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The map label for this gene is hom [H]

Identifier: 77457254

GI number: 77457254

Start: 1190744

End: 1192048

Strand: Direct

Name: hom [H]

Synonym: Pfl01_1027

Alternate gene names: 77457254

Gene position: 1190744-1192048 (Clockwise)

Preceding gene: 77457253

Following gene: 77457255

Centisome position: 18.49

GC content: 61.53

Gene sequence:

>1305_bases
GTGAAACCGGTCAAAGTAGGCATCTGTGGGTTAGGGACCGTCGGTGGCGGAACCTTCAACGTACTTCAGCGCAACGCCGA
GGAAATTGCTCGTCGTGCCGGGCGTGGAATCGAAGTGGCACAAATTGCCATGCGCACGCCAAAGCCTCAGTTCCAGACGA
CCGGTATTGCGATTACCAACGATGTCTTCGAAGTGGCCACGAACCCTGAGATCGACATCGTCATAGAGCTGATGGGCGGC
TATACCGTTGCCCGCGAGCTGGTACTCAAGGCCATCGAGAATGGCAAGCATGTGGTCACCGCGAACAAGGCTCTGATTGC
CGTTCACGGTAATGAAATTTTCGCCAAGGCACGCGAGAAAGGCGTGATCGTGGCGTTCGAAGCGGCGGTAGCCGGTGGCA
TTCCAGTGATCAAGGCGATCCGTGAAGGCCTGTCCGCCAACCGTATCAACTGGGTCGCCGGGATCATCAACGGCACCGGT
AACTTCATCCTCACCGAAATGCGCGAGAAGGGTCGCACCTTCGAAGACGTGCTGGCCGAGGCCCAAGCACTGGGTTACGC
CGAAGCCGATCCGACCTTCGACGTCGAAGGCATCGACGCCGCGCACAAGCTGACGATCCTGGCCTCGATCGCATTCGGTG
TTCCGCTGCAGTTCGACAAGGCTTACACCGAAGGCATCACCAAGCTGACCACCGCCGACGTGAATTACGCCGAAGCGCTG
GGCTACCGCATCAAGCACCTGGGCGTGGCACGCAGCACCGCCGCCGGTATCGAGCTGCGCGTACACCCGACGCTGATCCC
GGCCGATCGTCTGATCGCCAACGTCAACGGCGTGATGAACGCGGTGATGGTCAACGGTGACGCTGCCGGTTCGACCCTGT
TCTACGGCGCCGGCGCCGGCATGGAGCCGACCGCTTCGTCGGTGATCGCGGATCTGGTGGACGTGGTTCGCGCCATGACC
TCCGACCCGGAAAACCGCGTGCCGCACCTGGCCTTCCAGCCGGACTCGCTGTCGGCCCATCCGATCCTGCCAATCGAAGC
CTGTGAAAGCGCCTACTACCTGCGCATTCAGGCCAAGGACCATCCGGGCGTATTGGCTCAGGTGGCAAGCATCCTCTCGG
AGCGCGGCATCAACATCGAGTCGATCATGCAGAAGGAAGTCGAGGAACACGACGGCCTGGTGCCGATGATCCTGCTGACC
CACCGCGTGCTGGAGCAGCACATCAACGACGCGATCGCCGCCCTCGAAGCGCTGGCGGGCGTGGTCGGTCCGGTTGTGCG
GATCCGCGTCGAGCACTTGAACTAA

Upstream 100 bases:

>100_bases
TGGTCCGGCGGCAGGATTGCCGGGCCATCAACAGAGAGCCGCGAACCTGCGGTTGTTTTCACGGCCGGCCTCGCGTCGGC
CGTTTTATGGGGAGTTCACA

Downstream 100 bases:

>100_bases
GCCGATCTCCTTCACCGGTCCCGCCAGCGGGGCCGGTGTCGTGAACACTGTCCATTGGAGTCAGTCATGCGTTACATCAG
TACCCGCGGCCAGGCACCGG

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MKPVKVGICGLGTVGGGTFNVLQRNAEEIARRAGRGIEVAQIAMRTPKPQFQTTGIAITNDVFEVATNPEIDIVIELMGG
YTVARELVLKAIENGKHVVTANKALIAVHGNEIFAKAREKGVIVAFEAAVAGGIPVIKAIREGLSANRINWVAGIINGTG
NFILTEMREKGRTFEDVLAEAQALGYAEADPTFDVEGIDAAHKLTILASIAFGVPLQFDKAYTEGITKLTTADVNYAEAL
GYRIKHLGVARSTAAGIELRVHPTLIPADRLIANVNGVMNAVMVNGDAAGSTLFYGAGAGMEPTASSVIADLVDVVRAMT
SDPENRVPHLAFQPDSLSAHPILPIEACESAYYLRIQAKDHPGVLAQVASILSERGINIESIMQKEVEEHDGLVPMILLT
HRVLEQHINDAIAALEALAGVVGPVVRIRVEHLN

Sequences:

>Translated_434_residues
MKPVKVGICGLGTVGGGTFNVLQRNAEEIARRAGRGIEVAQIAMRTPKPQFQTTGIAITNDVFEVATNPEIDIVIELMGG
YTVARELVLKAIENGKHVVTANKALIAVHGNEIFAKAREKGVIVAFEAAVAGGIPVIKAIREGLSANRINWVAGIINGTG
NFILTEMREKGRTFEDVLAEAQALGYAEADPTFDVEGIDAAHKLTILASIAFGVPLQFDKAYTEGITKLTTADVNYAEAL
GYRIKHLGVARSTAAGIELRVHPTLIPADRLIANVNGVMNAVMVNGDAAGSTLFYGAGAGMEPTASSVIADLVDVVRAMT
SDPENRVPHLAFQPDSLSAHPILPIEACESAYYLRIQAKDHPGVLAQVASILSERGINIESIMQKEVEEHDGLVPMILLT
HRVLEQHINDAIAALEALAGVVGPVVRIRVEHLN
>Mature_434_residues
MKPVKVGICGLGTVGGGTFNVLQRNAEEIARRAGRGIEVAQIAMRTPKPQFQTTGIAITNDVFEVATNPEIDIVIELMGG
YTVARELVLKAIENGKHVVTANKALIAVHGNEIFAKAREKGVIVAFEAAVAGGIPVIKAIREGLSANRINWVAGIINGTG
NFILTEMREKGRTFEDVLAEAQALGYAEADPTFDVEGIDAAHKLTILASIAFGVPLQFDKAYTEGITKLTTADVNYAEAL
GYRIKHLGVARSTAAGIELRVHPTLIPADRLIANVNGVMNAVMVNGDAAGSTLFYGAGAGMEPTASSVIADLVDVVRAMT
SDPENRVPHLAFQPDSLSAHPILPIEACESAYYLRIQAKDHPGVLAQVASILSERGINIESIMQKEVEEHDGLVPMILLT
HRVLEQHINDAIAALEALAGVVGPVVRIRVEHLN

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6322599, Length=129, Percent_Identity=32.5581395348837, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 46198; Mature: 46198

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS01042 HOMOSER_DHGENASE ; PS00318 HMG_COA_REDUCTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPVKVGICGLGTVGGGTFNVLQRNAEEIARRAGRGIEVAQIAMRTPKPQFQTTGIAITN
CCCEEEEEEECCCCCCCHHHHHHCCHHHHHHHCCCCCEEHHHHHCCCCCCCEECCEEEEC
DVFEVATNPEIDIVIELMGGYTVARELVLKAIENGKHVVTANKALIAVHGNEIFAKAREK
CHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCEEEEECCEEEEEECCHHHHHHCCC
GVIVAFEAAVAGGIPVIKAIREGLSANRINWVAGIINGTGNFILTEMREKGRTFEDVLAE
CEEEEEECHHHCCCHHHHHHHCCCCCCCEEEEEEEECCCCCEEEEEHHHCCCCHHHHHHH
AQALGYAEADPTFDVEGIDAAHKLTILASIAFGVPLQFDKAYTEGITKLTTADVNYAEAL
HHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEECHHHHHCCCEEEECCCCHHHHH
GYRIKHLGVARSTAAGIELRVHPTLIPADRLIANVNGVMNAVMVNGDAAGSTLFYGAGAG
HHHHHHHCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHEEEEEECCCCCCCEEEEECCCC
MEPTASSVIADLVDVVRAMTSDPENRVPHLAFQPDSLSAHPILPIEACESAYYLRIQAKD
CCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCHHHCCCEEEEEEEECC
HPGVLAQVASILSERGINIESIMQKEVEEHDGLVPMILLTHRVLEQHINDAIAALEALAG
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVGPVVRIRVEHLN
HHCCEEEEEEECCC
>Mature Secondary Structure
MKPVKVGICGLGTVGGGTFNVLQRNAEEIARRAGRGIEVAQIAMRTPKPQFQTTGIAITN
CCCEEEEEEECCCCCCCHHHHHHCCHHHHHHHCCCCCEEHHHHHCCCCCCCEECCEEEEC
DVFEVATNPEIDIVIELMGGYTVARELVLKAIENGKHVVTANKALIAVHGNEIFAKAREK
CHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCEEEEECCEEEEEECCHHHHHHCCC
GVIVAFEAAVAGGIPVIKAIREGLSANRINWVAGIINGTGNFILTEMREKGRTFEDVLAE
CEEEEEECHHHCCCHHHHHHHCCCCCCCEEEEEEEECCCCCEEEEEHHHCCCCHHHHHHH
AQALGYAEADPTFDVEGIDAAHKLTILASIAFGVPLQFDKAYTEGITKLTTADVNYAEAL
HHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEECHHHHHCCCEEEECCCCHHHHH
GYRIKHLGVARSTAAGIELRVHPTLIPADRLIANVNGVMNAVMVNGDAAGSTLFYGAGAG
HHHHHHHCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHEEEEEECCCCCCCEEEEECCCC
MEPTASSVIADLVDVVRAMTSDPENRVPHLAFQPDSLSAHPILPIEACESAYYLRIQAKD
CCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCHHHCCCEEEEEEEECC
HPGVLAQVASILSERGINIESIMQKEVEEHDGLVPMILLTHRVLEQHINDAIAALEALAG
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVGPVVRIRVEHLN
HHCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]