNLSAKNGGKPKYSHIPGVGSVEAITAKVLEALS
HHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MRVILLGAPGAGKGTQAKFITEKFGIPQISTGDMLRAAVKAGTELGIKAKSIMDAGGLVS
CEEEEEECCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHCCCCCCC
DDLIIALVKDRIAQADCAKGFLFDGFPRTIPQAEALVTAGVELDAVVEIAVEDEEIVQRI
HHHHHHHHHHHHHHHHHHCCCEECCCCCCCCHHHHHHHCCCCEEEEEEEEECHHHHHHHH
AGRRVHEASGRVYHIVYNPPKIAGKDDITGEELVQRKDDTEETVRHRLSVYHSQTKPLVE
HCCCEECCCCCEEEEEECCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHH
FYQNLSAKNGGKPKYSHIPGVGSVEAITAKVLEALS
HHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA