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The map label for this gene is pntAA [H]

Identifier: 73539115

GI number: 73539115

Start: 2053897

End: 2055015

Strand: Reverse

Name: pntAA [H]

Synonym: Reut_B5292

Alternate gene names: 73539115

Gene position: 2055015-2053897 (Counterclockwise)

Preceding gene: 73539116

Following gene: 73539114

Centisome position: 75.38

GC content: 67.29

Gene sequence:

>1119_bases
ATGCAGATAGGCATCCCGACTGAAACTCGGGCGGGAGAGGCGCGCGTCGCCGCTACGCCGGAGACAGTCAAGAAATACGT
CGCACAAGGCCACAAGGTCGTGGTGCAGGCGGGCGCGGGCTTGCGTGCCAGCCAGACCGATAGCGCCTATGAGGCGGCCG
GTGCGACGATCGGCACCGCCGCCGACGCGCTCGGCGCGCCGCTCGTGCTCAAGGTGCGCGCACCTGAGAGCGCCGAACTG
GCGCAGATGAAGTCCGGCGCCGTGCTGGTGGGCATGCTCAACCCGTTCGATACCGAGAACAACGCGCGCATGACCGCCGC
CGGCATCACCGCCTTCGCGCTCGAAGCGGCACCGCGCACCACGCGTGCGCAGAGCATGGACGTGCTGTCCTCGCAGGCGA
ACATCGCCGGCTACAAGGCCGTGCTGGTCGCAGCGCATCACTACCAACGCTTCATGCCGATGCTGATGACCGCCGCGGGC
ACCGTCAAGGCCGCGCGCGTGCTGATCCTCGGCGCCGGCGTGGCGGGCTTGCAGGCCATCGCCACGGCCAAGCGCCTCGG
TGCGGTAATCGAAGCGTCAGACGTGCGCCCGGCGGTGAAGGAGCAGATCGAATCGCTCGGCGGCAAGTTCCTCGACGTGC
CGTTCGTGACCGACGAAGAGCGCGAGATCGCGCAAGGTGTCGGCGGTTATGCGCGGCCAATGCCGCCGGACTGGATGAAG
CGCCAGGCCGAGCTGGTGCACCAGCGTGCGATCCAGGCCGACATCATCATCACCACCGCGCTGATCCCAGGCCGCAAGGC
ACCCGTGCTGCTGCAGGAAGAAACCGTGCAGCAAATGAAGCCGGGCTCGGTGGTGGTCGACCTTGCCGCCGCGCAAGGCG
GCAATTGCCCGCTGACCGTGGCCGACGAAGTGGTCGAGCGCCATGGCGTGATCTTCGTGGGCCATACGAATCTGGCCAGC
ATGGTCGCCGCAGACGCCTCGGCGCTGTACGCGCGCAACGTGCTGGACTTCCTCAAGCTGGTCATCGACAAGGACGGCCA
GTTCTCGCTCAACCTCGAAGACGACATCGTCGCGGCTTGCCTGATGACGCGGCGCGAAGAAGCGGCGCTGGCCGGTTAA

Upstream 100 bases:

>100_bases
CACGAACCGACCGGCACCGCAGGCGGCACTGGCCCCACGCGGTGTCCGGCGCGCAGCGTCCCCATGCTGGTTGGCGCGGC
GGATCACAGGAGATGGAACC

Downstream 100 bases:

>100_bases
GGAGACAACCATGGAAATGGTGAACCACACGGTGATCAACCTGATCATCTTCGTGCTGGCGATCTACGTGGGCTACCACG
TGGTGTGGACGGTCACGCCC

Product: NAD(P)(+) transhydrogenase

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit alpha 1; Proton-translocating transhydrogenase component 1; Pyridine nucleotide transhydrogenase subunit alpha 1; dI [H]

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MQIGIPTETRAGEARVAATPETVKKYVAQGHKVVVQAGAGLRASQTDSAYEAAGATIGTAADALGAPLVLKVRAPESAEL
AQMKSGAVLVGMLNPFDTENNARMTAAGITAFALEAAPRTTRAQSMDVLSSQANIAGYKAVLVAAHHYQRFMPMLMTAAG
TVKAARVLILGAGVAGLQAIATAKRLGAVIEASDVRPAVKEQIESLGGKFLDVPFVTDEEREIAQGVGGYARPMPPDWMK
RQAELVHQRAIQADIIITTALIPGRKAPVLLQEETVQQMKPGSVVVDLAAAQGGNCPLTVADEVVERHGVIFVGHTNLAS
MVAADASALYARNVLDFLKLVIDKDGQFSLNLEDDIVAACLMTRREEAALAG

Sequences:

>Translated_372_residues
MQIGIPTETRAGEARVAATPETVKKYVAQGHKVVVQAGAGLRASQTDSAYEAAGATIGTAADALGAPLVLKVRAPESAEL
AQMKSGAVLVGMLNPFDTENNARMTAAGITAFALEAAPRTTRAQSMDVLSSQANIAGYKAVLVAAHHYQRFMPMLMTAAG
TVKAARVLILGAGVAGLQAIATAKRLGAVIEASDVRPAVKEQIESLGGKFLDVPFVTDEEREIAQGVGGYARPMPPDWMK
RQAELVHQRAIQADIIITTALIPGRKAPVLLQEETVQQMKPGSVVVDLAAAQGGNCPLTVADEVVERHGVIFVGHTNLAS
MVAADASALYARNVLDFLKLVIDKDGQFSLNLEDDIVAACLMTRREEAALAG
>Mature_372_residues
MQIGIPTETRAGEARVAATPETVKKYVAQGHKVVVQAGAGLRASQTDSAYEAAGATIGTAADALGAPLVLKVRAPESAEL
AQMKSGAVLVGMLNPFDTENNARMTAAGITAFALEAAPRTTRAQSMDVLSSQANIAGYKAVLVAAHHYQRFMPMLMTAAG
TVKAARVLILGAGVAGLQAIATAKRLGAVIEASDVRPAVKEQIESLGGKFLDVPFVTDEEREIAQGVGGYARPMPPDWMK
RQAELVHQRAIQADIIITTALIPGRKAPVLLQEETVQQMKPGSVVVDLAAAQGGNCPLTVADEVVERHGVIFVGHTNLAS
MVAADASALYARNVLDFLKLVIDKDGQFSLNLEDDIVAACLMTRREEAALAG

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG3288

COG function: function code C; NAD/NADP transhydrogenase alpha subunit

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=365, Percent_Identity=40.5479452054795, Blast_Score=258, Evalue=9e-69,
Organism=Homo sapiens, GI122939153, Length=365, Percent_Identity=40.5479452054795, Blast_Score=258, Evalue=9e-69,
Organism=Escherichia coli, GI1787887, Length=370, Percent_Identity=42.7027027027027, Blast_Score=281, Evalue=5e-77,
Organism=Caenorhabditis elegans, GI17550456, Length=367, Percent_Identity=41.9618528610354, Blast_Score=284, Evalue=4e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 38996; Mature: 38996

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIGIPTETRAGEARVAATPETVKKYVAQGHKVVVQAGAGLRASQTDSAYEAAGATIGTA
CCCCCCCCCCCCCEEEECCHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHCCCCHHHH
ADALGAPLVLKVRAPESAELAQMKSGAVLVGMLNPFDTENNARMTAAGITAFALEAAPRT
HHHCCCCEEEEEECCCCHHHHHHCCCEEEEEECCCCCCCCCCEEEEHHHHHEEECCCCCC
TRAQSMDVLSSQANIAGYKAVLVAAHHYQRFMPMLMTAAGTVKAARVLILGAGVAGLQAI
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHEEEEEEECCHHHHHHH
ATAKRLGAVIEASDVRPAVKEQIESLGGKFLDVPFVTDEEREIAQGVGGYARPMPPDWMK
HHHHHHHHHHCCCCCCHHHHHHHHHHCCCEEECCCCCCCHHHHHHCCCCCCCCCCHHHHH
RQAELVHQRAIQADIIITTALIPGRKAPVLLQEETVQQMKPGSVVVDLAAAQGGNCPLTV
HHHHHHHHHHHHHHEEEEEEECCCCCCCEEECHHHHHHCCCCCEEEEEECCCCCCCCEEH
ADEVVERHGVIFVGHTNLASMVAADASALYARNVLDFLKLVIDKDGQFSLNLEDDIVAAC
HHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHH
LMTRREEAALAG
HHHHHHHHHCCC
>Mature Secondary Structure
MQIGIPTETRAGEARVAATPETVKKYVAQGHKVVVQAGAGLRASQTDSAYEAAGATIGTA
CCCCCCCCCCCCCEEEECCHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHCCCCHHHH
ADALGAPLVLKVRAPESAELAQMKSGAVLVGMLNPFDTENNARMTAAGITAFALEAAPRT
HHHCCCCEEEEEECCCCHHHHHHCCCEEEEEECCCCCCCCCCEEEEHHHHHEEECCCCCC
TRAQSMDVLSSQANIAGYKAVLVAAHHYQRFMPMLMTAAGTVKAARVLILGAGVAGLQAI
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHEEEEEEECCHHHHHHH
ATAKRLGAVIEASDVRPAVKEQIESLGGKFLDVPFVTDEEREIAQGVGGYARPMPPDWMK
HHHHHHHHHHCCCCCCHHHHHHHHHHCCCEEECCCCCCCHHHHHHCCCCCCCCCCHHHHH
RQAELVHQRAIQADIIITTALIPGRKAPVLLQEETVQQMKPGSVVVDLAAAQGGNCPLTV
HHHHHHHHHHHHHHEEEEEEECCCCCCCEEECHHHHHHCCCCCEEEEEECCCCCCCCEEH
ADEVVERHGVIFVGHTNLASMVAADASALYARNVLDFLKLVIDKDGQFSLNLEDDIVAAC
HHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHH
LMTRREEAALAG
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8075801 [H]