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The map label for this gene is lepB [H]

Identifier: 77457220

GI number: 77457220

Start: 1155251

End: 1156105

Strand: Direct

Name: lepB [H]

Synonym: Pfl01_0993

Alternate gene names: 77457220

Gene position: 1155251-1156105 (Clockwise)

Preceding gene: 77457219

Following gene: 77457221

Centisome position: 17.94

GC content: 60.12

Gene sequence:

>855_bases
ATGTCACTAAATTTCCCGCTGTTGCTGGTCATTGCCGTGTTCGTCTGCGGTCTGTTGGCGTTGCTCGATCTGTTGATCCT
GGCACCGCGTCGGCGTGCCGCCATCGCCTCCTATCAGGGCAGCGTCAGCCAGCCTGATGTGGTGGTGGTCGAGAAGCTGA
ACAAGGAACCGCTGCTGGTCGAATACGGCAAGTCGTTCTTCCCGGTGCTGTTCATCGTGCTGGTGCTGCGTTCGTTTCTG
GTGGAGCCGTTCCAGATTCCGTCCGGCTCGATGAAACCGACCCTGGACGTCGGCGACTTCATTCTGGTGAACAAGTTTTC
CTACGGGATCCGTTTGCCGGTGATCGACAAGAAGATCATCGAAGTCGGTGACCCGCAGCGCGGCGATGTGATGGTGTTCC
GCTACCCGAGCGACCCGAACGTCAACTACATCAAGCGTGTAGTCGGCCTGCCGGGCGACACCGTGCGGTACACCGCCGAC
AAGCGTCTGTTCGTCAACGGCGAGTCGATTGCCGAACAACTGGTCGGCTCCGAGCCGGGCACGCTGGGCAGCGCGGAACT
CTACAAGGAAAAACTCGGCGTCGCCGAGCACCTGATCCGCAAGGAAATGAGCCGCTACCGCGCCACGCCGGACCATACCT
GGACCGTGCCGGCCGGGCACTACTTCATGATGGGCGACAACCGCGACAACTCGAACGACAGTCGTTACTGGGATGATCCG
AACATTCCCAAGGATCTGCTGGGCATGGTTCCCGACCAGAACATCGTCGGCAAGGCCTTCGCGGTCTGGATGAGCTGGCC
GGAACCGAAACTCAGCCACCTGCCGAATTTCTCGCGGGTCGGCCTGATCAAGTAA

Upstream 100 bases:

>100_bases
GAAGCAGAAGGCCGGTAAGAAACGCATGAAACAGGTCGGCAACGTGGAAATTCCACAAGAAGCCTTCCTCGCCGTGCTCA
GGTTGGAATAGTCAGGTCCT

Downstream 100 bases:

>100_bases
ACAAACACGGCGCTGTTGACCACAGCGCCGAATGCATTTCTGGCGTCGGCACAACCGGCTCCGGGGCATGAAGCCACGAT
ATTCAGGACGTCATTTTTGA

Product: signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 284; Mature: 283

Protein sequence:

>284_residues
MSLNFPLLLVIAVFVCGLLALLDLLILAPRRRAAIASYQGSVSQPDVVVVEKLNKEPLLVEYGKSFFPVLFIVLVLRSFL
VEPFQIPSGSMKPTLDVGDFILVNKFSYGIRLPVIDKKIIEVGDPQRGDVMVFRYPSDPNVNYIKRVVGLPGDTVRYTAD
KRLFVNGESIAEQLVGSEPGTLGSAELYKEKLGVAEHLIRKEMSRYRATPDHTWTVPAGHYFMMGDNRDNSNDSRYWDDP
NIPKDLLGMVPDQNIVGKAFAVWMSWPEPKLSHLPNFSRVGLIK

Sequences:

>Translated_284_residues
MSLNFPLLLVIAVFVCGLLALLDLLILAPRRRAAIASYQGSVSQPDVVVVEKLNKEPLLVEYGKSFFPVLFIVLVLRSFL
VEPFQIPSGSMKPTLDVGDFILVNKFSYGIRLPVIDKKIIEVGDPQRGDVMVFRYPSDPNVNYIKRVVGLPGDTVRYTAD
KRLFVNGESIAEQLVGSEPGTLGSAELYKEKLGVAEHLIRKEMSRYRATPDHTWTVPAGHYFMMGDNRDNSNDSRYWDDP
NIPKDLLGMVPDQNIVGKAFAVWMSWPEPKLSHLPNFSRVGLIK
>Mature_283_residues
SLNFPLLLVIAVFVCGLLALLDLLILAPRRRAAIASYQGSVSQPDVVVVEKLNKEPLLVEYGKSFFPVLFIVLVLRSFLV
EPFQIPSGSMKPTLDVGDFILVNKFSYGIRLPVIDKKIIEVGDPQRGDVMVFRYPSDPNVNYIKRVVGLPGDTVRYTADK
RLFVNGESIAEQLVGSEPGTLGSAELYKEKLGVAEHLIRKEMSRYRATPDHTWTVPAGHYFMMGDNRDNSNDSRYWDDPN
IPKDLLGMVPDQNIVGKAFAVWMSWPEPKLSHLPNFSRVGLIK

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Escherichia coli, GI1788921, Length=314, Percent_Identity=41.7197452229299, Blast_Score=213, Evalue=1e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 31848; Mature: 31716

Theoretical pI: Translated: 8.38; Mature: 8.38

Prosite motif: PS00501 SPASE_I_1 ; PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLNFPLLLVIAVFVCGLLALLDLLILAPRRRAAIASYQGSVSQPDVVVVEKLNKEPLLV
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCEEEEEECCCCCEEE
EYGKSFFPVLFIVLVLRSFLVEPFQIPSGSMKPTLDVGDFILVNKFSYGIRLPVIDKKII
HHCCHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCEEEEEECCCCEECCCCCHHHH
EVGDPQRGDVMVFRYPSDPNVNYIKRVVGLPGDTVRYTADKRLFVNGESIAEQLVGSEPG
HCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCCCEEEECCCEEEECHHHHHHHHHCCCCC
TLGSAELYKEKLGVAEHLIRKEMSRYRATPDHTWTVPAGHYFMMGDNRDNSNDSRYWDDP
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCEEEEECCCCCCCCCCCCCCCC
NIPKDLLGMVPDQNIVGKAFAVWMSWPEPKLSHLPNFSRVGLIK
CCCHHHHHCCCCCCHHHHHHEEEECCCCCHHHHCCCCCCCCCCC
>Mature Secondary Structure 
SLNFPLLLVIAVFVCGLLALLDLLILAPRRRAAIASYQGSVSQPDVVVVEKLNKEPLLV
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCEEEEEECCCCCEEE
EYGKSFFPVLFIVLVLRSFLVEPFQIPSGSMKPTLDVGDFILVNKFSYGIRLPVIDKKII
HHCCHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCEEEEEECCCCEECCCCCHHHH
EVGDPQRGDVMVFRYPSDPNVNYIKRVVGLPGDTVRYTADKRLFVNGESIAEQLVGSEPG
HCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCCCEEEECCCEEEECHHHHHHHHHCCCCC
TLGSAELYKEKLGVAEHLIRKEMSRYRATPDHTWTVPAGHYFMMGDNRDNSNDSRYWDDP
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCEEEEECCCCCCCCCCCCCCCC
NIPKDLLGMVPDQNIVGKAFAVWMSWPEPKLSHLPNFSRVGLIK
CCCHHHHHCCCCCCHHHHHHEEEECCCCCHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1546969 [H]