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The map label for this gene is hutH [H]

Identifier: 77456594

GI number: 77456594

Start: 418016

End: 419548

Strand: Direct

Name: hutH [H]

Synonym: Pfl01_0366

Alternate gene names: 77456594

Gene position: 418016-419548 (Clockwise)

Preceding gene: 77456593

Following gene: 77456595

Centisome position: 6.49

GC content: 64.45

Gene sequence:

>1533_bases
ATGACTGCGCTGAACCTGATCCCCGGCCAACTGAGCCTGGCCCAACTGCGTGACGTTTATCAGAACCCGGTCAAGCTGAC
CCTCGACAACAGCGCCAGCGCGCAGATCGAAGCCAGCGTGGCCTGCGTCGAGCAGATCCTCGCGGAAAACCGCACCGCCT
ACGGCATCAACACCGGTTTCGGCCTGCTGGCCTCGACCCGCATCGCCAGCGAAGACCTGGAAAACCTCCAGCGCTCGCTG
GTGCTGTCCCACGCCGCCGGCGTCGGCCAGCCGATCAGCGATGAGCTGGTGCGCCTGATCATGGTGCTCAAGGTCAACAG
CCTCAGCCGTGGTTTCTCCGGCATCCGTCGGGTGGTGATCGATGCGCTGATCGCCCTGATCAACGCCGAGGTATATCCGC
ACATTCCGTTGAAAGGCTCGGTCGGTGCCTCCGGTGACCTGGCGCCATTGGCGCACATGTCGCTGGTGCTGCTGGGCGAG
GGCAAGGCGCGCCACAAGGGCGAGTGGATGGATGCGACCGAAGCGCTGAAAGTCGCCGGTCTGACGCCGCTGACGCTGGC
GGCGAAAGAAGGTCTGGCGCTGCTCAACGGTACTCAGGTTTCCACTGCATTCGCGTTGCGTGGTCTGTTCGAAGGTGAAG
ACCTGTTCGCCGGCGCGCTGGCGCTGGGCGGTCTGACGGTGGAAGCGGTGCTGGGCTCGCGTTCGCCGTTCGATGCGCGC
ATCCACGCCGCCCGTGGCCAGAAAGGCCAGATCGACGCCGCTGCCGCTTACCGCGATCTGCTGGGCGAGCGCAGCGAAGT
CTCCGACTCGCACCAGAACTGCGAGAAGGTTCAGGACCCGTATTCGCTGCGTTGCCAGCCGCAAGTCATGGGTGCGTGTC
TGACTCAGTTCCGCCAGGCCGCCGAAGTGCTGGCCATCGAAGCCAACGCCGTATCCGACAACCCGCTGGTGTTCGCGGCC
GAAGGCGACGTGATTTCCGGCGGCAACTTCCACGCCGAACCAGTGGCCATGGCCGCTGACAACATGGCGCTGGCCATTGC
CGAAATCGGTTCCCTGAGTGAGCGCCGTATCTCGCTGATGATGGACAAGCACATGTCGCAACTGCCGCCGTTCCTGGTGG
CCAACGGTGGCGTGAACTCCGGTTTCATGATCGCCCAAGTGACCGCTGCGGCCCTGGCCAGCGAAAACAAGGCGCTGTCC
CATCCGCATTCGGTGGACAGCCTGCCGACTTCTGCCAACCAGGAAGACCACGTCTCCATGGCCCCGGCTGCCGGCAAGCG
CCTGTGGGAAATGGCCGAGAACACCCGCGGGATCCTCGCGGTGGAATGGTTGGCGGCGGTGCAGGGCCTGGACCTGCGCA
ACGGCCTGAAGACCTCGGCCAAACTGGAACAGGCCCGTGGGATTCTGCGTCGCGAAGTGCCGTTCTACGAGAAGGACCGC
TTCTTCGCGCCGGATATCAACGCGGCGACCGAGCTGCTGGCTTCGCGCATCTTGACTGAACTGGTCCCGGCGAAACTGCT
GCCGAGCCTGTAA

Upstream 100 bases:

>100_bases
GTGCCAAGGCGCGGATCGTCCAAAAGACGAGAGGCGACGGATAACGGAATGCTCCGGAGCGACTGGTAGTTAATAACAAT
GCCTCAAAAGGAGCATTTAA

Downstream 100 bases:

>100_bases
GAGCCACCCCTCACCCCAACCCTCCCGAAACGTCGGACCGCCCCAAGGGGGAGAGGGGGAAAGGGAGCCGATCTTCATGA
TTTTCCAGACTTGAGTTCGA

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 510; Mature: 509

Protein sequence:

>510_residues
MTALNLIPGQLSLAQLRDVYQNPVKLTLDNSASAQIEASVACVEQILAENRTAYGINTGFGLLASTRIASEDLENLQRSL
VLSHAAGVGQPISDELVRLIMVLKVNSLSRGFSGIRRVVIDALIALINAEVYPHIPLKGSVGASGDLAPLAHMSLVLLGE
GKARHKGEWMDATEALKVAGLTPLTLAAKEGLALLNGTQVSTAFALRGLFEGEDLFAGALALGGLTVEAVLGSRSPFDAR
IHAARGQKGQIDAAAAYRDLLGERSEVSDSHQNCEKVQDPYSLRCQPQVMGACLTQFRQAAEVLAIEANAVSDNPLVFAA
EGDVISGGNFHAEPVAMAADNMALAIAEIGSLSERRISLMMDKHMSQLPPFLVANGGVNSGFMIAQVTAAALASENKALS
HPHSVDSLPTSANQEDHVSMAPAAGKRLWEMAENTRGILAVEWLAAVQGLDLRNGLKTSAKLEQARGILRREVPFYEKDR
FFAPDINAATELLASRILTELVPAKLLPSL

Sequences:

>Translated_510_residues
MTALNLIPGQLSLAQLRDVYQNPVKLTLDNSASAQIEASVACVEQILAENRTAYGINTGFGLLASTRIASEDLENLQRSL
VLSHAAGVGQPISDELVRLIMVLKVNSLSRGFSGIRRVVIDALIALINAEVYPHIPLKGSVGASGDLAPLAHMSLVLLGE
GKARHKGEWMDATEALKVAGLTPLTLAAKEGLALLNGTQVSTAFALRGLFEGEDLFAGALALGGLTVEAVLGSRSPFDAR
IHAARGQKGQIDAAAAYRDLLGERSEVSDSHQNCEKVQDPYSLRCQPQVMGACLTQFRQAAEVLAIEANAVSDNPLVFAA
EGDVISGGNFHAEPVAMAADNMALAIAEIGSLSERRISLMMDKHMSQLPPFLVANGGVNSGFMIAQVTAAALASENKALS
HPHSVDSLPTSANQEDHVSMAPAAGKRLWEMAENTRGILAVEWLAAVQGLDLRNGLKTSAKLEQARGILRREVPFYEKDR
FFAPDINAATELLASRILTELVPAKLLPSL
>Mature_509_residues
TALNLIPGQLSLAQLRDVYQNPVKLTLDNSASAQIEASVACVEQILAENRTAYGINTGFGLLASTRIASEDLENLQRSLV
LSHAAGVGQPISDELVRLIMVLKVNSLSRGFSGIRRVVIDALIALINAEVYPHIPLKGSVGASGDLAPLAHMSLVLLGEG
KARHKGEWMDATEALKVAGLTPLTLAAKEGLALLNGTQVSTAFALRGLFEGEDLFAGALALGGLTVEAVLGSRSPFDARI
HAARGQKGQIDAAAAYRDLLGERSEVSDSHQNCEKVQDPYSLRCQPQVMGACLTQFRQAAEVLAIEANAVSDNPLVFAAE
GDVISGGNFHAEPVAMAADNMALAIAEIGSLSERRISLMMDKHMSQLPPFLVANGGVNSGFMIAQVTAAALASENKALSH
PHSVDSLPTSANQEDHVSMAPAAGKRLWEMAENTRGILAVEWLAAVQGLDLRNGLKTSAKLEQARGILRREVPFYEKDRF
FAPDINAATELLASRILTELVPAKLLPSL

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=496, Percent_Identity=43.75, Blast_Score=410, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI17567831, Length=483, Percent_Identity=41.2008281573499, Blast_Score=352, Evalue=2e-97,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 54109; Mature: 53977

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS00488 PAL_HISTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTALNLIPGQLSLAQLRDVYQNPVKLTLDNSASAQIEASVACVEQILAENRTAYGINTGF
CCCCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEECCCCH
GLLASTRIASEDLENLQRSLVLSHAAGVGQPISDELVRLIMVLKVNSLSRGFSGIRRVVI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DALIALINAEVYPHIPLKGSVGASGDLAPLAHMSLVLLGEGKARHKGEWMDATEALKVAG
HHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHEEEEEEECCCCCCCCCCCCHHHHHHHCC
LTPLTLAAKEGLALLNGTQVSTAFALRGLFEGEDLFAGALALGGLTVEAVLGSRSPFDAR
CCCHHHHHHCCCEEECCCHHHHHHHHHHHCCCCHHHHHHHHHCCEEEEHHHCCCCCCCHH
IHAARGQKGQIDAAAAYRDLLGERSEVSDSHQNCEKVQDPYSLRCQPQVMGACLTQFRQA
EEECCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
AEVLAIEANAVSDNPLVFAAEGDVISGGNFHAEPVAMAADNMALAIAEIGSLSERRISLM
HHHEEEEECCCCCCCEEEEECCCEECCCCCCCCCHHEECCCCEEEHHHHCCCHHHHHHHH
MDKHMSQLPPFLVANGGVNSGFMIAQVTAAALASENKALSHPHSVDSLPTSANQEDHVSM
HHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEE
APAAGKRLWEMAENTRGILAVEWLAAVQGLDLRNGLKTSAKLEQARGILRREVPFYEKDR
CCHHHHHHHHHHHCCCCEEHHHHHHHHHCCCHHCCCCHHHHHHHHHHHHHHCCCCCCCCC
FFAPDINAATELLASRILTELVPAKLLPSL
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TALNLIPGQLSLAQLRDVYQNPVKLTLDNSASAQIEASVACVEQILAENRTAYGINTGF
CCCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEECCCCH
GLLASTRIASEDLENLQRSLVLSHAAGVGQPISDELVRLIMVLKVNSLSRGFSGIRRVVI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DALIALINAEVYPHIPLKGSVGASGDLAPLAHMSLVLLGEGKARHKGEWMDATEALKVAG
HHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHEEEEEEECCCCCCCCCCCCHHHHHHHCC
LTPLTLAAKEGLALLNGTQVSTAFALRGLFEGEDLFAGALALGGLTVEAVLGSRSPFDAR
CCCHHHHHHCCCEEECCCHHHHHHHHHHHCCCCHHHHHHHHHCCEEEEHHHCCCCCCCHH
IHAARGQKGQIDAAAAYRDLLGERSEVSDSHQNCEKVQDPYSLRCQPQVMGACLTQFRQA
EEECCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
AEVLAIEANAVSDNPLVFAAEGDVISGGNFHAEPVAMAADNMALAIAEIGSLSERRISLM
HHHEEEEECCCCCCCEEEEECCCEECCCCCCCCCHHEECCCCEEEHHHHCCCHHHHHHHH
MDKHMSQLPPFLVANGGVNSGFMIAQVTAAALASENKALSHPHSVDSLPTSANQEDHVSM
HHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEE
APAAGKRLWEMAENTRGILAVEWLAAVQGLDLRNGLKTSAKLEQARGILRREVPFYEKDR
CCHHHHHHHHHHHCCCCEEHHHHHHHHHCCCHHCCCCHHHHHHHHHHHHHHCCCCCCCCC
FFAPDINAATELLASRILTELVPAKLLPSL
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA