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The map label for this gene is tauD [C]

Identifier: 73539116

GI number: 73539116

Start: 2055120

End: 2055914

Strand: Reverse

Name: tauD [C]

Synonym: Reut_B5293

Alternate gene names: 73539116

Gene position: 2055914-2055120 (Counterclockwise)

Preceding gene: 73539117

Following gene: 73539115

Centisome position: 75.41

GC content: 64.65

Gene sequence:

>795_bases
ATGACCATTGAAATCAAGCCGCTGACCGGTTCGGTCGGTGCATCCGTGACCGGCGTCAACCTGAATGACCCGATCAACGA
CGCCACCTTCAAGGTGCTGCACCAGGCGTTCCTCGAACACGGCATGCTCGTGTTCCGCGGCCAGTTCCTGCAGCCCGCTG
CGCAGGTGGCCTTCGCCCGGCTGTGGGGCACGCCCGTGCAGGGCAACCCGCTGCTCAAGGGGCTGGCGGAGTTCCCGGAA
CTGTTTCAGGTCACCAAGATTCCGAAGGAGACCGCCTCGACCGAGGCCTGGCACTCGGACTCGATCTACACCGCGGTGCC
GCCGAAGATCTCGATCCTGTCGGGCGTCACGATTCCCATCGGCGGCGACACCATGTGGTGCAACCAGTATCTCTCGTACG
AACGCCTGTCGCCGGTCATGCAGCGCCTGATCGAGGGCCTGCGCGCACGCTTCTCCGGCGCGCGCCTGGCCAAGATGACG
GGCTCGGACAAGGTGCCATCGGCGGTGCACCCGATCGTGCGCACGCATCCGGAGACGGGCCGCAAGGCACTGTACGTCGG
CCATCCGGACACCGCCGAATGCATCGAAGGCATGACCGAGGCCGAGAGCCGTCCGCTGCTCGACTTCCTGTACGAGCATT
CGGTCACGCCGGACAACGTCTACCGCCACATGTGGCAGGAAGGCGATGTGGTGATGTGGGACAACCGCTGCACCATGCAC
TACGCCGTCCATGACTACGGCAATGCCGAGCGCGTACTCAACCGCGTGACGCTCGAAGGCGAAGTGCCCAACTGA

Upstream 100 bases:

>100_bases
ACCGATATCCACGCGGCGCACGCATACATGAAGCAGGACCAGCACGTCGGCAAGATCGTGCTGCTGGTCGACTGAATCCA
CCGATAGAAGAGGAGACATC

Downstream 100 bases:

>100_bases
GCGGCACGAACCGACCGGCACCGCAGGCGGCACTGGCCCCACGCGGTGTCCGGCGCGCAGCGTCCCCATGCTGGTTGGCG
CGGCGGATCACAGGAGATGG

Product: taurine dioxygenase

Products: Aminoacetaldehyde; CO2; H+; Sulfite; Succinate [C]

Alternate protein names: NA

Number of amino acids: Translated: 264; Mature: 263

Protein sequence:

>264_residues
MTIEIKPLTGSVGASVTGVNLNDPINDATFKVLHQAFLEHGMLVFRGQFLQPAAQVAFARLWGTPVQGNPLLKGLAEFPE
LFQVTKIPKETASTEAWHSDSIYTAVPPKISILSGVTIPIGGDTMWCNQYLSYERLSPVMQRLIEGLRARFSGARLAKMT
GSDKVPSAVHPIVRTHPETGRKALYVGHPDTAECIEGMTEAESRPLLDFLYEHSVTPDNVYRHMWQEGDVVMWDNRCTMH
YAVHDYGNAERVLNRVTLEGEVPN

Sequences:

>Translated_264_residues
MTIEIKPLTGSVGASVTGVNLNDPINDATFKVLHQAFLEHGMLVFRGQFLQPAAQVAFARLWGTPVQGNPLLKGLAEFPE
LFQVTKIPKETASTEAWHSDSIYTAVPPKISILSGVTIPIGGDTMWCNQYLSYERLSPVMQRLIEGLRARFSGARLAKMT
GSDKVPSAVHPIVRTHPETGRKALYVGHPDTAECIEGMTEAESRPLLDFLYEHSVTPDNVYRHMWQEGDVVMWDNRCTMH
YAVHDYGNAERVLNRVTLEGEVPN
>Mature_263_residues
TIEIKPLTGSVGASVTGVNLNDPINDATFKVLHQAFLEHGMLVFRGQFLQPAAQVAFARLWGTPVQGNPLLKGLAEFPEL
FQVTKIPKETASTEAWHSDSIYTAVPPKISILSGVTIPIGGDTMWCNQYLSYERLSPVMQRLIEGLRARFSGARLAKMTG
SDKVPSAVHPIVRTHPETGRKALYVGHPDTAECIEGMTEAESRPLLDFLYEHSVTPDNVYRHMWQEGDVVMWDNRCTMHY
AVHDYGNAERVLNRVTLEGEVPN

Specific function: Catalyzes The Conversion Of Taurine And Alpha Ketoglutarate To Sulfite, Aminoacetaldehyde And Succinate. Required For The Utilization Of Taurine (2-Aminoethanesulfonic Acid) As An Alternative Sulfur Source. Pentane-Sulfonic Acid, 3- (N-Morpholino)Propanes

COG id: COG2175

COG function: function code Q; Probable taurine catabolism dioxygenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tfdA dioxygenase family [H]

Homologues:

Organism=Escherichia coli, GI1786565, Length=276, Percent_Identity=32.2463768115942, Blast_Score=153, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6322971, Length=281, Percent_Identity=28.4697508896797, Blast_Score=103, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003819 [H]

Pfam domain/function: PF02668 TauD [H]

EC number: 1.14.11.17 [C]

Molecular weight: Translated: 29357; Mature: 29226

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIEIKPLTGSVGASVTGVNLNDPINDATFKVLHQAFLEHGMLVFRGQFLQPAAQVAFAR
CEEEEEECCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHH
LWGTPVQGNPLLKGLAEFPELFQVTKIPKETASTEAWHSDSIYTAVPPKISILSGVTIPI
HHCCCCCCCHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCEEEECCCCEEECCCCEEEC
GGDTMWCNQYLSYERLSPVMQRLIEGLRARFSGARLAKMTGSDKVPSAVHPIVRTHPETG
CCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHCCCCCC
RKALYVGHPDTAECIEGMTEAESRPLLDFLYEHSVTPDNVYRHMWQEGDVVMWDNRCTMH
CEEEEECCCCHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHCCCCEEEECCCEEEE
YAVHDYGNAERVLNRVTLEGEVPN
EEECCCCCHHHHHHHHEECCCCCC
>Mature Secondary Structure 
TIEIKPLTGSVGASVTGVNLNDPINDATFKVLHQAFLEHGMLVFRGQFLQPAAQVAFAR
EEEEEECCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHH
LWGTPVQGNPLLKGLAEFPELFQVTKIPKETASTEAWHSDSIYTAVPPKISILSGVTIPI
HHCCCCCCCHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCEEEECCCCEEECCCCEEEC
GGDTMWCNQYLSYERLSPVMQRLIEGLRARFSGARLAKMTGSDKVPSAVHPIVRTHPETG
CCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHCCCCCC
RKALYVGHPDTAECIEGMTEAESRPLLDFLYEHSVTPDNVYRHMWQEGDVVMWDNRCTMH
CEEEEECCCCHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHCCCCEEEECCCEEEE
YAVHDYGNAERVLNRVTLEGEVPN
EEECCCCCHHHHHHHHEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Ascorbate. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2-Oxoglutarate; O2; Taurine [C]

Specific reaction: 2-Oxoglutarate + O2 + Taurine --> Aminoacetaldehyde + CO2 + H+ + Sulfite + Succinate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]