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The map label for this gene is hisA [H]

Identifier: 73542790

GI number: 73542790

Start: 3414326

End: 3415072

Strand: Reverse

Name: hisA [H]

Synonym: Reut_A3106

Alternate gene names: 73542790

Gene position: 3415072-3414326 (Counterclockwise)

Preceding gene: 73542791

Following gene: 73542789

Centisome position: 89.72

GC content: 62.52

Gene sequence:

>747_bases
ATGTTGCTCATTCCGGCCATCGACCTGAAGGACGGTCAGTGTGTACGCCTCAAACAAGGCGACATGGACCAGGCCACCGT
CTTTTCCGAAGATCCCGCCGCCATGGCACGCCATTGGGTCAATCAAGGGGCGCGCCGCCTGCACTTGGTCGATCTCAACG
GTGCATTTGTCGGCAAGCCCCGCAATGAAGCCGCCATCAAGGCCATCATCGCCGAGGTCGGCGACGAGATCCCGGTGCAG
CTCGGCGGTGGCATCCGCGACCTGAACACCATCGAACGGTGGCTGGACGACGGCCTGTCGTACGTCATCATCGGCACCGC
GGCGGTGAAGAACCCCGGTTTCCTGAAGGATGCCTGCTCGGCGTTCGGCGGTCACATCATCGTCGGACTCGATGCCAAGG
ACGGCAAGGTGGCGACCGACGGCTGGAGCAAGCTGACCGGCCACGAGGTGGCGGACCTGGCACGCAAGTACGAAGACTAC
GGCGTGGAGGCCATCATCTATACCGACATCGGACGCGACGGCATGCTGCAAGGGATCAATATCGATGCCACCGTCAAGCT
GGCGCAGTCGATGTCGATCCCGGTAATTGCCAGCGGCGGCCTGTCCAACCTGGCCGATATCGACAACCTGTGCGCCGTGG
AGAACGAAGGCGTGGAAGGCGTCATCTGCGGCCGTGCCATCTACTCCGGCGATCTCAACTTCACCGACGCGCAGGCGCGT
GCGGACAAGCTGAGCAACGGGGAATAA

Upstream 100 bases:

>100_bases
CAGCCAACGCCATTCTGGAATACTTGCCTATTGACCCGGACTGACCGGCCACTGGCCGGGCTGGCTCTATCTCTCTCACT
CAACCACGCTCGTCACGATT

Downstream 100 bases:

>100_bases
GCCAACGCGCCCCGCGGGGCGCTGCCACCGCCAGGCTGCTACCGGTCTCGCGGCGGACAAGGAATCTCATGCTAGCCAAA
CGTATCATCCCCTGCCTCGA

Product: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase [H]

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MLLIPAIDLKDGQCVRLKQGDMDQATVFSEDPAAMARHWVNQGARRLHLVDLNGAFVGKPRNEAAIKAIIAEVGDEIPVQ
LGGGIRDLNTIERWLDDGLSYVIIGTAAVKNPGFLKDACSAFGGHIIVGLDAKDGKVATDGWSKLTGHEVADLARKYEDY
GVEAIIYTDIGRDGMLQGINIDATVKLAQSMSIPVIASGGLSNLADIDNLCAVENEGVEGVICGRAIYSGDLNFTDAQAR
ADKLSNGE

Sequences:

>Translated_248_residues
MLLIPAIDLKDGQCVRLKQGDMDQATVFSEDPAAMARHWVNQGARRLHLVDLNGAFVGKPRNEAAIKAIIAEVGDEIPVQ
LGGGIRDLNTIERWLDDGLSYVIIGTAAVKNPGFLKDACSAFGGHIIVGLDAKDGKVATDGWSKLTGHEVADLARKYEDY
GVEAIIYTDIGRDGMLQGINIDATVKLAQSMSIPVIASGGLSNLADIDNLCAVENEGVEGVICGRAIYSGDLNFTDAQAR
ADKLSNGE
>Mature_248_residues
MLLIPAIDLKDGQCVRLKQGDMDQATVFSEDPAAMARHWVNQGARRLHLVDLNGAFVGKPRNEAAIKAIIAEVGDEIPVQ
LGGGIRDLNTIERWLDDGLSYVIIGTAAVKNPGFLKDACSAFGGHIIVGLDAKDGKVATDGWSKLTGHEVADLARKYEDY
GVEAIIYTDIGRDGMLQGINIDATVKLAQSMSIPVIASGGLSNLADIDNLCAVENEGVEGVICGRAIYSGDLNFTDAQAR
ADKLSNGE

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family [H]

Homologues:

Organism=Escherichia coli, GI87082028, Length=245, Percent_Identity=35.1020408163265, Blast_Score=134, Evalue=4e-33,
Organism=Escherichia coli, GI1788336, Length=248, Percent_Identity=24.1935483870968, Blast_Score=69, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00977 His_biosynth [H]

EC number: =5.3.1.16 [H]

Molecular weight: Translated: 26335; Mature: 26335

Theoretical pI: Translated: 4.45; Mature: 4.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLIPAIDLKDGQCVRLKQGDMDQATVFSEDPAAMARHWVNQGARRLHLVDLNGAFVGKP
CEEEEEEECCCCCEEEEECCCCCCEEEECCCHHHHHHHHHHCCCCEEEEEECCCEEECCC
RNEAAIKAIIAEVGDEIPVQLGGGIRDLNTIERWLDDGLSYVIIGTAAVKNPGFLKDACS
CCHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHCCCEEEEEEEEECCCCCCHHHHHH
AFGGHIIVGLDAKDGKVATDGWSKLTGHEVADLARKYEDYGVEAIIYTDIGRDGMLQGIN
HCCCEEEEEEECCCCEEECCCCHHCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCEECCC
IDATVKLAQSMSIPVIASGGLSNLADIDNLCAVENEGVEGVICGRAIYSGDLNFTDAQAR
CCCEEEEHHHCCCCEEECCCCCCHHHHHHHHEECCCCCCEEEECCEEEECCCCCCHHHHH
ADKLSNGE
HHHCCCCC
>Mature Secondary Structure
MLLIPAIDLKDGQCVRLKQGDMDQATVFSEDPAAMARHWVNQGARRLHLVDLNGAFVGKP
CEEEEEEECCCCCEEEEECCCCCCEEEECCCHHHHHHHHHHCCCCEEEEEECCCEEECCC
RNEAAIKAIIAEVGDEIPVQLGGGIRDLNTIERWLDDGLSYVIIGTAAVKNPGFLKDACS
CCHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHCCCEEEEEEEEECCCCCCHHHHHH
AFGGHIIVGLDAKDGKVATDGWSKLTGHEVADLARKYEDYGVEAIIYTDIGRDGMLQGIN
HCCCEEEEEEECCCCEEECCCCHHCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCEECCC
IDATVKLAQSMSIPVIASGGLSNLADIDNLCAVENEGVEGVICGRAIYSGDLNFTDAQAR
CCCEEEEHHHCCCCEEECCCCCCHHHHHHHHEECCCCCCEEEECCEEEECCCCCCHHHHH
ADKLSNGE
HHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA