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The map label for this gene is dsbC [H]

Identifier: 77457253

GI number: 77457253

Start: 1189880

End: 1190611

Strand: Direct

Name: dsbC [H]

Synonym: Pfl01_1026

Alternate gene names: 77457253

Gene position: 1189880-1190611 (Clockwise)

Preceding gene: 77457252

Following gene: 77457254

Centisome position: 18.48

GC content: 61.61

Gene sequence:

>732_bases
ATGCGTCTGACCCAGATTTTCGCCGCCGCAGCCATTGCGTTGGTCAGCACCTTTGCCGTCGCCGATGACGCGGCCGACAA
AGCGATTCGCCAAAGCCTGGAAAACCTCCAGCTCGACGTGCCGGTGGACACCATCACCGCCAGCCCGCTGCCGGGCCTTT
ACGAAGTCAAGCTCAAGGGCAGCCGCGTGCTGTACGCCAGCGCCGATGGCCAGTACATCGTTCAGGGGTACATGTTCCAG
CTCAAGGACGGCAAACCGGTCAACTTGACCGAGAAGACCGAGCGCCTGGGCATTTCCAAACTGATCAACGCGATCCCGGT
GGCCGAGACCGTGGTTTACCCGGCCGTGGGCGAAACCAAGTCGCACATCACCGTTTTCACCGACACCACCTGCCCGTATT
GCCACAAGCTGCACGCCGAAGTGCCGGAGCTGAACAAGCGCGGCATCGAAGTGCGCTACGTCGCGTTCCCGCGCCAAGGC
CTCGGCTCGCCGGGTGACGAACAGCTGCAAGCCGTGTGGTGCTCCAAAGACAAGAAAGCCGCCATGGACAAAATGGTCGA
CGGCAAGGAAATCAAGGCCGCCAAGTGCGAGAACCCGGTTTCCAAACAGTTCGCCCTCGGTCAGACGATCGGCGTGAACG
GTACACCGGCCATCGTTTTGGCCGACGGACAAGTCATTCCGGGCTACCAGCCTGCGCCACAAGTCGCCAAACTGGCGCTG
GGCGCGAAGTAA

Upstream 100 bases:

>100_bases
TATGTGGTAGGCTTTGCCGGTTTGCACGATGGGCGGTTATGACCCGGTGTTCCGGCACGGGCGTTCTGATCGTTCCATTT
GTCCGCCTTCAGGAGTTCTC

Downstream 100 bases:

>100_bases
TTCGCATCGTCACGCTCAGGCGTTGACGAGCGTGGTCCGGCGGCAGGATTGCCGGGCCATCAACAGAGAGCCGCGAACCT
GCGGTTGTTTTCACGGCCGG

Product: glutaredoxin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 243; Mature: 243

Protein sequence:

>243_residues
MRLTQIFAAAAIALVSTFAVADDAADKAIRQSLENLQLDVPVDTITASPLPGLYEVKLKGSRVLYASADGQYIVQGYMFQ
LKDGKPVNLTEKTERLGISKLINAIPVAETVVYPAVGETKSHITVFTDTTCPYCHKLHAEVPELNKRGIEVRYVAFPRQG
LGSPGDEQLQAVWCSKDKKAAMDKMVDGKEIKAAKCENPVSKQFALGQTIGVNGTPAIVLADGQVIPGYQPAPQVAKLAL
GAK

Sequences:

>Translated_243_residues
MRLTQIFAAAAIALVSTFAVADDAADKAIRQSLENLQLDVPVDTITASPLPGLYEVKLKGSRVLYASADGQYIVQGYMFQ
LKDGKPVNLTEKTERLGISKLINAIPVAETVVYPAVGETKSHITVFTDTTCPYCHKLHAEVPELNKRGIEVRYVAFPRQG
LGSPGDEQLQAVWCSKDKKAAMDKMVDGKEIKAAKCENPVSKQFALGQTIGVNGTPAIVLADGQVIPGYQPAPQVAKLAL
GAK
>Mature_243_residues
MRLTQIFAAAAIALVSTFAVADDAADKAIRQSLENLQLDVPVDTITASPLPGLYEVKLKGSRVLYASADGQYIVQGYMFQ
LKDGKPVNLTEKTERLGISKLINAIPVAETVVYPAVGETKSHITVFTDTTCPYCHKLHAEVPELNKRGIEVRYVAFPRQG
LGSPGDEQLQAVWCSKDKKAAMDKMVDGKEIKAAKCENPVSKQFALGQTIGVNGTPAIVLADGQVIPGYQPAPQVAKLAL
GAK

Specific function: Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbC is reoxidized by a yet uncharacterized protein. Also acts as a disulfide isomerase [H]

COG id: COG1651

COG function: function code O; Protein-disulfide isomerase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thioredoxin family. DsbC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789260, Length=227, Percent_Identity=43.1718061674009, Blast_Score=182, Evalue=2e-47,

Paralogues:

None

Copy number: 100 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018950
- InterPro:   IPR009094
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10411 DsbC_N [H]

EC number: 5.3.4.1

Molecular weight: Translated: 26065; Mature: 26065

Theoretical pI: Translated: 8.29; Mature: 8.29

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLTQIFAAAAIALVSTFAVADDAADKAIRQSLENLQLDVPVDTITASPLPGLYEVKLKG
CCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCEEECCHHHEECCCCCCEEEEEECC
SRVLYASADGQYIVQGYMFQLKDGKPVNLTEKTERLGISKLINAIPVAETVVYPAVGETK
CEEEEEECCCCEEEEEEEEEECCCCCCCCCHHHHHHCHHHHHHHCCHHHHEEECCCCCCC
SHITVFTDTTCPYCHKLHAEVPELNKRGIEVRYVAFPRQGLGSPGDEQLQAVWCSKDKKA
CEEEEEECCCCHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCCCCHHHHHEEECCCCHHH
AMDKMVDGKEIKAAKCENPVSKQFALGQTIGVNGTPAIVLADGQVIPGYQPAPQVAKLAL
HHHHHCCCCCCCHHHCCCCHHHHHHCCCEECCCCCCEEEEECCEECCCCCCCHHHHHHHC
GAK
CCC
>Mature Secondary Structure
MRLTQIFAAAAIALVSTFAVADDAADKAIRQSLENLQLDVPVDTITASPLPGLYEVKLKG
CCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCEEECCHHHEECCCCCCEEEEEECC
SRVLYASADGQYIVQGYMFQLKDGKPVNLTEKTERLGISKLINAIPVAETVVYPAVGETK
CEEEEEECCCCEEEEEEEEEECCCCCCCCCHHHHHHCHHHHHHHCCHHHHEEECCCCCCC
SHITVFTDTTCPYCHKLHAEVPELNKRGIEVRYVAFPRQGLGSPGDEQLQAVWCSKDKKA
CEEEEEECCCCHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCCCCHHHHHEEECCCCHHH
AMDKMVDGKEIKAAKCENPVSKQFALGQTIGVNGTPAIVLADGQVIPGYQPAPQVAKLAL
HHHHHCCCCCCCHHHCCCCHHHHHHCCCEECCCCCCEEEEECCEECCCCCCCHHHHHHHC
GAK
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677609; 9370270 [H]