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The map label for this gene is rnc [H]

Identifier: 77457221

GI number: 77457221

Start: 1156288

End: 1156977

Strand: Direct

Name: rnc [H]

Synonym: Pfl01_0994

Alternate gene names: 77457221

Gene position: 1156288-1156977 (Clockwise)

Preceding gene: 77457220

Following gene: 77457222

Centisome position: 17.96

GC content: 61.01

Gene sequence:

>690_bases
GTGAGCGTTTCTCTAAGCCGTCTCGAGCGTCAGCTCGGTTACACCTTCAAGGACCAGGAACTGATGGTCCTGGCCCTTAC
GCACCGCAGCTTTGCCGGACGCAACAACGAGCGTCTGGAATTCCTCGGCGATGCGATCCTCAACTTTGTGGCCGGCGAAG
CCCTGTTCGACCGTTTCCCGCTGGCTCGTGAAGGCCAGTTGTCGCGTTTGCGCGCGCGCTTGGTAAAAGGTGAGACGCTG
GCGGTGCTGGCCCGCGGTTTCGATCTGGGTGATTACCTGCGTCTGGGTTCCGGCGAGTTGAAGAGCGGCGGTTTCCGTCG
CGAATCGATTCTGGCTGACGCCCTTGAAGCACTGATCGGTGCGATCTACCTCGACGCCGGCATGGAAGTCGCCCGCGAAC
GCGTACTGGCCTGGCTGGCCGGCGAGTTCGAAGGCCTGACGCTGGTCGATACCAACAAGGATCCGAAGACGCGCCTGCAG
GAATTCCTGCAATCGCGCGGCTGCGAACTGCCGCGCTACGAAGTGGTGGACATCCAGGGCGAGCCGCACTGCCGTACCTT
CTTCGTCGAGTGCGAAGTTGTCCTATTGAATGAAAAAAGCCGGGGTCAGGGTGTGAGCCGTCGTATTGCCGAACAGGTAG
CGGCCGCCGCAGCACTGATTGCCCTGGGTGTGGAGAATGGCAATGACTGA

Upstream 100 bases:

>100_bases
TCAGGACGTCATTTTTGAACACAGCGTTAATTGTCCCAGGCCTGCGCCGTATCCCGGCGATGGCAGTGGAATCCAGCCAC
GAACTCAGCGTGGGTAAACC

Downstream 100 bases:

>100_bases
TACAAACGCAACGCGCTGTGGCTATGTTGCCATCGTCGGCCGTCCAAACGTGGGCAAGTCCACGCTGCTGAACCACATCC
TCGGCCAGAAGCTGGCAATC

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 229; Mature: 228

Protein sequence:

>229_residues
MSVSLSRLERQLGYTFKDQELMVLALTHRSFAGRNNERLEFLGDAILNFVAGEALFDRFPLAREGQLSRLRARLVKGETL
AVLARGFDLGDYLRLGSGELKSGGFRRESILADALEALIGAIYLDAGMEVARERVLAWLAGEFEGLTLVDTNKDPKTRLQ
EFLQSRGCELPRYEVVDIQGEPHCRTFFVECEVVLLNEKSRGQGVSRRIAEQVAAAAALIALGVENGND

Sequences:

>Translated_229_residues
MSVSLSRLERQLGYTFKDQELMVLALTHRSFAGRNNERLEFLGDAILNFVAGEALFDRFPLAREGQLSRLRARLVKGETL
AVLARGFDLGDYLRLGSGELKSGGFRRESILADALEALIGAIYLDAGMEVARERVLAWLAGEFEGLTLVDTNKDPKTRLQ
EFLQSRGCELPRYEVVDIQGEPHCRTFFVECEVVLLNEKSRGQGVSRRIAEQVAAAAALIALGVENGND
>Mature_228_residues
SVSLSRLERQLGYTFKDQELMVLALTHRSFAGRNNERLEFLGDAILNFVAGEALFDRFPLAREGQLSRLRARLVKGETLA
VLARGFDLGDYLRLGSGELKSGGFRRESILADALEALIGAIYLDAGMEVARERVLAWLAGEFEGLTLVDTNKDPKTRLQE
FLQSRGCELPRYEVVDIQGEPHCRTFFVECEVVLLNEKSRGQGVSRRIAEQVAAAAALIALGVENGND

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030236, Length=226, Percent_Identity=32.3008849557522, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI155030234, Length=226, Percent_Identity=32.3008849557522, Blast_Score=92, Evalue=4e-19,
Organism=Escherichia coli, GI1788920, Length=224, Percent_Identity=54.0178571428571, Blast_Score=228, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI17506883, Length=191, Percent_Identity=30.8900523560209, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI193202651, Length=191, Percent_Identity=30.8900523560209, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI17137682, Length=240, Percent_Identity=30.4166666666667, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 25375; Mature: 25244

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVSLSRLERQLGYTFKDQELMVLALTHRSFAGRNNERLEFLGDAILNFVAGEALFDRFP
CCCCHHHHHHHHCCCCCCCCEEEEEEEHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
LAREGQLSRLRARLVKGETLAVLARGFDLGDYLRLGSGELKSGGFRRESILADALEALIG
CCCCCHHHHHHHHHHCCCHHEEHCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHH
AIYLDAGMEVARERVLAWLAGEFEGLTLVDTNKDPKTRLQEFLQSRGCELPRYEVVDIQG
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCEEEEEECC
EPHCRTFFVECEVVLLNEKSRGQGVSRRIAEQVAAAAALIALGVENGND
CCCCEEEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SVSLSRLERQLGYTFKDQELMVLALTHRSFAGRNNERLEFLGDAILNFVAGEALFDRFP
CCCHHHHHHHHCCCCCCCCEEEEEEEHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
LAREGQLSRLRARLVKGETLAVLARGFDLGDYLRLGSGELKSGGFRRESILADALEALIG
CCCCCHHHHHHHHHHCCCHHEEHCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHH
AIYLDAGMEVARERVLAWLAGEFEGLTLVDTNKDPKTRLQEFLQSRGCELPRYEVVDIQG
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCEEEEEECC
EPHCRTFFVECEVVLLNEKSRGQGVSRRIAEQVAAAAALIALGVENGND
CCCCEEEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA