Click here to switch to the map view.

The map label for this gene is tyrB [H]

Identifier: 73538330

GI number: 73538330

Start: 1175795

End: 1176994

Strand: Direct

Name: tyrB [H]

Synonym: Reut_B4503

Alternate gene names: 73538330

Gene position: 1175795-1176994 (Clockwise)

Preceding gene: 73538329

Following gene: 73538331

Centisome position: 43.13

GC content: 66.5

Gene sequence:

>1200_bases
ATGTTTGCACATATCGAGGCCTTTCCTGGCGACCCGATCCTTTCGCTCAACGAAGACTTCCAGAAGGACCCGCGCACCGA
CAAGGTCAACCTGAGCATCGGCATCTATTTCGACGACGAAGGCCGGCTGCCGGTCATGGAAGCTGTCGAAAAGGCCGAGG
CCGCGCTGCTGGCCGACATGGGCCCGCGCCCCTACCTGCCGATGTCGGGCCTGGTGGCCTACCGCAATGCCGTGCAGGCG
CTGGTGTTCGGCGAGGACAGCGCGGCCCGCGCGACCGGCCGCGTCGCCACGCTGCAGACGCTGGGCGGCTCGGGCGCGCT
GCGCGTGGGTGCCGATTTTCTGAAGCGCTACTTCCCGCAGTCGCAGGTGTGGATCAGCGACCCGAGCTGGGAAAACCACC
GCGTGGTGTTCGAGCGCGCGGGCTTCACCGTCAACACGTATCCGTACTACGACGATGCCACCGGCGGCCTGAAGTTCGAC
GCCATGGTCGATGCGATCAGCAAGCTGCCCAAGCAGAGCATCGTGCTGCTGCACGTGTGTTGCCACAACCCGACCGGCGT
GGACCTGAACCAGGACCAGTGGCGCCAGCTGATCGGCGTGCTGAAGGCCAAGGAACTGCTGCCGTTCGTCGATATGGCCT
ACCAGGGCTTTGGCGAAGGCCTGGACGAAGACGCGTTCGCCATCCGCGAGCTGGACCGCCAGGGCGTGCCGTGCCTGGTC
GCGAACTCGTTCTCGAAGAACTTCTCGCTGTATGGCGAGCGTTGCGGCGGCCTGAGCGTGGTGTGCAACAGCGCGGCCGA
AGCGGCCAATGTGCTGGGCCAGCTGACCGGTGCCGTGCGCGCCAACTATAGCAACCCGCCGACGCACGGCGCGCGCGTGG
TGGCCAAGGTGCTGACCACGCCCGAACTGCGCACGCTGTGGCAGCAGGAGCTGGCCGCGATGTGCAACCGCATCACCCGC
ATGCGCGAGGCCATCCACCACCACCTGCGCGACCACGTCAGCGGCGAAGCGCTGTCGCGCTACCTGACCCAGCGCGGTAT
GTTCACGTACACGGGCCTTACCGCGGAGCAGGCCGACCGCCTGCGCGAAGACCACGGTGTGTACCTGTTGCGCTCGGGCC
GCATGTGCGTCGCCGGTCTCAATGAACGCAATGTGACCGTGGTGGCCAAGGCCATCGCCGCGGTGCTCGGCGGCAAGTAA

Upstream 100 bases:

>100_bases
CGACGCTTCATGGCGCGCCGCCGGTTACACTTCAGTCTGTGCGCCCGGTGCAAGGCCTGCGGCGCGCTCCCAGCCCCGAC
TCCAGAATCCTGAGAATCCC

Downstream 100 bases:

>100_bases
GCCCCGCGCCACAACGCGGTCCGGGCACTGCCCCGGACCGCGCTTTTCTTTCGCCCGTCCCTTCCCTTCCTCTGCGCGCT
TCAGCGCGCTCCCTTCGCCA

Product: aromatic amino acid aminotransferase

Products: NA

Alternate protein names: ARAT; AROAT [H]

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MFAHIEAFPGDPILSLNEDFQKDPRTDKVNLSIGIYFDDEGRLPVMEAVEKAEAALLADMGPRPYLPMSGLVAYRNAVQA
LVFGEDSAARATGRVATLQTLGGSGALRVGADFLKRYFPQSQVWISDPSWENHRVVFERAGFTVNTYPYYDDATGGLKFD
AMVDAISKLPKQSIVLLHVCCHNPTGVDLNQDQWRQLIGVLKAKELLPFVDMAYQGFGEGLDEDAFAIRELDRQGVPCLV
ANSFSKNFSLYGERCGGLSVVCNSAAEAANVLGQLTGAVRANYSNPPTHGARVVAKVLTTPELRTLWQQELAAMCNRITR
MREAIHHHLRDHVSGEALSRYLTQRGMFTYTGLTAEQADRLREDHGVYLLRSGRMCVAGLNERNVTVVAKAIAAVLGGK

Sequences:

>Translated_399_residues
MFAHIEAFPGDPILSLNEDFQKDPRTDKVNLSIGIYFDDEGRLPVMEAVEKAEAALLADMGPRPYLPMSGLVAYRNAVQA
LVFGEDSAARATGRVATLQTLGGSGALRVGADFLKRYFPQSQVWISDPSWENHRVVFERAGFTVNTYPYYDDATGGLKFD
AMVDAISKLPKQSIVLLHVCCHNPTGVDLNQDQWRQLIGVLKAKELLPFVDMAYQGFGEGLDEDAFAIRELDRQGVPCLV
ANSFSKNFSLYGERCGGLSVVCNSAAEAANVLGQLTGAVRANYSNPPTHGARVVAKVLTTPELRTLWQQELAAMCNRITR
MREAIHHHLRDHVSGEALSRYLTQRGMFTYTGLTAEQADRLREDHGVYLLRSGRMCVAGLNERNVTVVAKAIAAVLGGK
>Mature_399_residues
MFAHIEAFPGDPILSLNEDFQKDPRTDKVNLSIGIYFDDEGRLPVMEAVEKAEAALLADMGPRPYLPMSGLVAYRNAVQA
LVFGEDSAARATGRVATLQTLGGSGALRVGADFLKRYFPQSQVWISDPSWENHRVVFERAGFTVNTYPYYDDATGGLKFD
AMVDAISKLPKQSIVLLHVCCHNPTGVDLNQDQWRQLIGVLKAKELLPFVDMAYQGFGEGLDEDAFAIRELDRQGVPCLV
ANSFSKNFSLYGERCGGLSVVCNSAAEAANVLGQLTGAVRANYSNPPTHGARVVAKVLTTPELRTLWQQELAAMCNRITR
MREAIHHHLRDHVSGEALSRYLTQRGMFTYTGLTAEQADRLREDHGVYLLRSGRMCVAGLNERNVTVVAKAIAAVLGGK

Specific function: Biosynthesis of Phe, Tyr, Asp and Leu. [C]

COG id: COG1448

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI73486658, Length=396, Percent_Identity=43.1818181818182, Blast_Score=345, Evalue=3e-95,
Organism=Homo sapiens, GI4504067, Length=388, Percent_Identity=40.7216494845361, Blast_Score=301, Evalue=9e-82,
Organism=Homo sapiens, GI117414139, Length=381, Percent_Identity=28.3464566929134, Blast_Score=175, Evalue=7e-44,
Organism=Escherichia coli, GI1790488, Length=397, Percent_Identity=57.4307304785894, Blast_Score=472, Evalue=1e-134,
Organism=Escherichia coli, GI1787159, Length=396, Percent_Identity=44.1919191919192, Blast_Score=350, Evalue=1e-97,
Organism=Caenorhabditis elegans, GI71981858, Length=395, Percent_Identity=40.5063291139241, Blast_Score=337, Evalue=7e-93,
Organism=Caenorhabditis elegans, GI17569539, Length=395, Percent_Identity=42.0253164556962, Blast_Score=312, Evalue=2e-85,
Organism=Caenorhabditis elegans, GI25147133, Length=395, Percent_Identity=38.7341772151899, Blast_Score=310, Evalue=9e-85,
Organism=Caenorhabditis elegans, GI17569537, Length=381, Percent_Identity=33.0708661417323, Blast_Score=212, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI17550384, Length=264, Percent_Identity=37.8787878787879, Blast_Score=194, Evalue=7e-50,
Organism=Caenorhabditis elegans, GI25147136, Length=211, Percent_Identity=36.4928909952607, Blast_Score=163, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6323055, Length=405, Percent_Identity=39.2592592592593, Blast_Score=310, Evalue=2e-85,
Organism=Saccharomyces cerevisiae, GI6322743, Length=425, Percent_Identity=32.7058823529412, Blast_Score=234, Evalue=1e-62,
Organism=Drosophila melanogaster, GI24580972, Length=396, Percent_Identity=39.6464646464646, Blast_Score=317, Evalue=8e-87,
Organism=Drosophila melanogaster, GI24580970, Length=396, Percent_Identity=39.6464646464646, Blast_Score=317, Evalue=9e-87,
Organism=Drosophila melanogaster, GI19920542, Length=389, Percent_Identity=40.1028277634961, Blast_Score=314, Evalue=7e-86,
Organism=Drosophila melanogaster, GI24654046, Length=401, Percent_Identity=41.3965087281795, Blast_Score=313, Evalue=1e-85,
Organism=Drosophila melanogaster, GI19922362, Length=401, Percent_Identity=41.3965087281795, Blast_Score=313, Evalue=1e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR000796
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.57 [H]

Molecular weight: Translated: 43822; Mature: 43822

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: PS00070 ALDEHYDE_DEHYDR_CYS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFAHIEAFPGDPILSLNEDFQKDPRTDKVNLSIGIYFDDEGRLPVMEAVEKAEAALLADM
CCCEEECCCCCCCCCCCCHHCCCCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHCC
GPRPYLPMSGLVAYRNAVQALVFGEDSAARATGRVATLQTLGGSGALRVGADFLKRYFPQ
CCCCCCCHHHHHHHHHHHHEEEECCCCHHHHHCCEEEEEECCCCCCHHHHHHHHHHHCCC
SQVWISDPSWENHRVVFERAGFTVNTYPYYDDATGGLKFDAMVDAISKLPKQSIVLLHVC
CCEEECCCCCCCCEEEEEECCCEEECCCCCCCCCCCEEHHHHHHHHHHCCCHHEEEEEEE
CHNPTGVDLNQDQWRQLIGVLKAKELLPFVDMAYQGFGEGLDEDAFAIRELDRQGVPCLV
ECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCEEE
ANSFSKNFSLYGERCGGLSVVCNSAAEAANVLGQLTGAVRANYSNPPTHGARVVAKVLTT
ECCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCC
PELRTLWQQELAAMCNRITRMREAIHHHLRDHVSGEALSRYLTQRGMFTYTGLTAEQADR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEECCCHHHHHH
LREDHGVYLLRSGRMCVAGLNERNVTVVAKAIAAVLGGK
HHHCCCEEEEECCCEEEECCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFAHIEAFPGDPILSLNEDFQKDPRTDKVNLSIGIYFDDEGRLPVMEAVEKAEAALLADM
CCCEEECCCCCCCCCCCCHHCCCCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHCC
GPRPYLPMSGLVAYRNAVQALVFGEDSAARATGRVATLQTLGGSGALRVGADFLKRYFPQ
CCCCCCCHHHHHHHHHHHHEEEECCCCHHHHHCCEEEEEECCCCCCHHHHHHHHHHHCCC
SQVWISDPSWENHRVVFERAGFTVNTYPYYDDATGGLKFDAMVDAISKLPKQSIVLLHVC
CCEEECCCCCCCCEEEEEECCCEEECCCCCCCCCCCEEHHHHHHHHHHCCCHHEEEEEEE
CHNPTGVDLNQDQWRQLIGVLKAKELLPFVDMAYQGFGEGLDEDAFAIRELDRQGVPCLV
ECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCEEE
ANSFSKNFSLYGERCGGLSVVCNSAAEAANVLGQLTGAVRANYSNPPTHGARVVAKVLTT
ECCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCC
PELRTLWQQELAAMCNRITRMREAIHHHLRDHVSGEALSRYLTQRGMFTYTGLTAEQADR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEECCCHHHHHH
LREDHGVYLLRSGRMCVAGLNERNVTVVAKAIAAVLGGK
HHHCCCEEEEECCCEEEECCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3521591; 3907634; 8265357; 9278503; 3308851; 10417420 [H]