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The map label for this gene is hutH [H]

Identifier: 77456593

GI number: 77456593

Start: 416375

End: 417898

Strand: Direct

Name: hutH [H]

Synonym: Pfl01_0365

Alternate gene names: 77456593

Gene position: 416375-417898 (Clockwise)

Preceding gene: 77456592

Following gene: 77456594

Centisome position: 6.47

GC content: 64.24

Gene sequence:

>1524_bases
ATGTCCCAGGCTGAAAAAATCGTTATCGCCGACGCTCCGATGCGTTGGCAGGATGTGGTCGCAGTCGCCCGTCACGGCGC
GCAGCTCGAGCTGTCGGCGCAGACCTGGGCGCGCATTGAAAACGCGCAGGGCATCGTCCAGCGTATCGTCGCCAGCGGCG
AACGCGCCTATGGCGTGAACACCGGGCTCGGTGCGCTGTGCAACGTCTCGCTGAAAGACGAGCAGCTCAGTCAGCTGTCG
CGCAACACCTTGCTCAGCCATGCCTGCGGCGTCGGTCCGGTCCTGGCCGACGAGCAGACCCGGGCAATCATGTGCGCCGC
GATCCGCAACTACAGCCACGGCAAATCCGGCATTCATCGCCGGGTGGTTGAAGCGCTGCTGGCGCTGCTCAATCGCGGCA
TCACCCCGCAAGTGCCGTCCCAGGGTTCGGTGGGTTACCTGACCCACATGGCGCACATCGGCATCGCGCTGCTGGGCGTG
GGTAATGTCAGCTATCGCGGGCAAGTGGTTTGCGCGCAGCAGGCGCTGGCCGAAGAGGGCCTGCAACCGGTGCAGCTCGG
GGCGAAGGACGGTCTGTGTCTGGTCAACGGCACGCCGTGCATGACCGGCCTCGGTTGCCTGGCGATCGCCGACGCCACGC
GCCTGCTGCAATGGGCCGACGTGATCGGCGCCATGAGCTTCGAGGCCCAGCGTGGCCAGATCGCCGCGTTCGATGCCGAG
ATCATTGCGCTCAAACCGCATCCGGGCATGCAGCAGGTCGGCGTCAATCTGCGCGCCTTGCTCGATGGCAGTGAAGTGAT
TGCGTCGAGCAAAGGCATTCGCACTCAGGATGCCTTGAGCATCCGTTCGATCCCACAGGTGCACGGCGCCGCCCGCGATC
AACTGGAACACGCAATCAAACAGATCGAAACCGAGCTCAACGGCTGCACCGACAACCCGTTGCTGCTGGGCACGCCGGAT
GACTTCCGTGTCATGTCCCAGGCCAACCCGCACGGACAATCGGTGGCGCTGGCGGCGGATCTGCTGGCGATTGCGATGGC
CGAAATCGGCTCGATTGCCGAGCGGCGTCTGGATCGCCTGATCAACCCGCACGTCAGCGGTCTGCCGGCGTTTCTGGTGG
CCAATCCGGGGGTGAACTCCGGGATGATGATCGTGCAATACGTCGCCGCGTCGCTGTGCGCGGAAAACCGCCAGTTGGCG
CAACCGGCGGTGCTAGACAACTACGTCACCTCGGGCCTGCAGGAAGACCATCTGAGCATGGGCACCAACGCCGCGCTGAA
GCTGCATCGCGCGCTGGAAAACTGCACGCAGATCCTCGCCATCGAGTACCTGCTGGCGGCCCAGGCGTTTGAATTTCTCA
AGGAACAGCGATTCGGCGCCGGCACCGATACCGCCTGGCGACTGCTGCGCGAAAAAGTCCCGGCCTACGATCAGGACCGC
TGGCTGGCGCCGGACATCGCCGCTGCTGCAAGCGTTCTGAAAGACCCGGATCTGCTGCACAACGCATTACCGAATCTGCA
CTGA

Upstream 100 bases:

>100_bases
AGCAGGCTCGCTCCCACAGTTGGAATGCGGTCTCCTGTGGGAGCGAGCCTGCTCGCGATAGCGTCGGCAAAGCTGCATCA
ATGTTCGGATGAGGTTTTAG

Downstream 100 bases:

>100_bases
CAACTACCCATACCAGCGTGCCAAGGCGCGGATCGTCCAAAAGACGAGAGGCGACGGATAACGGAATGCTCCGGAGCGAC
TGGTAGTTAATAACAATGCC

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 507; Mature: 506

Protein sequence:

>507_residues
MSQAEKIVIADAPMRWQDVVAVARHGAQLELSAQTWARIENAQGIVQRIVASGERAYGVNTGLGALCNVSLKDEQLSQLS
RNTLLSHACGVGPVLADEQTRAIMCAAIRNYSHGKSGIHRRVVEALLALLNRGITPQVPSQGSVGYLTHMAHIGIALLGV
GNVSYRGQVVCAQQALAEEGLQPVQLGAKDGLCLVNGTPCMTGLGCLAIADATRLLQWADVIGAMSFEAQRGQIAAFDAE
IIALKPHPGMQQVGVNLRALLDGSEVIASSKGIRTQDALSIRSIPQVHGAARDQLEHAIKQIETELNGCTDNPLLLGTPD
DFRVMSQANPHGQSVALAADLLAIAMAEIGSIAERRLDRLINPHVSGLPAFLVANPGVNSGMMIVQYVAASLCAENRQLA
QPAVLDNYVTSGLQEDHLSMGTNAALKLHRALENCTQILAIEYLLAAQAFEFLKEQRFGAGTDTAWRLLREKVPAYDQDR
WLAPDIAAAASVLKDPDLLHNALPNLH

Sequences:

>Translated_507_residues
MSQAEKIVIADAPMRWQDVVAVARHGAQLELSAQTWARIENAQGIVQRIVASGERAYGVNTGLGALCNVSLKDEQLSQLS
RNTLLSHACGVGPVLADEQTRAIMCAAIRNYSHGKSGIHRRVVEALLALLNRGITPQVPSQGSVGYLTHMAHIGIALLGV
GNVSYRGQVVCAQQALAEEGLQPVQLGAKDGLCLVNGTPCMTGLGCLAIADATRLLQWADVIGAMSFEAQRGQIAAFDAE
IIALKPHPGMQQVGVNLRALLDGSEVIASSKGIRTQDALSIRSIPQVHGAARDQLEHAIKQIETELNGCTDNPLLLGTPD
DFRVMSQANPHGQSVALAADLLAIAMAEIGSIAERRLDRLINPHVSGLPAFLVANPGVNSGMMIVQYVAASLCAENRQLA
QPAVLDNYVTSGLQEDHLSMGTNAALKLHRALENCTQILAIEYLLAAQAFEFLKEQRFGAGTDTAWRLLREKVPAYDQDR
WLAPDIAAAASVLKDPDLLHNALPNLH
>Mature_506_residues
SQAEKIVIADAPMRWQDVVAVARHGAQLELSAQTWARIENAQGIVQRIVASGERAYGVNTGLGALCNVSLKDEQLSQLSR
NTLLSHACGVGPVLADEQTRAIMCAAIRNYSHGKSGIHRRVVEALLALLNRGITPQVPSQGSVGYLTHMAHIGIALLGVG
NVSYRGQVVCAQQALAEEGLQPVQLGAKDGLCLVNGTPCMTGLGCLAIADATRLLQWADVIGAMSFEAQRGQIAAFDAEI
IALKPHPGMQQVGVNLRALLDGSEVIASSKGIRTQDALSIRSIPQVHGAARDQLEHAIKQIETELNGCTDNPLLLGTPDD
FRVMSQANPHGQSVALAADLLAIAMAEIGSIAERRLDRLINPHVSGLPAFLVANPGVNSGMMIVQYVAASLCAENRQLAQ
PAVLDNYVTSGLQEDHLSMGTNAALKLHRALENCTQILAIEYLLAAQAFEFLKEQRFGAGTDTAWRLLREKVPAYDQDRW
LAPDIAAAASVLKDPDLLHNALPNLH

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=499, Percent_Identity=36.0721442885772, Blast_Score=314, Evalue=1e-85,
Organism=Caenorhabditis elegans, GI17567831, Length=500, Percent_Identity=36.8, Blast_Score=288, Evalue=6e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 54136; Mature: 54005

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQAEKIVIADAPMRWQDVVAVARHGAQLELSAQTWARIENAQGIVQRIVASGERAYGVN
CCCCCEEEEECCCCCHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHHHHHCCCCCCCCC
TGLGALCNVSLKDEQLSQLSRNTLLSHACGVGPVLADEQTRAIMCAAIRNYSHGKSGIHR
CCCHHHEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHH
RVVEALLALLNRGITPQVPSQGSVGYLTHMAHIGIALLGVGNVSYRGQVVCAQQALAEEG
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHEECCCCCCCCCCHHHHHHHHHCC
LQPVQLGAKDGLCLVNGTPCMTGLGCLAIADATRLLQWADVIGAMSFEAQRGQIAAFDAE
CCEEECCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCE
IIALKPHPGMQQVGVNLRALLDGSEVIASSKGIRTQDALSIRSIPQVHGAARDQLEHAIK
EEEECCCCCHHHHCCCHHEEECCHHHHHCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHH
QIETELNGCTDNPLLLGTPDDFRVMSQANPHGQSVALAADLLAIAMAEIGSIAERRLDRL
HHHHHHCCCCCCCEEEECCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
INPHVSGLPAFLVANPGVNSGMMIVQYVAASLCAENRQLAQPAVLDNYVTSGLQEDHLSM
HCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCHHHCCCHHHHHHHHCCCCHHHHHC
GTNAALKLHRALENCTQILAIEYLLAAQAFEFLKEQRFGAGTDTAWRLLREKVPAYDQDR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCC
WLAPDIAAAASVLKDPDLLHNALPNLH
CCCCHHHHHHHHHCCHHHHHHHCCCCC
>Mature Secondary Structure 
SQAEKIVIADAPMRWQDVVAVARHGAQLELSAQTWARIENAQGIVQRIVASGERAYGVN
CCCCEEEEECCCCCHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHHHHHCCCCCCCCC
TGLGALCNVSLKDEQLSQLSRNTLLSHACGVGPVLADEQTRAIMCAAIRNYSHGKSGIHR
CCCHHHEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHH
RVVEALLALLNRGITPQVPSQGSVGYLTHMAHIGIALLGVGNVSYRGQVVCAQQALAEEG
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHEECCCCCCCCCCHHHHHHHHHCC
LQPVQLGAKDGLCLVNGTPCMTGLGCLAIADATRLLQWADVIGAMSFEAQRGQIAAFDAE
CCEEECCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCE
IIALKPHPGMQQVGVNLRALLDGSEVIASSKGIRTQDALSIRSIPQVHGAARDQLEHAIK
EEEECCCCCHHHHCCCHHEEECCHHHHHCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHH
QIETELNGCTDNPLLLGTPDDFRVMSQANPHGQSVALAADLLAIAMAEIGSIAERRLDRL
HHHHHHCCCCCCCEEEECCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
INPHVSGLPAFLVANPGVNSGMMIVQYVAASLCAENRQLAQPAVLDNYVTSGLQEDHLSM
HCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCHHHCCCHHHHHHHHCCCCHHHHHC
GTNAALKLHRALENCTQILAIEYLLAAQAFEFLKEQRFGAGTDTAWRLLREKVPAYDQDR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCC
WLAPDIAAAASVLKDPDLLHNALPNLH
CCCCHHHHHHHHHCCHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA