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The map label for this gene is era [H]

Identifier: 77457222

GI number: 77457222

Start: 1156970

End: 1157872

Strand: Direct

Name: era [H]

Synonym: Pfl01_0995

Alternate gene names: 77457222

Gene position: 1156970-1157872 (Clockwise)

Preceding gene: 77457221

Following gene: 77457223

Centisome position: 17.97

GC content: 60.47

Gene sequence:

>903_bases
ATGACTGATACAAACGCAACGCGCTGTGGCTATGTTGCCATCGTCGGCCGTCCAAACGTGGGCAAGTCCACGCTGCTGAA
CCACATCCTCGGCCAGAAGCTGGCAATCACCTCGCGCAAGCCGCAGACCACTCGCCACAACATGCTCGGGATCAAGACCG
AGGGTGACGTGCAGGCGATCTACGTCGACACCCCCGGCATGCACAAGGGTGGCGAAAAAGCCCTGAACCGCTACATGAAC
AAGACCGCTTCGGCGGCGTTGAAAGACGTCGACGTGGTGATCTTCGTGGTCGATCGCACCAAGTGGACCGAAGAAGATCA
GATGGTGTTGGAGCGCGTGCAGTACGTGACCGGCCCGCTGATCGTCGCGCTGAACAAGACCGACCGCATCGAAGACAAGG
CCGAGCTGATGCCCCACCTGTCGTGGTTGCAGGAACAGCTGCCGAACGCGCAGATCATTCCAATCTCGGCGCAGCAGGGG
CACAACCTCGACGCGCTGGAAAAGGTTATCGCCGATCATCTGCCGGAGAACGATCACTTCTTCCCGGAAGACCAGATCAC
CGACCGCAGCAGCCGCTTCCTCGCCGCCGAACTGGTGCGCGAGAAGATCATGCGCCAGCTCGGCGCCGAGCTGCCGTACC
AGATCACCGTGGAAATCGAAGAGTTCAAGCAGCAGGGTGCGACGCTGCACATCCATGCGCTGATCCTCGTCGAGCGTGAC
GGCCAGAAGAAAATCATCATTGGCGACAAGGGCGAGCGCATCAAGCGCATCGGCACCGAGGCGCGCAAGGACATGGAGCT
GCTGTTCGACTCCAAGATCATGCTCAACCTGTGGGTCAAGGTGAAGGGCGGCTGGTCCGACGACGAGCGTGCGCTGCGTT
CGTTGGGTTACGGCGACCTGTAA

Upstream 100 bases:

>100_bases
CTATTGAATGAAAAAAGCCGGGGTCAGGGTGTGAGCCGTCGTATTGCCGAACAGGTAGCGGCCGCCGCAGCACTGATTGC
CCTGGGTGTGGAGAATGGCA

Downstream 100 bases:

>100_bases
GCGCTGATCCCGAGAACACCGATACCCACTGTGGGAGCGAGCCTGCTCGCGATAGCGGTATTTCAGTCGACATCCTTGTT
GTCTGATACACCCTCATCGC

Product: GTP-binding protein Era

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 300; Mature: 299

Protein sequence:

>300_residues
MTDTNATRCGYVAIVGRPNVGKSTLLNHILGQKLAITSRKPQTTRHNMLGIKTEGDVQAIYVDTPGMHKGGEKALNRYMN
KTASAALKDVDVVIFVVDRTKWTEEDQMVLERVQYVTGPLIVALNKTDRIEDKAELMPHLSWLQEQLPNAQIIPISAQQG
HNLDALEKVIADHLPENDHFFPEDQITDRSSRFLAAELVREKIMRQLGAELPYQITVEIEEFKQQGATLHIHALILVERD
GQKKIIIGDKGERIKRIGTEARKDMELLFDSKIMLNLWVKVKGGWSDDERALRSLGYGDL

Sequences:

>Translated_300_residues
MTDTNATRCGYVAIVGRPNVGKSTLLNHILGQKLAITSRKPQTTRHNMLGIKTEGDVQAIYVDTPGMHKGGEKALNRYMN
KTASAALKDVDVVIFVVDRTKWTEEDQMVLERVQYVTGPLIVALNKTDRIEDKAELMPHLSWLQEQLPNAQIIPISAQQG
HNLDALEKVIADHLPENDHFFPEDQITDRSSRFLAAELVREKIMRQLGAELPYQITVEIEEFKQQGATLHIHALILVERD
GQKKIIIGDKGERIKRIGTEARKDMELLFDSKIMLNLWVKVKGGWSDDERALRSLGYGDL
>Mature_299_residues
TDTNATRCGYVAIVGRPNVGKSTLLNHILGQKLAITSRKPQTTRHNMLGIKTEGDVQAIYVDTPGMHKGGEKALNRYMNK
TASAALKDVDVVIFVVDRTKWTEEDQMVLERVQYVTGPLIVALNKTDRIEDKAELMPHLSWLQEQLPNAQIIPISAQQGH
NLDALEKVIADHLPENDHFFPEDQITDRSSRFLAAELVREKIMRQLGAELPYQITVEIEEFKQQGATLHIHALILVERDG
QKKIIIGDKGERIKRIGTEARKDMELLFDSKIMLNLWVKVKGGWSDDERALRSLGYGDL

Specific function: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism [H]

COG id: COG1159

COG function: function code R; GTPase

Gene ontology:

Cell location: Cytoplasm. Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH type-2 domain [H]

Homologues:

Organism=Homo sapiens, GI24307899, Length=325, Percent_Identity=25.2307692307692, Blast_Score=89, Evalue=3e-18,
Organism=Escherichia coli, GI1788919, Length=296, Percent_Identity=58.4459459459459, Blast_Score=372, Evalue=1e-104,
Organism=Escherichia coli, GI87082120, Length=177, Percent_Identity=30.5084745762712, Blast_Score=69, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24646434, Length=311, Percent_Identity=24.1157556270096, Blast_Score=97, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005662
- InterPro:   IPR006073
- InterPro:   IPR015946
- InterPro:   IPR009019
- InterPro:   IPR004044
- InterPro:   IPR002917
- InterPro:   IPR005225 [H]

Pfam domain/function: PF07650 KH_2; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 33897; Mature: 33765

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS50823 KH_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDTNATRCGYVAIVGRPNVGKSTLLNHILGQKLAITSRKPQTTRHNMLGIKTEGDVQAI
CCCCCCCCCEEEEEEECCCCCHHHHHHHHHCCEEEECCCCCCCCCCCEEEEEECCCEEEE
YVDTPGMHKGGEKALNRYMNKTASAALKDVDVVIFVVDRTKWTEEDQMVLERVQYVTGPL
EEECCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHHHCCCE
IVALNKTDRIEDKAELMPHLSWLQEQLPNAQIIPISAQQGHNLDALEKVIADHLPENDHF
EEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCC
FPEDQITDRSSRFLAAELVREKIMRQLGAELPYQITVEIEEFKQQGATLHIHALILVERD
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHCCCEEEEEEEEEEEEC
GQKKIIIGDKGERIKRIGTEARKDMELLFDSKIMLNLWVKVKGGWSDDERALRSLGYGDL
CCEEEEECCCCHHHHHHHHHHHHHHHHHHCCEEEEEEEEEEECCCCHHHHHHHHCCCCCC
>Mature Secondary Structure 
TDTNATRCGYVAIVGRPNVGKSTLLNHILGQKLAITSRKPQTTRHNMLGIKTEGDVQAI
CCCCCCCCEEEEEEECCCCCHHHHHHHHHCCEEEECCCCCCCCCCCEEEEEECCCEEEE
YVDTPGMHKGGEKALNRYMNKTASAALKDVDVVIFVVDRTKWTEEDQMVLERVQYVTGPL
EEECCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHHHCCCE
IVALNKTDRIEDKAELMPHLSWLQEQLPNAQIIPISAQQGHNLDALEKVIADHLPENDHF
EEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCC
FPEDQITDRSSRFLAAELVREKIMRQLGAELPYQITVEIEEFKQQGATLHIHALILVERD
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHCCCEEEEEEEEEEEEC
GQKKIIIGDKGERIKRIGTEARKDMELLFDSKIMLNLWVKVKGGWSDDERALRSLGYGDL
CCEEEEECCCCHHHHHHHHHHHHHHHHHHCCEEEEEEEEEEECCCCHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12534463 [H]