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The map label for this gene is ubiB [H]

Identifier: 75674241

GI number: 75674241

Start: 46476

End: 48056

Strand: Direct

Name: ubiB [H]

Synonym: Nwi_0042

Alternate gene names: 75674241

Gene position: 46476-48056 (Clockwise)

Preceding gene: 75674240

Following gene: 75674242

Centisome position: 1.37

GC content: 66.98

Gene sequence:

>1581_bases
GTGATCTCCGCACTGGGCCATGTCGCGCGGCTGGCGCGCGCCGCGTTCGTGTTCGCGCGCGAGGGCGTGTTCGGCGTGGT
CGATCCATCGCTGGTGCCGGCTCCCGGCCAGCTCGCGCTGCGCATGGCGCGGCTGATCGAGCGCCGTGGCGCGAAATCCG
GATCGCGGTTGACGCGCGCGCTGACGCGGCTCGGGCCGGCCTATCTCAAGCTCGGACAGTTCCTGGCCACGCGCCCCGAT
GTCATCGGCGTCGCCATGGCGCGCGACCTGGAAAGCCTGCAGGACCGCCTGCCGCCGTTTTCGCAAGCGGAAGCCGAAGC
GGTGGTCGCGGCGGCGCTGGAGAAGCCCGTCGCGGACGCCTTCGCCAATTTCGGACCTTCGGTGGCGGCGGCCTCGATCG
CGCAGGTTCATCGCGGCGAGGTCGAAAAAAACGGCGTCCGCAGACAGGTGGCGATCAAGGTGCTGCGGCCCAACGTCGCC
ACGCGTTTCCGCCGCGATCTCTCCGATTTCTTTTTCGTCGCCAACAACGCCGAGGCGCATTCGGCCGAGGCGCGGCGGCT
GCGCCTCGTCGAGGTCATCAACACCATGTCGCGATCGGTGGCGATGGAGATGGACCTGCGGCTGGAAGCGGCCGCGCTGT
CGGAGATGGCGGAGAACACCCGCAACGATCCCGACTTCCGCGTGCCCGAGGTGGACTGGGACCGCACCACCCACAACGTG
CTGACGATGGAGTGGATCGACGGCATCGCGCTGAACGATCATGCGCGTCTTGCGCAATCGAAAGCCGACCTGCCCGAACT
GGGCCGCAAGGTGATCCAGAGCTTTCTGCGCCACGCGTTGCGCGACGGCTTCTTTCACGCCGACATGCATCCGGGCAACC
TTTTCCTCGACGGTTCGGGCCGTCTGGTCGCGGTCGACTTCGGCATCATGGGACGGCTGGGCCTGAAAGAGCGCCGTTTC
CTCGCCGAAATCCTGCTCGGCTTCATCACCCGCGACTACCGCCGCGTCGCCGAGGTGCATTTCGAGGCCGGCTACGTGCC
GGGCCATCACTCGGTGGAGAATTTCGCGCAAGCCATCCGCGCCATCGGCGAGCCGATCCACAATCGTACCGCCGAGGAAA
TCTCGATGGCCAAACTCTTGACCCTGCTGCTGGAGGTCACCGGCCTGTTCGACATGCAGACGCGGCCCGAACTGATCCTG
CTGCAAAAAACCATGGTGGTGGTCGAAGGCGTGGCGCGCAGCTTCGATCCCAAACTGGACATCTGGACGGTGGCCGATCC
GGTGGTTCGCGAATGGATCACGGAGAACCTCGGCCCGCTGGGGCGGATGCAGGGCGCGATCGCCGGCGCCGGAGAGCTGG
GCCGCCTGCTTGCCTCCTTGCCCGCGATCGCCTCGCGTTCGGTGGCGGTGCTTGAGCAAGTGGAGACCATGACCCGCGAC
GGGCTGGTGCTCGCACCCGAAACCGTCGCCACGCTGGCCTGCGCACGGGCAAGGCAGAACCGCTGGCGGACCATCGCGCT
CTGGATCATCGCCGTGACGCTGCTCGGCATTCTATGGGCCGTCAGCAGCCGGTTGATCTGA

Upstream 100 bases:

>100_bases
CGAACGCCTTCGCCGAGATGATCCGTGACGCCGGCTTCGCCCGCGTGTCCTGGCAGGCGCTTTCCGGCGGCATCGTCGCG
TTGCATTCGGGCTGGCGTTT

Downstream 100 bases:

>100_bases
TATCAATGCAATCATATGATGAAATCAAATGATATCGATCCGGATGCAGCGCAGGGAGCGAAATGGCCAGCCTGACCGTC
CGCAAACTCGACGACGCCGT

Product: 2-polyprenylphenol 6-hydroxylase

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 526; Mature: 526

Protein sequence:

>526_residues
MISALGHVARLARAAFVFAREGVFGVVDPSLVPAPGQLALRMARLIERRGAKSGSRLTRALTRLGPAYLKLGQFLATRPD
VIGVAMARDLESLQDRLPPFSQAEAEAVVAAALEKPVADAFANFGPSVAAASIAQVHRGEVEKNGVRRQVAIKVLRPNVA
TRFRRDLSDFFFVANNAEAHSAEARRLRLVEVINTMSRSVAMEMDLRLEAAALSEMAENTRNDPDFRVPEVDWDRTTHNV
LTMEWIDGIALNDHARLAQSKADLPELGRKVIQSFLRHALRDGFFHADMHPGNLFLDGSGRLVAVDFGIMGRLGLKERRF
LAEILLGFITRDYRRVAEVHFEAGYVPGHHSVENFAQAIRAIGEPIHNRTAEEISMAKLLTLLLEVTGLFDMQTRPELIL
LQKTMVVVEGVARSFDPKLDIWTVADPVVREWITENLGPLGRMQGAIAGAGELGRLLASLPAIASRSVAVLEQVETMTRD
GLVLAPETVATLACARARQNRWRTIALWIIAVTLLGILWAVSSRLI

Sequences:

>Translated_526_residues
MISALGHVARLARAAFVFAREGVFGVVDPSLVPAPGQLALRMARLIERRGAKSGSRLTRALTRLGPAYLKLGQFLATRPD
VIGVAMARDLESLQDRLPPFSQAEAEAVVAAALEKPVADAFANFGPSVAAASIAQVHRGEVEKNGVRRQVAIKVLRPNVA
TRFRRDLSDFFFVANNAEAHSAEARRLRLVEVINTMSRSVAMEMDLRLEAAALSEMAENTRNDPDFRVPEVDWDRTTHNV
LTMEWIDGIALNDHARLAQSKADLPELGRKVIQSFLRHALRDGFFHADMHPGNLFLDGSGRLVAVDFGIMGRLGLKERRF
LAEILLGFITRDYRRVAEVHFEAGYVPGHHSVENFAQAIRAIGEPIHNRTAEEISMAKLLTLLLEVTGLFDMQTRPELIL
LQKTMVVVEGVARSFDPKLDIWTVADPVVREWITENLGPLGRMQGAIAGAGELGRLLASLPAIASRSVAVLEQVETMTRD
GLVLAPETVATLACARARQNRWRTIALWIIAVTLLGILWAVSSRLI
>Mature_526_residues
MISALGHVARLARAAFVFAREGVFGVVDPSLVPAPGQLALRMARLIERRGAKSGSRLTRALTRLGPAYLKLGQFLATRPD
VIGVAMARDLESLQDRLPPFSQAEAEAVVAAALEKPVADAFANFGPSVAAASIAQVHRGEVEKNGVRRQVAIKVLRPNVA
TRFRRDLSDFFFVANNAEAHSAEARRLRLVEVINTMSRSVAMEMDLRLEAAALSEMAENTRNDPDFRVPEVDWDRTTHNV
LTMEWIDGIALNDHARLAQSKADLPELGRKVIQSFLRHALRDGFFHADMHPGNLFLDGSGRLVAVDFGIMGRLGLKERRF
LAEILLGFITRDYRRVAEVHFEAGYVPGHHSVENFAQAIRAIGEPIHNRTAEEISMAKLLTLLLEVTGLFDMQTRPELIL
LQKTMVVVEGVARSFDPKLDIWTVADPVVREWITENLGPLGRMQGAIAGAGELGRLLASLPAIASRSVAVLEQVETMTRD
GLVLAPETVATLACARARQNRWRTIALWIIAVTLLGILWAVSSRLI

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis [H]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily [H]

Homologues:

Organism=Homo sapiens, GI40254938, Length=313, Percent_Identity=25.2396166134185, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI41393593, Length=273, Percent_Identity=27.1062271062271, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI217035081, Length=277, Percent_Identity=26.3537906137184, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI32261307, Length=338, Percent_Identity=23.9644970414201, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI34147522, Length=259, Percent_Identity=27.7992277992278, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI27363457, Length=242, Percent_Identity=26.4462809917355, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI217416386, Length=242, Percent_Identity=26.4462809917355, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI2367309, Length=391, Percent_Identity=37.3401534526854, Blast_Score=270, Evalue=2e-73,
Organism=Caenorhabditis elegans, GI17559152, Length=304, Percent_Identity=25.9868421052632, Blast_Score=114, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI32565180, Length=350, Percent_Identity=24.5714285714286, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6325148, Length=455, Percent_Identity=24.3956043956044, Blast_Score=113, Evalue=8e-26,
Organism=Saccharomyces cerevisiae, GI6321319, Length=321, Percent_Identity=24.2990654205607, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24662575, Length=312, Percent_Identity=27.8846153846154, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI22024280, Length=286, Percent_Identity=23.4265734265734, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI18859849, Length=322, Percent_Identity=25.1552795031056, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR010232 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 57900; Mature: 57900

Theoretical pI: Translated: 9.80; Mature: 9.80

Prosite motif: PS50011 PROTEIN_KINASE_DOM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISALGHVARLARAAFVFAREGVFGVVDPSLVPAPGQLALRMARLIERRGAKSGSRLTRA
CCCHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHH
LTRLGPAYLKLGQFLATRPDVIGVAMARDLESLQDRLPPFSQAEAEAVVAAALEKPVADA
HHHHCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
FANFGPSVAAASIAQVHRGEVEKNGVRRQVAIKVLRPNVATRFRRDLSDFFFVANNAEAH
HHHCCCHHHHHHHHHHHHCCHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHEEEECCCCHH
SAEARRLRLVEVINTMSRSVAMEMDLRLEAAALSEMAENTRNDPDFRVPEVDWDRTTHNV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCE
LTMEWIDGIALNDHARLAQSKADLPELGRKVIQSFLRHALRDGFFHADMHPGNLFLDGSG
EEEHHHCCEEECCHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEECCCCCCCEEECCCC
RLVAVDFGIMGRLGLKERRFLAEILLGFITRDYRRVAEVHFEAGYVPGHHSVENFAQAIR
CEEEEECCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
AIGEPIHNRTAEEISMAKLLTLLLEVTGLFDMQTRPELILLQKTMVVVEGVARSFDPKLD
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHCCCCCE
IWTVADPVVREWITENLGPLGRMQGAIAGAGELGRLLASLPAIASRSVAVLEQVETMTRD
EEECCCHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GLVLAPETVATLACARARQNRWRTIALWIIAVTLLGILWAVSSRLI
CEEECCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MISALGHVARLARAAFVFAREGVFGVVDPSLVPAPGQLALRMARLIERRGAKSGSRLTRA
CCCHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHH
LTRLGPAYLKLGQFLATRPDVIGVAMARDLESLQDRLPPFSQAEAEAVVAAALEKPVADA
HHHHCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
FANFGPSVAAASIAQVHRGEVEKNGVRRQVAIKVLRPNVATRFRRDLSDFFFVANNAEAH
HHHCCCHHHHHHHHHHHHCCHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHEEEECCCCHH
SAEARRLRLVEVINTMSRSVAMEMDLRLEAAALSEMAENTRNDPDFRVPEVDWDRTTHNV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCE
LTMEWIDGIALNDHARLAQSKADLPELGRKVIQSFLRHALRDGFFHADMHPGNLFLDGSG
EEEHHHCCEEECCHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEECCCCCCCEEECCCC
RLVAVDFGIMGRLGLKERRFLAEILLGFITRDYRRVAEVHFEAGYVPGHHSVENFAQAIR
CEEEEECCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
AIGEPIHNRTAEEISMAKLLTLLLEVTGLFDMQTRPELILLQKTMVVVEGVARSFDPKLD
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHCCCCCE
IWTVADPVVREWITENLGPLGRMQGAIAGAGELGRLLASLPAIASRSVAVLEQVETMTRD
EEECCCHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GLVLAPETVATLACARARQNRWRTIALWIIAVTLLGILWAVSSRLI
CEEECCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA