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The map label for this gene is coaBC [H]

Identifier: 75674242

GI number: 75674242

Start: 48119

End: 49558

Strand: Direct

Name: coaBC [H]

Synonym: Nwi_0043

Alternate gene names: 75674242

Gene position: 48119-49558 (Clockwise)

Preceding gene: 75674241

Following gene: 75674243

Centisome position: 1.41

GC content: 66.18

Gene sequence:

>1440_bases
ATGGCCAGCCTGACCGTCCGCAAACTCGACGACGCCGTTAAGGCCCGGCTGCGAGCGCGCGCCGCAGTTTCCGGCCGCTC
GGTGGAGGAGGAGATCCGCGTCATCCTCCGTGAGGCGACCGTTATTCCCCCCCCCACGGCGTTCGACGATCCGGCCTCCC
GCAACGCAGCATCTCTGCGTGACAAAGGCTTCTTCAACGTTTCCAGTCGATTGACGAAAGTGACAGTGATCGTCGGCGGC
GGGATCGCCGCCTACAAGGCGCTCGACCTGATCCGGAGGCTCAGGGAACGCGGATTTTTTGTGCGATGCGTCATGACAAA
TGCTGCGCAGCAATTCGTCACGCCGCTCAGCGCTGGATCCCTCTCTAACGAGCGTTGCTATACGGATCTGTTCGATGCCA
GCAGCGAATTCGACGCGGGCCATATCCGGCTCGCCCGCGACTGTGACCTCATCGTGGTGGCGCCCGCCACCGCTGACCTG
ATGGCAAAGATGGCAAACGGCCTCGCCAACGATCTGGCGAGCGCCATTCTGCTCGCCTCCGACAGGCCGGTTTTGCTGGC
GCCGGCGATGAATCCGCTGATGTGGAATAACCCGGCGACACGCCGCAACGTGGCGCGGCTCGCGCGCGACGGCGTCGCCA
TGATCGGCCCCGACGCCGGCGAGATGGCGGAAGCAGGTGAAGCCGGCGTCGGCCGCATGGCCGAGCCCGTGGCGATCGCC
GCCGCCGCCGCGCGGATGCTCGGGCCACCGCAAACGCAAGCGCAACCTCTAAAAGGCCGTCGCGTCCTGATTACCGCCGG
CCCGACCCGGGAGGCGATCGATCCGGTGCGCTACATCGCCAACCGCTCCTCGGGCAAGCAGGGCTTTGCCATCGCCGCGG
CGGCGCAGGCGGCGGGAGCCGAAGTGACGCTGATTTCTGGCCCCGTGGATCTCGACGACCCCCCCGGCGTCACTGTGGCG
CATGTCGAATCCGCGCGCCAGATGCTGGCGGCCGTCGAGGCGGCGCTGCCTTCCGACATTGCGATTTTCACCGCCGCGGT
CGCCGACTGGCGTGTCGCGCATGCAGGTGCGCAGAAACTGAAGAAAACCGAAGCCGGAGTGCCGCCGCTGCAACTGATCG
AGAACCCGGACATTCTCGCGACCATTTCGAACCTGCGCGACGAACGCCCGCCGCTCGTGATCGGCTTCGCCGCCGAGACC
GAGCATCTCATCGGCAACGCCAAGGCGAAATTCGCGCGCAAGGGCTGCGACTGGATGATCGCCAATGACGTATCGCCGGG
AACCGGCGTGATGGGCGGCGACCGCAACACCGTGCATCTGCTGACGCGCGGCGAAGACGGAGAGATCAGGACCGAGTCCT
TCCCCGTCATGACCAAGGAAGAGGTGGCCGCCATGCTGATCGAACGCATCATCTCAGCCCTGCCGGGTCCGGCGGCATGA

Upstream 100 bases:

>100_bases
TCGGCATTCTATGGGCCGTCAGCAGCCGGTTGATCTGATATCAATGCAATCATATGATGAAATCAAATGATATCGATCCG
GATGCAGCGCAGGGAGCGAA

Downstream 100 bases:

>100_bases
GCGATCCGATCAAGGTCGATGTCCGGCAACTGCCGCATGCCGAGGGCCTTCCGCTGCCGTCCTACCAAAGCACCCAGGCG
GCCGGTCTTGACCTCATCGC

Product: bifunctional SbtC-like/phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 479; Mature: 478

Protein sequence:

>479_residues
MASLTVRKLDDAVKARLRARAAVSGRSVEEEIRVILREATVIPPPTAFDDPASRNAASLRDKGFFNVSSRLTKVTVIVGG
GIAAYKALDLIRRLRERGFFVRCVMTNAAQQFVTPLSAGSLSNERCYTDLFDASSEFDAGHIRLARDCDLIVVAPATADL
MAKMANGLANDLASAILLASDRPVLLAPAMNPLMWNNPATRRNVARLARDGVAMIGPDAGEMAEAGEAGVGRMAEPVAIA
AAAARMLGPPQTQAQPLKGRRVLITAGPTREAIDPVRYIANRSSGKQGFAIAAAAQAAGAEVTLISGPVDLDDPPGVTVA
HVESARQMLAAVEAALPSDIAIFTAAVADWRVAHAGAQKLKKTEAGVPPLQLIENPDILATISNLRDERPPLVIGFAAET
EHLIGNAKAKFARKGCDWMIANDVSPGTGVMGGDRNTVHLLTRGEDGEIRTESFPVMTKEEVAAMLIERIISALPGPAA

Sequences:

>Translated_479_residues
MASLTVRKLDDAVKARLRARAAVSGRSVEEEIRVILREATVIPPPTAFDDPASRNAASLRDKGFFNVSSRLTKVTVIVGG
GIAAYKALDLIRRLRERGFFVRCVMTNAAQQFVTPLSAGSLSNERCYTDLFDASSEFDAGHIRLARDCDLIVVAPATADL
MAKMANGLANDLASAILLASDRPVLLAPAMNPLMWNNPATRRNVARLARDGVAMIGPDAGEMAEAGEAGVGRMAEPVAIA
AAAARMLGPPQTQAQPLKGRRVLITAGPTREAIDPVRYIANRSSGKQGFAIAAAAQAAGAEVTLISGPVDLDDPPGVTVA
HVESARQMLAAVEAALPSDIAIFTAAVADWRVAHAGAQKLKKTEAGVPPLQLIENPDILATISNLRDERPPLVIGFAAET
EHLIGNAKAKFARKGCDWMIANDVSPGTGVMGGDRNTVHLLTRGEDGEIRTESFPVMTKEEVAAMLIERIISALPGPAA
>Mature_478_residues
ASLTVRKLDDAVKARLRARAAVSGRSVEEEIRVILREATVIPPPTAFDDPASRNAASLRDKGFFNVSSRLTKVTVIVGGG
IAAYKALDLIRRLRERGFFVRCVMTNAAQQFVTPLSAGSLSNERCYTDLFDASSEFDAGHIRLARDCDLIVVAPATADLM
AKMANGLANDLASAILLASDRPVLLAPAMNPLMWNNPATRRNVARLARDGVAMIGPDAGEMAEAGEAGVGRMAEPVAIAA
AAARMLGPPQTQAQPLKGRRVLITAGPTREAIDPVRYIANRSSGKQGFAIAAAAQAAGAEVTLISGPVDLDDPPGVTVAH
VESARQMLAAVEAALPSDIAIFTAAVADWRVAHAGAQKLKKTEAGVPPLQLIENPDILATISNLRDERPPLVIGFAAETE
HLIGNAKAKFARKGCDWMIANDVSPGTGVMGGDRNTVHLLTRGEDGEIRTESFPVMTKEEVAAMLIERIISALPGPAA

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=169, Percent_Identity=33.7278106508876, Blast_Score=76, Evalue=6e-14,
Organism=Escherichia coli, GI87082301, Length=403, Percent_Identity=45.1612903225806, Blast_Score=290, Evalue=1e-79,
Organism=Drosophila melanogaster, GI24657262, Length=186, Percent_Identity=29.5698924731183, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 50533; Mature: 50401

Theoretical pI: Translated: 7.51; Mature: 7.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASLTVRKLDDAVKARLRARAAVSGRSVEEEIRVILREATVIPPPTAFDDPASRNAASLR
CCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHH
DKGFFNVSSRLTKVTVIVGGGIAAYKALDLIRRLRERGFFVRCVMTNAAQQFVTPLSAGS
CCCCEECCCCCEEEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHCCCCCCC
LSNERCYTDLFDASSEFDAGHIRLARDCDLIVVAPATADLMAKMANGLANDLASAILLAS
CCCCCHHHHHHCCCCCCCCCCEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHEEEC
DRPVLLAPAMNPLMWNNPATRRNVARLARDGVAMIGPDAGEMAEAGEAGVGRMAEPVAIA
CCCEEEECCCCCCEECCCCHHHHHHHHHHCCCEEECCCCHHHHHCCCCCCCCCCCHHHHH
AAAARMLGPPQTQAQPLKGRRVLITAGPTREAIDPVRYIANRSSGKQGFAIAAAAQAAGA
HHHHHHCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCEEEEEEHHCCCC
EVTLISGPVDLDDPPGVTVAHVESARQMLAAVEAALPSDIAIFTAAVADWRVAHAGAQKL
EEEEEECCCCCCCCCCCEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
KKTEAGVPPLQLIENPDILATISNLRDERPPLVIGFAAETEHLIGNAKAKFARKGCDWMI
HHHHCCCCCHHHHCCCCHHHHHHHHHCCCCCEEEEECCCCHHHHCCHHHHHHHCCCCEEE
ANDVSPGTGVMGGDRNTVHLLTRGEDGEIRTESFPVMTKEEVAAMLIERIISALPGPAA
ECCCCCCCCCCCCCCCEEEEEEECCCCCEECCCCCCCCHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
ASLTVRKLDDAVKARLRARAAVSGRSVEEEIRVILREATVIPPPTAFDDPASRNAASLR
CCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHH
DKGFFNVSSRLTKVTVIVGGGIAAYKALDLIRRLRERGFFVRCVMTNAAQQFVTPLSAGS
CCCCEECCCCCEEEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHCCCCCCC
LSNERCYTDLFDASSEFDAGHIRLARDCDLIVVAPATADLMAKMANGLANDLASAILLAS
CCCCCHHHHHHCCCCCCCCCCEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHEEEC
DRPVLLAPAMNPLMWNNPATRRNVARLARDGVAMIGPDAGEMAEAGEAGVGRMAEPVAIA
CCCEEEECCCCCCEECCCCHHHHHHHHHHCCCEEECCCCHHHHHCCCCCCCCCCCHHHHH
AAAARMLGPPQTQAQPLKGRRVLITAGPTREAIDPVRYIANRSSGKQGFAIAAAAQAAGA
HHHHHHCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCEEEEEEHHCCCC
EVTLISGPVDLDDPPGVTVAHVESARQMLAAVEAALPSDIAIFTAAVADWRVAHAGAQKL
EEEEEECCCCCCCCCCCEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
KKTEAGVPPLQLIENPDILATISNLRDERPPLVIGFAAETEHLIGNAKAKFARKGCDWMI
HHHHCCCCCHHHHCCCCHHHHHHHHHCCCCCEEEEECCCCHHHHCCHHHHHHHCCCCEEE
ANDVSPGTGVMGGDRNTVHLLTRGEDGEIRTESFPVMTKEEVAAMLIERIISALPGPAA
ECCCCCCCCCCCCCCCEEEEEEECCCCCEECCCCCCCCHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA