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The map label for this gene is proY [H]

Identifier: 73539460

GI number: 73539460

Start: 2459839

End: 2461221

Strand: Direct

Name: proY [H]

Synonym: Reut_B5638

Alternate gene names: 73539460

Gene position: 2459839-2461221 (Clockwise)

Preceding gene: 73539459

Following gene: 73539464

Centisome position: 90.23

GC content: 58.93

Gene sequence:

>1383_bases
TTGAAACACCTGCAACGTAACCTGGGCGCGCGGCACATCCGCTTTCTTGCGCTTGGCTCGGCTATTGGCACGGGCCTGTT
CTATGGCTCCGCATCGGCCATCCAACTCGCTGGCCCGGCCGTCATTCTGGCCTATATCCTGGGCGGAGCGGCCGTCTACA
TGGTCATGCGCGCGCTCGGCGAAATGGCGGTTCGCGAGCCAGTATCCGGTTCCTTCGGACGGTATGCAAGCGAGTATCTT
GGGCCGCTCGCAGGCTTTCTCACCGGATGGACCTATATCCTCGAAATGATCATCGTTTGCCTCGCAGACGTGACCGCATT
CGGCATCTACATGGGATTCTGGTTCCCGGAAGTCCCGCAATGGATATGGGTGCTCGGCATCGTCATGCTGATCTGTGGGT
TGAACCTGTGCAACGTGAAGGTGTTCGGGGAACTGGAGTTCTGGCTTGCGTTGGTGAAGATCCTTGCCATCGGCGCGATG
ATCATTGGCGGCACCCTGATCCTGTTTCTAGGCGTCAAGATGAATGGCGAACACTCTCCGGGCCTGACCAATCTGTGGGC
GCACGGCGGTTTCCTCCCGCATGGCGCAGGAGGGCTGATCGCCTCGCTGGCGGTGGTGATGTTTGCGTACGGTGGCATCG
AGATCATCGGCATCACCGGCGGCGAAGCAAAGGAGCCGGAGAAGGTCATTCCAAGGGCGATCAATGCCGTACCTGCACGG
ATTCTGCTGTTCTACGTACTGACGATGGTCGTCCTGATGGCAATCTTTCCGTGGACCGGCATCGGCGGTCAGGGCAGCCC
GTTTGTACAGATATTCTCGGGACTGGGCATCAAGTCTGCCGCAGCGATTCTCAACCTGATCGTTATTTCCGCCGCCATCT
CGGCAATCAATAGCAACATCTTTGGTGCCGGACGGATGATGTTCGGCATGGCAGAGCAGGGCCAGGCACCCCGTCTTTTT
GCGATCACCTCGCGTCAAGGTGTGCCTTGGGTGACGGTGCTGGCGATGGCTGCCGCATTGCTCGGCGGCGTTGTGCTGAA
CTACCTGATTCCCGAGCAGGTGTTCGTGATCATTGCGTCGATCGCGACCTTTGCGACCGTATGGGTCTGGCTCATGATCC
TTCTGTCTCAGGTTGCCATGCGGCGTCGCCTGTCGGCCGAAGAGGTTCGCGCGCTCAAGTTCAAAGTGCCAATGTGGCCC
GTCGGTCCGGCGCTTGCAATTGCCTTCATGTTGTTTGTCATCTGTGTGCTGGGCTATGTCGAAGACACGCGCGTAGCGCT
TTATATCGGTGCGGGTTGGGTTGCCCTGCTGTCCCTCGCCTGGTACCTCAGGGCTAAGCCTCATGAAGACCGCATTCTCA
CCGGGGAGTCCAGCGCATTGTGA

Upstream 100 bases:

>100_bases
TCTAAGAAGAACGCAAAACGCTTACACCGGCGCTGAGCGGGCTAAGACCTGCGCGCCATGGGACTGCCGGTCCCCATCTC
GATATCTTTCTGGAGACAGC

Downstream 100 bases:

>100_bases
TGCCGCTTTGCTGAACAGGGTGTTCGAACTTTGACACCTCCCGCGAGGCGTGTTCGATGCCTGCCCATACGTGCTATGGC
CACTCACAGGGCTGCAGACG

Product: amino acid permease-associated protein

Products: Proton [Cytoplasm]; L-proline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MKHLQRNLGARHIRFLALGSAIGTGLFYGSASAIQLAGPAVILAYILGGAAVYMVMRALGEMAVREPVSGSFGRYASEYL
GPLAGFLTGWTYILEMIIVCLADVTAFGIYMGFWFPEVPQWIWVLGIVMLICGLNLCNVKVFGELEFWLALVKILAIGAM
IIGGTLILFLGVKMNGEHSPGLTNLWAHGGFLPHGAGGLIASLAVVMFAYGGIEIIGITGGEAKEPEKVIPRAINAVPAR
ILLFYVLTMVVLMAIFPWTGIGGQGSPFVQIFSGLGIKSAAAILNLIVISAAISAINSNIFGAGRMMFGMAEQGQAPRLF
AITSRQGVPWVTVLAMAAALLGGVVLNYLIPEQVFVIIASIATFATVWVWLMILLSQVAMRRRLSAEEVRALKFKVPMWP
VGPALAIAFMLFVICVLGYVEDTRVALYIGAGWVALLSLAWYLRAKPHEDRILTGESSAL

Sequences:

>Translated_460_residues
MKHLQRNLGARHIRFLALGSAIGTGLFYGSASAIQLAGPAVILAYILGGAAVYMVMRALGEMAVREPVSGSFGRYASEYL
GPLAGFLTGWTYILEMIIVCLADVTAFGIYMGFWFPEVPQWIWVLGIVMLICGLNLCNVKVFGELEFWLALVKILAIGAM
IIGGTLILFLGVKMNGEHSPGLTNLWAHGGFLPHGAGGLIASLAVVMFAYGGIEIIGITGGEAKEPEKVIPRAINAVPAR
ILLFYVLTMVVLMAIFPWTGIGGQGSPFVQIFSGLGIKSAAAILNLIVISAAISAINSNIFGAGRMMFGMAEQGQAPRLF
AITSRQGVPWVTVLAMAAALLGGVVLNYLIPEQVFVIIASIATFATVWVWLMILLSQVAMRRRLSAEEVRALKFKVPMWP
VGPALAIAFMLFVICVLGYVEDTRVALYIGAGWVALLSLAWYLRAKPHEDRILTGESSAL
>Mature_460_residues
MKHLQRNLGARHIRFLALGSAIGTGLFYGSASAIQLAGPAVILAYILGGAAVYMVMRALGEMAVREPVSGSFGRYASEYL
GPLAGFLTGWTYILEMIIVCLADVTAFGIYMGFWFPEVPQWIWVLGIVMLICGLNLCNVKVFGELEFWLALVKILAIGAM
IIGGTLILFLGVKMNGEHSPGLTNLWAHGGFLPHGAGGLIASLAVVMFAYGGIEIIGITGGEAKEPEKVIPRAINAVPAR
ILLFYVLTMVVLMAIFPWTGIGGQGSPFVQIFSGLGIKSAAAILNLIVISAAISAINSNIFGAGRMMFGMAEQGQAPRLF
AITSRQGVPWVTVLAMAAALLGGVVLNYLIPEQVFVIIASIATFATVWVWLMILLSQVAMRRRLSAEEVRALKFKVPMWP
VGPALAIAFMLFVICVLGYVEDTRVALYIGAGWVALLSLAWYLRAKPHEDRILTGESSAL

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of proline [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI181337167, Length=349, Percent_Identity=28.6532951289398, Blast_Score=93, Evalue=6e-19,
Organism=Homo sapiens, GI110347453, Length=355, Percent_Identity=27.0422535211268, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI258645169, Length=397, Percent_Identity=23.4256926952141, Blast_Score=66, Evalue=6e-11,
Organism=Escherichia coli, GI1786602, Length=452, Percent_Identity=59.7345132743363, Blast_Score=526, Evalue=1e-150,
Organism=Escherichia coli, GI1786789, Length=445, Percent_Identity=44.0449438202247, Blast_Score=374, Evalue=1e-105,
Organism=Escherichia coli, GI1786302, Length=445, Percent_Identity=42.247191011236, Blast_Score=365, Evalue=1e-102,
Organism=Escherichia coli, GI1790653, Length=449, Percent_Identity=38.3073496659243, Blast_Score=345, Evalue=5e-96,
Organism=Escherichia coli, GI48994972, Length=430, Percent_Identity=43.0232558139535, Blast_Score=331, Evalue=5e-92,
Organism=Escherichia coli, GI87081708, Length=455, Percent_Identity=37.3626373626374, Blast_Score=297, Evalue=1e-81,
Organism=Escherichia coli, GI87081915, Length=398, Percent_Identity=38.1909547738693, Blast_Score=296, Evalue=1e-81,
Organism=Escherichia coli, GI1789017, Length=412, Percent_Identity=36.1650485436893, Blast_Score=249, Evalue=3e-67,
Organism=Escherichia coli, GI1788480, Length=443, Percent_Identity=36.3431151241535, Blast_Score=235, Evalue=5e-63,
Organism=Escherichia coli, GI87081869, Length=194, Percent_Identity=26.2886597938144, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI87082023, Length=285, Percent_Identity=23.5087719298246, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17532491, Length=356, Percent_Identity=25, Blast_Score=78, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6324061, Length=441, Percent_Identity=33.7868480725624, Blast_Score=214, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6320772, Length=442, Percent_Identity=31.6742081447964, Blast_Score=192, Evalue=9e-50,
Organism=Saccharomyces cerevisiae, GI6324990, Length=415, Percent_Identity=29.6385542168675, Blast_Score=177, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6324553, Length=397, Percent_Identity=32.2418136020151, Blast_Score=172, Evalue=8e-44,
Organism=Saccharomyces cerevisiae, GI6324924, Length=440, Percent_Identity=30.2272727272727, Blast_Score=170, Evalue=4e-43,
Organism=Saccharomyces cerevisiae, GI6319824, Length=432, Percent_Identity=28.4722222222222, Blast_Score=169, Evalue=6e-43,
Organism=Saccharomyces cerevisiae, GI6324059, Length=453, Percent_Identity=29.5805739514349, Blast_Score=165, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6322892, Length=416, Percent_Identity=29.0865384615385, Blast_Score=161, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6321629, Length=407, Percent_Identity=26.5356265356265, Blast_Score=159, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6320251, Length=401, Percent_Identity=27.431421446384, Blast_Score=157, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6320717, Length=438, Percent_Identity=26.4840182648402, Blast_Score=154, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6319542, Length=401, Percent_Identity=27.6807980049875, Blast_Score=148, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6319543, Length=397, Percent_Identity=26.1964735516373, Blast_Score=142, Evalue=8e-35,
Organism=Saccharomyces cerevisiae, GI6321053, Length=425, Percent_Identity=26.1176470588235, Blast_Score=136, Evalue=6e-33,
Organism=Saccharomyces cerevisiae, GI6322967, Length=398, Percent_Identity=27.8894472361809, Blast_Score=135, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6319608, Length=381, Percent_Identity=29.1338582677165, Blast_Score=129, Evalue=7e-31,
Organism=Saccharomyces cerevisiae, GI6324981, Length=397, Percent_Identity=26.7002518891688, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6320364, Length=502, Percent_Identity=24.9003984063745, Blast_Score=120, Evalue=6e-28,
Organism=Drosophila melanogaster, GI24667468, Length=331, Percent_Identity=25.6797583081571, Blast_Score=79, Evalue=9e-15,
Organism=Drosophila melanogaster, GI161077963, Length=361, Percent_Identity=26.8698060941828, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 49323; Mature: 49323

Theoretical pI: Translated: 9.23; Mature: 9.23

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHLQRNLGARHIRFLALGSAIGTGLFYGSASAIQLAGPAVILAYILGGAAVYMVMRALG
CCCHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHH
EMAVREPVSGSFGRYASEYLGPLAGFLTGWTYILEMIIVCLADVTAFGIYMGFWFPEVPQ
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WIWVLGIVMLICGLNLCNVKVFGELEFWLALVKILAIGAMIIGGTLILFLGVKMNGEHSP
HHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCC
GLTNLWAHGGFLPHGAGGLIASLAVVMFAYGGIEIIGITGGEAKEPEKVIPRAINAVPAR
CCHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHH
ILLFYVLTMVVLMAIFPWTGIGGQGSPFVQIFSGLGIKSAAAILNLIVISAAISAINSNI
HHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCC
FGAGRMMFGMAEQGQAPRLFAITSRQGVPWVTVLAMAAALLGGVVLNYLIPEQVFVIIAS
CCCHHHHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IATFATVWVWLMILLSQVAMRRRLSAEEVRALKFKVPMWPVGPALAIAFMLFVICVLGYV
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHCCC
EDTRVALYIGAGWVALLSLAWYLRAKPHEDRILTGESSAL
CCCEEEEEECCHHHHHHHHHHHHHCCCCCCCEECCCCCCC
>Mature Secondary Structure
MKHLQRNLGARHIRFLALGSAIGTGLFYGSASAIQLAGPAVILAYILGGAAVYMVMRALG
CCCHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHH
EMAVREPVSGSFGRYASEYLGPLAGFLTGWTYILEMIIVCLADVTAFGIYMGFWFPEVPQ
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WIWVLGIVMLICGLNLCNVKVFGELEFWLALVKILAIGAMIIGGTLILFLGVKMNGEHSP
HHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCC
GLTNLWAHGGFLPHGAGGLIASLAVVMFAYGGIEIIGITGGEAKEPEKVIPRAINAVPAR
CCHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHH
ILLFYVLTMVVLMAIFPWTGIGGQGSPFVQIFSGLGIKSAAAILNLIVISAAISAINSNI
HHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCC
FGAGRMMFGMAEQGQAPRLFAITSRQGVPWVTVLAMAAALLGGVVLNYLIPEQVFVIIAS
CCCHHHHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IATFATVWVWLMILLSQVAMRRRLSAEEVRALKFKVPMWPVGPALAIAFMLFVICVLGYV
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHCCC
EDTRVALYIGAGWVALLSLAWYLRAKPHEDRILTGESSAL
CCCEEEEEECCHHHHHHHHHHHHHCCCCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-proline [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-proline [Periplasm] = Proton [Cytoplasm] + L-proline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]