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The map label for this gene is metR [H]

Identifier: 73538074

GI number: 73538074

Start: 897615

End: 898535

Strand: Reverse

Name: metR [H]

Synonym: Reut_B4244

Alternate gene names: 73538074

Gene position: 898535-897615 (Counterclockwise)

Preceding gene: 73538077

Following gene: 73538072

Centisome position: 32.96

GC content: 67.21

Gene sequence:

>921_bases
ATGATCGAGGTCCGGCATTTACGCTCGCTGGTGGCCATCGCCGAATCCGGCAAGCTGGCTACCGCCGCCGAGCGCGTTCA
CGTGAGCCAGTCAGCGCTGTCTCACCAGATCAAGGCGATCGAGGCGCACTACGGCCTGCCGCTGTTCGACCGCACGCGGC
AGGGGTTACGGTTCACGCCAGCTGGCGAGCGCCTGCTGGCCTTGGCGCGCGAGGTGCTCGCGGCGGTGAGCGAGGCGGAT
CGGGATATCGAACGGCTCAAGGGTGACACGCGCGGCGAGCTGCGCGTCGTGCTGGAGTGCCACACCTGCTTTGACTGGCT
GATGCCGGTGATGGACGAGTTCCGCCGGCGCTGGCCCGAAGTGGAGGTCGACCTTGTGGCGGGCTTCCACGCGGACCCGA
TCGCGTTGATCGGCGAGGGGCGTGCAGACATGGTGATTGGTTCATTGCCGGCCACGCGTCGCGGGCTGGAAGTGGCGCCG
CTGTTCCGCTTCGAGATTCTTGCGGTCATGGCTAACGAGCACCGGCTGCGCAACAAGCGCCGCATCGAAGCCGCTGACCT
GGAGGGCGAGACGCTGATCACCTATCCCGTGCCCGAGCAACGCATCGACCTGATCCGGGAAGTGCTGGAGCCCGCCGGCA
TCCGCCTGCAGCGCCGCACCGCCGAGTTGACGGTGGCCGTGCTGCAACTCGTGGCAAGCCGTCGCGGCGTCGCGGCGTTG
CCAAACTGGGGTGTGAAGAACTACGTCGATCACGACTACGTGCTGGCCAAGCGAATCGGGGCGCGGGGCCTGTGGAGCGA
GCTGTACGCCACGGTTCCCGCCGCCATCTCGCAGCGGCCGTATGTGGCGGATTTCGTGGCGATCGTCCGCGATATCTGCG
CGGCGCAGCTCGACGGCATCGAACTGCTTGCGCCTGCCTGA

Upstream 100 bases:

>100_bases
GTCGGTTTCACCGTAAAATGAATCAAGCGACAAGTTTTAAACAAAGTATGAATGAATTTCATATCACCCGAAGCCACAAT
GAAACGGGCAGGGTCACGTC

Downstream 100 bases:

>100_bases
GCGAATCGGTCAGGCGTGCAGGGCTACGGCAGGCATGAAAGCGGGGAGTGCGGGAGCGCTTTTGTCGACTGCCTCATCGA
GATCGTCGTCGCCGAAATCC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MIEVRHLRSLVAIAESGKLATAAERVHVSQSALSHQIKAIEAHYGLPLFDRTRQGLRFTPAGERLLALAREVLAAVSEAD
RDIERLKGDTRGELRVVLECHTCFDWLMPVMDEFRRRWPEVEVDLVAGFHADPIALIGEGRADMVIGSLPATRRGLEVAP
LFRFEILAVMANEHRLRNKRRIEAADLEGETLITYPVPEQRIDLIREVLEPAGIRLQRRTAELTVAVLQLVASRRGVAAL
PNWGVKNYVDHDYVLAKRIGARGLWSELYATVPAAISQRPYVADFVAIVRDICAAQLDGIELLAPA

Sequences:

>Translated_306_residues
MIEVRHLRSLVAIAESGKLATAAERVHVSQSALSHQIKAIEAHYGLPLFDRTRQGLRFTPAGERLLALAREVLAAVSEAD
RDIERLKGDTRGELRVVLECHTCFDWLMPVMDEFRRRWPEVEVDLVAGFHADPIALIGEGRADMVIGSLPATRRGLEVAP
LFRFEILAVMANEHRLRNKRRIEAADLEGETLITYPVPEQRIDLIREVLEPAGIRLQRRTAELTVAVLQLVASRRGVAAL
PNWGVKNYVDHDYVLAKRIGARGLWSELYATVPAAISQRPYVADFVAIVRDICAAQLDGIELLAPA
>Mature_306_residues
MIEVRHLRSLVAIAESGKLATAAERVHVSQSALSHQIKAIEAHYGLPLFDRTRQGLRFTPAGERLLALAREVLAAVSEAD
RDIERLKGDTRGELRVVLECHTCFDWLMPVMDEFRRRWPEVEVDLVAGFHADPIALIGEGRADMVIGSLPATRRGLEVAP
LFRFEILAVMANEHRLRNKRRIEAADLEGETLITYPVPEQRIDLIREVLEPAGIRLQRRTAELTVAVLQLVASRRGVAAL
PNWGVKNYVDHDYVLAKRIGARGLWSELYATVPAAISQRPYVADFVAIVRDICAAQLDGIELLAPA

Specific function: Control of the last step in methionine biosynthesis; metR is a positive activator of the metA, metE and metH genes [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790262, Length=291, Percent_Identity=40.5498281786942, Blast_Score=231, Evalue=6e-62,
Organism=Escherichia coli, GI1787879, Length=195, Percent_Identity=32.8205128205128, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI157672245, Length=213, Percent_Identity=29.5774647887324, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1790208, Length=154, Percent_Identity=32.4675324675325, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1788887, Length=301, Percent_Identity=26.2458471760797, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1786401, Length=154, Percent_Identity=31.1688311688312, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87081904, Length=270, Percent_Identity=28.5185185185185, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1790399, Length=194, Percent_Identity=31.4432989690722, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI145693105, Length=243, Percent_Identity=25.5144032921811, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1789506, Length=184, Percent_Identity=23.9130434782609, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1787806, Length=169, Percent_Identity=27.810650887574, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1788748, Length=121, Percent_Identity=31.404958677686, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1787530, Length=202, Percent_Identity=25.7425742574257, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI1787589, Length=127, Percent_Identity=30.7086614173228, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1789173, Length=121, Percent_Identity=32.2314049586777, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI87082024, Length=269, Percent_Identity=22.6765799256506, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1786713, Length=99, Percent_Identity=30.3030303030303, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1787601, Length=147, Percent_Identity=25.1700680272109, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34138; Mature: 34138

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEVRHLRSLVAIAESGKLATAAERVHVSQSALSHQIKAIEAHYGLPLFDRTRQGLRFTP
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCEECC
AGERLLALAREVLAAVSEADRDIERLKGDTRGELRVVLECHTCFDWLMPVMDEFRRRWPE
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCC
VEVDLVAGFHADPIALIGEGRADMVIGSLPATRRGLEVAPLFRFEILAVMANEHRLRNKR
CEEEEEECCCCCCEEEEECCCHHEEEECCCCCCCCCEECHHHHHHHHHHHHHHHHHHHHH
RIEAADLEGETLITYPVPEQRIDLIREVLEPAGIRLQRRTAELTVAVLQLVASRRGVAAL
CCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHCCCCCCC
PNWGVKNYVDHDYVLAKRIGARGLWSELYATVPAAISQRPYVADFVAIVRDICAAQLDGI
CCCCCHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCC
ELLAPA
EEECCC
>Mature Secondary Structure
MIEVRHLRSLVAIAESGKLATAAERVHVSQSALSHQIKAIEAHYGLPLFDRTRQGLRFTP
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCEECC
AGERLLALAREVLAAVSEADRDIERLKGDTRGELRVVLECHTCFDWLMPVMDEFRRRWPE
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCC
VEVDLVAGFHADPIALIGEGRADMVIGSLPATRRGLEVAPLFRFEILAVMANEHRLRNKR
CEEEEEECCCCCCEEEEECCCHHEEEECCCCCCCCCEECHHHHHHHHHHHHHHHHHHHHH
RIEAADLEGETLITYPVPEQRIDLIREVLEPAGIRLQRRTAELTVAVLQLVASRRGVAAL
CCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHCCCCCCC
PNWGVKNYVDHDYVLAKRIGARGLWSELYATVPAAISQRPYVADFVAIVRDICAAQLDGI
CCCCCHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCC
ELLAPA
EEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]