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The map label for this gene is aroP [H]

Identifier: 73538329

GI number: 73538329

Start: 1174289

End: 1175674

Strand: Direct

Name: aroP [H]

Synonym: Reut_B4502

Alternate gene names: 73538329

Gene position: 1174289-1175674 (Clockwise)

Preceding gene: 73538328

Following gene: 73538330

Centisome position: 43.07

GC content: 62.55

Gene sequence:

>1386_bases
ATGGTTGAAAGCAATAATGACGGCACGCTGAAGCGTGGCCTCAAGAACCGGCACATCCAGCTGATCGCGCTCGGCGGCGC
GATCGGCACCGGGCTGTTCCTGGGCATCGCCCAGACCATCAAGATGGCCGGCCCCTCGGTGCTGCTCGGCTACGCGGTGG
CGGGCATCGTGGCGTTCTTCATCATGCGCCAGCTCGGCGAGATGGTCGTCGATGAACCCGTGGCGGGCTCGTTCAGCTAC
TTCGCCAACAAGTACTGTGGCCACTTCGCCGGCTTCATGTCGGGCTGGAACTACTGGGTGCTGTACATCCTGGTCAGCAT
GGCCGAGCTGTCGGCGGTCGGCATCTATGTCCAGTACTGGTGGCCCGGCATCCCGACCTGGATCTCGGCGCTGGCGTTCT
TCCTGATCATCAACGCGATCAACCTGTCGAGCGTGAAGTCCTTCGGCGAGATGGAGTTCTGGTTCTCGATCATCAAGGTC
GCGGCCATCATCGGCATGATCGGCTTCGGCGGCTACCTGCTGATGTCCGGTAATGCCGGTCCGCAGGCCAGCATCACGAA
CCTGTGGCAGCACGGCGGCTTCTTCCCGAACGGCCTGGGCGGCCTGGTCATGGCCATGGCGGTGATCATGTTCTCGTTCG
GCGGACTGGAGCTTGTCGGCATCACGGCGGCGGAAGCAGATCAACCGGAAAAGAGCATCCCGAAGGCGACCAACCAGGTC
ATCTACCGTATCCTGATTTTCTACGTTGGCGCGCTGGCCGTGCTGCTGTCGCTGTACCCGTGGGAAAACGTCGTGACCGG
CGGCAGCCCGTTCGTGCTGATCTTCCACGCGCTGAACAGCAACTGGGTCGCCAATGTGCTGAACGTTGTCGTGCTGACGG
CCGCGCTGTCGGTCTATAACAGCGGCGTGTACTGCAACAGCCGCATGCTGTTCGGCCTGGCCCAGCAGGGCAATGCGCCG
AAGTCGCTGCTCAAGGTCAGCAAGCGCGGCATTCCGCTGACGGCGCTGGGCGTGTCGGCGGCGGCCACCGGCCTGTGCGT
GCTGATCAACTACTTCATGCCGGGCAAGGCGTTTGAACTGCTGATGGGCCTGGTGGTTTCGGCCCTGATCATCAACTGGG
CCATGATCAGCATCATTCACCTGAAGTTCCGCGCCGACAAGCGCAAGGCTGGTCAGGAAACGCGCTTCAAGAGCTTCGGC
TACCCGCTCACGAACTACCTGTGCCTGGCTTTCCTGGGCGGCATCCTGGTCGTGATGTACCTGACCGATGGCCTGCGCAT
CTCGGTGTACCTGATCCCGGTGTGGCTGGCGGTTCTGGGCATCAGCTACCGCCTGCGGCAGAAGAATGCCGTGCCGGCCC
TGCAGGGCAGCGTCTCGGCCCAGTAA

Upstream 100 bases:

>100_bases
TTCCCGGCGGTCTTCAAGGCCCAGGCGTCCCACCCTCCTCACATTAAGAGACGCCAGGCTCCGCATGCCATTCCATAAGA
GTGGGTAGAGGAAACAATTC

Downstream 100 bases:

>100_bases
GCCTCCCGGCGGCGCGTTCACGACGCTTCATGGCGCGCCGCCGGTTACACTTCAGTCTGTGCGCCCGGTGCAAGGCCTGC
GGCGCGCTCCCAGCCCCGAC

Product: amino acid permease-associated protein

Products: L-tryptophan [Cytoplasm]; Proton [Cytoplasm]; Proton [Cytoplasm]; L-tyrosine [Cytoplasm]; Proton [Cytoplasm]; L-phenylalanine [Cytoplasm] [C]

Alternate protein names: General aromatic amino acid permease [H]

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MVESNNDGTLKRGLKNRHIQLIALGGAIGTGLFLGIAQTIKMAGPSVLLGYAVAGIVAFFIMRQLGEMVVDEPVAGSFSY
FANKYCGHFAGFMSGWNYWVLYILVSMAELSAVGIYVQYWWPGIPTWISALAFFLIINAINLSSVKSFGEMEFWFSIIKV
AAIIGMIGFGGYLLMSGNAGPQASITNLWQHGGFFPNGLGGLVMAMAVIMFSFGGLELVGITAAEADQPEKSIPKATNQV
IYRILIFYVGALAVLLSLYPWENVVTGGSPFVLIFHALNSNWVANVLNVVVLTAALSVYNSGVYCNSRMLFGLAQQGNAP
KSLLKVSKRGIPLTALGVSAAATGLCVLINYFMPGKAFELLMGLVVSALIINWAMISIIHLKFRADKRKAGQETRFKSFG
YPLTNYLCLAFLGGILVVMYLTDGLRISVYLIPVWLAVLGISYRLRQKNAVPALQGSVSAQ

Sequences:

>Translated_461_residues
MVESNNDGTLKRGLKNRHIQLIALGGAIGTGLFLGIAQTIKMAGPSVLLGYAVAGIVAFFIMRQLGEMVVDEPVAGSFSY
FANKYCGHFAGFMSGWNYWVLYILVSMAELSAVGIYVQYWWPGIPTWISALAFFLIINAINLSSVKSFGEMEFWFSIIKV
AAIIGMIGFGGYLLMSGNAGPQASITNLWQHGGFFPNGLGGLVMAMAVIMFSFGGLELVGITAAEADQPEKSIPKATNQV
IYRILIFYVGALAVLLSLYPWENVVTGGSPFVLIFHALNSNWVANVLNVVVLTAALSVYNSGVYCNSRMLFGLAQQGNAP
KSLLKVSKRGIPLTALGVSAAATGLCVLINYFMPGKAFELLMGLVVSALIINWAMISIIHLKFRADKRKAGQETRFKSFG
YPLTNYLCLAFLGGILVVMYLTDGLRISVYLIPVWLAVLGISYRLRQKNAVPALQGSVSAQ
>Mature_461_residues
MVESNNDGTLKRGLKNRHIQLIALGGAIGTGLFLGIAQTIKMAGPSVLLGYAVAGIVAFFIMRQLGEMVVDEPVAGSFSY
FANKYCGHFAGFMSGWNYWVLYILVSMAELSAVGIYVQYWWPGIPTWISALAFFLIINAINLSSVKSFGEMEFWFSIIKV
AAIIGMIGFGGYLLMSGNAGPQASITNLWQHGGFFPNGLGGLVMAMAVIMFSFGGLELVGITAAEADQPEKSIPKATNQV
IYRILIFYVGALAVLLSLYPWENVVTGGSPFVLIFHALNSNWVANVLNVVVLTAALSVYNSGVYCNSRMLFGLAQQGNAP
KSLLKVSKRGIPLTALGVSAAATGLCVLINYFMPGKAFELLMGLVVSALIINWAMISIIHLKFRADKRKAGQETRFKSFG
YPLTNYLCLAFLGGILVVMYLTDGLRISVYLIPVWLAVLGISYRLRQKNAVPALQGSVSAQ

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of the aromatic amino acids (phenylalanine, tyrosine, and tryptophan) [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Escherichia coli, GI1786302, Length=451, Percent_Identity=70.0665188470066, Blast_Score=644, Evalue=0.0,
Organism=Escherichia coli, GI1786789, Length=446, Percent_Identity=65.695067264574, Blast_Score=601, Evalue=1e-173,
Organism=Escherichia coli, GI1786602, Length=453, Percent_Identity=47.4613686534216, Blast_Score=354, Evalue=6e-99,
Organism=Escherichia coli, GI48994972, Length=432, Percent_Identity=42.3611111111111, Blast_Score=350, Evalue=9e-98,
Organism=Escherichia coli, GI1790653, Length=458, Percent_Identity=39.7379912663755, Blast_Score=345, Evalue=4e-96,
Organism=Escherichia coli, GI87081915, Length=401, Percent_Identity=37.9052369077307, Blast_Score=296, Evalue=2e-81,
Organism=Escherichia coli, GI1789017, Length=432, Percent_Identity=37.5, Blast_Score=290, Evalue=1e-79,
Organism=Escherichia coli, GI87081708, Length=415, Percent_Identity=34.9397590361446, Blast_Score=258, Evalue=6e-70,
Organism=Escherichia coli, GI1788480, Length=407, Percent_Identity=36.3636363636364, Blast_Score=243, Evalue=2e-65,
Organism=Escherichia coli, GI87082023, Length=190, Percent_Identity=27.8947368421053, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI87081869, Length=187, Percent_Identity=25.668449197861, Blast_Score=63, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6320772, Length=441, Percent_Identity=34.6938775510204, Blast_Score=223, Evalue=3e-59,
Organism=Saccharomyces cerevisiae, GI6324061, Length=438, Percent_Identity=32.648401826484, Blast_Score=211, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6324924, Length=447, Percent_Identity=31.9910514541387, Blast_Score=202, Evalue=9e-53,
Organism=Saccharomyces cerevisiae, GI6322892, Length=408, Percent_Identity=33.3333333333333, Blast_Score=199, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6324990, Length=421, Percent_Identity=31.8289786223278, Blast_Score=187, Evalue=3e-48,
Organism=Saccharomyces cerevisiae, GI6324553, Length=397, Percent_Identity=31.9899244332494, Blast_Score=181, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6324059, Length=437, Percent_Identity=32.7231121281465, Blast_Score=178, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6321053, Length=413, Percent_Identity=30.0242130750605, Blast_Score=177, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6319608, Length=427, Percent_Identity=28.1030444964871, Blast_Score=176, Evalue=6e-45,
Organism=Saccharomyces cerevisiae, GI6319824, Length=415, Percent_Identity=30.1204819277108, Blast_Score=173, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6320251, Length=407, Percent_Identity=29.97542997543, Blast_Score=169, Evalue=6e-43,
Organism=Saccharomyces cerevisiae, GI6320717, Length=415, Percent_Identity=27.710843373494, Blast_Score=166, Evalue=8e-42,
Organism=Saccharomyces cerevisiae, GI6321629, Length=397, Percent_Identity=29.2191435768262, Blast_Score=164, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6319542, Length=421, Percent_Identity=28.978622327791, Blast_Score=160, Evalue=4e-40,
Organism=Saccharomyces cerevisiae, GI6319543, Length=403, Percent_Identity=29.0322580645161, Blast_Score=159, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6322967, Length=397, Percent_Identity=28.9672544080605, Blast_Score=155, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6324981, Length=404, Percent_Identity=28.960396039604, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6320364, Length=459, Percent_Identity=25.2723311546841, Blast_Score=100, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24667468, Length=404, Percent_Identity=23.5148514851485, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24666159, Length=420, Percent_Identity=20, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI221512776, Length=420, Percent_Identity=20, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 49830; Mature: 49830

Theoretical pI: Translated: 9.75; Mature: 9.75

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVESNNDGTLKRGLKNRHIQLIALGGAIGTGLFLGIAQTIKMAGPSVLLGYAVAGIVAFF
CCCCCCCCHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
IMRQLGEMVVDEPVAGSFSYFANKYCGHFAGFMSGWNYWVLYILVSMAELSAVGIYVQYW
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHEEEEEEE
WPGIPTWISALAFFLIINAINLSSVKSFGEMEFWFSIIKVAAIIGMIGFGGYLLMSGNAG
CCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCC
PQASITNLWQHGGFFPNGLGGLVMAMAVIMFSFGGLELVGITAAEADQPEKSIPKATNQV
CCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHCCHHHHHH
IYRILIFYVGALAVLLSLYPWENVVTGGSPFVLIFHALNSNWVANVLNVVVLTAALSVYN
HHHHHHHHHHHHHHHHHHCCCCHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHC
SGVYCNSRMLFGLAQQGNAPKSLLKVSKRGIPLTALGVSAAATGLCVLINYFMPGKAFEL
CCCEECCHHHEEECCCCCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHCCCHHHHH
LMGLVVSALIINWAMISIIHLKFRADKRKAGQETRFKSFGYPLTNYLCLAFLGGILVVMY
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHH
LTDGLRISVYLIPVWLAVLGISYRLRQKNAVPALQGSVSAQ
HCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCC
>Mature Secondary Structure
MVESNNDGTLKRGLKNRHIQLIALGGAIGTGLFLGIAQTIKMAGPSVLLGYAVAGIVAFF
CCCCCCCCHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
IMRQLGEMVVDEPVAGSFSYFANKYCGHFAGFMSGWNYWVLYILVSMAELSAVGIYVQYW
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHEEEEEEE
WPGIPTWISALAFFLIINAINLSSVKSFGEMEFWFSIIKVAAIIGMIGFGGYLLMSGNAG
CCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCC
PQASITNLWQHGGFFPNGLGGLVMAMAVIMFSFGGLELVGITAAEADQPEKSIPKATNQV
CCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHCCHHHHHH
IYRILIFYVGALAVLLSLYPWENVVTGGSPFVLIFHALNSNWVANVLNVVVLTAALSVYN
HHHHHHHHHHHHHHHHHHCCCCHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHC
SGVYCNSRMLFGLAQQGNAPKSLLKVSKRGIPLTALGVSAAATGLCVLINYFMPGKAFEL
CCCEECCHHHEEECCCCCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHCCCHHHHH
LMGLVVSALIINWAMISIIHLKFRADKRKAGQETRFKSFGYPLTNYLCLAFLGGILVVMY
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHH
LTDGLRISVYLIPVWLAVLGISYRLRQKNAVPALQGSVSAQ
HCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-tryptophan [Periplasm]; Proton [Periplasm]; Proton [Periplasm]; L-tyrosine [Periplasm]; Proton [Periplasm]; L-phenylalanine [Periplasm] [C]

Specific reaction: L-tryptophan [Periplasm] + Proton [Periplasm] = L-tryptophan [Cytoplasm] + Proton [Cytoplasm] Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] Proton [Periplasm] + L-phenylalanine [Periplasm] = Proton [Cytoplasm] +

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]