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The map label for this gene is ribBA [H]

Identifier: 73538071

GI number: 73538071

Start: 895870

End: 896466

Strand: Reverse

Name: ribBA [H]

Synonym: Reut_B4241

Alternate gene names: 73538071

Gene position: 896466-895870 (Counterclockwise)

Preceding gene: 73538072

Following gene: 73538070

Centisome position: 32.88

GC content: 62.98

Gene sequence:

>597_bases
ATGAACGACACAGAGATTGCGCTGATCGATTCAGCGCGCCTGCCGACCCGATTCGGCGAATTTACCGCTCACGCTTTCAA
AGGCGTGGACTCGGGCATCGAGCACCTTGCCCTCAGCGTGGGGGACATCACGGGCGAAGATGTGCTGATTCGCATGCACT
CGGAGTGCCTGACCGGTGATGTGTTCGGCTCGTGCCGCTGTGACTGCGGTCCCCAGCTCGAACTGGCGATGGAGAAGATC
GCCGCCGAAGGCCGCGGCATCCTGCTGTACCTGCGCGGCCACGAAGGCCGGGGAATCGGCCTGGCGGAGAAGATCCGTGC
CTATGCGCTGCAGGACACCGGCCTCGACACGGTCGATGCCAATCTTGCCCTCGGCCAGGCCATCGACGCCCGCAACTACG
CGTTTGCCGCCGACCTGCTGCATCAGTGGGGCGTGAAGTCCGTGCGCCTGATGAGCAACAACCCGCTCAAGGCTGCGGCG
CTGGAGAAGGCCGGCATCGTCGTGAAGGAGCAGCTGCGGCACATCGTGCCGTCGAATGCCGAGAACGAAAAATATCTGGC
GACCAAGCGGTCGCGAATGGGACATTTGCTGGATTGA

Upstream 100 bases:

>100_bases
AGGTGCCTGCCGGCGGGGTCGGCAAGCGTAAAGATACAATTCCGCTCATAATGTCGAGCGGTGCCGGCCCGGCCGGCTCC
CGATCTTCTTGAATACCGGT

Downstream 100 bases:

>100_bases
GTTTGGTCGGCCGGCACGTGCCGGTCGACATAGCAAGGATTGGACGCCCTTGGGTTTTGCCCAGGGGCGTTGTCATTTCA
TGGTTAGACGGTTTGCAATT

Product: GTP cyclohydrolase II

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 198; Mature: 198

Protein sequence:

>198_residues
MNDTEIALIDSARLPTRFGEFTAHAFKGVDSGIEHLALSVGDITGEDVLIRMHSECLTGDVFGSCRCDCGPQLELAMEKI
AAEGRGILLYLRGHEGRGIGLAEKIRAYALQDTGLDTVDANLALGQAIDARNYAFAADLLHQWGVKSVRLMSNNPLKAAA
LEKAGIVVKEQLRHIVPSNAENEKYLATKRSRMGHLLD

Sequences:

>Translated_198_residues
MNDTEIALIDSARLPTRFGEFTAHAFKGVDSGIEHLALSVGDITGEDVLIRMHSECLTGDVFGSCRCDCGPQLELAMEKI
AAEGRGILLYLRGHEGRGIGLAEKIRAYALQDTGLDTVDANLALGQAIDARNYAFAADLLHQWGVKSVRLMSNNPLKAAA
LEKAGIVVKEQLRHIVPSNAENEKYLATKRSRMGHLLD
>Mature_198_residues
MNDTEIALIDSARLPTRFGEFTAHAFKGVDSGIEHLALSVGDITGEDVLIRMHSECLTGDVFGSCRCDCGPQLELAMEKI
AAEGRGILLYLRGHEGRGIGLAEKIRAYALQDTGLDTVDANLALGQAIDARNYAFAADLLHQWGVKSVRLMSNNPLKAAA
LEKAGIVVKEQLRHIVPSNAENEKYLATKRSRMGHLLD

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1787533, Length=195, Percent_Identity=52.8205128205128, Blast_Score=192, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6319438, Length=196, Percent_Identity=40.8163265306122, Blast_Score=127, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 21498; Mature: 21498

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDTEIALIDSARLPTRFGEFTAHAFKGVDSGIEHLALSVGDITGEDVLIRMHSECLTGD
CCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHCCC
VFGSCRCDCGPQLELAMEKIAAEGRGILLYLRGHEGRGIGLAEKIRAYALQDTGLDTVDA
CCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCC
NLALGQAIDARNYAFAADLLHQWGVKSVRLMSNNPLKAAALEKAGIVVKEQLRHIVPSNA
CHHHCCHHCCCCHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHCCHHHHHHHHHHCCCCC
ENEKYLATKRSRMGHLLD
CCCHHHHHHHHHCCCCCC
>Mature Secondary Structure
MNDTEIALIDSARLPTRFGEFTAHAFKGVDSGIEHLALSVGDITGEDVLIRMHSECLTGD
CCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHCCC
VFGSCRCDCGPQLELAMEKIAAEGRGILLYLRGHEGRGIGLAEKIRAYALQDTGLDTVDA
CCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCC
NLALGQAIDARNYAFAADLLHQWGVKSVRLMSNNPLKAAALEKAGIVVKEQLRHIVPSNA
CHHHCCHHCCCCHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHCCHHHHHHHHHHCCCCC
ENEKYLATKRSRMGHLLD
CCCHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA