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The map label for this gene is thrC [H]

Identifier: 77457255

GI number: 77457255

Start: 1192115

End: 1193524

Strand: Direct

Name: thrC [H]

Synonym: Pfl01_1028

Alternate gene names: 77457255

Gene position: 1192115-1193524 (Clockwise)

Preceding gene: 77457254

Following gene: 77457256

Centisome position: 18.52

GC content: 60.57

Gene sequence:

>1410_bases
ATGCGTTACATCAGTACCCGCGGCCAGGCACCGGCCCTGAATTTCGAAGACGTCCTGCTGGCCGGTCTTGCCACCGACGG
CGGTCTGTACGTCCCGGAAAACCTGCCACGCTTCACCCAGGAAGAAATCGCTTCCTGGGCCGGCCTGCCGTATCACGAGC
TGGCTTTCCGCGTCATGCGCCCGTTCGTCACCGGCAGCATTCCGGACGCCGATTTCAAAAAGATTCTTGAAGAAACCTAC
GGTGTGTTCGCCCACAACGCCGTTGCGCCGCTGCGTCAGCTGAACGGCAACGAATGGGTGCTGGAGCTGTTCCACGGCCC
GACCCTGGCGTTCAAGGACTTCGCCCTGCAACTGCTCGGTCGCTTGCTCGACTACGTGCTGGAAAAGCGCGGCGAGCGCG
TGGTGATCGTCGGCGCCACTTCGGGTGACACCGGTTCGGCCGCCATCGAAGGCTGCAAGCACTGCGAAAACGTCGACATC
TTCATCCTGCACCCGCACAACCGTGTGTCCGACGTGCAGCGTCGGCAGATGACCACCATCCTCGGTGAGAACATCCACAA
CATCGCCATCGAAGGCAACTTCGATGACTGCCAGGAAATGGTCAAGGCCAGCTTCGCCGACCAGAGTTTCCTCAAGGGCA
CTCGCCTGGTTGCAGTCAACTCTATCAACTGGGCGCGGATCATGGCCCAGATCGTTTACTACTTCCACGCCGCCCTGCAA
TTGGGCGGCCCGGCGCGTTCGGTGTCGTTCTCGGTGCCGACCGGCAACTTCGGCGACATCTTCGCCGGTTACCTGGCGCG
CAATATGGGCCTGCCGATCAACCAGTTGATCGTCGCCACCAACCGCAACGACATCCTGCACCGCTTCATGAGCGGCAACC
AGTACGTCAAGGAAACCCTGCACGCTACGCTGTCGCCGTCGATGGACATCATGGTCTCGTCGAACTTCGAACGCCTGCTG
TTCGACCTGCACGGTCGCAACGGCGCGGCGATTGCCGGCCTGATGGATTCGTTCAAGCAGGGCGGCGGTTTCAGCGTCGA
CCAGGAACGCTGGACCGAAGCACGCAAGCTGTTCGATTCTCTGGCCGTGGACGATGCGCAAACCTGCGAAACCATCGCCG
AAGTCTACGAGCAGACCGGTGAAGTGCTGGATCCGCACACCGCCATCGGCGTGAAAGCCGCTCGCGAATGCCGTCGCAGC
CTGGATATCCCGATGGTGATTCTGGGCACGGCGCATCCGGTCAAGTTCCCGGACGCGGTGGAGAAAGCCGGTGTAGGAAA
AGCTCTCGAACTACCTGCACATCTTTCTGATTTGTTTGAGAGAGAAGAGCGCTGCACTGTGCTGCCGAATGAGCTCAAAG
CCGTGCAGGCCTTTGTCAGTCAGCATGGCAACCGCGGCAAGCCTCTTTAA

Upstream 100 bases:

>100_bases
GGTTGTGCGGATCCGCGTCGAGCACTTGAACTAAGCCGATCTCCTTCACCGGTCCCGCCAGCGGGGCCGGTGTCGTGAAC
ACTGTCCATTGGAGTCAGTC

Downstream 100 bases:

>100_bases
GCGCGCAAAGCTGTCACATTTTGAAGCCCGTCTCCTGACGGGCTTTCTTGTTTTTGCATGCCACACTGCGCGCGTTTCGC
CCACCAAGGACGGGCGAGTC

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MRYISTRGQAPALNFEDVLLAGLATDGGLYVPENLPRFTQEEIASWAGLPYHELAFRVMRPFVTGSIPDADFKKILEETY
GVFAHNAVAPLRQLNGNEWVLELFHGPTLAFKDFALQLLGRLLDYVLEKRGERVVIVGATSGDTGSAAIEGCKHCENVDI
FILHPHNRVSDVQRRQMTTILGENIHNIAIEGNFDDCQEMVKASFADQSFLKGTRLVAVNSINWARIMAQIVYYFHAALQ
LGGPARSVSFSVPTGNFGDIFAGYLARNMGLPINQLIVATNRNDILHRFMSGNQYVKETLHATLSPSMDIMVSSNFERLL
FDLHGRNGAAIAGLMDSFKQGGGFSVDQERWTEARKLFDSLAVDDAQTCETIAEVYEQTGEVLDPHTAIGVKAARECRRS
LDIPMVILGTAHPVKFPDAVEKAGVGKALELPAHLSDLFEREERCTVLPNELKAVQAFVSQHGNRGKPL

Sequences:

>Translated_469_residues
MRYISTRGQAPALNFEDVLLAGLATDGGLYVPENLPRFTQEEIASWAGLPYHELAFRVMRPFVTGSIPDADFKKILEETY
GVFAHNAVAPLRQLNGNEWVLELFHGPTLAFKDFALQLLGRLLDYVLEKRGERVVIVGATSGDTGSAAIEGCKHCENVDI
FILHPHNRVSDVQRRQMTTILGENIHNIAIEGNFDDCQEMVKASFADQSFLKGTRLVAVNSINWARIMAQIVYYFHAALQ
LGGPARSVSFSVPTGNFGDIFAGYLARNMGLPINQLIVATNRNDILHRFMSGNQYVKETLHATLSPSMDIMVSSNFERLL
FDLHGRNGAAIAGLMDSFKQGGGFSVDQERWTEARKLFDSLAVDDAQTCETIAEVYEQTGEVLDPHTAIGVKAARECRRS
LDIPMVILGTAHPVKFPDAVEKAGVGKALELPAHLSDLFEREERCTVLPNELKAVQAFVSQHGNRGKPL
>Mature_469_residues
MRYISTRGQAPALNFEDVLLAGLATDGGLYVPENLPRFTQEEIASWAGLPYHELAFRVMRPFVTGSIPDADFKKILEETY
GVFAHNAVAPLRQLNGNEWVLELFHGPTLAFKDFALQLLGRLLDYVLEKRGERVVIVGATSGDTGSAAIEGCKHCENVDI
FILHPHNRVSDVQRRQMTTILGENIHNIAIEGNFDDCQEMVKASFADQSFLKGTRLVAVNSINWARIMAQIVYYFHAALQ
LGGPARSVSFSVPTGNFGDIFAGYLARNMGLPINQLIVATNRNDILHRFMSGNQYVKETLHATLSPSMDIMVSSNFERLL
FDLHGRNGAAIAGLMDSFKQGGGFSVDQERWTEARKLFDSLAVDDAQTCETIAEVYEQTGEVLDPHTAIGVKAARECRRS
LDIPMVILGTAHPVKFPDAVEKAGVGKALELPAHLSDLFEREERCTVLPNELKAVQAFVSQHGNRGKPL

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI149193323, Length=457, Percent_Identity=36.980306345733, Blast_Score=308, Evalue=8e-84,
Organism=Homo sapiens, GI153792148, Length=453, Percent_Identity=34.4370860927152, Blast_Score=241, Evalue=1e-63,
Organism=Escherichia coli, GI1786185, Length=466, Percent_Identity=33.2618025751073, Blast_Score=232, Evalue=4e-62,
Organism=Saccharomyces cerevisiae, GI6319901, Length=460, Percent_Identity=44.5652173913043, Blast_Score=372, Evalue=1e-104,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 51799; Mature: 51799

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYISTRGQAPALNFEDVLLAGLATDGGLYVPENLPRFTQEEIASWAGLPYHELAFRVMR
CCCCCCCCCCCCCCHHHHHHHHCCCCCCEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHH
PFVTGSIPDADFKKILEETYGVFAHNAVAPLRQLNGNEWVLELFHGPTLAFKDFALQLLG
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHH
RLLDYVLEKRGERVVIVGATSGDTGSAAIEGCKHCENVDIFILHPHNRVSDVQRRQMTTI
HHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHH
LGENIHNIAIEGNFDDCQEMVKASFADQSFLKGTRLVAVNSINWARIMAQIVYYFHAALQ
HCCCCEEEEEECCHHHHHHHHHHHHCCHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHH
LGGPARSVSFSVPTGNFGDIFAGYLARNMGLPINQLIVATNRNDILHRFMSGNQYVKETL
CCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCHHHEEEECCCHHHHHHHHCCCHHHHHHH
HATLSPSMDIMVSSNFERLLFDLHGRNGAAIAGLMDSFKQGGGFSVDQERWTEARKLFDS
HHHCCCCEEEEECCCHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
LAVDDAQTCETIAEVYEQTGEVLDPHTAIGVKAARECRRSLDIPMVILGTAHPVKFPDAV
HCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHH
EKAGVGKALELPAHLSDLFEREERCTVLPNELKAVQAFVSQHGNRGKPL
HHCCCCCHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MRYISTRGQAPALNFEDVLLAGLATDGGLYVPENLPRFTQEEIASWAGLPYHELAFRVMR
CCCCCCCCCCCCCCHHHHHHHHCCCCCCEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHH
PFVTGSIPDADFKKILEETYGVFAHNAVAPLRQLNGNEWVLELFHGPTLAFKDFALQLLG
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHH
RLLDYVLEKRGERVVIVGATSGDTGSAAIEGCKHCENVDIFILHPHNRVSDVQRRQMTTI
HHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHH
LGENIHNIAIEGNFDDCQEMVKASFADQSFLKGTRLVAVNSINWARIMAQIVYYFHAALQ
HCCCCEEEEEECCHHHHHHHHHHHHCCHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHH
LGGPARSVSFSVPTGNFGDIFAGYLARNMGLPINQLIVATNRNDILHRFMSGNQYVKETL
CCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCHHHEEEECCCHHHHHHHHCCCHHHHHHH
HATLSPSMDIMVSSNFERLLFDLHGRNGAAIAGLMDSFKQGGGFSVDQERWTEARKLFDS
HHHCCCCEEEEECCCHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
LAVDDAQTCETIAEVYEQTGEVLDPHTAIGVKAARECRRSLDIPMVILGTAHPVKFPDAV
HCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHH
EKAGVGKALELPAHLSDLFEREERCTVLPNELKAVQAFVSQHGNRGKPL
HHCCCCCHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]