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The map label for this gene is lrp [H]

Identifier: 73538072

GI number: 73538072

Start: 896648

End: 897178

Strand: Reverse

Name: lrp [H]

Synonym: Reut_B4242

Alternate gene names: 73538072

Gene position: 897178-896648 (Counterclockwise)

Preceding gene: 73538074

Following gene: 73538071

Centisome position: 32.91

GC content: 59.13

Gene sequence:

>531_bases
ATGAATTGTCTCTTGAGCGTAGAATTCAAGGATTATCCATCTGTCGCAAAGACACTCCTCATGCCAACCATCCCGAAGCT
CGACGACGTTGACCGTCGCATCCTGCGTGAACTGCGGCGTGATGGCCGCCTGTCGAACGCAAAGCTGGCGGAACACGTCG
GCCTGTCCGCGACACCATGCTGGAACCGGGTGCGCGCACTGGAAGAGAGCGGCGTCATTGAAGGCTATGCGGCGTTGCTC
AACCAGAAGGCGCTCGGATTGCCCGATACCGTACTGATCGAAGTGACGCTTGATCGACACGACGATGACATGCTCCACCG
GTTCGGGCAAGCACTCGCCGAACTGCCGGAAGTCCTCGAGGCCCATTTGCTCACGGGCGAGTACGACTACCTGATCAAGG
TCGCGGTAGCGGGCACCGAGGGCTATGAGGAATTCCTGCGTCACAAGCTGTACAAGCTGCCCGGCCTGCGCCATAGCCAT
TCCACCTTTGTGCTGCGCACATTGAAGCGCGAGCTGTCAGTCGCGCCTTAG

Upstream 100 bases:

>100_bases
TGGCATGTGGCGTCTGAAGCAAGAATGTCGGTCAGGTAAATTTACCAGTGGACCGGCAAAATGAGCTTCTGAATTTCCTG
CCGTCTCGGTATGTTTGTAG

Downstream 100 bases:

>100_bases
CTCACGTGAAGCATGCGCCCTACAGTAGGTACTGCGCTGGCGCATCAGCAAGCCGGTTACCGCCCGGTCAATGCACGGTT
GAGGTGCCTGCCGGCGGGGT

Product: AsnC family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 176; Mature: 176

Protein sequence:

>176_residues
MNCLLSVEFKDYPSVAKTLLMPTIPKLDDVDRRILRELRRDGRLSNAKLAEHVGLSATPCWNRVRALEESGVIEGYAALL
NQKALGLPDTVLIEVTLDRHDDDMLHRFGQALAELPEVLEAHLLTGEYDYLIKVAVAGTEGYEEFLRHKLYKLPGLRHSH
STFVLRTLKRELSVAP

Sequences:

>Translated_176_residues
MNCLLSVEFKDYPSVAKTLLMPTIPKLDDVDRRILRELRRDGRLSNAKLAEHVGLSATPCWNRVRALEESGVIEGYAALL
NQKALGLPDTVLIEVTLDRHDDDMLHRFGQALAELPEVLEAHLLTGEYDYLIKVAVAGTEGYEEFLRHKLYKLPGLRHSH
STFVLRTLKRELSVAP
>Mature_176_residues
MNCLLSVEFKDYPSVAKTLLMPTIPKLDDVDRRILRELRRDGRLSNAKLAEHVGLSATPCWNRVRALEESGVIEGYAALL
NQKALGLPDTVLIEVTLDRHDDDMLHRFGQALAELPEVLEAHLLTGEYDYLIKVAVAGTEGYEEFLRHKLYKLPGLRHSH
STFVLRTLKRELSVAP

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes [H]

COG id: COG1522

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=144, Percent_Identity=43.0555555555556, Blast_Score=127, Evalue=3e-31,
Organism=Escherichia coli, GI87081742, Length=148, Percent_Identity=37.8378378378378, Blast_Score=112, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 19899; Mature: 19899

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNCLLSVEFKDYPSVAKTLLMPTIPKLDDVDRRILRELRRDGRLSNAKLAEHVGLSATPC
CCCEEEECCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCH
WNRVRALEESGVIEGYAALLNQKALGLPDTVLIEVTLDRHDDDMLHRFGQALAELPEVLE
HHHHHHHHHCCCHHHHHHHHCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHH
AHLLTGEYDYLIKVAVAGTEGYEEFLRHKLYKLPGLRHSHSTFVLRTLKRELSVAP
HHHCCCCCCEEEEEEEECCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNCLLSVEFKDYPSVAKTLLMPTIPKLDDVDRRILRELRRDGRLSNAKLAEHVGLSATPC
CCCEEEECCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCH
WNRVRALEESGVIEGYAALLNQKALGLPDTVLIEVTLDRHDDDMLHRFGQALAELPEVLE
HHHHHHHHHCCCHHHHHHHHCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHH
AHLLTGEYDYLIKVAVAGTEGYEEFLRHKLYKLPGLRHSHSTFVLRTLKRELSVAP
HHHCCCCCCEEEEEEEECCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]